Bone marrow microvascular and neuropathic alterations in patients with critical limb ischemia.

abstract：:To determine whether or not salt loading restricted to the brain would elevate blood pressure, chronically implanted osmotic minipumps were used to infuse hypertonic sodium chloride solutions made in artificial cerebrospinal fluid into a jugular vein intravenously or the third cerebral ventricle, intracerebroventricul...

journal_title：Circulation research

authors： Miyajima E,Buñag RD

更新日期：1984-05-01 00:00:00

abstract：:Hemodynamics play an important role in cardiovascular development, and changes in blood flow can cause congenital heart malformations. The endothelium and endocardium are subjected to mechanical forces, of which fluid shear stress is correlated to blood flow velocity. The shear stress responsive genes lung Krüppel-lik...

journal_title：Circulation research

authors： Groenendijk BC,Hierck BP,Vrolijk J,Baiker M,Pourquie MJ,Gittenberger-de Groot AC,Poelmann RE

更新日期：2005-06-24 00:00:00

abstract：:A surgical technique was developed to place sutures around the pulmonary arteries of young rats (about 1 month old and 100 g body weight). As the operated rats grew, the pulmonary arteries were gradually constricted, leading after 4-6 weeks to the development of severe right ventricular hypertrophy with free wall weig...

journal_title：Circulation research

authors： Julian FJ,Morgan DL,Moss RL,Gonzalez M,Dwivedi P

更新日期：1981-12-01 00:00:00

abstract：RATIONALE:Pulmonary arterial hypertension (PAH) remains a progressive and eventually lethal disease characterized by increased pulmonary vascular resistance because of loss of functional lung microvasculature, primarily at the distal (intracinar) arteriolar level. Cell-based therapies offer the potential to repair and ...

journal_title：Circulation research

authors： Granton J,Langleben D,Kutryk MB,Camack N,Galipeau J,Courtman DW,Stewart DJ

更新日期：2015-09-11 00:00:00

abstract：:The mechanism of propranolol-inhibited sarcolemmal membrane lipid peroxidation was investigated by electron spin resonance spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 2-methyl-2-nitrosopropane (MNP). Highly purified canine myocytic sarcolemma were peroxidized by a superoxide-driven (from ...

journal_title：Circulation research

authors： Mak IT,Arroyo CM,Weglicki WB

更新日期：1989-10-01 00:00:00

abstract：:Studies were carried out to determine the contribution of cardiopulmonary receptors to the renal responses to head-out water immersion in the nonhuman primate. Immersion to the suprasternal notch was associated with significant increases in central venous pressure, urine flow, and sodium excretion. The increased sodiu...

journal_title：Circulation research

authors： Gilmore JP,Zucker IH

更新日期：1978-02-01 00:00:00

abstract：:Because phospholemman (PLM) regulates the Na(+)/K(+) pump (NKA) and is a major cardiac phosphorylation target for both protein kinase A (at Ser68) and protein kinase C (PKC) (at both Ser63 and Ser68), we evaluated whether PLM mediates the PKC-dependent regulation of NKA function and protein kinase A/PKC crosstalk in v...

journal_title：Circulation research

authors： Han F,Bossuyt J,Despa S,Tucker AL,Bers DM

更新日期：2006-12-08 00:00:00

abstract：:This report evaluates pulse wave propagation with respect to contributions by vascular wall elastic and geometric properties, vessel wall and blood viscosity, and nonlinearities in system parameters and in the equations of motion. Discrepancies in results obtained with different experimental methods and theory are dis...

journal_title：Circulation research

authors： Li JK,Melbin J,Riffle RA,Noordergraaf A

更新日期：1981-08-01 00:00:00

abstract：:We tested the hypothesis that accumulation of H+ or inorganic phosphate (Pi) is responsible for the early contractile failure of hypoxia by measuring maximal Ca2+-activated pressure and 31P nuclear magnetic resonance spectra in Langendorff-perfused ferret hearts at 30 degrees C. Maximal Ca2+-activated pressure was ide...

journal_title：Circulation research

authors： Kusuoka H,Weisfeldt ML,Zweier JL,Jacobus WE,Marban E

更新日期：1986-09-01 00:00:00

abstract：:The deposition of platelets at the site of balloon angioplasty is thought to play a major role in the pathogenesis of restenosis. The antibody AZ-1, which binds to the rabbit platelet glycoprotein IIb/IIIa receptor and inhibits platelet function both in vitro and in vivo, was produced and tested in an experimental mod...

journal_title：Circulation research

authors： Azrin MA,Ling FS,Chen Q,Pawashe A,Migliaccio F,Homer R,Todd M,Ezekowitz MD

更新日期：1994-08-01 00:00:00

abstract：:This study addresses the structural requirements for the intracellular processing and receptor binding properties of endothelin-1 (ET-1). Point mutants of preproendothelin-1 cDNA, with replacement of the codons for Lys9 of ET-1 by ones for Ala and Glu and of Ile20 and Trp21 by ones encoding Ala, were expressed in COS-...

journal_title：Circulation research

authors： Ergul A,Tackett RL,Puett D

更新日期：1995-12-01 00:00:00

abstract：:Transforming growth factor (TGF)-beta(1) is a potent stimulator of intimal growth. We showed previously that TGF-beta(1) stimulates intimal growth through early upregulation of plasminogen activator inhibitor-1 (PAI-1) and, subsequently, PAI-1-dependent increases in cell migration and matrix accumulation. We also show...

journal_title：Circulation research

authors： Otsuka G,Stempien-Otero A,Frutkin AD,Dichek DA

更新日期：2007-05-11 00:00:00

abstract：:Heart failure (HF) has been singled out as an epidemic and is a staggering clinical and public health problem, associated with significant mortality, morbidity, and healthcare expenditures, particularly among those aged ≥ 65 years. The case mix of HF is changing over time with a growing proportion of cases presenting ...

journal_title：Circulation research

authors： Roger VL

更新日期：2013-08-30 00:00:00

abstract：:We used a genetic approach to determine whether increasing the level of A3 adenosine receptors (A3ARs) expressed in the heart confers protection against ischemia without causing cardiac pathology. We generated mice carrying one (A3tg.1) or six (A3tg.6) copies of a transgene consisting of the cardiomyocyte-specific alp...

journal_title：Circulation research

authors： Black RG Jr,Guo Y,Ge ZD,Murphree SS,Prabhu SD,Jones WK,Bolli R,Auchampach JA

更新日期：2002-07-26 00:00:00

abstract：:Volume densities of mitochondria, myofibrils, and unspecified cytoplasm were measured by ultrastructural morphometry in myocardium from dogs, rats, hamsters, mice, and in biopsied tissue from human hearts. Human myocardium was composed of 23% mitochondria, 59% myofibrils, and 18% cytoplasm. Volume densities for mitoch...

journal_title：Circulation research

authors： Schaper J,Meiser E,Stämmler G

更新日期：1985-03-01 00:00:00

abstract：:C-reactive protein (CRP), a characteristic inflammatory marker, is a powerful predictor of cardiovascular events. Recent data suggest that CRP may also promote atherogenesis through inducing endothelial dysfunction. Lectin-like oxidized low-density lipoprotein (oxLDL) receptor-1 (LOX-1) is a newly identified endotheli...

journal_title：Circulation research

authors： Li L,Roumeliotis N,Sawamura T,Renier G

更新日期：2004-10-29 00:00:00

abstract：:Recent studies in isolated cardiac tissue preparations have demonstrated the applicability of a one-dimensional difference equation model describing the global behavior of a driven nonpacemaker cell to the understanding of rate-dependent cardiac excitation. As a first approximation to providing an ionic basis to compl...

journal_title：Circulation research

authors： Vinet A,Chialvo DR,Michaels DC,Jalife J

更新日期：1990-12-01 00:00:00

abstract：:Oxidation converts low-density lipoprotein (LDL) into a cytotoxin in vitro. Oxidized LDL exists in vivo in atherosclerotic lesions and possibly in plasma. Many cell functions are altered in vitro by oxidized LDL, but few have been examined in vivo. To test whether oxidized LDL could injure endothelial cells and alter ...

journal_title：Circulation research

authors： Rangaswamy S,Penn MS,Saidel GM,Chisolm GM

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:Lymphatic vasculature constitutes a second vascular system essential for immune surveillance and tissue fluid homeostasis. Maturation of the hierarchical vascular structure, with a highly branched network of capillaries and ducts, is crucial for its function. Environmental cues mediate the remodeling process,...

journal_title：Circulation research

authors： Morooka N,Futaki S,Sato-Nishiuchi R,Nishino M,Totani Y,Shimono C,Nakano I,Nakajima H,Mochizuki N,Sekiguchi K

更新日期：2017-04-14 00:00:00

abstract：RATIONALE:Unlike conventional dendritic cells, plasmacytoid DCs (PDC) are poor in antigen presentation and critical for type I interferon response. Though proposed to be present in human atherosclerotic lesions, their role in atherosclerosis remains elusive. OBJECTIVE:To investigate the role of PDC in atherosclerosis....

journal_title：Circulation research

authors： Daissormont IT,Christ A,Temmerman L,Sampedro Millares S,Seijkens T,Manca M,Rousch M,Poggi M,Boon L,van der Loos C,Daemen M,Lutgens E,Halvorsen B,Aukrust P,Janssen E,Biessen EA

更新日期：2011-12-09 00:00:00

abstract：RATIONALE:Histone deacetylase (HDAC)7 is expressed in the early stages of embryonic development and may play a role in endothelial function. OBJECTIVE:This study aimed to investigate the role of HDAC7 in endothelial cell (EC) proliferation and growth and the underlying mechanism. METHODS AND RESULTS:Overexpression of...

journal_title：Circulation research

authors： Margariti A,Zampetaki A,Xiao Q,Zhou B,Karamariti E,Martin D,Yin X,Mayr M,Li H,Zhang Z,De Falco E,Hu Y,Cockerill G,Xu Q,Zeng L

更新日期：2010-04-16 00:00:00

abstract：:-The vascular endothelial growth factor receptor Flk-1/KDR is highly expressed during development and almost disappears in adult tissues. Despite its biological relevance, little is known about the molecular mechanisms controlling its expression. In the present work, it is shown that cAMP response element binding prot...

journal_title：Circulation research

authors： Illi B,Puri P,Morgante L,Capogrossi MC,Gaetano C

更新日期：2000-06-23 00:00:00

abstract：:Ventricular muscle fibers from dog hearts were superfused with K+-free, high Ca2+ solutions after exposure to a K+-free, Ca2+-free superfusate. Following a series of driven action potentials, oscillatory after potentials (OAPs) were elicited in all 40 preparations at a resting potential of greater than -60 mV. The OAP...

journal_title：Circulation research

authors： Hiraoka M,Okamoto Y,Sano T

更新日期：1981-04-01 00:00:00

abstract：:Although morphological studies suggest that coronary vascular injury is a result of prolonged ischemia and subsequent reperfusion, whether functional coronary microvascular injury develops during brief in vivo ischemia is unclear. In other organs, permeability is a sensitive indicator of functional vascular injury. Th...

journal_title：Circulation research

authors： Dauber IM,VanBenthuysen KM,McMurtry IF,Wheeler GS,Lesnefsky EJ,Horwitz LD,Weil JV

更新日期：1990-04-01 00:00:00

abstract：:The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore seems an att...

journal_title：Circulation research

authors： Duisters RF,Tijsen AJ,Schroen B,Leenders JJ,Lentink V,van der Made I,Herias V,van Leeuwen RE,Schellings MW,Barenbrug P,Maessen JG,Heymans S,Pinto YM,Creemers EE

更新日期：2009-01-30 00:00:00

abstract：:Pathological remodeling of the left ventricle (LV) after myocardial infarction (MI) is a major cause of heart failure. Although cardiac hypertrophy after increased loading conditions has been recognized as a clinical risk factor for human heart failure, it is unknown whether post-MI hypertrophic remodeling of the myoc...

journal_title：Circulation research

authors： van Rooij E,Doevendans PA,Crijns HJ,Heeneman S,Lips DJ,van Bilsen M,Williams RS,Olson EN,Bassel-Duby R,Rothermel BA,De Windt LJ

更新日期：2004-02-20 00:00:00

abstract：:Heme oxygenase (HO)-1 is a protective antioxidant enzyme that prevents cardiomyocyte apoptosis, for instance, during progressive cardiomyopathy. Here we identify a fundamental aspect of the HO-1 protection mechanism by demonstrating that HO-1 activity in mouse heart stimulates the bigenomic mitochondrial biogenesis pr...

journal_title：Circulation research

authors： Piantadosi CA,Carraway MS,Babiker A,Suliman HB

更新日期：2008-11-21 00:00:00

abstract：:We studied the effect of histamine and H1 or H2 blockers on the diameter of pial arteries (39-227 micron) using microapplication into the perivascular space. Concentration-response curves for histamine showed dilations which started at 10(-7) M and were maximal at 10(-5) and 10(-4) M. The H2 blocker, cimetidine, induc...

journal_title：Circulation research

authors： Wahl M,Kuschinsky W

更新日期：1979-02-01 00:00:00

abstract：:Increased glomerular capillary hydrostatic pressure (PGC) is an important hemodynamic determinant of glomerular injury, but the molecular events responsible for this association are poorly understood. PGC is normal in spontaneously hypertensive rats (SHR), but uninephrectomy leads to an increase in PGC and accelerated...

journal_title：Circulation research

authors： Shankland SJ,Ly H,Thai K,Scholey JW

更新日期：1994-11-01 00:00:00

abstract：:To investigate the regulation of the actomyosin crossbridge cycle in cardiac muscles, the effects of ATP, ADP, Pi, and creatine phosphate (CP) on the rate of force redevelopment (ktr) were measured. We report that CP is a primary determinant in controlling the actomyosin crossbridge cycling kinetics of cardiac muscles...

journal_title：Circulation research

authors： Ogut O,Brozovich FV

更新日期：2003-07-11 00:00:00