High-Density Lipoprotein Carries Markers That Track With Recovery From Stroke.

abstract：:To evaluate the degree and lateral extent of dysfunction in nonischemic myocardium adjacent to ischemic muscle, we measured systolic wall thickening with sonomicrometers during circumflex coronary occlusion in 12 anesthetized, open-chest dogs. The locations of the wall thickness measurements relative to the perfusion ...

journal_title：Circulation research

authors： Gallagher KP,Gerren RA,Stirling MC,Choy M,Dysko RC,McManimon SP,Dunham WR

更新日期：1986-04-01 00:00:00

abstract：:Acute increases in arterial pulsatile load imposed on the left ventricle can increase coronary flow without commensurate changes in myocardial oxygen consumption. One explanation is that augmenting pulsatile perfusion at the same mean pressure itself stimulates flow by releasing endothelium-mediated vasorelaxant facto...

journal_title：Circulation research

authors： Recchia FA,Senzaki H,Saeki A,Byrne BJ,Kass DA

更新日期：1996-10-01 00:00:00

abstract：:Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption. We have developed a rabbit model in which an atherosclerotic plaque can be ruptured at will after an inflatable balloon becomes embedded into the plaque. Furthermor...

journal_title：Circulation research

authors： Rekhter MD,Hicks GW,Brammer DW,Work CW,Kim JS,Gordon D,Keiser JA,Ryan MJ

更新日期：1998-10-05 00:00:00

abstract：:By using excised postmortem hearts obtained from 15 mongrel dogs with the pericardium intact, we investigated mechanical interactions between the four heart chambers from the standpoint of ventricular pressure-volume relationships. The interactions investigated were those between (1) the atrium and the ventricle, (2) ...

journal_title：Circulation research

authors： Maruyama Y,Ashikawa K,Isoyama S,Kanatsuka H,Ino-Oka E,Takishima T

更新日期：1982-01-01 00:00:00

abstract：:Life threatening ventricular arrhythmias leading to sudden cardiac death are a major cause of morbidity and mortality. In the absence of structural heart disease, these arrhythmias, especially in the younger population, are often an outcome of genetic defects in specialized membrane proteins called ion channels. In th...

journal_title：Circulation research

authors： Garg P,Garg V,Shrestha R,Sanguinetti MC,Kamp TJ,Wu JC

更新日期：2018-07-06 00:00:00

abstract：:Choline acetyltransferase is the enzyme that catalyzes the biosynthesis of acetylcholine, the neurotransmitter of the pre- and postganglionic parasympathetic system. To assess the extent of parasympathetic innervation, enzyme activity was measured in specialized and contractile regions throughout the guinea pig heart....

journal_title：Circulation research

authors： Schmid PG,Greif BJ,Lund DD,Roskoski R Jr

更新日期：1978-05-01 00:00:00

abstract：:Recent studies from our laboratory involving syncytial preparations have delineated electrophysiological distinctions between epicardium, endocardium, and a unique population of cells in the deep subepicardial to midmyocardial layers (M region) of the canine ventricle. In the present study, we used standard microelect...

journal_title：Circulation research

authors： Liu DW,Gintant GA,Antzelevitch C

更新日期：1993-03-01 00:00:00

abstract：:Although the ultrasonic pulsatility index (PI) is used as a test of arterial inflow, the relationship between proximal arterial stenosis and PI has not been fully evaluated. In a series of experiments on dogs, over 200 measurements of pressure, flow (using an indwelling electromagnetic flowmeter), and PI were made dis...

journal_title：Circulation research

authors： Evans DH,Barrie WW,Asher MJ,Bentley S,Bell PR

更新日期：1980-04-01 00:00:00

abstract：:The relationship between cell swelling and plasma membrane disruption has been evaluated in thin myocardial slices incubated in oxygenated or anoxic Krebs-Ringer phosphate media. Electron microscopy and measurements of inulin-diffusible space were used to monitor plasma membrane integrity. Inulin is excluded from the ...

journal_title：Circulation research

authors： Steenbergen C,Hill ML,Jennings RB

更新日期：1985-12-01 00:00:00

abstract：:Although functional coupling between protein kinase Cepsilon (PKCepsilon) and mitochondria has been implicated in the genesis of cardioprotection, the signal transduction mechanisms that enable this link and the identities of the mitochondrial proteins modulated by PKCepsilon remain unknown. Based on recent evidence t...

journal_title：Circulation research

authors： Baines CP,Song CX,Zheng YT,Wang GW,Zhang J,Wang OL,Guo Y,Bolli R,Cardwell EM,Ping P

更新日期：2003-05-02 00:00:00

abstract：:To isolate specific markers of both differentiated and proliferating vascular smooth muscle cells (VSMCs), we used the technique of differential cDNA screening using RNA from cultured rat aortic VSMCs. The tissue specificity of expression of all of the cDNAs isolated was determined by Northern analysis. We isolated se...

journal_title：Circulation research

authors： Shanahan CM,Weissberg PL,Metcalfe JC

更新日期：1993-07-01 00:00:00

abstract：:Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-...

journal_title：Circulation research

authors： Shorofsky SR,January CT

更新日期：1992-03-01 00:00:00

abstract：RATIONALE:Remote ischemic conditioning (RIC) or ischemic postconditioning (PostC) may protect the myocardium from ischemia-reperfusion injury in patients with ST-segment-elevation myocardial infarction. OBJECTIVE:To determine whether combined intrahospital RIC and PostC or PostC alone in addition to primary percutaneo...

journal_title：Circulation research

authors： Stiermaier T,Jensen JO,Rommel KP,de Waha-Thiele S,Fuernau G,Desch S,Thiele H,Eitel I

更新日期：2019-05-10 00:00:00

abstract：:Many indices have been proposed to describee the diastolic pressure-volume curve mathematically and permit quantification of the elastic properties of the myocardium itself in hopes that changes in the muscle caused by disease would b.e reflected in the diastolic pressure-volume curve. To date, none of the proposed in...

journal_title：Circulation research

authors： Glantz SA

更新日期：1976-12-01 00:00:00

abstract：:Diadenosine triphosphate is present in platelet-dense granules and released quantitatively on platelet aggregation. We have found that intact porcine aortic endothelial cells can efficiently hydrolyze extracellular diadenosine triphosphate. The products of diadenosine triphosphate hydrolysis are adenosine monophosphat...

journal_title：Circulation research

authors： Goldman SJ,Gordon EL,Slakey LL

更新日期：1986-09-01 00:00:00

abstract：RATIONALE:The mechanisms driving atherothrombotic risk in individuals with JAK2 V617F ( Jak2 VF) positive clonal hematopoiesis or myeloproliferative neoplasms are poorly understood. OBJECTIVE:The goal of this study was to assess atherosclerosis and underlying mechanisms in hypercholesterolemic mice with hematopoietic ...

journal_title：Circulation research

authors： Wang W,Liu W,Fidler T,Wang Y,Tang Y,Woods B,Welch C,Cai B,Silvestre-Roig C,Ai D,Yang YG,Hidalgo A,Soehnlein O,Tabas I,Levine RL,Tall AR,Wang N

更新日期：2018-11-09 00:00:00

abstract：:Genome-wide association studies have provided a rich collection of ≈ 58 coronary artery disease (CAD) loci that suggest the existence of previously unsuspected new biology relevant to atherosclerosis. However, these studies only identify genomic loci associated with CAD, and many questions remain even after a genomic ...

journal_title：Circulation research

authors： Nurnberg ST,Zhang H,Hand NJ,Bauer RC,Saleheen D,Reilly MP,Rader DJ

更新日期：2016-02-19 00:00:00

abstract：:Effects of blood flow on the production of prostacyclin (PGI2) were examined in the canine femoral artery perfused ex vivo. Each artery was perfused in situ with medium 199, under conditions of simulated blood flow. To simulate the normal and abnormal blood flow waveforms at the same mean flow rate, we developed a flo...

journal_title：Circulation research

authors： Onohara T,Okadome K,Yamamura S,Mii S,Sugimachi K

更新日期：1991-04-01 00:00:00

abstract：:We determined whether local bradykinin production modulates cardiac adrenergic activity. Depolarization of guinea pig heart sympathetic nerve endings (synaptosomes) with 1 to 100 mmol/L K+ caused the release of endogenous norepinephrine (10% to 50% above basal level). This release was exocytotic, because it depended o...

journal_title：Circulation research

authors： Seyedi N,Win T,Lander HM,Levi R

更新日期：1997-11-01 00:00:00

abstract：:In newborn lambs, pulmonary prostacyclin (PGI2) production increases acutely in response to low oxygen. We tested the hypothesis that decreased oxygenation directly stimulates PGI2 synthesis in arterial segments and cultured endothelial cells from newborn lamb intrapulmonary arteries. In segments studied at PO2 of 680...

journal_title：Circulation research

authors： North AJ,Brannon TS,Wells LB,Campbell WB,Shaul PW

更新日期：1994-07-01 00:00:00

abstract：:Congenital heart defects affect almost 1% of human newborns. Recently, mutations in Notch ligands and receptors have been found to cause a variety of heart defects in rodents and humans. However, the molecular effects downstream of Notch are still poorly understood. Here we report that combined inactivation of Hey1 an...

journal_title：Circulation research

authors： Fischer A,Steidl C,Wagner TU,Lang E,Jakob PM,Friedl P,Knobeloch KP,Gessler M

更新日期：2007-03-30 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)γ agonists attenuate atherosclerosis and abdominal aortic aneurysms (AAAs). PPARγ, a nuclear receptor, is expressed on many cell types including smooth muscle cells (SMCs). OBJECTIVE:To determine whether a PPARγ agonist reduces angiotensin II (Ang II)-induced ...

journal_title：Circulation research

authors： Subramanian V,Golledge J,Ijaz T,Bruemmer D,Daugherty A

更新日期：2010-10-15 00:00:00

abstract：:We determined the effects of indomethacin and meclofenamate, two inhibitors of prostaglandin synthesis, on renal vascular resistance and on renal responses to nerve stimulation, pressor and depressor hormones in the in situ feline kidney under conditions of controlled blood flow. Both inhibitors produced a gradual ris...

journal_title：Circulation research

authors： Chapnick BM,Paustian PW,Feigen LP,Joiner PD,Hyman AL,Kadowitz PJ

更新日期：1977-04-01 00:00:00

abstract：RATIONALE:Human clinical trials using type 1 angiotensin (AT(1)) receptor antagonists indicate that angiotensin II is a critical mediator of cardiovascular and renal disease. However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hyper...

journal_title：Circulation research

authors： Zhang JD,Patel MB,Song YS,Griffiths R,Burchette J,Ruiz P,Sparks MA,Yan M,Howell DN,Gomez JA,Spurney RF,Coffman TM,Crowley SD

更新日期：2012-06-08 00:00:00

abstract：:The circulatory effects associated with lifelong plasma atrial natriuretic factor (ANF) elevation were examined by generating transgenic mice, which constitutively express a fusion gene consisting of the transthyretin promoter and the ANF structural gene. These mice have chronically elevated ANF levels as compared wit...

journal_title：Circulation research

authors： Barbee RW,Perry BD,Ré RN,Murgo JP,Field LJ

更新日期：1994-04-01 00:00:00

abstract：:We have used an immunological approach to investigate the role of myosin light chain phosphorylation (MLC-Pi) in the control of contractility in smooth muscle. Our aim was to specifically inhibit myosin light chain kinase (MLCK) in the presence of physiologically activating levels of Ca2+ so that other putative Ca2(+)...

journal_title：Circulation research

authors： De Lanerolle P,Strauss JD,Felsen R,Doerman GE,Paul RJ

更新日期：1991-02-01 00:00:00

abstract：:Pharmacological evidence indicates that angiotensin (Ang II) converting enzyme inhibitors attenuate cardiovascular responses to sympathetic stimulation. To investigate the physiological significance of this attenuation, the pressor and heart rate responses to bilateral carotid occlusion (BCO) were studied before and a...

journal_title：Circulation research

authors： Isaacson JS,Reid IA

更新日期：1990-03-01 00:00:00

abstract：:Ventricular repolarization was analyzed by measuring epicardial potential distributions in intact dogs with single or multiple ectopic foci and a minimum at the terminal site(s) of excitation. During the latter half of the T wave the distributions became more complex, and two maxima evolved from the initial one at eac...

journal_title：Circulation research

authors： Spach MS,Barr RC

更新日期：1976-10-01 00:00:00

abstract：RATIONALE:Myosin light chain (MLC) phosphorylation determines vascular contractile status. In addition to the classic Ca²⁺-dependent MLC kinase (MLCK), another unidentified kinase(s) also contributes to MLC phosphorylation in living cells. Inhibitor κB kinase 2 (IKK2)-deficient mouse embryonic fibroblasts demonstrate a...

journal_title：Circulation research

authors： Ying Z,do Carmo JM,Xiang L,da Silva AA,Chen M,Ryan MJ,Ostrowski M,Rajagopalan S,Hall JE

更新日期：2013-08-16 00:00:00

abstract：RATIONALE:One goal of cardiac tissue engineering is the generation of a living, human pump in vitro that could replace animal models and eventually serve as an in vivo therapeutic. Models that replicate the geometrically complex structure of the heart, harboring chambers and large vessels with soft biomaterials, can be...

journal_title：Circulation research

authors： Kupfer ME,Lin WH,Ravikumar V,Qiu K,Wang L,Gao L,Bhuiyan DB,Lenz M,Ai J,Mahutga RR,Townsend D,Zhang J,McAlpine MC,Tolkacheva EG,Ogle BM

更新日期：2020-07-03 00:00:00