TRPC1 channels are critical for hypertrophic signaling in the heart.

abstract：:Cell-cell communication has proven to be even more complex than previously thought since the discovery that extracellular vesicles serve as containers of biological information on various pathophysiological settings. Extracellular vesicles are classified into exosomes, microvesicles/microparticles, or apoptotic bodies...

journal_title：Circulation research

authors： Loyer X,Vion AC,Tedgui A,Boulanger CM

更新日期：2014-01-17 00:00:00

abstract：:p21ras is a potent regulator of myogenic cell growth and differentiation. It has been implicated as playing a major role in the genesis of cardiac hypertrophy. We examined the effect of Ras overexpression on human atrial natriuretic peptide (hANP) gene expression, a marker of hypertrophy, in neonatal rat ventricular m...

journal_title：Circulation research

authors： Kovacic-Milivojevic B,Zlock DW,Gardner DG

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cells make important contributions to OFT formation and aortic arch remodeling. Although numerous signal...

journal_title：Circulation research

authors： Singh N,Trivedi CM,Lu M,Mullican SE,Lazar MA,Epstein JA

更新日期：2011-11-11 00:00:00

abstract：:Mitochondria play a key role in determining cell fate during exposure to stress. Their role during ischemia/reperfusion is particularly critical because of the conditions that promote both apoptosis by the mitochondrial pathway and necrosis by irreversible damage to mitochondria in association with mitochondrial perme...

journal_title：Circulation research

authors： Weiss JN,Korge P,Honda HM,Ping P

更新日期：2003-08-22 00:00:00

abstract：:Transforming growth factor (TGF)-beta plays a major role in the development of vascular diseases. Despite the pleiotropic effects of TGF-ss on vascular smooth muscle cells (VSMCs), only a few genes have been characterized as direct targets of TGF-beta in VSMCs. Cardiac ankyrin repeat protein (CARP) has been thought to...

journal_title：Circulation research

authors： Kanai H,Tanaka T,Aihara Y,Takeda S,Kawabata M,Miyazono K,Nagai R,Kurabayashi M

更新日期：2001-01-19 00:00:00

abstract：RATIONALE:Remote ischemic conditioning (RIC) or ischemic postconditioning (PostC) may protect the myocardium from ischemia-reperfusion injury in patients with ST-segment-elevation myocardial infarction. OBJECTIVE:To determine whether combined intrahospital RIC and PostC or PostC alone in addition to primary percutaneo...

journal_title：Circulation research

authors： Stiermaier T,Jensen JO,Rommel KP,de Waha-Thiele S,Fuernau G,Desch S,Thiele H,Eitel I

更新日期：2019-05-10 00:00:00

abstract：:Mammalian cardiomyocytes irreversibly lose their capacity to proliferate soon after birth, yet the underlying mechanisms have been unclear. Cyclin D1 and its partner, cyclin-dependent kinase 4 (CDK4), are important for promoting the G1-to-S phase progression via phosphorylation of the retinoblastoma (Rb) protein. Mito...

journal_title：Circulation research

authors： Tamamori-Adachi M,Ito H,Sumrejkanchanakij P,Adachi S,Hiroe M,Shimizu M,Kawauchi J,Sunamori M,Marumo F,Kitajima S,Ikeda MA

更新日期：2003-01-10 00:00:00

abstract：:Changes in angiotensin-converting enzyme were measured in the lungs of fetal rabbits isolated and perfused in situ at varying ages from 22 days gestation to 7 days of age under controlled conditions of flow, pH, and temperature. Enzyme activity was assessed by infusing bradykinin or angiotensin I in Krebs-Henseleit so...

journal_title：Circulation research

authors： Stalcup SA,Pang LM,Lipset JS,Odya CE,Goodfriend TL,Mellins RB

更新日期：1978-11-01 00:00:00

abstract：:Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear str...

journal_title：Circulation research

authors： Lin T,Zeng L,Liu Y,DeFea K,Schwartz MA,Chien S,Shyy JY

更新日期：2003-06-27 00:00:00

abstract：RATIONALE:Elevations in C-reactive protein (CRP) are associated with increased cardiovascular disease risk and endothelial dysfunction. CRP antagonizes endothelial nitric oxide synthase (eNOS) through processes mediated by the IgG receptor Fcγ receptor IIB (FcγRIIB), its immunoreceptor tyrosine-based inhibitory motif, ...

journal_title：Circulation research

authors： Sundgren NC,Zhu W,Yuhanna IS,Chambliss KL,Ahmed M,Tanigaki K,Umetani M,Mineo C,Shaul PW

更新日期：2011-10-28 00:00:00

abstract：:The abundance of membrane cholesterol is an important determinant of the functional properties of biomembranes. To determine whether arterial smooth muscle acquires altered contractile properties in a high cholesterol environment, isolated canine coronary arteries were exposed to cholesterol in stable aqueous solution...

journal_title：Circulation research

authors： Yokoyama M,Henry PD

更新日期：1979-10-01 00:00:00

abstract：:Modulation of the inward Na+ current (I(Na)) by protein kinase C (PKC) was investigated by intracellular perfusion of a peptide corresponding to the catalytic subunit of PKC (PKCP). The effects of PKC activation independent of membrane-receptor pathways were studied in neonatal rat ventricular myocytes using whole-cel...

journal_title：Circulation research

authors： Watson CL,Gold MR

更新日期：1997-09-01 00:00:00

abstract：:We studied the time-dependent changes in the response of heart rate (sinus cycle length) to 30-second trains of vagal stimulation (8 Hz), repeated every 2 minutes, in canine neonates aged 7.1 +/- 2.5 (mean +/- SD) days. The first vagal train prolonged the sinus cycle length by 58 +/- 35%, but the response was attenuat...

journal_title：Circulation research

authors： Yamasaki S,Stolfi A,Mas MS,Fox LS,Pickoff AS

更新日期：1991-08-01 00:00:00

abstract：:Whole-cell Ca2+ channel currents were recorded from isolated single canine Purkinje and ventricular cells to determine whether there were multiple types of Ca2+ channels in these two cell types, as in many other excitable tissues. The experimental conditions were such that currents other than Ca2+ channel currents wer...

journal_title：Circulation research

authors： Tseng GN,Boyden PA

更新日期：1989-12-01 00:00:00

abstract：:Angiotensin II (Ang II) increases renal sympathetic nerve activity in anesthetized mice before and after ganglionic blockade, suggesting that Ang II may directly activate postganglionic sympathetic neurons. The present study directly tested this hypothesis in vitro. Neurons were dissociated from aortic-renal and celia...

journal_title：Circulation research

authors： Ma X,Chapleau MW,Whiteis CA,Abboud FM,Bielefeldt K

更新日期：2001-04-27 00:00:00

abstract：:The cellular basis of reactive oxygen intermediate-induced arrhythmias was investigated in isolated rabbit ventricular cells using the whole-cell voltage- and current-clamp techniques. Singlet oxygen and superoxide were generated by the photoactivation of rose bengal. Single ventricular cells exposed to rose bengal (1...

journal_title：Circulation research

authors： Matsuura H,Shattock MJ

更新日期：1991-02-01 00:00:00

abstract：:Previously, it was shown that the D enantiomer of isoidide dinitrate was 10-fold more potent than the L enantiomer and 10-fold less potent than glyceryl trinitrate for stimulating cyclic GMP accumulation and relaxation of isolated rat aorta. In the present study, these organic nitrates were tested for their ability to...

journal_title：Circulation research

authors： Bennett BM,Schröder H,Hayward LD,Waldman SA,Murad F

更新日期：1988-10-01 00:00:00

abstract：:To determine whether calcium channel agonists and antagonists bind to distinct pharmacologically active sites, the binding of dihydropyridine calcium channel agonists and antagonists was related to calcium flux and contractile state in primary monolayer cultures of spontaneously contracting chick embryo ventricular ce...

journal_title：Circulation research

authors： Lee RT,Smith TW,Marsh JD

更新日期：1987-05-01 00:00:00

abstract：RATIONALE:Giant-cell arteritis (GCA) is a large-vessel vasculitis characterized by immune cell infiltration, yet the potential involvement of neutrophils has rarely been studied. OBJECTIVE:We investigated whether alterations in neutrophil reactivity occurred in the pathogenesis of GCA or during its clinical management...

journal_title：Circulation research

authors： Nadkarni S,Dalli J,Hollywood J,Mason JC,Dasgupta B,Perretti M

更新日期：2014-01-17 00:00:00

abstract：:Proteases of the plasminogen activator (PA) and matrix metalloproteinase (MMP) system play an important role in smooth muscle cell (SMC) migration and neointima formation after vascular injury. Inhibition of either PAs or MMPs has previously been shown to result in decreased neointima formation in vivo. To inhibit bot...

journal_title：Circulation research

authors： Lamfers ML,Grimbergen JM,Aalders MC,Havenga MJ,de Vries MR,Huisman LG,van Hinsbergh VW,Quax PH

更新日期：2002-11-15 00:00:00

abstract：:Cardiovascular disease is a major killer in postmenopausal women in the industrialized societies. To investigate the effect of progestogen and 17 beta-estradiol replacement therapy on atherogenesis, we studied 60 cholesterol-fed ovariectomized rabbits for 13 weeks. They were randomly assigned to four groups of 15 rabb...

journal_title：Circulation research

authors： Haarbo J,Svendsen OL,Christiansen C

更新日期：1992-06-01 00:00:00

abstract：RATIONALE:Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. However, the long-term (>5 weeks) effects, potential tumorigenicity, and fate of transplanted CPCs are unknown. OBJECTIVE:To assess the outcome of CPC therapy at 1 year. METHODS AND...

journal_title：Circulation research

authors： Tang XL,Li Q,Rokosh G,Sanganalmath SK,Chen N,Ou Q,Stowers H,Hunt G,Bolli R

更新日期：2016-04-01 00:00:00

abstract：:Myocardial stunning is a form of reversible myocardial ischemia/reperfusion injury associated with systolic and diastolic contractile dysfunction. In the isolated rat heart model, myocardial stunning is characterized by specific C-terminal proteolysis of the myofilament protein, troponin I (cTnI) that yields cTnI1-193...

journal_title：Circulation research

authors： Foster DB,Noguchi T,VanBuren P,Murphy AM,Van Eyk JE

更新日期：2003-11-14 00:00:00

abstract：:The goals of this article were (1) to identify cell surface proteins whose expression was regulated by diabetes and (2) to assess their contribution to diabetic complications. We purified heat shock protein 90alpha (Hsp90alpha) from the membrane fraction of high glucose-treated endothelial cells (ECs) as a binding par...

journal_title：Circulation research

authors： Lei H,Romeo G,Kazlauskas A

更新日期：2004-04-16 00:00:00

abstract：:Pathological remodeling of the left ventricle (LV) after myocardial infarction (MI) is a major cause of heart failure. Although cardiac hypertrophy after increased loading conditions has been recognized as a clinical risk factor for human heart failure, it is unknown whether post-MI hypertrophic remodeling of the myoc...

journal_title：Circulation research

authors： van Rooij E,Doevendans PA,Crijns HJ,Heeneman S,Lips DJ,van Bilsen M,Williams RS,Olson EN,Bassel-Duby R,Rothermel BA,De Windt LJ

更新日期：2004-02-20 00:00:00

abstract：:We studied DNA (mtDNA) replication in adult female rat hearts undergoing hypertrophy secondary to constriction of the ascending aorta. MtDNA was measured in isolated mitochondria by a fluorometric method adapted for that purpose. The conditions for removal of contaminating nuclear DNA were developed, and the purity of...

journal_title：Circulation research

authors： Rajamanickam C,Merten S,Kwiatkowska-Patzer B,Chuang CH,Zak R,Rabinowitz M

更新日期：1979-10-01 00:00:00

abstract：:Calcific aortic valve sclerosis involves inflammatory processes and occurs preferentially on the aortic side of endothelialized valve leaflets. Although the endothelium is recognized to play critical roles in focal vascular sclerosis, the contributions of valvular endothelial phenotypes to aortic valve sclerosis and s...

journal_title：Circulation research

authors： Simmons CA,Grant GR,Manduchi E,Davies PF

更新日期：2005-04-15 00:00:00

abstract：:Although morphological studies suggest that coronary vascular injury is a result of prolonged ischemia and subsequent reperfusion, whether functional coronary microvascular injury develops during brief in vivo ischemia is unclear. In other organs, permeability is a sensitive indicator of functional vascular injury. Th...

journal_title：Circulation research

authors： Dauber IM,VanBenthuysen KM,McMurtry IF,Wheeler GS,Lesnefsky EJ,Horwitz LD,Weil JV

更新日期：1990-04-01 00:00:00

abstract：:In the mammalian myocardium, potassium (K(+)) channels control resting potentials, action potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple types of K(+) channels that subserve these functions are expressed. Molecular cloning has revealed the presence of a large number of K...

journal_title：Circulation research

authors： Nerbonne JM,Nichols CG,Schwarz TL,Escande D

更新日期：2001-11-23 00:00:00

abstract：RATIONALE:The mammalian diaphanous-related formin (mDia1), governs microtubule and microfilament dynamics while functioning as an effector for Rho small GTP-binding proteins during key cellular processes such as adhesion, cytokinesis, cell polarity, and morphogenesis. The cytoplasmic domain of the receptor for advanced...

journal_title：Circulation research

authors： Touré F,Fritz G,Li Q,Rai V,Daffu G,Zou YS,Rosario R,Ramasamy R,Alberts AS,Yan SF,Schmidt AM

更新日期：2012-05-11 00:00:00