Changes in mitochondrial DNA in cardiac hypertrophy in the rat.

abstract：:We studied mitochondrial structure and intermediates of fatty acid metabolism in mitochondria isolated from ischemic hearts. By electron microscopy, no structural difference was detected between mitochondria isolated from control hearts and from ischemic hearts receiving glucose as the only substrate. However, major d...

journal_title：Circulation research

authors： Feuvray D,Plouët J

更新日期：1981-05-01 00:00:00

abstract：:It is believed that inotropic agents exert their effects in cardiac muscle via a modulation of Ca2+ cycling; however, the involvement of phospholipase activation and the biochemical pathways participating in inotropic responsiveness remain unclear. The aim of the current study was to determine whether arachidonic acid...

journal_title：Circulation research

authors： Damron DS,Bond M

更新日期：1993-02-01 00:00:00

abstract：:The site of earliest extracellular electrical activation in the sinoatrial node (SAN) is known to shift in response to autonomic stimuli, but the mechanisms underlying this phenomenon and the determinants of the location of dominant pacemaker activity have not been elucidated. The present study was designed to charact...

journal_title：Circulation research

authors： Beau SL,Hand DE,Schuessler RB,Bromberg BI,Kwon B,Boineau JP,Saffitz JE

更新日期：1995-11-01 00:00:00

abstract：:Three models of altered autonomic innervation of the chick heart have been developed in the last few years. These include sympathetically aneural heart, parasympathetically aneural heart, and heart with cholinergic innervation reconstituted from the nodose placodes. The neural status of these hearts has been assessed ...

journal_title：Circulation research

authors： Kirby ML,Creazzo TL,Christiansen JL

更新日期：1989-12-01 00:00:00

abstract：:Whole-cell voltage-clamp experiments were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to test the hypothesis that the differences in the amplitude of transient outward current (Ito) contribute to the difference ...

journal_title：Circulation research

authors： Furukawa T,Myerburg RJ,Furukawa N,Bassett AL,Kimura S

更新日期：1990-11-01 00:00:00

abstract：:On endothelial cells, thrombin binds to thrombomodulin (TM), an integral membrane-bound glycoprotein, and to protease-activated receptors (PARs). Thrombin binding to TM modulates endothelial cell and smooth muscle cell proliferation mediated through PAR1. We studied the phosphorylation and nuclear translocation of ext...

journal_title：Circulation research

authors： Olivot JM,Estebanell E,Lafay M,Brohard B,Aiach M,Rendu F

更新日期：2001-04-13 00:00:00

abstract：:Although urinary sodium excretion is positively influenced by acute changes in renal perfusion pressure, micropuncture studies show highly conflicting results concerning the response of superficial proximal tubule sodium reabsorption to changes in renal perfusion pressure. In the present study, the changes of superfic...

journal_title：Circulation research

authors： Kinoshita Y,Knox FG

更新日期：1990-05-01 00:00:00

abstract：:Rat myocardium expresses the 240- and 235-kD polypeptides antigenically related to alpha- and beta-subunits of brain calspectin (nonerythroid spectrin or fodrin), respectively. In the subcellular fractions of the myocardium, alpha-calspectin was found in the 600g, 10,000g, and 100,000g pellets, whereas beta-calspectin...

journal_title：Circulation research

authors： Yoshida K,Inui M,Harada K,Saido TC,Sorimachi Y,Ishihara T,Kawashima S,Sobue K

更新日期：1995-09-01 00:00:00

abstract：:Five fetal sheep (gestational age, 118 to 125 days) were instrumented to measure impedances of the lower abdominal aorta. Four days after surgery, flow and pressure pulses were recorded during control conditions and during infusion of norepinephrine (0.3 to 3 micrograms.min-1.kg-1 body weight) or angiotensin II (0.2 t...

journal_title：Circulation research

authors： Schröder H,Cetin E,Hüneke B,Carstensen M

更新日期：1994-04-01 00:00:00

abstract：:We have previously demonstrated pressure-dependent membrane depolarization and action potential generation in cat cerebral arteries. It was the purpose of this study to examine and compare the membrane electrical responses to increasing transmural pressure in spontaneously hypertensive rats with those of their normote...

journal_title：Circulation research

authors： Harder DR,Smeda J,Lombard J

更新日期：1985-08-01 00:00:00

abstract：:Activation of protein kinase C has been implicated in the regulation of a variety of cellular reactions. Although we, and others, have found protein kinase C and its substrate proteins to be present in both membrane and cytosolic fractions in the heart, the physiologic role of this kinase in the regulation of cardiac ...

journal_title：Circulation research

authors： Yuan SH,Sunahara FA,Sen AK

更新日期：1987-09-01 00:00:00

abstract：RATIONALE:We have recently shown that the bone morphogenetic protein (BMP) antagonist Gremlin 2 (Grem2) is required for early cardiac development and cardiomyocyte differentiation. Our initial studies discovered that Grem2 is strongly induced in the adult heart after experimental myocardial infarction (MI). However, th...

journal_title：Circulation research

authors： Sanders LN,Schoenhard JA,Saleh MA,Mukherjee A,Ryzhov S,McMaster WG Jr,Nolan K,Gumina RJ,Thompson TB,Magnuson MA,Harrison DG,Hatzopoulos AK

更新日期：2016-07-22 00:00:00

abstract：:This study investigations the phenomenon of sustained mechanical alternans (SMA) through the use of quantitative criteria. Discrete analysis is used to demonstrate that the hemodynamic variables during SMA are governed by a simple mathematical relation. The analysis shows that the value of the slope created by the two...

journal_title：Circulation research

authors： Adler D,Nikolic S,Sonnenblick EH,Yellin EL

更新日期：1991-07-01 00:00:00

abstract：:The present series of experiments used gas chromatography to identify vapor-phase photoproducts liberated during excimer laser irradiation of cardiovascular tissues in air and blood. In air, laser beams produced from ArF (193 nm) and XeF (351 nm) excimer laser gas mixtures were delivered to samples of myocardium and a...

journal_title：Circulation research

authors： Clarke RH,Isner JM,Donaldson RF,Jones G 2nd

更新日期：1987-03-01 00:00:00

abstract：RATIONALE:Smooth muscle precursor cells have previously been reported to reside in bone marrow and in the circulation, but little is currently known regarding the proximate stimuli for smooth muscle cell differentiation of these putative progenitors. OBJECTIVE:Because local thrombin generation occurs as an initial res...

journal_title：Circulation research

authors： Martin K,Weiss S,Metharom P,Schmeckpeper J,Hynes B,O'Sullivan J,Caplice N

更新日期：2009-07-31 00:00:00

abstract：RATIONALE:Immune cells play an important role during the generation and resolution of thrombosis. T cells are powerful regulators of immune and nonimmune cell function, however, their role in sterile inflammation in venous thrombosis has not been systematically examined. OBJECTIVE:This study investigated the recruitme...

journal_title：Circulation research

authors： Luther N,Shahneh F,Brähler M,Krebs F,Jäckel S,Subramaniam S,Stanger C,Schönfelder T,Kleis-Fischer B,Reinhardt C,Probst HC,Wenzel P,Schäfer K,Becker C

更新日期：2016-12-09 00:00:00

abstract：:Quinidine is the most commonly used drug for the chronic treatment of ventricular arrhythmias, but it may be arrhythmogenic. Much information exists concerning quinidine's effects on active properties in cardiac tissues, but virtually nothing is known of its effects on passive properties. We studied the effects of qui...

journal_title：Circulation research

authors： Arnsdorf MF,Sawicki GJ

更新日期：1987-08-01 00:00:00

abstract：RATIONALE:Pulmonary arterial hypertension (PAH) remains a progressive and eventually lethal disease characterized by increased pulmonary vascular resistance because of loss of functional lung microvasculature, primarily at the distal (intracinar) arteriolar level. Cell-based therapies offer the potential to repair and ...

journal_title：Circulation research

authors： Granton J,Langleben D,Kutryk MB,Camack N,Galipeau J,Courtman DW,Stewart DJ

更新日期：2015-09-11 00:00:00

abstract：RATIONALE:Pulmonary hypertensive remodeling is characterized by excessive proliferation, migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts maintain a similar activated phenotype. The mechanisms responsible for generation/maintenance of this phenotype remain unknown. OBJECTIV...

journal_title：Circulation research

authors： Wang D,Zhang H,Li M,Frid MG,Flockton AR,McKeon BA,Yeager ME,Fini MA,Morrell NW,Pullamsetti SS,Velegala S,Seeger W,McKinsey TA,Sucharov CC,Stenmark KR

更新日期：2014-01-03 00:00:00

abstract：RATIONALE:Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and c...

journal_title：Circulation research

authors： Fang F,Yang Y,Yuan Z,Gao Y,Zhou J,Chen Q,Xu Y

更新日期：2011-04-01 00:00:00

abstract：:The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves substantial proteolysis of the arterial extracellular matrix. The lysosomal cysteine proteases can exert potent elastolytic and collagenolytic activity. Human atherosclerotic plaques have increased cysteine protease content and decreased levels...

journal_title：Circulation research

authors： Sukhova GK,Wang B,Libby P,Pan JH,Zhang Y,Grubb A,Fang K,Chapman HA,Shi GP

更新日期：2005-02-18 00:00:00

abstract：:The smooth muscle myosin heavy chain (SM-MHC) gene encodes a major contractile protein whose expression exclusively marks the smooth muscle cell (SMC) lineage. To better understand smooth muscle differentiation at the transcriptional level, we have initiated studies to identify those DNA sequences critical for express...

journal_title：Circulation research

authors： Madsen CS,Regan CP,Hungerford JE,White SL,Manabe I,Owens GK

更新日期：1998-05-04 00:00:00

abstract：:We report the cloning of cDNAs encoding two different human nonmuscle myosin heavy chains designated NMMHC-A and NMMHC-B. The mRNAs encoding NMMHC-A and NMMHC-B are both 7.5 kb in size but are shown to be the products of different genes, which are localized to chromosome 22q11.2 and chromosome 17q13, respectively. In ...

journal_title：Circulation research

authors： Simons M,Wang M,McBride OW,Kawamoto S,Yamakawa K,Gdula D,Adelstein RS,Weir L

更新日期：1991-08-01 00:00:00

abstract：:We developed a mouse myocardial preparation to study cellular dysfunction in acute coxsackievirus myocarditis. Thin right ventricular papillary muscles from normal mice (n = 8) were compared with muscles from mice 7 days after coxsackievirus infection (n = 7). Sarcomere shortening was studied with laser diffraction (H...

journal_title：Circulation research

authors： Hamrell BB,Huber SA,Leslie KO

更新日期：1994-09-01 00:00:00

abstract：RATIONALE:A hallmark of chronic inflammatory disorders is persistence of proinflammatory macrophages in diseased tissues. In atherosclerosis, this is associated with dyslipidemia and oxidative stress, but mechanisms linking these phenomena to macrophage activation remain incompletely understood. OBJECTIVE:To investiga...

journal_title：Circulation research

authors： Chen Y,Yang M,Huang W,Chen W,Zhao Y,Schulte ML,Volberding P,Gerbec Z,Zimmermann MT,Zeighami A,Demos W,Zhang J,Knaack DA,Smith BC,Cui W,Malarkannan S,Sodhi K,Shapiro JI,Xie Z,Sahoo D,Silverstein RL

更新日期：2019-12-06 00:00:00

abstract：RATIONALE:Natural killer (NK) cells are lymphocytes of the innate immune system that play specialized and niche-specific roles in distinct organs. OBJECTIVE:We investigated the possible function of NK cells in the pathogenesis of congestive heart failure after myocardial infarction. METHODS AND RESULTS:Depletion of N...

journal_title：Circulation research

authors： Yan X,Hegab AE,Endo J,Anzai A,Matsuhashi T,Katsumata Y,Ito K,Yamamoto T,Betsuyaku T,Shinmura K,Shen W,Vivier E,Fukuda K,Sano M

更新日期：2014-02-14 00:00:00

abstract：:Isovolumic relaxation abnormalities have been noted in the ischemic left ventricle, but altered end-diastolic distensibility, as well as the role of right ventricular distention, is debated. Accordingly, left ventricular end-diastolic pressure and myocardial segment length were studied in the open-chest dogs with crit...

journal_title：Circulation research

authors： Momomura S,Bradley AB,Grossman W

更新日期：1984-08-01 00:00:00

abstract：:Ventricular arrhythmias that accompany myocardial infarction in dogs may be secondary to the altered electrophysiological properties of the subendocardial Purkinje fibers that survive 24 hours after the coronary occlusion. To better understand the ionic mechanisms that underlie the altered electrical activity of these...

journal_title：Circulation research

authors： Boyden PA,Albala A,Dresdner KP Jr

更新日期：1989-10-01 00:00:00

abstract：:Electrical field stimulation (EFS) of phenylephrine-contracted bovine mesenteric arteries pretreated with guanethidine elicited a relaxation that amounted to roughly 40%. This relaxation was sensitive to tetrodotoxin pretreatment, suggesting a neurogenic origin. The EFS-induced relaxation was correlated to an increase...

journal_title：Circulation research

authors： Ahlner J,Ljusegren ME,Grundström N,Axelsson KL

更新日期：1991-03-01 00:00:00

abstract：RATIONALE:Transcatheter, intramyocardial injections of bone marrow-derived cell therapy produces reverse remodeling in large animal models of ischemic cardiomyopathy. OBJECTIVE:We used cardiac MRI (CMR) in patients with left ventricular (LV) dysfunction related to remote myocardial infarction (MI) to test the hypothes...

journal_title：Circulation research

authors： Williams AR,Trachtenberg B,Velazquez DL,McNiece I,Altman P,Rouy D,Mendizabal AM,Pattany PM,Lopera GA,Fishman J,Zambrano JP,Heldman AW,Hare JM

更新日期：2011-04-01 00:00:00