Abstract:
RATIONALE:Adoptive transfer of cardiac progenitor cells (CPCs) has entered clinical application, despite limited mechanistic understanding of the endogenous response after myocardial infarction (MI). Extracellular matrix undergoes dramatic changes after MI and therefore might be linked to CPC-mediated repair. OBJECTIVE:To demonstrate the significance of fibronectin (Fn), a component of the extracellular matrix, for induction of the endogenous CPC response to MI. METHODS AND RESULTS:This report shows that presence of CPCs correlates with the expression of Fn during cardiac development and after MI. In vivo, genetic conditional ablation of Fn blunts CPC response measured 7 days after MI through reduced proliferation and diminished survival. Attenuated vasculogenesis and cardiogenesis during recovery were evident at the end of a 12-week follow-up period. Impaired CPC-dependent reparative remodeling ultimately leads to continuous decline of cardiac function in Fn knockout animals. In vitro, Fn protects and induces proliferation of CPCs via β₁-integrin-focal adhesion kinase-signal transducer and activator of transcription 3-Pim1 independent of Akt. CONCLUSIONS:Fn is essential for endogenous CPC expansion and repair required for stabilization of cardiac function after MI.
journal_name
Circ Resjournal_title
Circulation researchauthors
Konstandin MH,Toko H,Gastelum GM,Quijada P,De La Torre A,Quintana M,Collins B,Din S,Avitabile D,Völkers M,Gude N,Fässler R,Sussman MAdoi
10.1161/CIRCRESAHA.113.301152subject
Has Abstractpub_date
2013-07-05 00:00:00pages
115-25issue
2eissn
0009-7330issn
1524-4571pii
CIRCRESAHA.113.301152journal_volume
113pub_type
杂志文章abstract::We determined the effects of changing the spatial dispersion of acetylcholine release on the phase-dependent chronotropic responses to vagal stimulation in anesthetized dogs. We stimulated the vagus nerves with one brief burst of electrical pulses each cardiac cycle, and we changed the timing of the stimulus by a smal...
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更新日期:2010-10-29 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-02-02 00:00:00
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更新日期:2005-09-16 00:00:00
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更新日期:1987-09-01 00:00:00
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更新日期:2008-04-11 00:00:00
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pub_type: 杂志文章,收录出版
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更新日期:2014-01-17 00:00:00
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更新日期:2012-03-16 00:00:00
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更新日期:2015-02-13 00:00:00
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更新日期:1987-07-01 00:00:00