Dilated Cardiomyopathy: Genetic Determinants and Mechanisms.

Abstract:

:Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of the large number of genes and alleles attributed to DCM, comprehensive genetic testing encompasses ever-increasing gene panels. Genetic diagnosis can help predict prognosis, especially with regard to arrhythmia risk for certain subtypes. Moreover, cascade genetic testing in family members can identify those who are at risk or with early stage disease, offering the opportunity for early intervention. This review will address diagnosis and management of DCM, including the role of genetic evaluation. We will also overview distinct genetic pathways linked to DCM and their pathogenetic mechanisms. Historically, cardiac morphology has been used to classify cardiomyopathy subtypes. Determining genetic variants is emerging as an additional adjunct to help further refine subtypes of DCM, especially where arrhythmia risk is increased, and ultimately contribute to clinical management.

journal_name

Circ Res

journal_title

Circulation research

authors

McNally EM,Mestroni L

doi

10.1161/CIRCRESAHA.116.309396

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

731-748

issue

7

eissn

0009-7330

issn

1524-4571

pii

CIRCRESAHA.116.309396

journal_volume

121

pub_type

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