Pressure releases a transferable endothelial contractile factor in cat cerebral arteries.

Abstract:

:When exposed to an increasing transmural pressure, middle cerebral arteries of the cat exhibit reduction of internal diameter which is mediated by vascular muscle cell depolarization. This laboratory has recently demonstrated that this "pressure-induced" activation is dependent upon the presence of an intact endothelium. The present studies were undertaken to determine if this phenomenon is due to inhibition of tonically released endothelium-derived relaxing factors (EDRF) or release of a contractile substance. When cerebral arterial segments were pressurized to between 40 and 160 mm Hg there was 13.2% reduction in internal diameter accompanied by significant muscle cell depolarization from -53 +/- 2.7 to -22 +/- 1.4 mV. There was a significant positive correlation between the delta Em and step increases in transmural pressure. These excitatory responses were lost and vessels dilated to pressure when the endothelium was removed. Upon exposing the denuded vessel to a pressurized intact donor, the denuded vessel recovered its ability to contract and depolarize suggesting that a contractile substance might be released from the vascular endothelium upon pressurization. The EDRF antagonist oxyhemoglobin did not alter the excitatory response to pressure in these isolated cerebral arteries further suggesting that the reduction in diameter and muscle cell depolarization results from the release of a contractile substance from the vascular endothelium and not inhibition of EDRF.

journal_name

Circ Res

journal_title

Circulation research

authors

Harder DR,Sanchez-Ferrer C,Kauser K,Stekiel WJ,Rubanyi GM

doi

10.1161/01.res.65.1.193

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

193-8

issue

1

eissn

0009-7330

issn

1524-4571

journal_volume

65

pub_type

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