Abstract:
:To test the hypothesis that the capacity to develop left ventricular (LV) hypertrophy might diminish with advancing age, we examined the hypertrophic response to ascending aortic constriction in 3 groups of adult Fischer 344 rats (9 months, 18 months, and 22 months of age). Aortic constriction was created so that aortic cross-sectional areas would be the same for the 3 groups of rats. Four weeks after imposition of aortic constriction, there was no significant difference in peak LV pressure, peak-to-peak and mean systolic pressure gradients between left ventricle and aorta, cardiac output, LV minute work, or cross-sectional area of the aortic constrictions in the 3 groups. In 9-month-old aortic-constricted rats, LV dry wt (LVDW)/body wt, LVDW/tibial length, and myocyte width increased by 23% (p less than 0.01), 14% (p less than 0.01), and 27% (p less than 0.01), respectively, compared with sham-operated rats. In contrast, in 18-month-old and 22-month-old aortic-constricted rats, LVDW/body wt and LVDW/tibial length were unchanged compared with sham-operated controls, and increases in myocyte width were only modest 4 weeks following constriction. RNA concentration in the myocardium 5 days after constriction increased by 21% (p less than 0.001) in 9-month-old rats but showed no significant rise in 18-month-old rats. These results suggest that advancing age is associated with a diminished capacity to develop myocardial hypertrophy in response to acute pressure overload and that a reduced ability to synthesize protein may be one of the major contributing factors to a diminished capacity for hypertrophy in advanced age.
journal_name
Circ Resjournal_title
Circulation researchauthors
Isoyama S,Wei JY,Izumo S,Fort P,Schoen FJ,Grossman Wdoi
10.1161/01.res.61.3.337subject
Has Abstractpub_date
1987-09-01 00:00:00pages
337-45issue
3eissn
0009-7330issn
1524-4571journal_volume
61pub_type
杂志文章abstract::Pinocytotic vesicles are one of several anatomic factors relevant to the permeability for macromolecules of capillary endothelia. We quantitified the number and distribution of pinocytotic vesicles present in the endothelium of pulmonary capillaries. Several similar studies have been reported in the past for endotheli...
journal_title:Circulation research
pub_type: 杂志文章
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doi:10.1161/01.res.77.1.37
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2006-08-18 00:00:00
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pub_type: 杂志文章
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更新日期:1989-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.RES.0000247932.71270.2c
更新日期:2006-10-27 00:00:00
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doi:10.1161/01.res.75.2.268
更新日期:1994-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-08-24 00:00:00
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pub_type: 杂志文章
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更新日期:1983-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.74.6.1141
更新日期:1994-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000059562.91384.1A
更新日期:2003-03-07 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-09-28 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.36.6.761
更新日期:1975-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000038887.17976.33
更新日期:2002-10-18 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.243790
更新日期:2011-08-19 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.83.3.279
更新日期:1998-08-10 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.83.7.705
更新日期:1998-10-05 00:00:00
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更新日期:1996-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.76.5.742
更新日期:1995-05-01 00:00:00
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更新日期:1983-03-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1999-01-08 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/hh1301.092508
更新日期:2001-07-06 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000134921.50377.61
更新日期:2004-07-23 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.69.2.530
更新日期:1991-08-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.85.5.403
更新日期:1999-09-03 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.68.3.683
更新日期:1991-03-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2000-11-10 00:00:00
abstract::It has been reported that immunization against tonin normalizes blood pressure, and that sialoadenectomy, during which the tonin-rich salivary glands are removed, decreases blood pressure in one-kidney, one-clip hypertension. To investigate the role of tonin on this form of hypertension further, we actively immunized ...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.55.5.580
更新日期:1984-11-01 00:00:00