Abstract:
:We recorded 60 DC simultaneous electrograms from isolated porcine and canine hearts in the first minutes after coronary occlusion. Ventricular premature beats (VPB) originated from the normal side of the ischemic border, which was frequently separated from the central ischemic area showing delayed activity by a small zone of inexcitable tissue. We attempted in a computer model to generate VPB's at one side of an area showing conduction block. In computer simulations,,, the presence of elements capable of automatic activity greatly facilitated the induction of VPB's. By coupling automatic elements to nonautomatic elements, overt pacemaking activity could be suppressed. Subthreshold depolarizations transmitted through a zone of conduction block could, when properly timed, trigger the latent automatic elements into overt automatic activity, resulting in single or repetitive VPB's. The ventricular premature beats in the intact hearts with acute regional ischemia may be caused by "triggered automaticity" in which the trigger is provided by the "injury current" flowing from ischemic cells showing delayed repolarization via a segment of inexcitable ischemic cells in the border zone to normally perfused cells with suppressed automaticity.
journal_name
Circ Resjournal_title
Circulation researchauthors
Janse MJ,van Capelle FJdoi
10.1161/01.res.50.4.527subject
Has Abstractpub_date
1982-04-01 00:00:00pages
527-37issue
4eissn
0009-7330issn
1524-4571journal_volume
50pub_type
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-07-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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更新日期:1990-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.36.5.590
更新日期:1975-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.107.160176
更新日期:2008-02-15 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.76.1.73
更新日期:1995-01-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.66.6.1591
更新日期:1990-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.0000030861.13850.f1
更新日期:2002-08-23 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-01-02 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:
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更新日期:2008-08-29 00:00:00
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更新日期:2014-09-26 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1998-02-23 00:00:00
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pub_type: 杂志文章
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更新日期:1986-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-06-08 00:00:00
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更新日期:2001-01-19 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.84.12.1388
更新日期:1999-06-25 00:00:00
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更新日期:2004-02-20 00:00:00