MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation.

abstract：:Freshly dispersed rabbit ear artery cells were studied using patch-clamp techniques to measure membrane currents in whole cells and single-channel currents in membrane patches. Whole-cell calcium currents recorded at physiologic extracellular calcium concentrations were small (approximately 10 pA). Recordings with 110...

journal_title：Circulation research

authors： Benham CD,Hess P,Tsien RW

更新日期：1987-10-01 00:00:00

abstract：:We studied postclamp renal artery pressure and renin release in eight conscious dogs with one-kidney Goldblatt hypertension. On normal sodium intake, intrarenal blockade of angiotensin II with Sar1-Ala8-angiotension II (P-113, saralasin acetate) markedly decreased postclamp renal artery pressure and increased renin re...

journal_title：Circulation research

authors： Ayers CR,Katholi RE,Vaughan ED Jr,Carey RM,Kimbrough HM Jr,Yancey MR,Morton CL

更新日期：1977-03-01 00:00:00

abstract：RATIONALE:Deep vein thrombosis (DVT) and its complication pulmonary embolism have high morbidity reducing quality of life and leading to death. Cellular mechanisms of DVT initiation remain poorly understood. OBJECTIVE:We sought to determine the role of mast cells (MCs) in DVT initiation and validate MCs as a potential...

journal_title：Circulation research

authors： Ponomaryov T,Payne H,Fabritz L,Wagner DD,Brill A

更新日期：2017-09-29 00:00:00

abstract：:Successful implementation of local arterial drug delivery requires transmural distribution of drug. The physicochemical properties of the applied compound, which govern its transport and tissue binding, become as important as the mode of delivery. Hydrophilic compounds distribute freely but are cleared rapidly. Hydrop...

journal_title：Circulation research

authors： Creel CJ,Lovich MA,Edelman ER

更新日期：2000-04-28 00:00:00

abstract：RATIONALE:The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cells make important contributions to OFT formation and aortic arch remodeling. Although numerous signal...

journal_title：Circulation research

authors： Singh N,Trivedi CM,Lu M,Mullican SE,Lazar MA,Epstein JA

更新日期：2011-11-11 00:00:00

abstract：:Intussusceptive angiogenesis is a novel mode of blood vessel formation and remodeling, which occurs by internal division of the preexisting capillary plexus without sprouting. In this study, the process is demonstrated in developing chicken eye vasculature and in the chorioallantoic membrane by methylmethacrylate (Mer...

journal_title：Circulation research

authors： Djonov V,Schmid M,Tschanz SA,Burri PH

更新日期：2000-02-18 00:00:00

abstract：:Sixteen years ago, mutations in cardiac troponin (Tn)T and α-tropomyosin were linked to familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β-myosin heavy chain to a disease of the cardiac sarcomere. From the outset, studies suggested that mutations in the regulatory thin filamen...

journal_title：Circulation research

authors： Tardiff JC

更新日期：2011-03-18 00:00:00

abstract：:By making use of immunoblotting and immunocytochemical analysis, we explored whether stimulation of adenosine A1 receptors would promote the activation of delta-protein kinase C (delta-PKC) immunolabeled with a polyclonal antibody. Immunoblot analysis of Triton X-100-soluble cell membrane and cytosolic fractions revea...

journal_title：Circulation research

authors： Henry P,Demolombe S,Pucéat M,Escande D

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Postconditioning at the time of primary percutaneous coronary intervention (PCI) for ST-segment-elevation myocardial infarction may reduce infarct size and improve myocardial salvage. However, clinical trials have shown inconsistent benefit. OBJECTIVE:We performed the first National Heart, Lung, and Blood In...

journal_title：Circulation research

authors： Traverse JH,Swingen CM,Henry TD,Fox J,Wang YL,Chavez IJ,Lips DL,Lesser JR,Pedersen WR,Burke NM,Pai A,Lindberg JL,Garberich RF

更新日期：2019-03-01 00:00:00

abstract：:Dystrophin has a key role in striated muscle mechanotransduction. In mice lacking the gene encoding for dystrophin (mdx mice), the absence of dystrophin and several other proteins of the dystrophin-glycoprotein complex induces a defect in flow (shear stress)-mediated NO-dependent dilation (FMD). Because the endotheliu...

journal_title：Circulation research

authors： Loufrani L,Levy BI,Henrion D

更新日期：2002-12-13 00:00:00

abstract：:The potential for heparin to enhance the training-induced increase in collateral-dependent blood flow to the distal hind-limb muscles was evaluated after bilateral femoral artery ligation in adult male rats (approximately 350 g). Rats received either saline (n = 34) or heparin (n = 36) injections and were kept sedenta...

journal_title：Circulation research

authors： Yang HT,Ogilvie RW,Terjung RL

更新日期：1995-03-01 00:00:00

abstract：:Mononuclear phagocytes (MPs) relevant to atherosclerosis include monocytes, macrophages, and dendritic cells. A decade ago, studies on macrophage behavior in atherosclerotic lesions were often limited to quantification of total macrophage area in cross-sections of plaques. Although technological advances are still nee...

journal_title：Circulation research

authors： Randolph GJ

更新日期：2014-05-23 00:00:00

abstract：:Animal and preliminary human studies of adult cell therapy following acute myocardial infarction have shown an overall improvement of cardiac function. Myocardial and vascular regeneration have been initially proposed as mechanisms of stem cell action. However, in many cases, the frequency of stem cell engraftment and...

journal_title：Circulation research

authors： Gnecchi M,Zhang Z,Ni A,Dzau VJ

更新日期：2008-11-21 00:00:00

abstract：:We have measured the apparent Ca2+ sensitivities of force development in skinned cardiac trabeculae at different sarcome lengths together with shifts in troponin (Tn) T subunits on specimens from the same hearts and drawn insights into the pathogenesis of myocardial dysfunction in the diabetic rat. The Ca(2+)-force re...

journal_title：Circulation research

authors： Akella AB,Ding XL,Cheng R,Gulati J

更新日期：1995-04-01 00:00:00

abstract：:Acetylcholine (ACh) evokes the conduction of vasodilation along resistance microvessels. However, it is not known which cell layer (endothelium or smooth muscle) serves as the conduction pathway. In isolated, cannulated feed arteries ( approximately 70 microm in diameter at 75 mm Hg; length approximately 4 mm) of the ...

journal_title：Circulation research

authors： Emerson GG,Segal SS

更新日期：2000-01-07 00:00:00

abstract：:The pulmonary vein is sleeved by myocardium, which is a major source of atrial fibrillation and is involved in congenital sinus venosus defects. Little is known about the cellular origin and mechanism of formation of the pulmonary myocardium. We observed a biphasic process of pulmonary myocardium formation in mice. Fi...

journal_title：Circulation research

authors： Mommersteeg MT,Brown NA,Prall OW,de Gier-de Vries C,Harvey RP,Moorman AF,Christoffels VM

更新日期：2007-10-26 00:00:00

abstract：:We studied mitochondrial structure and intermediates of fatty acid metabolism in mitochondria isolated from ischemic hearts. By electron microscopy, no structural difference was detected between mitochondria isolated from control hearts and from ischemic hearts receiving glucose as the only substrate. However, major d...

journal_title：Circulation research

authors： Feuvray D,Plouët J

更新日期：1981-05-01 00:00:00

abstract：:Isolated adult rat hearts perfused in an isovolumic mode were used to study the effects of sodium-potassium pump inhibition and sodium-calcium exchange alterations on the tissue content of adenosine triphosphate, phosphocreatine, inorganic phosphate, and intracellular pH, all measured by phosphorus-31 nuclear magnetic...

journal_title：Circulation research

authors： Hoerter JA,Miceli MV,Renlund DG,Jacobus WE,Gerstenblith G,Lakatta EG

更新日期：1986-04-01 00:00:00

abstract：:-The vascular endothelial growth factor receptor Flk-1/KDR is highly expressed during development and almost disappears in adult tissues. Despite its biological relevance, little is known about the molecular mechanisms controlling its expression. In the present work, it is shown that cAMP response element binding prot...

journal_title：Circulation research

authors： Illi B,Puri P,Morgante L,Capogrossi MC,Gaetano C

更新日期：2000-06-23 00:00:00

abstract：:The sphingolipid metabolites, sphingosine (SPH), SPH 1-phosphate (S1P), and sphingosylphosphorylcholine (SPC), can act as intracellular as well as extracellular signaling molecules. These compounds have been implicated in the regulation of cell growth, differentiation, and programmed cell death in nonmyocytes, but the...

journal_title：Circulation research

authors： Sekiguchi K,Yokoyama T,Kurabayashi M,Okajima F,Nagai R

更新日期：1999-11-26 00:00:00

abstract：:Originally identified as moderate biological modifiers, microRNAs have recently emerged as powerful regulators of diverse cellular processes with especially important roles in disease and tissue remodeling. The rapid pace of studies on microRNA regulation and function necessitates the development of suitable technique...

journal_title：Circulation research

authors： van Rooij E

更新日期：2011-01-21 00:00:00

abstract：:The effects of mechanical factors on nuclear factor (NF)-kappaB activation and its potential functional roles have been very little explored in the intact vessel. Thus, we chose to study the regulation of NF-kappaB by intraluminal pressure using an organ culture model of mouse carotid arteries maintained at 80 or 150 ...

journal_title：Circulation research

authors： Lemarié CA,Esposito B,Tedgui A,Lehoux S

更新日期：2003-08-08 00:00:00

abstract：:During myocardial ischemia, electrical uncoupling and contracture herald irreversible damage. In the present study, we tested the hypothesis that an increase of intracellular Ca2+ is an important factor initiating these events. Therefore, we simultaneously determined tissue resistance, mechanical activity, pH(0), and ...

journal_title：Circulation research

authors： Dekker LR,Fiolet JW,VanBavel E,Coronel R,Opthof T,Spaan JA,Janse MJ

更新日期：1996-08-01 00:00:00

abstract：:The study was performed to determine whether there is a structural vascular abnormality in normotensive subjects with hypertensive relatives. We examined maximal vasodilator capacity of forearm resistance vessels in 23 normotensive young men (mean blood pressure 94 +/- 0.4 mm Hg, mean +/- SE) with hypertensive relativ...

journal_title：Circulation research

authors： Takeshita A,Imaizumi T,Ashihara T,Yamamoto K,Hoka S,Nakamura M

更新日期：1982-05-01 00:00:00

abstract：:To evaluate the degree and lateral extent of dysfunction in nonischemic myocardium adjacent to ischemic muscle, we measured systolic wall thickening with sonomicrometers during circumflex coronary occlusion in 12 anesthetized, open-chest dogs. The locations of the wall thickness measurements relative to the perfusion ...

journal_title：Circulation research

authors： Gallagher KP,Gerren RA,Stirling MC,Choy M,Dysko RC,McManimon SP,Dunham WR

更新日期：1986-04-01 00:00:00

abstract：:We studied the effects of rapid atrial pacing during the final 10 minutes of a 70-minute, 31% reduction in coronary blood flow in anesthetized swine to understand the significance of apparent metabolic improvements during the initial 60 minutes of segmental ischemia. Within 5-10 minutes of ischemia, subendocardial pho...

journal_title：Circulation research

authors： Arai AE,Pantely GA,Anselone CG,Bristow J,Bristow JD

更新日期：1991-12-01 00:00:00

abstract：:High-density lipoprotein (HDL) is a complex mixture of lipoproteins that is associated with many minor proteins and lipids that influence the function of HDL. Although HDL is a promising marker and potential therapeutic target based on its epidemiological data and the effects of healthy HDL in vitro in endothelial cel...

journal_title：Circulation research

authors： Lüscher TF,Landmesser U,von Eckardstein A,Fogelman AM

更新日期：2014-01-03 00:00:00

abstract：:Subthreshold potentials are thought to be mediated by time-independent, "passive" background currents. In this study, we show that the background current-voltage (I-V) relation of guinea pig ventricular myocytes is changed significantly by repetitive stimulation, in such a way that cell excitability becomes enhanced. ...

journal_title：Circulation research

authors： Delmar M,Ibarra J,Davidenko J,Lorente P,Jalife J

更新日期：1991-11-01 00:00:00

abstract：RATIONALE:G protein-coupled receptor kinase 2 (GRK2) is abundantly expressed in the heart, and its expression and activity are increased in injured or stressed myocardium. This upregulation has been shown to be pathological. GRK2 can promote cell death in ischemic myocytes, and its inhibition by a peptide comprising th...

journal_title：Circulation research

authors： Chen M,Sato PY,Chuprun JK,Peroutka RJ,Otis NJ,Ibetti J,Pan S,Sheu SS,Gao E,Koch WJ

更新日期：2013-04-12 00:00:00

abstract：:The spatial and dynamic properties of ventricular fibrillation (VF) may be random or related to cellular electrical properties of the normal heart. Local activation intervals (AIs) in VF may depend on the local refractory period (RP), and sustained VF may require a steep action potential (AP) restitution curve. In gui...

journal_title：Circulation research

authors： Choi BR,Liu T,Salama G

更新日期：2001-03-16 00:00:00