Atrial fibrillation in KCNE1-null mice.

Abstract:

:Although atrial fibrillation is the most common serious cardiac arrhythmia, the fundamental molecular pathways remain undefined. Mutations in KCNQ1, one component of a sympathetically activated cardiac potassium channel complex, cause familial atrial fibrillation, although the mechanisms in vivo are unknown. We show here that mice with deletion of the KCNQ1 protein partner KCNE1 have spontaneous episodes of atrial fibrillation despite normal atrial size and structure. Isoproterenol abolishes these abnormalities, but vagomimetic interventions have no effect. Whereas loss of KCNE1 function prolongs ventricular action potentials in humans, KCNE1-/- mice displayed unexpectedly shortened atrial action potentials, and multiple potential mechanisms were identified: (1) K+ currents (total and those sensitive to the KCNQ1 blocker chromanol 293B) were significantly increased in atrial cells from KCNE1-/- mice compared with controls, and (2) when CHO cells expressing KCNQ1 and KCNE1 were pulsed very rapidly (at rates comparable to the normal mouse heart and to human atrial fibrillation), the sigmoidicity of IKs activation prevented current accumulation, whereas cells expressing KCNQ1 alone displayed marked current accumulation at these very rapid rates. Thus, KCNE1 deletion in mice unexpectedly leads to increased outward current in atrial myocytes, shortens atrial action potentials, and enhances susceptibility to atrial fibrillation.

journal_name

Circ Res

journal_title

Circulation research

authors

Temple J,Frias P,Rottman J,Yang T,Wu Y,Verheijck EE,Zhang W,Siprachanh C,Kanki H,Atkinson JB,King P,Anderson ME,Kupershmidt S,Roden DM

doi

10.1161/01.RES.0000173047.42236.88

subject

Has Abstract

pub_date

2005-07-08 00:00:00

pages

62-9

issue

1

eissn

0009-7330

issn

1524-4571

pii

01.RES.0000173047.42236.88

journal_volume

97

pub_type

杂志文章
  • Opioids in cerebrospinal fluid in hypotensive newborn pigs.

    abstract::This study was designed to determine if opioids were detectable in cerebrospinal fluid (CSF) and if these concentrations were altered by hemorrhagic hypotension. This study was further designed to determine the effects of topically administered opioids on pial arteriolar diameter during normotension and hypotension. C...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.68.4.922

    authors: Armstead WM,Mirro R,Busija DW,Desiderio DM,Leffler CW

    更新日期:1991-04-01 00:00:00

  • Cardiovascular consequences when nitric oxide and lipid signaling converge.

    abstract::The identification of nitric oxide ((*)NO) as an endogenously produced free radical mediator of endothelial-dependent relaxation and host defense has fundamentally changed concepts of cell signal transduction. Ligand-receptor oriented paradigms of cell signaling were originally centered on the concept of a high affini...

    journal_title:Circulation research

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCRESAHA.109.202077

    authors: Rudolph V,Freeman BA

    更新日期:2009-09-11 00:00:00

  • Time course of denervation of efferent sympathetic and vagal nerves after occlusion of the coronary artery in the canine heart.

    abstract::To determine the time course of efferent sympathetic denervation after transmural myocardial infarction (TMI) and of efferent vagal denervation after transmural or nontransmural myocardial infarction (NTMI), we measured effective refractory periods (ERP) basal and apical to TMI or NTMI in secobarbital-anesthetized, op...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.62.6.1111

    authors: Inoue H,Zipes DP

    更新日期:1988-06-01 00:00:00

  • Molecular pathway for the localized formation of the sinoatrial node.

    abstract::The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been define...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000258019.74591.b3

    authors: Mommersteeg MT,Hoogaars WM,Prall OW,de Gier-de Vries C,Wiese C,Clout DE,Papaioannou VE,Brown NA,Harvey RP,Moorman AF,Christoffels VM

    更新日期:2007-02-16 00:00:00

  • Control of cardiac sarcolemmal adenylate cyclase and sodium, potassium-activated adenosinetriphosphatase activities.

    abstract::A plasma membrane preparation purified from guinea pig ventricles without the use of high concentrations of detergents or structure-disrupting salts was used to compare the mechanisms of controlling sodium, potassium-activated adenosinetriphosphatase (Na, K-ATPase) and adenylate cyclase activities. The basal ATPase ac...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.36.1.8

    authors: Tada M,Kirchberger MA,Iorio JM,Katz AM

    更新日期:1975-01-01 00:00:00

  • Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive rats.

    abstract::The myocardium contains collagen matrix that is a major determinant of its architecture, structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I and type III collagens having epimysial, perimysial, and endomysial components. The present study shows the alteration of collagen...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.67.6.1474

    authors: Mukherjee D,Sen S

    更新日期:1990-12-01 00:00:00

  • Vascular endothelial growth factor overexpression in ischemic skeletal muscle enhances myoglobin expression in vivo.

    abstract::Therapeutic angiogenesis using vascular endothelial growth factor (VEGF) is considered a promising new therapy for patients with arterial obstructive disease. Clinical improvements observed consist of improved muscle function and regression of rest pain or angina. However, direct evidence for improved vascularization,...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000133247.69803.c3

    authors: van Weel V,Deckers MM,Grimbergen JM,van Leuven KJ,Lardenoye JH,Schlingemann RO,van Nieuw Amerongen GP,van Bockel JH,van Hinsbergh VW,Quax PH

    更新日期:2004-07-09 00:00:00

  • Selective antagonism of hormone-induced vasoconstriction by synthetic atrial natriuretic factor in the rat microcirculation.

    abstract::Synthetic atrial natriuretic factor (ANF) was either added to suffusate solutions (30 nM) or infused into the jugular vein (0.1 nanomol/min/100 g) of anesthetized rats. Steady-state blood flow was calculated from arteriolar diameter and red blood cell velocity measurements using video microscopy in the intestinal or s...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.61.1.42

    authors: Proctor KG,Bealer SL

    更新日期:1987-07-01 00:00:00

  • Expression of mutant p193 and p53 permits cardiomyocyte cell cycle reentry after myocardial infarction in transgenic mice.

    abstract::Previous studies have demonstrated that expression of p193 and p53 mutants with dominant-interfering activities renders embryonic stem cell-derived cardiomyocytes responsive to the growth promoting activities of the E1A viral oncoproteins. In this study, the effects of p53 and p193 antagonization on cardiomyocyte cell...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000132279.99249.f4

    authors: Nakajima H,Nakajima HO,Tsai SC,Field LJ

    更新日期:2004-06-25 00:00:00

  • Signaling during epicardium and coronary vessel development.

    abstract::The epicardium, the tissue layer covering the cardiac muscle (myocardium), develops from the proepicardium, a mass of coelomic progenitors located at the venous pole of the embryonic heart. Proepicardium cells attach to and spread over the myocardium to form the primitive epicardial epithelium. The epicardium subseque...

    journal_title:Circulation research

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCRESAHA.111.245589

    authors: Pérez-Pomares JM,de la Pompa JL

    更新日期:2011-12-09 00:00:00

  • Developmental changes in long-opening behavior of L-type Ca2+ channels in embryonic chick heart cells.

    abstract::In the early (3-day) stage of development, long-lasting openings of the L-type Ca2+ channels (mode 2) occur in embryonic chick heart cells. Since mode-2 behavior is infrequently observed in adult heart cells of other species, in the present study, developmental change in behavior of the Ca2+ channel was examined in yo...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.71.2.376

    authors: Tohse N,Mészáros J,Sperelakis N

    更新日期:1992-08-01 00:00:00

  • Detection of moving flow separation in pulsatile flow and the degree of stenosis by power of Doppler shift signals.

    abstract::Power ratios were derived from the principle of ultrasonic Doppler velocimetry to determine a ratio of the volume of vortices to the total vessel volume under the ultrasonic beam. This ratio also equals the ratio of the cross-sectional area of vortices to the vessel lumen. In vitro pulsatile flow experiments were perf...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.67.1.166

    authors: Tamura T,Fronek A

    更新日期:1990-07-01 00:00:00

  • Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.

    abstract::The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves substantial proteolysis of the arterial extracellular matrix. The lysosomal cysteine proteases can exert potent elastolytic and collagenolytic activity. Human atherosclerotic plaques have increased cysteine protease content and decreased levels...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000155964.34150.F7

    authors: Sukhova GK,Wang B,Libby P,Pan JH,Zhang Y,Grubb A,Fang K,Chapman HA,Shi GP

    更新日期:2005-02-18 00:00:00

  • Influence of prostaglandin E2, indomethacin, and reserpine on renal vascular responses to nerve stimulation, pressor and depressor hormones.

    abstract::The effects of prostaglandin E2 (PGE2) indomethacin, and reserpine were evaluated in the rabbit renal vascular bed in situ under conditions of controlled blood flow. Intrarenal infusion of PGE2, 0.03 and 0.3 microgram/min, decreased responses to renal nerve stimulation, intra-arterial norepinephrine, and angiotensin. ...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.41.2.172

    authors: Fink GD,Chapnick BM,Goldberg MR,Paustian PW,Kadowitz PJ

    更新日期:1977-08-01 00:00:00

  • Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury.

    abstract::Matrix metalloproteinases (MMPs) and, in particular, MMP-9 are important for smooth muscle cell (SMC) migration into the intima. In this study, we sought to determine whether MMP-9 is critical for SMC migration and for the formation of a neointima by using mice in which the gene was deleted (MMP-9(-/-) mice). A denudi...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.0000040420.17366.2e

    authors: Cho A,Reidy MA

    更新日期:2002-11-01 00:00:00

  • Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo.

    abstract::Inwardly rectifying K+ (Kir) channels are responsible for maintaining endothelial membrane potential and play a key role in endothelium-dependent vasorelaxation. In this study, we show that endothelial Kir channels are suppressed by hypercholesterolemic levels of lipoproteins in vitro and by serum hypercholesterolemia...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000218776.87842.43

    authors: Fang Y,Mohler ER 3rd,Hsieh E,Osman H,Hashemi SM,Davies PF,Rothblat GH,Wilensky RL,Levitan I

    更新日期:2006-04-28 00:00:00

  • Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats.

    abstract::Two NO synthase (NOS) isoforms have been described in vessels, an endothelial constitutive NOS (eNOS) and an inducible NOS (iNOS). The purpose of the present study was to examine the endothelium-dependent and endothelium-independent hypotensive response in aging rats, analyzing the ability of their vessels to produce ...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.83.3.279

    authors: Cernadas MR,Sánchez de Miguel L,García-Durán M,González-Fernández F,Millás I,Montón M,Rodrigo J,Rico L,Fernández P,de Frutos T,Rodríguez-Feo JA,Guerra J,Caramelo C,Casado S,López-Farré

    更新日期:1998-08-10 00:00:00

  • Changes in cellular Na+, K+, and Ca2+ contents, monovalent cation transport rate, and contractile state during washout of cardiac glycosides from cultured chick heart cells.

    abstract::To delineate more clearly the importance of altered monovalent cation transport rate in the mediation of the positive inotropic effects of cardiac glycosides, we studied changes in the contractile state and rate of uptake of K+ and Rb+ by monolayer cultures of chick embryo ventricular cells during exposure to and wash...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.49.1.141

    authors: Barry WH,Biedert S,Miura DS,Smith TW

    更新日期:1981-07-01 00:00:00

  • Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation.

    abstract::RhoA and Rac1 regulate formation of stress fibers and intercellular junctions, thus modulating endothelial monolayer permeability. Posttranslational modifications of RhoA and Rac1 regulate enzyme activity and subcellular localization, resulting in altered cellular function. The role of RhoA and Rac1 carboxyl methylati...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000113923.85084.C1

    authors: Lu Q,Harrington EO,Hai CM,Newton J,Garber M,Hirase T,Rounds S

    更新日期:2004-02-20 00:00:00

  • The mechanism by which adenosine and cholinergic agents reduce contractility in rat myocardium. Correlation with cyclic adenosine monophosphate and receptor densities.

    abstract::The adenosine analogue phenylisopropyladenosine decreased the basal and isoproterenol-stimulated contractile state of isolated rat left atria. The ED50 levels for both responses were similar, suggesting that direct and antiadrenergic effects may be mediated by the same receptor. Phenylisopropyladenosine decreased the ...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.56.5.728

    authors: Linden J,Hollen CE,Patel A

    更新日期:1985-05-01 00:00:00

  • Role of nitric oxide, muscarinic receptors, and the ATP-sensitive K+ channel in mediating the effects of acetylcholine to mimic preconditioning in dogs.

    abstract::The aims of the current study were to examine the efficacy of acetylcholine (ACh) to mimic ischemic preconditioning in dogs and to determine the role of nitric oxide (NO), muscarinic receptors, and ATP-sensitive K+ (KATP) channels in mediating its effects. Barbital-anesthetized open-chest dogs were subjected to 60 min...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.73.6.1193

    authors: Yao Z,Gross GJ

    更新日期:1993-12-01 00:00:00

  • Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.

    abstract:RATIONALE:A hallmark of chronic inflammatory disorders is persistence of proinflammatory macrophages in diseased tissues. In atherosclerosis, this is associated with dyslipidemia and oxidative stress, but mechanisms linking these phenomena to macrophage activation remain incompletely understood. OBJECTIVE:To investiga...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.119.315833

    authors: Chen Y,Yang M,Huang W,Chen W,Zhao Y,Schulte ML,Volberding P,Gerbec Z,Zimmermann MT,Zeighami A,Demos W,Zhang J,Knaack DA,Smith BC,Cui W,Malarkannan S,Sodhi K,Shapiro JI,Xie Z,Sahoo D,Silverstein RL

    更新日期:2019-12-06 00:00:00

  • Activation of ATP-sensitive K+ channels by cromakalim. Effects on cellular K+ loss and cardiac function in ischemic and reperfused mammalian ventricle.

    abstract::Pharmacological modulation of [K+]o accumulation and action potential changes during acute myocardial ischemia is under evaluation as a promising new antiarrhythmic and cardioprotective strategy during myocardial ischemia and reperfusion. We studied the effects of cromakalim, a K+ channel opener that activates ATP-sen...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.71.6.1324

    authors: Venkatesh N,Stuart JS,Lamp ST,Alexander LD,Weiss JN

    更新日期:1992-12-01 00:00:00

  • Role of glycogen synthase kinase-3beta in cardioprotection.

    abstract::Limitation of infarct size by ischemic/pharmacological pre- and postconditioning involves activation of a complex set of cell-signaling pathways. Multiple lines of evidence implicate the mitochondrial permeability transition pore (mPTP) as a key end effector of ischemic/pharmacological pre- and postconditioning. Incre...

    journal_title:Circulation research

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCRESAHA.109.197996

    authors: Juhaszova M,Zorov DB,Yaniv Y,Nuss HB,Wang S,Sollott SJ

    更新日期:2009-06-05 00:00:00

  • Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.

    abstract::The cardiac troponin T (TnT) I79N mutation has been linked to familial hypertrophic cardiomyopathy and high incidence of sudden death, despite causing little or no cardiac hypertrophy in patients. Transgenic mice expressing mutant human TnT (I79N-Tg) have increased cardiac contractility, but no ventricular hypertrophy...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000059562.91384.1A

    authors: Knollmann BC,Kirchhof P,Sirenko SG,Degen H,Greene AE,Schober T,Mackow JC,Fabritz L,Potter JD,Morad M

    更新日期:2003-03-07 00:00:00

  • Binding of charged ferritin to alveolar wall components and charge selectivity of macromolecular transport in permeability pulmonary edema in rats.

    abstract::Rat lungs were inflated and incubated in either anionic or cationic ferritin, and alveolar and capillary basement membranes were examined by electron microscopy. Cationic ferritin bound to heparan sulfate proteoglycans on the external surface of the alveolar basement membrane, whereas cationic ferritin bound to the la...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.55.2.155

    authors: Brody JS,Vaccaro CA,Hill NS,Rounds S

    更新日期:1984-08-01 00:00:00

  • Animal model that mimics atherosclerotic plaque rupture.

    abstract::Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption. We have developed a rabbit model in which an atherosclerotic plaque can be ruptured at will after an inflatable balloon becomes embedded into the plaque. Furthermor...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.83.7.705

    authors: Rekhter MD,Hicks GW,Brammer DW,Work CW,Kim JS,Gordon D,Keiser JA,Ryan MJ

    更新日期:1998-10-05 00:00:00

  • Biphasic restitution of action potential duration and complex dynamics in ventricular myocardium.

    abstract::The purpose of this study was to determine whether biphasic restitution of action potential duration (APD) in ventricular muscle permits the development of complex dynamic behavior. Such behavior is expected because of the steep ascending slope of restitution and the presence of a maximum. Action potentials recorded f...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.76.5.915

    authors: Watanabe M,Otani NF,Gilmour RF Jr

    更新日期:1995-05-01 00:00:00

  • Hypersensitivity of BKCa to Ca2+ sparks underlies hyporeactivity of arterial smooth muscle in shock.

    abstract::Large conductance Ca(2+)-activated K(+) channels (BK(Ca)) play a critical role in blood pressure regulation by tuning the vascular smooth muscle tone, and hyposensitivity of BK(Ca) to Ca(2+) sparks resulting from its altered beta1 subunit stoichiometry underlies vasoconstriction in animal models of hypertension. Here ...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.107.157271

    authors: Zhao G,Zhao Y,Pan B,Liu J,Huang X,Zhang X,Cao C,Hou N,Wu C,Zhao KS,Cheng H

    更新日期:2007-08-31 00:00:00

  • Balloon injury and interleukin-1 beta induce nitric oxide synthase activity in rat carotid arteries.

    abstract::Experiments were performed to investigate whether balloon injury induces nitric oxide synthase activity in the blood vessel wall. Contractions to phenylephrine were compared in left carotid arteries of the rat, previously injured by balloon catheterization and excised either immediately (t = 0), 6, or 24 hours after t...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.71.2.331

    authors: Joly GA,Schini VB,Vanhoutte PM

    更新日期:1992-08-01 00:00:00