Role of a pertussis toxin-sensitive protein in the modulation of canine Purkinje fiber automaticity.

abstract：:We previously observed that stimulation of vascular smooth muscle cell (VSMC) proliferation with growth factors is associated with dismantling of cadherin junctions and nuclear translocation of beta-catenin. In this study we demonstrate directly that growth factors stimulate beta-catenin/T-cell factor (TCF) signaling ...

journal_title：Circulation research

authors： Quasnichka H,Slater SC,Beeching CA,Boehm M,Sala-Newby GB,George SJ

更新日期：2006-12-08 00:00:00

abstract：:Calcium channel blockers are among the most commonly used therapeutic drugs. Nevertheless, the utility of calcium channel blockers for heart disease is limited because of the potent vasodilatory effect that causes hypotension, and other side effects attributable to blockade of noncardiac channels. Therefore, focal cal...

journal_title：Circulation research

authors： Murata M,Cingolani E,McDonald AD,Donahue JK,Marbán E

更新日期：2004-08-20 00:00:00

abstract：:Previous studies have demonstrated that in adult rats with chronic hyponatremia, both symptoms of encephalopathy and mortality largely depend upon the gender of the animal and the presence of elevated plasma levels of vasopressin (AVP). Since effects of AVP on blood vessels may be gender dependent, the present study w...

journal_title：Circulation research

authors： Kozniewska E,Roberts TP,Vexler ZS,Oseka M,Kucharczyk J,Arieff AI

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodeling and cardiac hypertrophy. However, enhancement of particular aspects of cAMP/protein kinase A signaling seems to be beneficial for the failing heart. cAMP is a pleiotropic second messenger with t...

journal_title：Circulation research

authors： Zoccarato A,Surdo NC,Aronsen JM,Fields LA,Mancuso L,Dodoni G,Stangherlin A,Livie C,Jiang H,Sin YY,Gesellchen F,Terrin A,Baillie GS,Nicklin SA,Graham D,Szabo-Fresnais N,Krall J,Vandeput F,Movsesian M,Furlan L,Corse

更新日期：2015-09-25 00:00:00

abstract：:Nitrite has recently emerged as an important bioactive molecule, capable of conferring cardioprotection and a variety of other benefits in the cardiovascular system and elsewhere. The mechanisms by which it accomplishes these functions remain largely unclear. To characterize the dose response and corresponding cardiac...

journal_title：Circulation research

authors： Perlman DH,Bauer SM,Ashrafian H,Bryan NS,Garcia-Saura MF,Lim CC,Fernandez BO,Infusini G,McComb ME,Costello CE,Feelisch M

更新日期：2009-03-27 00:00:00

abstract：:The extracellular epicardial potential fields produced by simple depolarization waves in the in situ canine left ventricular myocardium were analyzed. A mathematical model that included tissue anisotrophy was developed to explain the observed fields. Values of intracellular (i), extracellular (o), longitudinal (l), an...

journal_title：Circulation research

authors： Roberts DE,Scher AM

更新日期：1982-03-01 00:00:00

abstract：:The mechanisms underlying the blunted contractile response to beta-adrenergic receptor (beta-AR) stimulation in heart failure (HF) are incompletely understood, especially with regard to beta-AR subtype-specific regulation of L-type Ca2+ channels. We evaluated the impact of HF induced by pacing tachycardia on beta-AR r...

journal_title：Circulation research

authors： He JQ,Balijepalli RC,Haworth RA,Kamp TJ

更新日期：2005-09-16 00:00:00

abstract：:Mitochondrial quality is a crucial determinant of cell viability, and mitochondrial autophagy plays a central role in this control mechanism. Based on studies in yeast, numerous investigations of this process have been conducted, and the framework of mammalian mitochondrial autophagy is progressively appearing. Howeve...

journal_title：Circulation research

authors： Saito T,Sadoshima J

更新日期：2015-04-10 00:00:00

abstract：:Ventricular arrhythmias that accompany myocardial infarction in dogs may be secondary to the altered electrophysiological properties of the subendocardial Purkinje fibers that survive 24 hours after the coronary occlusion. To better understand the ionic mechanisms that underlie the altered electrical activity of these...

journal_title：Circulation research

authors： Boyden PA,Albala A,Dresdner KP Jr

更新日期：1989-10-01 00:00:00

abstract：:Our goal in this review is to discuss the pathophysiology, diagnosis, and treatment of stroke caused by atherosclerosis of the major intracranial arteries. References for the review were identified by searching PubMed for related studies published from 1955 to June 2016 using search terms intracranial stenosis and int...

journal_title：Circulation research

authors： Banerjee C,Chimowitz MI

更新日期：2017-02-03 00:00:00

abstract：:Cardiac and arterial tissues of six male and six female adult baboons were examined for nuclear uptake of tritiated 5-alpha-dihydrotestosterone (3H-DHT) or tritiated estradiol-17 beta (3H-E2) by autoradiography. 3H-DHT uptake occurred in nuclei of most atrial and ventricular myocardial fibers, no cardiac interstitial ...

journal_title：Circulation research

authors： McGill HC Jr,Sheridan PJ

更新日期：1981-02-01 00:00:00

abstract：RATIONALE:Adoptive transfer of cardiac progenitor cells (CPCs) has entered clinical application, despite limited mechanistic understanding of the endogenous response after myocardial infarction (MI). Extracellular matrix undergoes dramatic changes after MI and therefore might be linked to CPC-mediated repair. OBJECTIV...

journal_title：Circulation research

authors： Konstandin MH,Toko H,Gastelum GM,Quijada P,De La Torre A,Quintana M,Collins B,Din S,Avitabile D,Völkers M,Gude N,Fässler R,Sussman MA

更新日期：2013-07-05 00:00:00

abstract：RATIONALE:Cardiac muscle adapts to increase workload by altering cardiomyocyte size and function resulting in cardiac hypertrophy. G protein-coupled receptor signaling is known to govern the hypertrophic response through the regulation of ion channel activity and downstream signaling in failing cardiomyocytes. OBJECTI...

journal_title：Circulation research

authors： Seth M,Zhang ZS,Mao L,Graham V,Burch J,Stiber J,Tsiokas L,Winn M,Abramowitz J,Rockman HA,Birnbaumer L,Rosenberg P

更新日期：2009-11-06 00:00:00

abstract：:Pharmacological evidence indicates that angiotensin (Ang II) converting enzyme inhibitors attenuate cardiovascular responses to sympathetic stimulation. To investigate the physiological significance of this attenuation, the pressor and heart rate responses to bilateral carotid occlusion (BCO) were studied before and a...

journal_title：Circulation research

authors： Isaacson JS,Reid IA

更新日期：1990-03-01 00:00:00

abstract：:Mechanisms of denervation supersensitivity to sympathomimetic amines were studied in conscious animals. Norepinephrine, 0.1 micrograms/kg, increased left ventricular dP/dt significantly more (4208 +/- 828 mm Hg/sec) in dogs with cardiac denervation than in intact dogs (1029 +/- 280 mm Hg/sec), P less than 0.01, wherea...

journal_title：Circulation research

authors： Vatner DE,Lavallee M,Amano J,Finizola A,Homcy CJ,Vatner SF

更新日期：1985-07-01 00:00:00

abstract：:To determine whether coronary vasodilator reserve that persists during myocardial ischemia is present in all left ventricular regions, we measured regional blood flow in 192 left ventricular pieces (mean weight, 201 mg) in each of eight dogs by using radioactive microspheres while perfusing the left main coronary arte...

journal_title：Circulation research

authors： Coggins DL,Flynn AE,Austin RE Jr,Aldea GS,Muehrcke D,Goto M,Hoffman JI

更新日期：1990-08-01 00:00:00

abstract：RATIONALE:Prospective cohort studies question the value of HDL-C (high-density lipoprotein cholesterol) for stroke risk prediction. OBJECTIVE:Investigate the relationship between long-term functional recovery and HDL proteome and function. METHODS AND RESULTS:Changes in HDL protein composition and function (cholester...

journal_title：Circulation research

authors： Plubell DL,Fenton AM,Rosario S,Bergstrom P,Wilmarth PA,Clark WM,Zakai NA,Quinn JF,Minnier J,Alkayed NJ,Fazio S,Pamir N

更新日期：2020-10-23 00:00:00

abstract：:During ischemia and reperfusion, with an increase in intracellular Na+ and a depolarized membrane potential, Ca2+ may enter the myocyte in exchange for intracellular Na+ via reverse-mode Na+-Ca2+ exchange (NCX). To test the role of Ca2+ entry via NCX during ischemia and reperfusion, we studied mice with cardiac-specif...

journal_title：Circulation research

authors： Imahashi K,Pott C,Goldhaber JI,Steenbergen C,Philipson KD,Murphy E

更新日期：2005-10-28 00:00:00

abstract：RATIONALE:There is a critical need to develop robust, mechanistic strategies to identify patients at increased risk of cancer therapeutics-related cardiac dysfunction (CTRCD). OBJECTIVE:We aimed to discover new biomarkers associated with doxorubicin- and trastuzumab-induced CTRCD using high-throughput proteomic profil...

journal_title：Circulation research

authors： Beer LA,Kossenkov AV,Liu Q,Luning Prak E,Domchek S,Speicher DW,Ky B

更新日期：2016-10-28 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombinant protein rhVEGF-B...

journal_title：Circulation research

authors： Silvestre JS,Tamarat R,Ebrahimian TG,Le-Roux A,Clergue M,Emmanuel F,Duriez M,Schwartz B,Branellec D,Lévy BI

更新日期：2003-07-25 00:00:00

abstract：:Endothelial cells release nitric oxide (NO) more potently in response to increased shear stress than to agonists which elevate intracellular free calcium concentration ([Ca2+]i). To determine mechanistic differences in the regulation of endothelial constitutive NO synthase (ecNOS), we measured NO production by bovine ...

journal_title：Circulation research

authors： Corson MA,James NL,Latta SE,Nerem RM,Berk BC,Harrison DG

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca(2+) channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule-sarcoplasmic reticulum anchoring...

journal_title：Circulation research

authors： Li RC,Tao J,Guo YB,Wu HD,Liu RF,Bai Y,Lv ZZ,Luo GZ,Li LL,Wang M,Yang HQ,Gao W,Han QD,Zhang YY,Wang XJ,Xu M,Wang SQ

更新日期：2013-02-15 00:00:00

abstract：:G-protein receptor kinase 2 (GRK2) is 1 of 7 mammalian GRKs that phosphorylate ligand-bound 7-transmembrane receptors, causing receptor uncoupling from G proteins and potentially activating non-G-protein signaling pathways. GRK2 is unique among members of the GRK family in that its genetic ablation causes embryonic le...

journal_title：Circulation research

authors： Matkovich SJ,Diwan A,Klanke JL,Hammer DJ,Marreez Y,Odley AM,Brunskill EW,Koch WJ,Schwartz RJ,Dorn GW 2nd

更新日期：2006-10-27 00:00:00

abstract：:Abnormalities of myocardial gap junction-mediated cell coupling have been implicated in cardiac arrhythmogenesis. The potential role of gap junctional dysfunction in the generation of reperfusion-induced arrhythmias is uncertain. The purpose of this study was to measure the effects of myocardial ischemia and reperfusi...

journal_title：Circulation research

authors： Kieval RS,Spear JF,Moore EN

更新日期：1992-07-01 00:00:00

abstract：RATIONALE:Cardiac myocyte-specific deletion of either glycogen synthase kinase (GSK)-3α and GSK-3β leads to cardiac protection after myocardial infarction, suggesting that deletion of both isoforms may provide synergistic protection. This is an important consideration because of the fact that all GSK-3-targeted drugs, ...

journal_title：Circulation research

authors： Zhou J,Ahmad F,Parikh S,Hoffman NE,Rajan S,Verma VK,Song J,Yuan A,Shanmughapriya S,Guo Y,Gao E,Koch W,Woodgett JR,Madesh M,Kishore R,Lal H,Force T

更新日期：2016-04-15 00:00:00

abstract：:The kinetics of contractions and Ca(2+) transients are slowed in myocytes from failing hearts. The mechanisms accounting for these abnormalities remain unclear. Myocardial infarction (MI) was produced by ligation of the circumflex artery in rabbits. We used confocal microscopy to record spatially resolved Ca(2+) trans...

journal_title：Circulation research

authors： Litwin SE,Zhang D,Bridge JH

更新日期：2000-11-24 00:00:00

abstract：:A variety of delivery systems have been used to genetically modify vascular endothelial cells and smooth muscle cells (SMCs), but currently available systems suffer from either inefficient in vivo gene transfer, transient episomal vector expression, or significant immune responses and inflammation. In the present stud...

journal_title：Circulation research

authors： Lynch CM,Hara PS,Leonard JC,Williams JK,Dean RH,Geary RL

更新日期：1997-04-01 00:00:00

abstract：:To delineate more clearly the importance of altered monovalent cation transport rate in the mediation of the positive inotropic effects of cardiac glycosides, we studied changes in the contractile state and rate of uptake of K+ and Rb+ by monolayer cultures of chick embryo ventricular cells during exposure to and wash...

journal_title：Circulation research

authors： Barry WH,Biedert S,Miura DS,Smith TW

更新日期：1981-07-01 00:00:00

abstract：:Confocal imaging was used to study the influence of cytosolic ATP on the properties of spontaneous Ca(2+) sparks in permeabilized ventricular myocytes. Cells were perfused with mock intracellular solutions containing fluo 3. Reducing [ATP] to <0.5 mmol/L decreased the frequency but increased the amplitude of spontaneo...

journal_title：Circulation research

authors： Yang Z,Steele DS

更新日期：2001-09-14 00:00:00

abstract：:A specific difference-spectrophotometric method was used to measure nitric oxide (NO) release into the coronary effluent perfusate of isolated, constant-flow-perfused guinea pig hearts. Authentic NO applied into the coronary circulation decreased vascular resistance dose dependently and enhanced coronary release of cy...

journal_title：Circulation research

authors： Kelm M,Schrader J

更新日期：1990-06-01 00:00:00