From pulsus to pulseless: the saga of cardiac alternans.

abstract：:The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in liv...

journal_title：Circulation research

authors： Soeller C,Cannell MB

更新日期：1999-02-19 00:00:00

abstract：:In newborn lambs, pulmonary prostacyclin (PGI2) production increases acutely in response to low oxygen. We tested the hypothesis that decreased oxygenation directly stimulates PGI2 synthesis in arterial segments and cultured endothelial cells from newborn lamb intrapulmonary arteries. In segments studied at PO2 of 680...

journal_title：Circulation research

authors： North AJ,Brannon TS,Wells LB,Campbell WB,Shaul PW

更新日期：1994-07-01 00:00:00

abstract：RATIONALE:Macrophages are essential regulators of atherosclerosis. They secrete cytokines, process lipoproteins and cholesterol, and take up apoptotic cells. Multiple subsets of plaque macrophages exist and their differential roles are emerging. OBJECTIVE:Here, we explore macrophage heterogeneity in atherosclerosis pl...

journal_title：Circulation research

authors： McArdle S,Buscher K,Ghosheh Y,Pramod AB,Miller J,Winkels H,Wolf D,Ley K

更新日期：2019-12-06 00:00:00

abstract：:The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow patterns are important factors in atherosclerosis. Although disturbed flows in the branches and curved regions are proatherogenic, laminar flows in the straight parts are atheroprotective. Results from in vitro studies on c...

journal_title：Circulation research

authors： Shyy JY,Chien S

更新日期：2002-11-01 00:00:00

abstract：:We have recently characterized the promoter region of the rabbit embryonic smooth muscle myosin heavy chain (SMemb/NMHC-B) gene and identified the 15-bp sequence, designated SE1, located at -105 from the transcriptional start site as an important regulatory element for its transcriptional activity in a smooth muscle c...

journal_title：Circulation research

authors： Watanabe N,Kurabayashi M,Shimomura Y,Kawai-Kowase K,Hoshino Y,Manabe I,Watanabe M,Aikawa M,Kuro-o M,Suzuki T,Yazaki Y,Nagai R

更新日期：1999-07-23 00:00:00

abstract：:Brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are novel natriuretic peptides, originally isolated from porcine brain. Similar to atrial natriuretic peptide (ANP), BNP is also synthesized in and secreted from cardiocytes, but CNP is not expressed at significant levels in normal adult myocardium. ...

journal_title：Circulation research

authors： Takahashi T,Allen PD,Izumo S

更新日期：1992-07-01 00:00:00

abstract：:Cardiac allograft vasculopathy (CAV) continues to be a major cause of late graft failure after cardiac transplantation. We have demonstrated that Rho-kinase, an effector of the small GTPase Rho, plays an important role in the pathogenesis of arteriosclerosis. In this study, we examined whether the Rho-kinase-mediated ...

journal_title：Circulation research

authors： Hattori T,Shimokawa H,Higashi M,Hiroki J,Mukai Y,Kaibuchi K,Takeshita A

更新日期：2004-01-09 00:00:00

abstract：:Increased glomerular capillary hydrostatic pressure (PGC) is an important hemodynamic determinant of glomerular injury, but the molecular events responsible for this association are poorly understood. PGC is normal in spontaneously hypertensive rats (SHR), but uninephrectomy leads to an increase in PGC and accelerated...

journal_title：Circulation research

authors： Shankland SJ,Ly H,Thai K,Scholey JW

更新日期：1994-11-01 00:00:00

abstract：RATIONALE:Obesity leads to increased ischemic heart disease (IHD) risk, but the risk is thought to be mediated through intermediate variables and may not be caused by increased weight per se. OBJECTIVE:To test the hypothesis that the increased IHD risk because of obesity is mediated through lipoproteins, blood pressur...

journal_title：Circulation research

authors： Varbo A,Benn M,Smith GD,Timpson NJ,Tybjaerg-Hansen A,Nordestgaard BG

更新日期：2015-02-13 00:00:00

abstract：:Although peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have an antihypertensive effect in vivo, the precise mechanism has not been fully elucidated. We examined their effects on Rho/Rho kinase pathway, a key regulator of vascular tone. In cultured rat aortic smooth muscle cells (RASMC), Rho kina...

journal_title：Circulation research

authors： Wakino S,Hayashi K,Kanda T,Tatematsu S,Homma K,Yoshioka K,Takamatsu I,Saruta T

更新日期：2004-09-03 00:00:00

abstract：RATIONALE:The embryonic epicardium is a crucial cell source of the cardiac fibrous skeleton as well as of the coronary system. Genetic lineage tracing systems based on Wt1 regulatory sequences provided evidence that epicardium-derived cells also adopt a myocardial fate in the mouse. OBJECTIVE:To define the adequacy of...

journal_title：Circulation research

authors： Rudat C,Kispert A

更新日期：2012-07-06 00:00:00

abstract：:The small (21 kDa) guanine nucleotide-binding protein (small G protein) superfamily comprises 5 subfamilies (Ras, Rho, ADP ribosylation factors [ARFs], Rab, and Ran) that act as molecular switches to regulate numerous cellular responses. Cardiac myocyte hypertrophy is associated with cell growth and changes in the cyt...

journal_title：Circulation research

authors： Clerk A,Sugden PH

更新日期：2000-05-26 00:00:00

abstract：:CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation. CD40 has recently been described on platelets but platelet activation by CD40 has not been descr...

journal_title：Circulation research

authors： Inwald DP,McDowall A,Peters MJ,Callard RE,Klein NJ

更新日期：2003-05-16 00:00:00

abstract：:Vagal afferents from the cardiopulmonary region exert a tonic inhibition on the vasomotor center. This is demonstrated by constriction of systemic resistance and splanchnic capacitance vessels and by increased output of renin when the vagi are cut or blocked. In dogs, removal or selective denervation of organs showed ...

journal_title：Circulation research

authors： Thorén PN,Donald DE,Shepherd JT

更新日期：1976-06-01 00:00:00

abstract：:Effects of concentrations of intracellular calcium, [Ca2+]i, on the voltage-dependent Ca2+ current (ICa) recorded from dispersed single smooth muscle cells of the rabbit portal vein were studied, using a whole cell voltage clamp method combined with an intracellular perfusion technique. Outward currents were minimized...

journal_title：Circulation research

authors： Ohya Y,Kitamura K,Kuriyama H

更新日期：1988-02-01 00:00:00

abstract：:The synthesis of an angiotensin II (A II) antagonist, sarcosyl1-cysteinyl(S-methyl)8-angiotensin II [Sar1-Cys(Me)8-A II], showing partial organ selectivity and properties of a noncompetitive antagonist, is described. The compound was found to be an extremely potent antagonist on vascular smooth muscle both in vitro (p...

journal_title：Circulation research

authors： Freer RJ,Sutherland JC Jr,Day AR

更新日期：1980-05-01 00:00:00

abstract：RATIONALE:GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, an inflammatory disease associated with increased cardiovascular risk, provides a model to study inflammatory biomarkers in cardiovascular disease (CVD). Whether GlycA associates with psoriasis a...

journal_title：Circulation research

authors： Joshi AA,Lerman JB,Aberra TM,Afshar M,Teague HL,Rodante JA,Krishnamoorthy P,Ng Q,Aridi TZ,Salahuddin T,Natarajan B,Lockshin BN,Ahlman MA,Chen MY,Rader DJ,Reilly MP,Remaley AT,Bluemke DA,Playford MP,Gelfand JM,Meht

更新日期：2016-11-11 00:00:00

abstract：:It has been proposed that lipopolysaccharide (LPS) bound to the 60-kD LPS binding protein (LBP) forms an LPS/LBP complex that, in turn, binds to the CD14 receptor on monocytes/macrophages and stimulates the release of cytokines. We examined the role of LBP and CD14 in tumor necrosis factor-alpha (TNF-alpha) production...

journal_title：Circulation research

authors： Ishii Y,Wang Y,Haziot A,del Vecchio PJ,Goyert SM,Malik AB

更新日期：1993-07-01 00:00:00

abstract：:Studies were carried out to determine the contribution of cardiopulmonary receptors to the renal responses to head-out water immersion in the nonhuman primate. Immersion to the suprasternal notch was associated with significant increases in central venous pressure, urine flow, and sodium excretion. The increased sodiu...

journal_title：Circulation research

authors： Gilmore JP,Zucker IH

更新日期：1978-02-01 00:00:00

abstract：:In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate....

journal_title：Circulation research

authors： Taegtmeyer H,Young ME,Lopaschuk GD,Abel ED,Brunengraber H,Darley-Usmar V,Des Rosiers C,Gerszten R,Glatz JF,Griffin JL,Gropler RJ,Holzhuetter HG,Kizer JR,Lewandowski ED,Malloy CR,Neubauer S,Peterson LR,Portman MA,Recch

更新日期：2016-05-13 00:00:00

abstract：:Complete knowledge of myocardial structure, metabolism, and function is crucial to understanding the response of the heart to injury such as ischemia. Increasingly, this type of knowledge is required at multiple levels, from that of the isolated myocyte to the functioning organism, to provide basic scientists and clin...

journal_title：Circulation research

authors： Wu KC,Lima JA

更新日期：2003-12-12 00:00:00

abstract：RATIONALE:G protein-coupled receptor kinase 2 (GRK2) is abundantly expressed in the heart, and its expression and activity are increased in injured or stressed myocardium. This upregulation has been shown to be pathological. GRK2 can promote cell death in ischemic myocytes, and its inhibition by a peptide comprising th...

journal_title：Circulation research

authors： Chen M,Sato PY,Chuprun JK,Peroutka RJ,Otis NJ,Ibetti J,Pan S,Sheu SS,Gao E,Koch WJ

更新日期：2013-04-12 00:00:00

abstract：RATIONALE:The low-density lipoprotein (LDL) receptor (LDLR) is a central determinant of circulating LDL-cholesterol and as such subject to tight regulation. Recent studies and genetic evidence implicate the inducible degrader of the LDLR (IDOL) as a regulator of LDLR abundance and of circulating levels of LDL-cholester...

journal_title：Circulation research

authors： Nelson JK,Sorrentino V,Avagliano Trezza R,Heride C,Urbe S,Distel B,Zelcer N

更新日期：2016-02-05 00:00:00

abstract：:E1A can evoke G1 exit in cardiac myocytes and other cell types by displacing E2F transcription factors from tumor suppressor "pocket" proteins and by a less well-characterized p300-dependent pathway. Bypassing pocket proteins (through overexpression of E2F-1) reproduces the effect of inactivating pocket proteins (thro...

journal_title：Circulation research

authors： Akli S,Zhan S,Abdellatif M,Schneider MD

更新日期：1999-08-20 00:00:00

abstract：RATIONALE:ATP-binding cassette transporter A1 (ABCA1) plays a critical role in eliminating excess free cholesterol from tissues by effluxing cellular free cholesterol and phospholipids to lipid-poor apolipoprotein AI. Macrophage ABCA1 also dampens proinflammatory myeloid differentiation primary-response protein 88-depe...

journal_title：Circulation research

authors： Zhu X,Westcott MM,Bi X,Liu M,Gowdy KM,Seo J,Cao Q,Gebre AK,Fessler MB,Hiltbold EM,Parks JS

更新日期：2012-11-09 00:00:00

abstract：:We hypothesized that a redox-sensitive transcription factor, redox factor-1 (Ref-1) (HAP1, APE, and APEX), was critical in the regulation of endothelial cell survival in response to hypoxia and cytokines, including tumor necrosis factor (TNF)-alpha. Hypoxia resulted in a significant decrease in Ref-1 protein expressio...

journal_title：Circulation research

authors： Hall JL,Wang X,Van Adamson,Zhao Y,Gibbons GH

更新日期：2001-06-22 00:00:00

abstract：RATIONALE:The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cells make important contributions to OFT formation and aortic arch remodeling. Although numerous signal...

journal_title：Circulation research

authors： Singh N,Trivedi CM,Lu M,Mullican SE,Lazar MA,Epstein JA

更新日期：2011-11-11 00:00:00

abstract：:Mitogen-activated protein kinase kinase (MKK)4 is a critical member of the mitogen-activated protein kinase family. It is able to activate the c-Jun NH(2)-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase in response to environmental stresses. JNK and p38 are strongly implicated in pathological ca...

journal_title：Circulation research

authors： Liu W,Zi M,Jin J,Prehar S,Oceandy D,Kimura TE,Lei M,Neyses L,Weston AH,Cartwright EJ,Wang X

更新日期：2009-04-10 00:00:00

abstract：:A series of new phenylethanolamines with 2-methoxy and/or 4-methyl, 4-chloro, or 4-bromo ring substituents and either N-isopropyl or N-tert butyl substituents have been synthesized and tested for beta 1- and beta 2-adrenoceptor blocking activity using isolated guinea pig atrial and tracheal preparations. Each of the d...

journal_title：Circulation research

authors： Letts LG,Temple DM,Williams LR

更新日期：1980-06-01 00:00:00

abstract：:The major goal of this study was to determine the interactions of VLDL surface and core lipids with the artery wall. We first demonstrated in vitro that surface lipid in VLDL could be traced using the phospholipid-like fluorescent probe 1,1'-dioctadecyl-3,3, 3',3'-tetramethyl-indocarbocyanine (DiI). The core of VLDL p...

journal_title：Circulation research

authors： Rutledge JC,Mullick AE,Gardner G,Goldberg IJ

更新日期：2000-04-14 00:00:00