Triadin overexpression stimulates excitation-contraction coupling and increases predisposition to cellular arrhythmia in cardiac myocytes.

abstract：:The mitochondrial enzyme monoamine oxidase (MAO), its isoform MAO-A, plays a major role in reactive oxygen species-dependent cardiomyocyte apoptosis and postischemic cardiac damage. In the current study, we investigated whether sphingolipid metabolism can account for mediating MAO-A- and reactive oxygen species-depend...

journal_title：Circulation research

authors： Pchejetski D,Kunduzova O,Dayon A,Calise D,Seguelas MH,Leducq N,Seif I,Parini A,Cuvillier O

更新日期：2007-01-05 00:00:00

abstract：:The effects of exercise training on the coronary vasodilation following activation of the Bezold-Jarisch reflex were examined in conscious dogs. Mongrel dogs were chronically instrumented using sterile techniques for measurements of systemic hemodynamics and left circumflex coronary blood flow (CBF). With the heart ra...

journal_title：Circulation research

authors： Zhao G,Zhang X,Xu X,Ochoa M,Hintze TH

更新日期：1997-06-01 00:00:00

abstract：:Vascular disease in diabetics could arise in part from altered vessel wall catebolism. Specific activities of hydrolases in aortic smooth muscle cells from rats with streptozotocin-induced diabetes were measured. Enyzmes included: neutral alpha-glucosidase, alpha-mannosidase, and lysosomal N-acetyl beta-glucosaminidas...

journal_title：Circulation research

authors： Wolinsky H,Goldfischer S,Capron L,Capron F,Coltoff-Schiller B,Kasak L

更新日期：1978-06-01 00:00:00

abstract：:Endothelial cells, either in vivo or freshly isolated, respond when exposed to muscarinic agonists with an increase in cytosolic free calcium concentration ([Ca2+]i) and release of endothelium-derived relaxing factor (EDRF). When placed in culture, however, endothelial cells rapidly lose these responses, which may be ...

journal_title：Circulation research

authors： Tracey WR,Peach MJ

更新日期：1992-02-01 00:00:00

abstract：:When exposed to an increasing transmural pressure, middle cerebral arteries of the cat exhibit reduction of internal diameter which is mediated by vascular muscle cell depolarization. This laboratory has recently demonstrated that this "pressure-induced" activation is dependent upon the presence of an intact endotheli...

journal_title：Circulation research

authors： Harder DR,Sanchez-Ferrer C,Kauser K,Stekiel WJ,Rubanyi GM

更新日期：1989-07-01 00:00:00

abstract：:We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor of coronary artery disease (CAD), is associated with increased atherosclerosis and decreased plasma high-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient (CBS(-/-)/apoE(-/-)) mice. We o...

journal_title：Circulation research

authors： Liao D,Tan H,Hui R,Li Z,Jiang X,Gaubatz J,Yang F,Durante W,Chan L,Schafer AI,Pownall HJ,Yang X,Wang H

更新日期：2006-09-15 00:00:00

abstract：:A mathematical model for the regulation of mechanical activity in cardiac muscle has been developed based on a three-element rheological model of this muscle. The contractile element has been modeled taking into account the results of extensive mechanical tests that involved the recording of length-force and force-vel...

journal_title：Circulation research

authors： Izakov VYa,Katsnelson LB,Blyakhman FA,Markhasin VS,Shklyar TF

更新日期：1991-11-01 00:00:00

abstract：RATIONALE:Complementation of pluripotency genes may improve adult stem cell functions. OBJECTIVES:Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or ...

journal_title：Circulation research

authors： Koyanagi M,Iwasaki M,Rupp S,Tedesco FS,Yoon CH,Boeckel JN,Trauth J,Schütz C,Ohtani K,Goetz R,Iekushi K,Bushoven P,Momma S,Mummery C,Passier R,Henschler R,Akintuerk H,Schranz D,Urbich C,Galvez BG,Cossu G,Zeiher A

更新日期：2010-04-16 00:00:00

abstract：:The functional disturbance of microvasculature is recognized as an initiating mechanism that underlies the development of various diabetic complications. Although a causal relationship between microvascular leakage and tissue damage has been well documented in diabetic kidneys and eyes, there is a lack of information ...

journal_title：Circulation research

authors： Yuan SY,Ustinova EE,Wu MH,Tinsley JH,Xu W,Korompai FL,Taulman AC

更新日期：2000-09-01 00:00:00

abstract：:Left ventricular (LV) remodeling after experimental myocardial infarction (MI) is associated with hypertrophy of noninfarcted myocardium and electrophysiological alterations. We have recently shown that post-MI hypertrophied LV myocytes have prolonged action potential duration (APD) and generate triggered activity fro...

journal_title：Circulation research

authors： Gidh-Jain M,Huang B,Jain P,el-Sherif N

更新日期：1996-10-01 00:00:00

abstract：:The present study assesses effects of acutely infarcted myocardium on apparent microsphere loss as a function of time, determines effects of apparent microsphere loss on blood flow measurements to ischemic regions, and determines to what extent apparent microsphere loss alters interpretation of serial measurements of ...

journal_title：Circulation research

authors： Murdock RH Jr,Cobb FR

更新日期：1980-11-01 00:00:00

abstract：:To investigate the dynamic control of cardiac ATP synthesis, we simultaneously determined the time course of mitochondrial oxygen consumption with the time course of changes in high-energy phosphates following steps in cardiac energy demand. Isolated isovolumically contracting rabbit hearts were perfused with Tyrode's...

journal_title：Circulation research

authors： Eijgelshoven MH,van Beek JH,Mottet I,Nederhoff MG,van Echteld CJ,Westerhof N

更新日期：1994-10-01 00:00:00

abstract：:We investigated the effect of medium conditioned by bovine aortic endothelial cells on collagen accumulation and total protein formation by human embryonic fibroblasts or bovine smooth muscle cells in cultures. The conditioned medium at a 1:10 dilution induced a twofold increase in collagen and total protein accumulat...

journal_title：Circulation research

authors： Villanueva AG,Farber HW,Rounds S,Goldstein RH

更新日期：1991-07-01 00:00:00

abstract：:To isolate specific markers of both differentiated and proliferating vascular smooth muscle cells (VSMCs), we used the technique of differential cDNA screening using RNA from cultured rat aortic VSMCs. The tissue specificity of expression of all of the cDNAs isolated was determined by Northern analysis. We isolated se...

journal_title：Circulation research

authors： Shanahan CM,Weissberg PL,Metcalfe JC

更新日期：1993-07-01 00:00:00

abstract：:Baroreceptor reflexes can be demonstrated during fetal life, but whether baroreceptors normally regulate fetal arterial pressure is unknown. This problem was addressed directly by measuring arterial pressure and analyzing its variation in eight unanesthetized fetal lambs throughout the last third of gestation, and com...

journal_title：Circulation research

authors： Yardley RW,Bowes G,Wilkinson M,Cannata JP,Maloney JE,Ritchie BC,Walker AM

更新日期：1983-05-01 00:00:00

abstract：:The recent discovery of neutral active choline and ethanolamine glycerophospholipid specific phospholipase C in myocardium (Wolf RA, Gross RW. J Biol Chem 1985;260:7295) has demonstrated a novel catabolic pathway that potentially contributes to the accumulation of amphiphilic metabolites during myocardial ischemia. To...

journal_title：Circulation research

authors： Ford DA,Gross RW

更新日期：1989-01-01 00:00:00

abstract：:Since the first description of the anatomical atrioventricular nodes (AVNs), a large number of studies have provided insights into the heterogeneity of the structure as well as a repertoire of ion channel proteins that govern this complex conduction pathway between the atria and ventricles. These studies have revealed...

journal_title：Circulation research

authors： Zhang Q,Timofeyev V,Lu L,Li N,Singapuri A,Long MK,Bond CT,Adelman JP,Chiamvimonvat N

更新日期：2008-02-29 00:00:00

abstract：:Membrane current abnormalities have been described in human heart failure. To determine whether similar current changes are observed in a large animal model of heart failure, we studied dogs with pacing-induced cardiomyopathy. Myocytes isolated from the midmyocardium of 13 dogs with heart failure induced by 3 to 4 wee...

journal_title：Circulation research

authors： Kääb S,Nuss HB,Chiamvimonvat N,O'Rourke B,Pak PH,Kass DA,Marban E,Tomaselli GF

更新日期：1996-02-01 00:00:00

abstract：:The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) plays a critical role in the contractile performance of cardiac and slow-twitch skeletal muscle by restoring cytosolic calcium to low resting levels during the contractile cycle. We have previously shown that SERCA2 expression in the heart is altered by a number of pat...

journal_title：Circulation research

authors： Fisher SA,Buttrick PM,Sukovich D,Periasamy M

更新日期：1993-10-01 00:00:00

abstract：:We carried out a systematic study on the effects of elevating [K]o on the properties of a transient outward potassium channel encoded by a cardiac cDNA (RHK1) and compared them with those on two Shaker potassium channels (H-4 and H-37). The amino acid sequences of all three channels are known, and their structure-func...

journal_title：Circulation research

authors： Tseng GN,Tseng-Crank J

更新日期：1992-09-01 00:00:00

abstract：:Genome-wide association studies have provided a rich collection of ≈ 58 coronary artery disease (CAD) loci that suggest the existence of previously unsuspected new biology relevant to atherosclerosis. However, these studies only identify genomic loci associated with CAD, and many questions remain even after a genomic ...

journal_title：Circulation research

authors： Nurnberg ST,Zhang H,Hand NJ,Bauer RC,Saleheen D,Reilly MP,Rader DJ

更新日期：2016-02-19 00:00:00

abstract：:Ischemia and simulated ischemic conditions induce enhanced release of norepinephrine (NE) in the brain and the heart. Although studies with neuronal preparations demonstrated a rise in [Ca2+]i under energy-depleted conditions, such release of NE in the heart appears to be predominantly Ca2+ independent. Since Ca2+ ove...

journal_title：Circulation research

authors： Du XJ,Bobik A,Little PJ,Esler MD,Dart AM

更新日期：1997-02-01 00:00:00

abstract：RATIONALE:In ventricular myocytes of large mammals with low T-tubule density, a significant number of ryanodine receptors (RyRs) are not coupled to the sarcolemma; cardiac remodeling increases noncoupled RyRs. OBJECTIVE:Our aim was to test the hypothesis that coupled and noncoupled RyRs have distinct microdomain-depen...

journal_title：Circulation research

authors： Dries E,Bito V,Lenaerts I,Antoons G,Sipido KR,Macquaide N

更新日期：2013-11-08 00:00:00

abstract：:Recent evidence suggests that functional diversity of vascular smooth muscle is produced in part by a differential expression of ion channels. The aim of the present study was to examine the role of Ca(2+)-activated K(+) channels (K(Ca) channels) in the expression of smooth muscle cell functional phenotype. We found t...

journal_title：Circulation research

authors： Neylon CB,Lang RJ,Fu Y,Bobik A,Reinhart PH

更新日期：1999-10-29 00:00:00

abstract：:We investigated whether the heart, like other mammalian organs, possesses internal clocks, and, if so, whether pressure overload-induced hypertrophy alters the clock mechanism. Clock genes are intrinsically maintained, as shown by rhythmic changes even in single cells. Clocks are believed to confer a selective advanta...

journal_title：Circulation research

authors： Young ME,Razeghi P,Taegtmeyer H

更新日期：2001-06-08 00:00:00

abstract：:The aims of the current study were to examine the efficacy of acetylcholine (ACh) to mimic ischemic preconditioning in dogs and to determine the role of nitric oxide (NO), muscarinic receptors, and ATP-sensitive K+ (KATP) channels in mediating its effects. Barbital-anesthetized open-chest dogs were subjected to 60 min...

journal_title：Circulation research

authors： Yao Z,Gross GJ

更新日期：1993-12-01 00:00:00

abstract：:We determined the effects of indomethacin and meclofenamate, two inhibitors of prostaglandin synthesis, on renal vascular resistance and on renal responses to nerve stimulation, pressor and depressor hormones in the in situ feline kidney under conditions of controlled blood flow. Both inhibitors produced a gradual ris...

journal_title：Circulation research

authors： Chapnick BM,Paustian PW,Feigen LP,Joiner PD,Hyman AL,Kadowitz PJ

更新日期：1977-04-01 00:00:00

abstract：:A number of scavengers of reactive oxygen metabolites reduce myocardial injury when given before ischemia and reperfusion, but few, if any, have proven to be effective when given near the onset of reperfusion. This is particularly true when infarct size is measured after at least 48 hours of reperfusion, when the full...

journal_title：Circulation research

authors： Carrea FP,Lesnefsky EJ,Repine JE,Shikes RH,Horwitz LD

更新日期：1991-06-01 00:00:00

abstract：:The hypothesis that availability of functional Ca2+ channels in vascular smooth muscle is augmented in hypertension was tested in basilar artery cells from Wistar rats exhibiting stable systolic blood pressure (BPsys) for 2 to 11 weeks after partial renal artery ligation (Goldblatt 2-kidney 1-clip [2K1C] model). Cells...

journal_title：Circulation research

authors： Simard JM,Li X,Tewari K

更新日期：1998-06-29 00:00:00

abstract：RATIONALE:We have previously demonstrated that the importance of endothelium-derived hyperpolarizing factor (EDHF) increases as the vessel size decreases and that endothelium-derived hydrogen peroxide (H(2)O(2)) is an EDHF in animals and humans, for which endothelial nitric oxide synthase (eNOS) is the major source. Re...

journal_title：Circulation research

authors： Nakajima S,Ohashi J,Sawada A,Noda K,Fukumoto Y,Shimokawa H

更新日期：2012-06-22 00:00:00