Stroke Caused by Atherosclerosis of the Major Intracranial Arteries.

abstract：RATIONALE:Myocardial ischemia-reperfusion (I/R) results in the generation of oxygen-derived free radicals and the accumulation of lipid peroxidation-derived unsaturated aldehydes. However, the contribution of aldehydes to myocardial I/R injury has not been assessed. OBJECTIVE:We tested the hypothesis that removal of a...

journal_title：Circulation research

authors： Conklin DJ,Guo Y,Jagatheesan G,Kilfoil PJ,Haberzettl P,Hill BG,Baba SP,Guo L,Wetzelberger K,Obal D,Rokosh DG,Prough RA,Prabhu SD,Velayutham M,Zweier JL,Hoetker JD,Riggs DW,Srivastava S,Bolli R,Bhatnagar A

更新日期：2015-08-14 00:00:00

abstract：RATIONALE:Kawasaki disease (KD), an acute febrile vasculitis, is the most common cause of acquired heart disease in childhood; however, diagnosing KD can be difficult. OBJECTIVE:To identify unique proteomic biomarkers that can be used to facilitate earlier diagnosis of KD. METHODS AND RESULTS:We enrolled 214 children...

journal_title：Circulation research

authors： Ko TM,Kuo HC,Chang JS,Chen SP,Liu YM,Chen HW,Tsai FJ,Lee YC,Chen CH,Wu JY,Chen YT

更新日期：2015-02-27 00:00:00

abstract：:C-reactive protein (CRP), a characteristic inflammatory marker, is a powerful predictor of cardiovascular events. Recent data suggest that CRP may also promote atherogenesis through inducing endothelial dysfunction. Lectin-like oxidized low-density lipoprotein (oxLDL) receptor-1 (LOX-1) is a newly identified endotheli...

journal_title：Circulation research

authors： Li L,Roumeliotis N,Sawamura T,Renier G

更新日期：2004-10-29 00:00:00

abstract：:5-Hydroxytryptamine (5-HT)(1B) receptors mediate contraction in human pulmonary arteries, and 5-HT(1B) receptor-mediated contraction is enhanced in pulmonary arteries from hypoxic rats. Here we further examine the role of this receptor in the development of pulmonary hypertension (PHT) by examining (1) the effects of ...

journal_title：Circulation research

authors： Keegan A,Morecroft I,Smillie D,Hicks MN,MacLean MR

更新日期：2001-12-07 00:00:00

abstract：:Recovery of postischemic function may be limited by energy synthesis by mitochondria, energy transfer via the creatine kinase reaction, or energy utilization at myofibrils. To identify the limiting step, we defined the relations among oxygen consumption, creatine kinase reaction velocity and cardiac performance in myo...

journal_title：Circulation research

authors： Neubauer S,Hamman BL,Perry SB,Bittl JA,Ingwall JS

更新日期：1988-07-01 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombinant protein rhVEGF-B...

journal_title：Circulation research

authors： Silvestre JS,Tamarat R,Ebrahimian TG,Le-Roux A,Clergue M,Emmanuel F,Duriez M,Schwartz B,Branellec D,Lévy BI

更新日期：2003-07-25 00:00:00

abstract：RATIONALE:Congestive heart failure (CHF) frequently results in remodeling and increased tone of pulmonary resistance vessels. This adaptive response, which aggravates pulmonary hypertension and thus, promotes right ventricular failure, has been attributed to lung endothelial dysfunction. OBJECTIVE:We applied real-time...

journal_title：Circulation research

authors： Kerem A,Yin J,Kaestle SM,Hoffmann J,Schoene AM,Singh B,Kuppe H,Borst MM,Kuebler WM

更新日期：2010-04-02 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) is a widely distributed mitogen that mediates the growth-promoting effects of platelet-derived growth factor in mesenchymal cells. We show that rat aortic IGF-I messenger RNA (mRNA) is induced 24 hours after deendothelialization, at a time when smooth muscle cell proliferation with...

journal_title：Circulation research

authors： Cercek B,Fishbein MC,Forrester JS,Helfant RH,Fagin JA

更新日期：1990-06-01 00:00:00

abstract：:The purpose of this study was to investigate if myogenic responses of isolated coronary arterioles were dependent on an intact, functional endothelium. Arterioles were located in situ by intracoronary perfusion with india ink-gelatin solution and then dissected and cannulated at both ends with glass micropipettes. Int...

journal_title：Circulation research

authors： Kuo L,Chilian WM,Davis MJ

更新日期：1990-03-01 00:00:00

abstract：:In 57 normal subjects (age 20-60 years), we analyzed the spontaneous beat-to-beat oscillation in R-R interval during control recumbent position, 90 degrees upright tilt, controlled respiration (n = 16) and acute (n = 10) and chronic (n = 12) beta-adrenergic receptor blockade. Automatic computer analysis provided the a...

journal_title：Circulation research

authors： Pagani M,Lombardi F,Guzzetti S,Rimoldi O,Furlan R,Pizzinelli P,Sandrone G,Malfatto G,Dell'Orto S,Piccaluga E

更新日期：1986-08-01 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)γ agonists attenuate atherosclerosis and abdominal aortic aneurysms (AAAs). PPARγ, a nuclear receptor, is expressed on many cell types including smooth muscle cells (SMCs). OBJECTIVE:To determine whether a PPARγ agonist reduces angiotensin II (Ang II)-induced ...

journal_title：Circulation research

authors： Subramanian V,Golledge J,Ijaz T,Bruemmer D,Daugherty A

更新日期：2010-10-15 00:00:00

abstract：:Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a major cause of death worldwide. Disturbed Na and Ca handling is known to be a major predisposing factor for life-threatening tachyarrhythmias. In cardiomyocytes, many ion channels and transporters, including voltage-gated Na and...

journal_title：Circulation research

authors： Wagner S,Maier LS,Bers DM

更新日期：2015-06-05 00:00:00

abstract：:We developed a mouse myocardial preparation to study cellular dysfunction in acute coxsackievirus myocarditis. Thin right ventricular papillary muscles from normal mice (n = 8) were compared with muscles from mice 7 days after coxsackievirus infection (n = 7). Sarcomere shortening was studied with laser diffraction (H...

journal_title：Circulation research

authors： Hamrell BB,Huber SA,Leslie KO

更新日期：1994-09-01 00:00:00

abstract：:Endothelin-1 (ET-1) and endothelin-3 (ET-3) produced positive inotropic effects on electrically stimulated left atria and increased the frequency of spontaneously beating right atria of adult rats. The potency of the inotropic effect of ET-1 was greater than that of ET-3, but the potencies of the chronotropic effects ...

journal_title：Circulation research

authors： Ishikawa T,Li LM,Shinmi O,Kimura S,Yanagisawa M,Goto K,Masaki T

更新日期：1991-10-01 00:00:00

abstract：:The purpose of this study was to evaluate the limitations of the double sucrose gap voltage clamp technique in the determination of tension-voltage relationships for frog atrial muscle. Tension-voltage relationships were determined under two conditions. In one case we determined both the tension response and slow inwa...

journal_title：Circulation research

authors： Tarr M,Trank JW

更新日期：1976-07-01 00:00:00

abstract：:Studies of the stellate ganglion and middle cervical ganglion indicate that sympathetic efferent nerve activity can be modified by peripheral excitatory inputs and that these neural connections may function as pathways for a peripheral reflex at the level of the thoracic sympathetic ganglia. This excitatory synaptic i...

journal_title：Circulation research

authors： Bosnjak ZJ,Kampine JP

更新日期：1989-03-01 00:00:00

abstract：:Choline acetyltransferase activity, which is rate limiting in acetylcholine biosynthesis, was measured in the four heart chambers of guinea pigs subjected to (1) sham surgery, (2) constriction of the ascending aorta, (3) constriction of the descending thoracic aorta, and (4) constriction of the pulmonary artery. After...

journal_title：Circulation research

authors： Roskoski R Jr,Schmid PG,Mayer HE,Abboud FM

更新日期：1975-04-01 00:00:00

abstract：:The aim of this study is to quantify the porcine coronary arterial branching pattern and to use this quantification for the interpretation of flow heterogeneity. Two casts of the coronary arterial tree were made at diastolic arrest and maximal dilation. The relation between length and diameter of arterial segments was...

journal_title：Circulation research

authors： VanBavel E,Spaan JA

更新日期：1992-11-01 00:00:00

abstract：RATIONALE:Hydrogen peroxide (H(2)O(2)) serves as a key endothelium-derived hyperpolarizing factor mediating flow-induced dilation in human coronary arterioles (HCAs). The precise mechanisms by which H(2)O(2) elicits smooth muscle hyperpolarization are not well understood. An important mode of action of H(2)O(2) involve...

journal_title：Circulation research

authors： Zhang DX,Borbouse L,Gebremedhin D,Mendoza SA,Zinkevich NS,Li R,Gutterman DD

更新日期：2012-02-03 00:00:00

abstract：:We recorded 60 DC simultaneous electrograms from isolated porcine and canine hearts in the first minutes after coronary occlusion. Ventricular premature beats (VPB) originated from the normal side of the ischemic border, which was frequently separated from the central ischemic area showing delayed activity by a small ...

journal_title：Circulation research

authors： Janse MJ,van Capelle FJ

更新日期：1982-04-01 00:00:00

abstract：:In patients with congestive heart failure, skeletal muscle is characterized by a smaller proportion of slow-twitch oxidative fibers and reduced oxidative enzyme activity. However, whether these changes result from disuse or occur as a direct consequence of heart failure is unresolved. To address this issue, 18 rats wi...

journal_title：Circulation research

authors： Simonini A,Long CS,Dudley GA,Yue P,McElhinny J,Massie BM

更新日期：1996-07-01 00:00:00

abstract：:Isolated cardiac conduction disease is an autosomal dominant defect that includes various combinations of bundle branch or fascicular blocks. These defects can cause sudden death due to a complete heart block. We used a genome-wide screening approach with polymorphic (CA)n repeat markers to determine the chromosomal p...

journal_title：Circulation research

authors： de Meeus A,Stephan E,Debrus S,Jean MK,Loiselet J,Weissenbach J,Demaille J,Bouvagnet P

更新日期：1995-10-01 00:00:00

abstract：:Rat myocardium expresses the 240- and 235-kD polypeptides antigenically related to alpha- and beta-subunits of brain calspectin (nonerythroid spectrin or fodrin), respectively. In the subcellular fractions of the myocardium, alpha-calspectin was found in the 600g, 10,000g, and 100,000g pellets, whereas beta-calspectin...

journal_title：Circulation research

authors： Yoshida K,Inui M,Harada K,Saido TC,Sorimachi Y,Ishihara T,Kawashima S,Sobue K

更新日期：1995-09-01 00:00:00

abstract：:Mononuclear phagocytes (MPs) relevant to atherosclerosis include monocytes, macrophages, and dendritic cells. A decade ago, studies on macrophage behavior in atherosclerotic lesions were often limited to quantification of total macrophage area in cross-sections of plaques. Although technological advances are still nee...

journal_title：Circulation research

authors： Randolph GJ

更新日期：2014-05-23 00:00:00

abstract：:We evaluated the hypothesis that stunning swine myocardium with brief ischemia reduces oxygen demand in the stunned region and increases tolerance of myocardium to longer periods of ischemia. Wall function was quantified with ultrasonic crystals aligned to measure wall thickening, and stunning was achieved with two cy...

journal_title：Circulation research

authors： Schott RJ,Rohmann S,Braun ER,Schaper W

更新日期：1990-04-01 00:00:00

abstract：:Pharmacological modulation of [K+]o accumulation and action potential changes during acute myocardial ischemia is under evaluation as a promising new antiarrhythmic and cardioprotective strategy during myocardial ischemia and reperfusion. We studied the effects of cromakalim, a K+ channel opener that activates ATP-sen...

journal_title：Circulation research

authors： Venkatesh N,Stuart JS,Lamp ST,Alexander LD,Weiss JN

更新日期：1992-12-01 00:00:00

abstract：RATIONALE:Mitochondria, although required for cellular ATP production, are also known to have other important functions that may include modulating cellular responses to environmental stimuli. However, the mechanisms whereby mitochondria impact cellular phenotype are not yet clear. OBJECTIVE:To determine how mitochond...

journal_title：Circulation research

authors： Shimasaki Y,Pan N,Messina LM,Li C,Chen K,Liu L,Cooper MP,Vita JA,Keaney JF Jr

更新日期：2013-09-13 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1) stimulates the formation of a collateral circulation on arterial occlusion. The present study served to determine whether these proarteriogenic properties of MCP-1 are preserved in hyperlipidemic apolipoprotein E-deficient (apoE-/-) mice and whether it affects the systemic de...

journal_title：Circulation research

authors： van Royen N,Hoefer I,Böttinger M,Hua J,Grundmann S,Voskuil M,Bode C,Schaper W,Buschmann I,Piek JJ

更新日期：2003-02-07 00:00:00

abstract：:The purpose of this study was to determine whether a quantitative relationship existed between a reduction in regional myocardial blood flow, measured by radiolabeled microspheres, and the degree and type of changes in myocardial activation recorded in bipolar left ventricular subepicardial and subendocardial electrog...

journal_title：Circulation research

authors： Ruffy R,Lovelace DE,Mueller TM,Knoebel SB,Zipes DP

更新日期：1979-12-01 00:00:00

abstract：:This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and proinflammatory cytokines, contribute to atherogenesis. In addition, adaptive ...

journal_title：Circulation research

authors： Hansson GK,Libby P,Schönbeck U,Yan ZQ

更新日期：2002-08-23 00:00:00