Abstract:
:In the mammalian myocardium, potassium (K(+)) channels control resting potentials, action potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple types of K(+) channels that subserve these functions are expressed. Molecular cloning has revealed the presence of a large number of K(+) channel pore forming (alpha) and accessory (beta) subunits in the heart, and considerable progress has been made recently in defining the relationships between expressed K(+) channel subunits and functional cardiac K(+) channels. To date, more than 20 mouse models with altered K(+) channel expression/functioning have been generated using dominant-negative transgenic and targeted gene deletion approaches. In several instances, the genetic manipulation of K(+) channel subunit expression has revealed the role of specific K(+) channel subunit subfamilies or individual K(+) channel subunit genes in the generation of myocardial K(+) channels. In other cases, however, the phenotypic consequences have been unexpected. This review summarizes what has been learned from the in situ genetic manipulation of cardiac K(+) channel functioning in the mouse, discusses the limitations of the models developed to date, and explores the likely directions of future research.
journal_name
Circ Resjournal_title
Circulation researchauthors
Nerbonne JM,Nichols CG,Schwarz TL,Escande Ddoi
10.1161/hh2301.100349subject
Has Abstractpub_date
2001-11-23 00:00:00pages
944-56issue
11eissn
0009-7330issn
1524-4571journal_volume
89pub_type
杂志文章,评审abstract::The subcellular distribution of cardiac muscarinic receptors was defined in canine ventricular myocardium, and receptors were solubilized from subcellular fractions enriched in muscarinic receptor content. The subcellular location of muscarinic receptors in cardiac tissue was determined by measurement of the distribut...
journal_title:Circulation research
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journal_title:Circulation research
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更新日期:1982-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-30 00:00:00
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更新日期:1996-09-01 00:00:00
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更新日期:2007-05-11 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.45.3.347
更新日期:1979-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.65.5.1390
更新日期:1989-11-01 00:00:00
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更新日期:1975-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-10-01 00:00:00