Progestogens do not affect aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits.

abstract：:Transmural heterogeneity of myocardial metabolism and function are present in the left ventricle under normal and ischemic conditions. To determine if endocardial versus epicardial differences of [Ca2+]i are also present, perfused rat heart studies using indo-1 fluorescence as an index of [Ca2+]i were performed in the...

journal_title：Circulation research

authors： Figueredo VM,Brandes R,Weiner MW,Massie BM,Camacho SA

更新日期：1993-05-01 00:00:00

abstract：:Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-...

journal_title：Circulation research

authors： Shorofsky SR,January CT

更新日期：1992-03-01 00:00:00

abstract：:Genetically hypertensive (GH) rats of the New Zealand strain and normotensive (N) rats were sympathectomized from birth with 6-hydroxydopamine (100 mg/kg,s.c, on alternate days, seven treatments). In adult treated rats from each strain (GHTr and NTr), blood pressure was lower than normal. Functional tests and electron...

journal_title：Circulation research

authors： Clark DW,Jones DR,Phelan EL,Devine CE

更新日期：1978-08-01 00:00:00

abstract：RATIONALE:Closure of the ductus arteriosus (DA) is essential for the transition from fetal to neonatal patterns of circulation. Initial PO2-dependent vasoconstriction causes functional DA closure within minutes. Within days a fibrogenic, proliferative mechanism causes anatomic closure. Though modulated by endothelial-d...

journal_title：Circulation research

authors： Hong Z,Kutty S,Toth PT,Marsboom G,Hammel JM,Chamberlain C,Ryan JJ,Zhang HJ,Sharp WW,Morrow E,Trivedi K,Weir EK,Archer SL

更新日期：2013-03-01 00:00:00

abstract：RATIONALE:Mitochondria are key integrators of convergent intracellular signaling pathways. Two important second messengers modulated by mitochondria are calcium and reactive oxygen species. To date, coherent mechanisms describing mitochondrial integration of calcium and oxidative signaling in arterial smooth muscle are...

journal_title：Circulation research

authors： Chaplin NL,Nieves-Cintrón M,Fresquez AM,Navedo MF,Amberg GC

更新日期：2015-12-04 00:00:00

abstract：:It has been reported that immunization against tonin normalizes blood pressure, and that sialoadenectomy, during which the tonin-rich salivary glands are removed, decreases blood pressure in one-kidney, one-clip hypertension. To investigate the role of tonin on this form of hypertension further, we actively immunized ...

journal_title：Circulation research

authors： Seto S,Rabito SF,Scicli AG,Carretero OA

更新日期：1984-11-01 00:00:00

abstract：RATIONALE:Circulating progenitor cells (CPCs) mobilize in response to ischemic injury, but their predictive value remains unknown in acute coronary syndrome (ACS). OBJECTIVE:We aimed to investigate the number of CPCs in ACS compared with those with stable coronary artery disease (CAD), relationship between bone marrow...

journal_title：Circulation research

authors： Samman Tahhan A,Hammadah M,Raad M,Almuwaqqat Z,Alkhoder A,Sandesara PB,Mohamed-Kelli H,Hayek SS,Kim JH,O'Neal WT,Topel ML,Grant AJ,Sabbak N,Heinl RE,Gafeer MM,Obideen M,Kaseer B,Abdelhadi N,Ko YA,Liu C,Hesaroieh I

更新日期：2018-05-25 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) is a widely distributed mitogen that mediates the growth-promoting effects of platelet-derived growth factor in mesenchymal cells. We show that rat aortic IGF-I messenger RNA (mRNA) is induced 24 hours after deendothelialization, at a time when smooth muscle cell proliferation with...

journal_title：Circulation research

authors： Cercek B,Fishbein MC,Forrester JS,Helfant RH,Fagin JA

更新日期：1990-06-01 00:00:00

abstract：RATIONALE:Immune cells play an important role during the generation and resolution of thrombosis. T cells are powerful regulators of immune and nonimmune cell function, however, their role in sterile inflammation in venous thrombosis has not been systematically examined. OBJECTIVE:This study investigated the recruitme...

journal_title：Circulation research

authors： Luther N,Shahneh F,Brähler M,Krebs F,Jäckel S,Subramaniam S,Stanger C,Schönfelder T,Kleis-Fischer B,Reinhardt C,Probst HC,Wenzel P,Schäfer K,Becker C

更新日期：2016-12-09 00:00:00

abstract：RATIONALE:Diabetes mellitus is frequently complicated by cardiovascular disease, such as vascular calcification and endothelial dysfunction, which have been associated with bone morphogenetic proteins (BMPs). OBJECTIVE:To determine whether hyperglycemia in vitro and diabetes in vivo promote vascular BMP activity and c...

journal_title：Circulation research

authors： Boström KI,Jumabay M,Matveyenko A,Nicholas SB,Yao Y

更新日期：2011-02-18 00:00:00

abstract：:Aging of the vasculature plays a central role in morbidity and mortality of older people. To develop novel treatments for amelioration of unsuccessful vascular aging and prevention of age-related vascular pathologies, it is essential to understand the cellular and functional changes that occur in the vasculature durin...

journal_title：Circulation research

authors： Ungvari Z,Tarantini S,Donato AJ,Galvan V,Csiszar A

更新日期：2018-09-14 00:00:00

abstract：:The epicardium, the tissue layer covering the cardiac muscle (myocardium), develops from the proepicardium, a mass of coelomic progenitors located at the venous pole of the embryonic heart. Proepicardium cells attach to and spread over the myocardium to form the primitive epicardial epithelium. The epicardium subseque...

journal_title：Circulation research

authors： Pérez-Pomares JM,de la Pompa JL

更新日期：2011-12-09 00:00:00

abstract：:The aim of this study was to determine the mechanism of action of norepinephrine (NE) on arterial baroreceptors (BRs), with the focus on regularly discharging, presumably myelinated fibers. With the use of an in vitro aortic arch/aortic nerve preparation from rats, BR single-fiber discharge was recorded simultaneously...

journal_title：Circulation research

authors： Munch PA,Thoren PN,Brown AM

更新日期：1987-09-01 00:00:00

abstract：:Mechanisms of denervation supersensitivity to sympathomimetic amines were studied in conscious animals. Norepinephrine, 0.1 micrograms/kg, increased left ventricular dP/dt significantly more (4208 +/- 828 mm Hg/sec) in dogs with cardiac denervation than in intact dogs (1029 +/- 280 mm Hg/sec), P less than 0.01, wherea...

journal_title：Circulation research

authors： Vatner DE,Lavallee M,Amano J,Finizola A,Homcy CJ,Vatner SF

更新日期：1985-07-01 00:00:00

abstract：:We previously observed that stimulation of vascular smooth muscle cell (VSMC) proliferation with growth factors is associated with dismantling of cadherin junctions and nuclear translocation of beta-catenin. In this study we demonstrate directly that growth factors stimulate beta-catenin/T-cell factor (TCF) signaling ...

journal_title：Circulation research

authors： Quasnichka H,Slater SC,Beeching CA,Boehm M,Sala-Newby GB,George SJ

更新日期：2006-12-08 00:00:00

abstract：:High affinity binding sites of angiotensin II (A II) have been characterized in rabbit renomedullary interstitial cells in tissue culture. Binding was rapid, specific, and saturable. Scatchard analysis of steady state saturation binding data at 22 degrees C indicated a single binding site with an equilibrium dissociat...

journal_title：Circulation research

authors： Brown CA,Zusman RM,Haber E

更新日期：1980-06-01 00:00:00

abstract：:Controversy exists regarding the mechanism by which catecholamines stimulate renin secretion in vivo. A sensitive rat kidney slice system was utilized to study the direct effects of adrenergic agonists and antagonists on renin release in vitro. Catecholamines were protected from degradation by the addition of ascorbic...

journal_title：Circulation research

authors： Weinberger MH,Aoi W,Henry DP

更新日期：1975-09-01 00:00:00

abstract：:Rationale: The overuse of antibiotics has been an important clinical issue, and antibiotic exposure is linked to alterations in gut microbiota, which has been related to risks of various chronic diseases such as cardiovascular disease and cancer. Also, duration of antibiotic exposure may be a risk factor of premature ...

journal_title：Circulation research

authors： Heianza Y,Ma W,Li X,Cao Y,Chan AT,Rimm EB,Hu FB,Rexrode KM,Manson JE,Qi L

更新日期：2020-01-31 00:00:00

abstract：:We have identified immunologically the protein kinase C (PKC) isoforms present in rat mesenteric small arteries, defined their distribution between particulate and soluble fractions, and studied their involvement in phorbol ester-induced contraction. Our analysis revealed the presence of the CA(2+)-dependent PKCs (alp...

journal_title：Circulation research

authors： Ohanian V,Ohanian J,Shaw L,Scarth S,Parker PJ,Heagerty AM

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and c...

journal_title：Circulation research

authors： Fang F,Yang Y,Yuan Z,Gao Y,Zhou J,Chen Q,Xu Y

更新日期：2011-04-01 00:00:00

abstract：:Pulsatile pulmonary hemodynamics were analyzed in a chronic awake canine high flow model. Standard mean flow and pulsatile flow hemodynamics were measured and alterations in the proximal pulmonary vascular physical properties were quantified by the characteristic impedance (Zo). Pulmonary vascular resistance (PVR), wh...

journal_title：Circulation research

authors： Hopkins RA,Hammon JW Jr,McHale PA,Smith PK,Anderson RW

更新日期：1979-08-01 00:00:00

abstract：RATIONALE:Carriers of the most common prothrombotic mutations FVL (factor V Leiden) and FII (prothrombin) 20210G>A show a highly variable clinical phenotype. Using standardized in vivo coagulation activation followed by activity pattern analysis we have recently shown, that the FVL mutation accelerates thrombin and APC...

journal_title：Circulation research

authors： Rühl H,Berens C,Winterhagen FI,Reda S,Müller J,Oldenburg J,Pötzsch B

更新日期：2019-08-16 00:00:00

abstract：:Previous studies have demonstrated a role for voltage-gated K+ (Kv) channel alpha subunits of the Kv4 subfamily in the generation of rapidly inactivating/recovering cardiac transient outward K+ current, I(to,f), channels. Biochemical studies suggest that mouse ventricular I(to,f) channels reflect the heteromeric assem...

journal_title：Circulation research

authors： Guo W,Jung WE,Marionneau C,Aimond F,Xu H,Yamada KA,Schwarz TL,Demolombe S,Nerbonne JM

更新日期：2005-12-09 00:00:00

abstract：:Angiotensin II and its metabolites, [des-Asp-1]-angiotensin II (angiotensin III), [des-(Asp-1,Arg-2)]angiotensin II, and [des-(Asp-1,Arg-2,val-3)]angiotensin II, were measured in arterial and venous plasma from normal rats. Paper chromatography was used to separate the peptides which were measured with a radioimmunoas...

journal_title：Circulation research

authors： Semple PF,Morton JJ

更新日期：1976-06-01 00:00:00

abstract：RATIONALE:Wnt signaling regulates key aspects of diabetic vascular disease. OBJECTIVE:We generated SM22-Cre;LRP6(fl/fl);LDLR(-/-) mice to determine contributions of Wnt coreceptor low-density lipoprotein receptor-related protein 6 (LRP6) in the vascular smooth muscle lineage of male low-density lipoprotein receptor-nu...

journal_title：Circulation research

authors： Cheng SL,Ramachandran B,Behrmann A,Shao JS,Mead M,Smith C,Krchma K,Bello Arredondo Y,Kovacs A,Kapoor K,Brill LM,Perera R,Williams BO,Towler DA

更新日期：2015-07-03 00:00:00

abstract：:Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies. Cardiac malformations have been produced in multiple experimental animal models, by perturbing selected molecules that function in the developmental pathways involved in myocyte specification, differentiation, or cardiac morphogene...

journal_title：Circulation research

authors： Fahed AC,Gelb BD,Seidman JG,Seidman CE

更新日期：2013-02-15 00:00:00

abstract：:Leukocyte rolling along the endothelium in inflammation is caused by continuous formation and breakage of bonds between selectin adhesion molecules and their ligands. We investigated trauma-induced leukocyte rolling in venules (diameter, 23 to 58 microns; wall shear stress, 1.2 to 35 dyne/cm2) of the exteriorized rat ...

journal_title：Circulation research

authors： Damiano ER,Westheider J,Tözeren A,Ley K

更新日期：1996-12-01 00:00:00

abstract：:The purpose of this study was to determine whether a cyclic adenosine 3',5'-monophosphate-dependent process can be involved in the regulation of vascular smooth muscle alpha 1-adrenergic receptor responsiveness. Experiments were performed in cultured rabbit aortic smooth muscle cells which were characterized previousl...

journal_title：Circulation research

authors： Colucci WS

更新日期：1986-02-01 00:00:00

abstract：:Pharmacological evidence indicates that angiotensin (Ang II) converting enzyme inhibitors attenuate cardiovascular responses to sympathetic stimulation. To investigate the physiological significance of this attenuation, the pressor and heart rate responses to bilateral carotid occlusion (BCO) were studied before and a...

journal_title：Circulation research

authors： Isaacson JS,Reid IA

更新日期：1990-03-01 00:00:00

abstract：:Platelet-activating factor (acetyl-glyceryl-ether-phosphorylcholine; 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine), which is released by stimulated neutrophils and platelets, possesses the ability to alter vascular tone and permeability and to activate various formed blood elements. We have characterized the he...

journal_title：Circulation research

authors： Jackson CV,Schumacher WA,Kunkel SL,Driscoll EM,Lucchesi BR

更新日期：1986-02-01 00:00:00