Abstract:
:Quinidine is the most commonly used drug for the chronic treatment of ventricular arrhythmias, but it may be arrhythmogenic. Much information exists concerning quinidine's effects on active properties in cardiac tissues, but virtually nothing is known of its effects on passive properties. We studied the effects of quinidine, in a clinically relevant concentration, on the balance among active and passive cellular properties that comprise the electrophysiologic matrix that determines cardiac excitability. The multiple microelectrode method of intracellular-current application and transmembrane voltage recording was used in sheep Purkinje fibers to determine strength-duration and constant current-voltage relations as well as cable properties. A rapid, on-line computerized data analysis system tracked in time the alterations in the active and passive properties relevant to excitability. In normal fibers at [K+]o = 5.4 mM, quinidine increased cardiac excitability as manifested by a decrease in the current required to attain threshold and/or a downward shift in strength- and charge-duration relations by altering passive properties despite a depressed sodium system and a slowed conduction velocity. During washout, excitability and passive properties remained altered despite a return of descriptive action potential parameters such as the resting potential, the maximum rate of rise of phase 0, overshoot, and the action potential duration to or nearly to normal. At [K+]o = 8.0 mM, quinidine could either increase or decrease excitability; net excitability depends on the balance between altered passive properties and the depressed sodium system. The results explain, in part, the antiarrhythmic actions and arrhythmogenic potential of quinidine. The data for quinidine and other antiarrhythmic drugs are interpreted in terms of the electrophysiologic matrix, which we believe has important advantages over traditional hierarchical classifications.
journal_name
Circ Resjournal_title
Circulation researchauthors
Arnsdorf MF,Sawicki GJdoi
10.1161/01.res.61.2.244subject
Has Abstractpub_date
1987-08-01 00:00:00pages
244-55issue
2eissn
0009-7330issn
1524-4571journal_volume
61pub_type
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2004-02-20 00:00:00
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更新日期:1998-08-24 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-05-08 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.56.3.359
更新日期:1985-03-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.66.2.511
更新日期:1990-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.114.304056
更新日期:2014-09-12 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.86.8.879
更新日期:2000-04-28 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/01.res.82.4.407
更新日期:1998-03-09 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.RES.0000113923.85084.C1
更新日期:2004-02-20 00:00:00
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更新日期:2000-09-15 00:00:00
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pub_type: 杂志文章
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更新日期:1998-03-23 00:00:00
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更新日期:2010-04-16 00:00:00
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更新日期:2010-04-30 00:00:00
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pub_type: 杂志文章
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更新日期:1996-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-02-17 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.85.9.e33
更新日期:1999-10-29 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.82.2.195
更新日期:1998-02-09 00:00:00
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doi:10.1161/01.res.58.4.539
更新日期:1986-04-01 00:00:00
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doi:10.1161/CIRCRESAHA.107.168153
更新日期:2008-04-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.110.233924
更新日期:2011-01-21 00:00:00