Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis.

abstract：RATIONALE:Transmural dispersion of repolarization has been shown to play a role in the genesis of ventricular tachycardia and fibrillation in different animal models of heart failure (HF). Heterogeneous changes of repolarization within the midmyocardial population of ventricular cells have been considered an important ...

journal_title：Circulation research

authors： Glukhov AV,Fedorov VV,Lou Q,Ravikumar VK,Kalish PW,Schuessler RB,Moazami N,Efimov IR

更新日期：2010-03-19 00:00:00

abstract：RATIONALE:Lymphatic vessels in the respiratory tract normally mature into a functional network during the neonatal period, but under some pathological conditions they can grow as enlarged, dilated sacs that result in the potentially lethal condition of pulmonary lymphangiectasia. OBJECTIVE:We sought to determine wheth...

journal_title：Circulation research

authors： Yao LC,Testini C,Tvorogov D,Anisimov A,Vargas SO,Baluk P,Pytowski B,Claesson-Welsh L,Alitalo K,McDonald DM

更新日期：2014-02-28 00:00:00

abstract：:In our morphometric study of the effects of exercise on the heart, male Wistar-Kyoto rats at 5 weeks of age were subjected daily to a moderate treadmill running program that lasted for 7 weeks. The heart responded to physical conditioning by different magnitudes of tissue growth of the right (22%) and left (7%) ventri...

journal_title：Circulation research

authors： Anversa P,Levicky V,Beghi C,McDonald SL,Kikkawa Y

更新日期：1983-01-01 00:00:00

abstract：:Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been shown to metabolize toxic aldehydes generated by lipid peroxidation, suggesting that it may serve as an antioxidant defense. To investigate its role in the late phase of ischemic preconditioning (PC), conscious rabbits underwent 6 cycles ...

journal_title：Circulation research

authors： Shinmura K,Bolli R,Liu SQ,Tang XL,Kodani E,Xuan YT,Srivastava S,Bhatnagar A

更新日期：2002-08-09 00:00:00

abstract：:The lung parenchyma as a tissue has a rather unusual stress-strain relationship. A theoretical derivation of this relationship is presented which connects the surface tension and the tissue elastic stress in the alveolar septa with the alveolar geometry. The mathematical expression contains a few meaningful physical c...

journal_title：Circulation research

authors： Fung YC

更新日期：1975-10-01 00:00:00

abstract：:Pathological remodeling of the left ventricle (LV) after myocardial infarction (MI) is a major cause of heart failure. Although cardiac hypertrophy after increased loading conditions has been recognized as a clinical risk factor for human heart failure, it is unknown whether post-MI hypertrophic remodeling of the myoc...

journal_title：Circulation research

authors： van Rooij E,Doevendans PA,Crijns HJ,Heeneman S,Lips DJ,van Bilsen M,Williams RS,Olson EN,Bassel-Duby R,Rothermel BA,De Windt LJ

更新日期：2004-02-20 00:00:00

abstract：:Radiolabeled triiodothyronine (T3) binding to isolated nuclei was measured to compare the binding characteristics of the nuclear receptors in rabbit ventricular and atrial muscle cells. Scatchard analysis of the binding data yielded a maximum binding capacity of 170 +/- 20 fmol per mg DNA and apparent dissociation con...

journal_title：Circulation research

authors： Banerjee SK,Ulrich JM,Kaldor GJ

更新日期：1988-07-01 00:00:00

abstract：RATIONALE:Hypoxia followed by reoxygenation promotes inflammation by activating nuclear factor κB transcription factors in endothelial cells (ECs). This process involves modification of the signaling intermediary tumor necrosis factor receptor-associated factor 6 with polyubiquitin chains. Thus, cellular mechanisms tha...

journal_title：Circulation research

authors： Luong le A,Fragiadaki M,Smith J,Boyle J,Lutz J,Dean JL,Harten S,Ashcroft M,Walmsley SR,Haskard DO,Maxwell PH,Walczak H,Pusey C,Evans PC

更新日期：2013-06-07 00:00:00

abstract：:We have identified immunologically the protein kinase C (PKC) isoforms present in rat mesenteric small arteries, defined their distribution between particulate and soluble fractions, and studied their involvement in phorbol ester-induced contraction. Our analysis revealed the presence of the CA(2+)-dependent PKCs (alp...

journal_title：Circulation research

authors： Ohanian V,Ohanian J,Shaw L,Scarth S,Parker PJ,Heagerty AM

更新日期：1996-05-01 00:00:00

abstract：:A period of prolonged vasodilation follows flow-restricted exercise of skeletal muscle. We tested the hypothesis that adenosine participates in mediating this vascular response. Vascularly isolated, anterior calf muscles of anesthetized dogs were stimulated to contract at a rate of 4 twitches/sec. Blood flow was held ...

journal_title：Circulation research

authors： Belloni FL,Phair RD,Sparks HV

更新日期：1979-06-01 00:00:00

abstract：:We used two experimental techniques to study the effect of lidocaine hydrochloride on the early inward transient (sodium) current as it is reflected by the maximum rate of change of action potential phase 0 (Vmax). We assessed the effect of lidocaine on Vmax as Purkinje fibers were slowly depolarized by increasing the...

journal_title：Circulation research

authors： Weld FM,Bigger JT Jr

更新日期：1975-11-01 00:00:00

abstract：:Neuropeptide Y is stored in sympathetic nerve terminals throughout the heart and has direct and indirect effects on cardiac function. Although neuropeptide Y has been shown to be released upon intense (16-30 Hz) cardiac sympathetic stimulation, we sought to determine whether effective quantities of neuropeptide Y were...

journal_title：Circulation research

authors： Warner MR,Levy MN

更新日期：1989-05-01 00:00:00

abstract：RATIONALE:Slow nonuniform electric propagation in the border zone (BZ) of a healed myocardial infarct (MI) can give rise to reentrant arrhythmia. The extent to which this is influenced by structural rather than cellular electric remodeling is unclear. OBJECTIVE:To determine whether structural remodeling alone in the i...

journal_title：Circulation research

authors： Rutherford SL,Trew ML,Sands GB,LeGrice IJ,Smaill BH

更新日期：2012-07-20 00:00:00

abstract：:Basic calcium phosphate (BCP) crystal deposition underlies the development of arterial calcification. Inflammatory macrophages colocalize with BCP deposits in developing atherosclerotic lesions and in vitro can promote calcification through the release of TNF alpha. Here we have investigated whether BCP crystals can e...

journal_title：Circulation research

authors： Nadra I,Mason JC,Philippidis P,Florey O,Smythe CD,McCarthy GM,Landis RC,Haskard DO

更新日期：2005-06-24 00:00:00

abstract：:An extensive investigation of the cardiac actions of phorbol esters and the potential role of the Na(+)-H+ exchanger in those actions was carried out using isolated rat hearts. Sixty minutes of perfusion with 10(-9) M phorbol 12-myristate 13-acetate (PMA) or 10(-8) M phorbol 12,13-dibutyrate (PDBu) produced marked car...

journal_title：Circulation research

authors： Watson JE,Karmazyn M

更新日期：1991-10-01 00:00:00

abstract：:The circulatory effects associated with lifelong plasma atrial natriuretic factor (ANF) elevation were examined by generating transgenic mice, which constitutively express a fusion gene consisting of the transthyretin promoter and the ANF structural gene. These mice have chronically elevated ANF levels as compared wit...

journal_title：Circulation research

authors： Barbee RW,Perry BD,Ré RN,Murgo JP,Field LJ

更新日期：1994-04-01 00:00:00

abstract：:Abstract: Macrophages, a key component of the innate defense against pathogens, participate in the initiation and resolution of inflammation, and in the maintenance of tissues. These diverse and at times antithetical functions of macrophages are executed via distinct activation states, ranging from classical to altern...

journal_title：Circulation research

authors： Chawla A

更新日期：2010-05-28 00:00:00

abstract：:We recorded 60 DC simultaneous electrograms from isolated porcine and canine hearts in the first minutes after coronary occlusion. Ventricular premature beats (VPB) originated from the normal side of the ischemic border, which was frequently separated from the central ischemic area showing delayed activity by a small ...

journal_title：Circulation research

authors： Janse MJ,van Capelle FJ

更新日期：1982-04-01 00:00:00

abstract：RATIONALE:GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, an inflammatory disease associated with increased cardiovascular risk, provides a model to study inflammatory biomarkers in cardiovascular disease (CVD). Whether GlycA associates with psoriasis a...

journal_title：Circulation research

authors： Joshi AA,Lerman JB,Aberra TM,Afshar M,Teague HL,Rodante JA,Krishnamoorthy P,Ng Q,Aridi TZ,Salahuddin T,Natarajan B,Lockshin BN,Ahlman MA,Chen MY,Rader DJ,Reilly MP,Remaley AT,Bluemke DA,Playford MP,Gelfand JM,Meht

更新日期：2016-11-11 00:00:00

abstract：:In the early (3-day) stage of development, long-lasting openings of the L-type Ca2+ channels (mode 2) occur in embryonic chick heart cells. Since mode-2 behavior is infrequently observed in adult heart cells of other species, in the present study, developmental change in behavior of the Ca2+ channel was examined in yo...

journal_title：Circulation research

authors： Tohse N,Mészáros J,Sperelakis N

更新日期：1992-08-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitor was used in dogs with uranyl nitrate-induced acute renal failure to evaluate (1) a possible protective effect of angiotensin blockade and (2)the role of angiotensin II in the generation of renal failure in this model. Angiotensin-converting enzyme inhibitor treatment attenuated ...

journal_title：Circulation research

authors： Lindner A,Cutler RE,Bell AJ

更新日期：1982-08-01 00:00:00

abstract：:Magnesium modulates vascular smooth muscle cell (VSMC) function. However, molecular mechanisms regulating VSMC Mg2+ remain unknown. Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated. Rat, m...

journal_title：Circulation research

authors： He Y,Yao G,Savoia C,Touyz RM

更新日期：2005-02-04 00:00:00

abstract：:The purpose of this study was to determine whether biphasic restitution of action potential duration (APD) in ventricular muscle permits the development of complex dynamic behavior. Such behavior is expected because of the steep ascending slope of restitution and the presence of a maximum. Action potentials recorded f...

journal_title：Circulation research

authors： Watanabe M,Otani NF,Gilmour RF Jr

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:We previously discovered several phosphorylations to the beta subunit of the mitochondrial F(1)F(o) ATP synthase complex in isolated rabbit myocytes on adenosine treatment, an agent that induces cardioprotection. The role of these phosphorylations is unknown. OBJECTIVE:The present study focuses on the functi...

journal_title：Circulation research

authors： Kane LA,Youngman MJ,Jensen RE,Van Eyk JE

更新日期：2010-02-19 00:00:00

abstract：:We have previously studied the relation between long-chain fatty acid and pyruvate metabolism in reperfused myocardium and noted a rapid return of fatty acid oxidation to at least preischemic values accompanied by a marked decrease in pyruvate oxidation. The purpose of the present report is to further characterize car...

journal_title：Circulation research

authors： Renstrom B,Nellis SH,Liedtke AJ

更新日期：1989-10-01 00:00:00

abstract：:Inhibition of vascular smooth muscle (VSM) delayed rectifier K+ channels (K(DR)) by 4-aminopyridine (4-AP; 200 micromol/L) or correolide (1 micromol/L), a selective inhibitor of Kv1 channels, enhanced myogenic contraction of rat mesenteric arteries (RMAs) in response to increases in intraluminal pressure. The molecula...

journal_title：Circulation research

authors： Plane F,Johnson R,Kerr P,Wiehler W,Thorneloe K,Ishii K,Chen T,Cole W

更新日期：2005-02-04 00:00:00

abstract：:To test the hypothesis that early interventional treatment with insulin-like growth factor-1 (IGF-1) alleviates subsequent development of dilated cardiomyopathy, cardiac-specific IGF-1 expression was introduced by selective cross-breeding into a transgenic mouse model of heart failure that displays phenotypic characte...

journal_title：Circulation research

authors： Welch S,Plank D,Witt S,Glascock B,Schaefer E,Chimenti S,Andreoli AM,Limana F,Leri A,Kajstura J,Anversa P,Sussman MA

更新日期：2002-04-05 00:00:00

abstract：:To test the hypothesis that the capacity to develop left ventricular (LV) hypertrophy might diminish with advancing age, we examined the hypertrophic response to ascending aortic constriction in 3 groups of adult Fischer 344 rats (9 months, 18 months, and 22 months of age). Aortic constriction was created so that aort...

journal_title：Circulation research

authors： Isoyama S,Wei JY,Izumo S,Fort P,Schoen FJ,Grossman W

更新日期：1987-09-01 00:00:00

abstract：:The kinetics of contractions and Ca(2+) transients are slowed in myocytes from failing hearts. The mechanisms accounting for these abnormalities remain unclear. Myocardial infarction (MI) was produced by ligation of the circumflex artery in rabbits. We used confocal microscopy to record spatially resolved Ca(2+) trans...

journal_title：Circulation research

authors： Litwin SE,Zhang D,Bridge JH

更新日期：2000-11-24 00:00:00

abstract：:We have recently characterized the promoter region of the rabbit embryonic smooth muscle myosin heavy chain (SMemb/NMHC-B) gene and identified the 15-bp sequence, designated SE1, located at -105 from the transcriptional start site as an important regulatory element for its transcriptional activity in a smooth muscle c...

journal_title：Circulation research

authors： Watanabe N,Kurabayashi M,Shimomura Y,Kawai-Kowase K,Hoshino Y,Manabe I,Watanabe M,Aikawa M,Kuro-o M,Suzuki T,Yazaki Y,Nagai R

更新日期：1999-07-23 00:00:00