Effects of infarcted myocardium on regional blood flow measurements to ischemic regions in canine heart.

abstract：BACKGROUND:Myocyte contractile dysfunction occurs in pathological remodeling in association with abnormalities in calcium regulation. Mice with cardiac myocyte-specific overexpression of Galphaq develop progressive left ventricular failure associated with myocyte contractile dysfunction and calcium dysregulation. OBJE...

journal_title：Circulation research

authors： Lancel S,Qin F,Lennon SL,Zhang J,Tong X,Mazzini MJ,Kang YJ,Siwik DA,Cohen RA,Colucci WS

更新日期：2010-07-23 00:00:00

abstract：:Despite intense interest in understanding the differentiation of vascular smooth muscle, very little is known about the cellular and molecular mechanisms that control differentiation of this cell type. Progress in this field has been hampered by the lack of an inducible in vitro system for study of the early steps of ...

journal_title：Circulation research

authors： Blank RS,Swartz EA,Thompson MM,Olson EN,Owens GK

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:One of the physiological mechanisms by which the heart adapts to a rise in blood pressure is by augmenting myocyte stretch-mediated intracellular calcium, with a subsequent increase in contractility. This slow force response was first described over a century ago and has long been considered compensatory, but...

journal_title：Circulation research

authors： Cingolani OH,Kirk JA,Seo K,Koitabashi N,Lee DI,Ramirez-Correa G,Bedja D,Barth AS,Moens AL,Kass DA

更新日期：2011-12-09 00:00:00

abstract：:Leukocyte rolling along the endothelium in inflammation is caused by continuous formation and breakage of bonds between selectin adhesion molecules and their ligands. We investigated trauma-induced leukocyte rolling in venules (diameter, 23 to 58 microns; wall shear stress, 1.2 to 35 dyne/cm2) of the exteriorized rat ...

journal_title：Circulation research

authors： Damiano ER,Westheider J,Tözeren A,Ley K

更新日期：1996-12-01 00:00:00

abstract：:We administered ascitic fluid containing atrial natriuretic factor (ANF) monoclonal antibody to rats after 3 weeks of exposure to hypoxia while the rats were still hypoxic. In additional chronically hypoxic rats, we infused synthetic rat ANF. In conscious chronically instrumented rats, after a bolus dose of 5 microgra...

journal_title：Circulation research

authors： Raffestin B,Levame M,Eddahibi S,Viossat I,Braquet P,Chabrier PE,Cantin M,Adnot S

更新日期：1992-01-01 00:00:00

abstract：:Recent studies in isolated cardiac tissue preparations have demonstrated the applicability of a one-dimensional difference equation model describing the global behavior of a driven nonpacemaker cell to the understanding of rate-dependent cardiac excitation. As a first approximation to providing an ionic basis to compl...

journal_title：Circulation research

authors： Vinet A,Chialvo DR,Michaels DC,Jalife J

更新日期：1990-12-01 00:00:00

abstract：RATIONALE:Remote ischemic preconditioning (rIPC) with short episodes of ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to protect against myocardial I/R injury. The signal transduction pathways for the cross talk between the remote site and the heart remain unclear in detail. OBJEC...

journal_title：Circulation research

authors： Rassaf T,Totzeck M,Hendgen-Cotta UB,Shiva S,Heusch G,Kelm M

更新日期：2014-05-09 00:00:00

abstract：:The global prevalence of overweight and obesity has risen substantially over the past 4 decades and is accompanied by an increasing burden of cardiovascular risk factors such as hypertension. Metabolic surgery is the most effective method to treat obesity and may further improve associated conditions. Although most re...

journal_title：Circulation research

authors： Pareek M,Bhatt DL,Schiavon CA,Schauer PR

更新日期：2019-03-29 00:00:00

abstract：:To elucidate the local effects of renin in the coronary circulation, we examined local angiotensin (Ang) I and II formation, as well as coronary vasoconstriction in response to renin administration, and compared the effects with exogenous infused Ang I. We perfused isolated hearts from rats overexpressing the human an...

journal_title：Circulation research

authors： Müller DN,Fischli W,Clozel JP,Hilgers KF,Bohlender J,Ménard J,Busjahn A,Ganten D,Luft FC

更新日期：1998-01-09 00:00:00

abstract：:Pinacidil belongs to a novel group of compounds that enhance the potassium permeability of vascular smooth muscle. Evidence also exists that this drug enhances the potassium permeability of cardiac tissue. The purpose of the present investigation was to determine if pinacidil alters potassium-channel activity in heart...

journal_title：Circulation research

authors： Arena JP,Kass RS

更新日期：1989-08-01 00:00:00

abstract：:[3H](+/-)Carazolol, a newly available beta-adrenergic receptor antagonist, can be used to characterize beta-adrenergic receptor subtypes present in membrane vesicles derived from canine ventricular myocardium and canine lung. [3H](+/-)Carazolol binding is saturable, of high affinity, and is displaceable by beta-adrene...

journal_title：Circulation research

authors： Manalan AS,Besch HR Jr,Watanabe AM

更新日期：1981-08-01 00:00:00

abstract：RATIONALE:Immune cells play an important role during the generation and resolution of thrombosis. T cells are powerful regulators of immune and nonimmune cell function, however, their role in sterile inflammation in venous thrombosis has not been systematically examined. OBJECTIVE:This study investigated the recruitme...

journal_title：Circulation research

authors： Luther N,Shahneh F,Brähler M,Krebs F,Jäckel S,Subramaniam S,Stanger C,Schönfelder T,Kleis-Fischer B,Reinhardt C,Probst HC,Wenzel P,Schäfer K,Becker C

更新日期：2016-12-09 00:00:00

abstract：:The extracellular epicardial potential fields produced by simple depolarization waves in the in situ canine left ventricular myocardium were analyzed. A mathematical model that included tissue anisotrophy was developed to explain the observed fields. Values of intracellular (i), extracellular (o), longitudinal (l), an...

journal_title：Circulation research

authors： Roberts DE,Scher AM

更新日期：1982-03-01 00:00:00

abstract：:Human peripheral blood leukocytes, activated by phorbol myristate acetate, disrupt canine sarcoplasmic reticulum calcium transport, in vitro, by an oxygen-derived free radical mechanism. Activated leukocytes significantly depress Ca++ uptake activity and Ca++ -stimulated, Mg++ -dependent ATPase activity. The depressio...

journal_title：Circulation research

authors： Rowe GT,Manson NH,Caplan M,Hess ML

更新日期：1983-11-01 00:00:00

abstract：:The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation. TM is an essential cofactor in protein C activation by thrombin, and a direct inhibitor of thrombin-induced platelet activation and fibrinogen clotting. Protease nexin-1 (PN-1) is a serpin synthesized...

journal_title：Circulation research

authors： Bouton MC,Venisse L,Richard B,Pouzet C,Arocas V,Jandrot-Perrus M

更新日期：2007-04-27 00:00:00

abstract：:Two gap junction proteins, connexin43 (Cx43) and connexin45 (Cx45), are coexpressed in many cardiac and other cells. Homomeric channels formed by these proteins differ in unitary conductance, permeability, and regulation. We sought to determine the ability of Cx43 and Cx45 to oligomerize with each other to form hetero...

journal_title：Circulation research

authors： Martinez AD,Hayrapetyan V,Moreno AP,Beyer EC

更新日期：2002-05-31 00:00:00

abstract：:Electrotonic coupling of cardiac myocytes at gap junctions may influence patterns of conduction in myocardium. To delineate the three-dimensional structure and distribution of intercellular junctions, we analyzed serial ultrathin sections of canine myocardium with transmission electron microscopy and disaggregated myo...

journal_title：Circulation research

authors： Hoyt RH,Cohen ML,Saffitz JE

更新日期：1989-03-01 00:00:00

abstract：:Modulation of the inward Na+ current (I(Na)) by protein kinase C (PKC) was investigated by intracellular perfusion of a peptide corresponding to the catalytic subunit of PKC (PKCP). The effects of PKC activation independent of membrane-receptor pathways were studied in neonatal rat ventricular myocytes using whole-cel...

journal_title：Circulation research

authors： Watson CL,Gold MR

更新日期：1997-09-01 00:00:00

abstract：:Although peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have an antihypertensive effect in vivo, the precise mechanism has not been fully elucidated. We examined their effects on Rho/Rho kinase pathway, a key regulator of vascular tone. In cultured rat aortic smooth muscle cells (RASMC), Rho kina...

journal_title：Circulation research

authors： Wakino S,Hayashi K,Kanda T,Tatematsu S,Homma K,Yoshioka K,Takamatsu I,Saruta T

更新日期：2004-09-03 00:00:00

abstract：:The accumulation of inositol 1,4,5-trisphosphate (IP3) after hormonal stimulation has a physiological role, possibly by alteration of Ca2+ levels in cardiac myocyte. However, this accumulation has not been studied under pathophysiological conditions. In this report, we examine phosphatidylinositol metabolism during ce...

journal_title：Circulation research

authors： Kawaguchi H,Sano H,Iizuka K,Okada H,Kudo T,Kageyama K,Muramoto S,Murakami T,Okamoto H,Mochizuki N

更新日期：1993-05-01 00:00:00

abstract：:Increased activity of matrix metalloproteinases (MMPs) has been implicated in numerous disease processes, including tumor growth and metastasis, arthritis, and periodontal disease. It is now becoming increasingly clear that extracellular matrix degradation by MMPs is also involved in the pathogenesis of cardiovascular...

journal_title：Circulation research

authors： Creemers EE,Cleutjens JP,Smits JF,Daemen MJ

更新日期：2001-08-03 00:00:00

abstract：:Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, including PITX2, TBX5, PRRX1, and ZFHX3. Moreover, the vast majority of the AF-associated variants li...

journal_title：Circulation research

authors： van Ouwerkerk AF,Hall AW,Kadow ZA,Lazarevic S,Reyat JS,Tucker NR,Nadadur RD,Bosada FM,Bianchi V,Ellinor PT,Fabritz L,Martin JF,de Laat W,Kirchhof P,Moskowitz IP,Christoffels VM

更新日期：2020-06-19 00:00:00

abstract：:Although clinical studies suggest that chronic hypercapnic acidosis may be associated with renal sodium retention, little information is available on the effect of acute hypercapnic acidosis on renal sodium excretion. We, therefore, increased PCO2 from 23 to 74 mm Hg in anesthetized dogs and observed a marked antinatr...

journal_title：Circulation research

authors： Anderson RJ,Henrich WL,Gross PA,Dillingham MA

更新日期：1982-02-01 00:00:00

abstract：:In intact porcine aorta, endothelium-derived nitric oxide released on thrombin stimulation inhibits the concomitant production of endothelin. Experiments were designed to examine the effect of hirudin (which inactivates thrombin) and the nitrovasodilators nitroglycerin and 3-morpholinosydnonimine on the spontaneous an...

journal_title：Circulation research

authors： Boulanger CM,Lüscher TF

更新日期：1991-06-01 00:00:00

abstract：:Postischemic endothelial dysfunction may occur as a result of the effects of endogenous oxidants like hydrogen peroxide. Since endothelium-dependent vasodilator function may be affected by pHi, the effect of hydrogen peroxide on endothelial pHi was examined. Hydrogen peroxide (100 micromol/L for 10 minutes) decreased ...

journal_title：Circulation research

authors： Hu Q,Xia Y,Corda S,Zweier JL,Ziegelstein RC

更新日期：1998-09-21 00:00:00

abstract：:To isolate specific markers of both differentiated and proliferating vascular smooth muscle cells (VSMCs), we used the technique of differential cDNA screening using RNA from cultured rat aortic VSMCs. The tissue specificity of expression of all of the cDNAs isolated was determined by Northern analysis. We isolated se...

journal_title：Circulation research

authors： Shanahan CM,Weissberg PL,Metcalfe JC

更新日期：1993-07-01 00:00:00

abstract：:Myocardial stunning is a form of reversible myocardial ischemia/reperfusion injury associated with systolic and diastolic contractile dysfunction. In the isolated rat heart model, myocardial stunning is characterized by specific C-terminal proteolysis of the myofilament protein, troponin I (cTnI) that yields cTnI1-193...

journal_title：Circulation research

authors： Foster DB,Noguchi T,VanBuren P,Murphy AM,Van Eyk JE

更新日期：2003-11-14 00:00:00

abstract：:The interaction between inflammatory cytokines and endothelial cells is a critical step in atherogenesis leading to endothelial dysfunction and inflammation. We have previously reported that the tumor necrosis factor superfamily member LIGHT could be involved in atherogenesis through its ability to promote vascular in...

journal_title：Circulation research

authors： Sandberg WJ,Halvorsen B,Yndestad A,Smith C,Otterdal K,Brosstad FR,Frøland SS,Olofsson PS,Damås JK,Gullestad L,Hansson GK,Oie E,Aukrust P

更新日期：2009-01-02 00:00:00

abstract：:The effects of prostaglandin E2 (PGE2) indomethacin, and reserpine were evaluated in the rabbit renal vascular bed in situ under conditions of controlled blood flow. Intrarenal infusion of PGE2, 0.03 and 0.3 microgram/min, decreased responses to renal nerve stimulation, intra-arterial norepinephrine, and angiotensin. ...

journal_title：Circulation research

authors： Fink GD,Chapnick BM,Goldberg MR,Paustian PW,Kadowitz PJ

更新日期：1977-08-01 00:00:00

abstract：:We studied DNA (mtDNA) replication in adult female rat hearts undergoing hypertrophy secondary to constriction of the ascending aorta. MtDNA was measured in isolated mitochondria by a fluorometric method adapted for that purpose. The conditions for removal of contaminating nuclear DNA were developed, and the purity of...

journal_title：Circulation research

authors： Rajamanickam C,Merten S,Kwiatkowska-Patzer B,Chuang CH,Zak R,Rabinowitz M

更新日期：1979-10-01 00:00:00