Abstract:
:Aging of the vasculature plays a central role in morbidity and mortality of older people. To develop novel treatments for amelioration of unsuccessful vascular aging and prevention of age-related vascular pathologies, it is essential to understand the cellular and functional changes that occur in the vasculature during aging. In this review, the pathophysiological roles of fundamental cellular and molecular mechanisms of aging, including oxidative stress, mitochondrial dysfunction, impaired resistance to molecular stressors, chronic low-grade inflammation, genomic instability, cellular senescence, epigenetic alterations, loss of protein homeostasis, deregulated nutrient sensing, and stem cell dysfunction in the vascular system are considered in terms of their contribution to the pathogenesis of both microvascular and macrovascular diseases associated with old age. The importance of progeronic and antigeronic circulating factors in relation to development of vascular aging phenotypes are discussed. Finally, future directions and opportunities to develop novel interventions to prevent/delay age-related vascular pathologies by targeting fundamental cellular and molecular aging processes are presented.
journal_name
Circ Resjournal_title
Circulation researchauthors
Ungvari Z,Tarantini S,Donato AJ,Galvan V,Csiszar Adoi
10.1161/CIRCRESAHA.118.311378subject
Has Abstractpub_date
2018-09-14 00:00:00pages
849-867issue
7eissn
0009-7330issn
1524-4571journal_volume
123pub_type
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journal_title:Circulation research
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1983-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.52.3.312
更新日期:1983-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.82.2.195
更新日期:1998-02-09 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.59.6.704
更新日期:1986-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-05-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2004-05-14 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,收录出版
doi:10.1161/CIRCRESAHA.109.207266
更新日期:2009-11-20 00:00:00
abstract::Over the last 4 decades, heart transplantation (HTx) has evolved as a mainstream therapy for heart failure. Approximately half of patients needing HTx have organ failure consequent to atherosclerosis. Despite advances in immunosuppressive drugs, long-term success of HTx is limited by the development of a particular ty...
journal_title:Circulation research
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更新日期:2006-10-13 00:00:00
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更新日期:1976-08-01 00:00:00
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更新日期:2014-02-28 00:00:00
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更新日期:2005-07-08 00:00:00
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