Epidemiology of heart failure.

abstract：:Ventricular arrhythmias that accompany myocardial infarction in dogs may be secondary to the altered electrophysiological properties of the subendocardial Purkinje fibers that survive 24 hours after the coronary occlusion. To better understand the ionic mechanisms that underlie the altered electrical activity of these...

journal_title：Circulation research

authors： Boyden PA,Albala A,Dresdner KP Jr

更新日期：1989-10-01 00:00:00

abstract：:Changes in cardiac filling pressure (central venous pressure) were measured following carotid occlusion and infusions of catecholamines in awake dogs while cardiac output was held constant. After carotid occlusion in dogs with vagi blocked, central venous pressure increased about 0.8 mm Hg (an estimated decrease in va...

journal_title：Circulation research

authors： Bennett TD,Wyss CR,Scher AM

更新日期：1984-10-01 00:00:00

abstract：RATIONALE:During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca(2+) channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule-sarcoplasmic reticulum anchoring...

journal_title：Circulation research

authors： Li RC,Tao J,Guo YB,Wu HD,Liu RF,Bai Y,Lv ZZ,Luo GZ,Li LL,Wang M,Yang HQ,Gao W,Han QD,Zhang YY,Wang XJ,Xu M,Wang SQ

更新日期：2013-02-15 00:00:00

abstract：RATIONALE:The epicardium contributes to the majority of nonmyocardial cells in the adult heart. Recent studies have reported that the epicardium is derived from Nkx2.5-positive progenitors and can differentiate into cardiomyocytes. Not much is known about the relation between the myocardial and epicardial lineage durin...

journal_title：Circulation research

authors： van Wijk B,van den Berg G,Abu-Issa R,Barnett P,van der Velden S,Schmidt M,Ruijter JM,Kirby ML,Moorman AF,van den Hoff MJ

更新日期：2009-08-28 00:00:00

abstract：:In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the limited regenerative capacity of the myocardium, resulting in the formation of a collagen-based scar. Necrotic cells release danger signals, activating innate immune pathways and triggering an intense inflammatory response. Stimula...

journal_title：Circulation research

authors： Prabhu SD,Frangogiannis NG

更新日期：2016-06-24 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) plays a pivotal role in the coordinated transactivation of cytokine and adhesion molecule genes involved in endothelial activation. Although recent reports have documented the contribution of NF-kappaB to apoptosis, it is still controversial. Especially, the r...

journal_title：Circulation research

authors： Matsushita H,Morishita R,Nata T,Aoki M,Nakagami H,Taniyama Y,Yamamoto K,Higaki J,Yasufumi K,Ogihara T

更新日期：2000-05-12 00:00:00

abstract：:To determine whether coronary vasodilator reserve that persists during myocardial ischemia is present in all left ventricular regions, we measured regional blood flow in 192 left ventricular pieces (mean weight, 201 mg) in each of eight dogs by using radioactive microspheres while perfusing the left main coronary arte...

journal_title：Circulation research

authors： Coggins DL,Flynn AE,Austin RE Jr,Aldea GS,Muehrcke D,Goto M,Hoffman JI

更新日期：1990-08-01 00:00:00

abstract：RATIONALE:Lipid-free apolipoprotein (apo) A-I and discoidal reconstituted high-density lipoproteins (rHDL) containing apoA-I, (A-I)rHDL, inhibit vascular inflammation by increasing 3β-hydroxysteroid-Δ24 reductase (DHCR24) expression. OBJECTIVE:To determine whether the lipid-free apoA-I-mediated and (A-I)rHDL-mediated ...

journal_title：Circulation research

authors： Wu BJ,Chen K,Shrestha S,Ong KL,Barter PJ,Rye KA

更新日期：2013-01-18 00:00:00

abstract：:Although Ca(2+) waves in cardiac myocytes are regarded as arrhythmogenic substrates, their properties in the heart in situ are poorly understood. On the hypothesis that Ca(2+) waves in the heart behave diversely and some of them influence the cardiac function, we analyzed their incidence, propagation velocity, and int...

journal_title：Circulation research

authors： Kaneko T,Tanaka H,Oyamada M,Kawata S,Takamatsu T

更新日期：2000-05-26 00:00:00

abstract：:Although urinary sodium excretion is positively influenced by acute changes in renal perfusion pressure, micropuncture studies show highly conflicting results concerning the response of superficial proximal tubule sodium reabsorption to changes in renal perfusion pressure. In the present study, the changes of superfic...

journal_title：Circulation research

authors： Kinoshita Y,Knox FG

更新日期：1990-05-01 00:00:00

abstract：:Heart failure is associated with death of cardiomyocytes leading to loss of contractility. Previous studies using membrane-targeted Akt (myristolated-Akt), an enzyme involved in antiapoptotic signaling, showed inhibition of cell death and prevention of pathogenesis induced by cardiomyopathic stimuli. However, recent s...

journal_title：Circulation research

authors： Shiraishi I,Melendez J,Ahn Y,Skavdahl M,Murphy E,Welch S,Schaefer E,Walsh K,Rosenzweig A,Torella D,Nurzynska D,Kajstura J,Leri A,Anversa P,Sussman MA

更新日期：2004-04-16 00:00:00

abstract：:The accumulation of inositol 1,4,5-trisphosphate (IP3) after hormonal stimulation has a physiological role, possibly by alteration of Ca2+ levels in cardiac myocyte. However, this accumulation has not been studied under pathophysiological conditions. In this report, we examine phosphatidylinositol metabolism during ce...

journal_title：Circulation research

authors： Kawaguchi H,Sano H,Iizuka K,Okada H,Kudo T,Kageyama K,Muramoto S,Murakami T,Okamoto H,Mochizuki N

更新日期：1993-05-01 00:00:00

abstract：:Ischemia/reperfusion (I/R) affects the integrity of the endoplasmic reticulum (ER), the site of synthesis and folding of numerous proteins. Therefore, I/R may activate the unfolded protein response (UPR), resulting in the induction of a collection of ER stress proteins, many of which are protective and function to res...

journal_title：Circulation research

authors： Martindale JJ,Fernandez R,Thuerauf D,Whittaker R,Gude N,Sussman MA,Glembotski CC

更新日期：2006-05-12 00:00:00

abstract：:We have used an immunological approach to investigate the role of myosin light chain phosphorylation (MLC-Pi) in the control of contractility in smooth muscle. Our aim was to specifically inhibit myosin light chain kinase (MLCK) in the presence of physiologically activating levels of Ca2+ so that other putative Ca2(+)...

journal_title：Circulation research

authors： De Lanerolle P,Strauss JD,Felsen R,Doerman GE,Paul RJ

更新日期：1991-02-01 00:00:00

abstract：:Fcγ receptors (FcγRs) classically modulate intracellular signaling on binding of the Fc region of IgG in immune response cells. How FcγR and their ligands affect cardiovascular health and disease has been interrogated recently in both preclinical and clinical studies. The stimulation of activating FcγR in endothelial ...

journal_title：Circulation research

authors： Tanigaki K,Sundgren N,Khera A,Vongpatanasin W,Mineo C,Shaul PW

更新日期：2015-01-16 00:00:00

abstract：:Controversy exists whether positive end-expiratory pressure (PEEP) ventilation lowers cardiac output by reducing left ventricular preload, or by a combination of mechanisms. Sixteen open-chest dogs were instrumented for measurement of left and right ventricular pressure, aortic flow, and left ventricular dimensions. W...

journal_title：Circulation research

authors： Darsee JR,Mikolich JR,Walter PF,Schlant RC

更新日期：1981-10-01 00:00:00

abstract：:In response to hypoxia and reoxygenation, mammalian cells are known to express a variety of genes to adapt to these external stresses or lead to further cell damage. We investigated the intracellular signaling cascades in cultured rat cardiac myocytes subjected to hypoxia followed by reoxygenation (hypoxia/reoxygenati...

journal_title：Circulation research

authors： Seko Y,Tobe K,Ueki K,Kadowaki T,Yazaki Y

更新日期：1996-01-01 00:00:00

abstract：:The objective of this study was to elucidate the mechanisms associated with the reciprocal relation between magnesium and calcium on vascular smooth muscle tone in bovine pulmonary artery and vein. Rapid removal of magnesium from Krebs-bicarbonate medium used to bathe isolated rings of precontracted artery or vein cau...

journal_title：Circulation research

authors： Gold ME,Buga GM,Wood KS,Byrns RE,Chaudhuri G,Ignarro LJ

更新日期：1990-02-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) plays an important role in regulating vascular smooth muscle cell (VSMC) proliferation and directed migration. The mitogenic and chemotactic actions of IGF-I are mediated through the IGF-I receptor, but how the activation of the IGF-I receptor leads to these biological responses is...

journal_title：Circulation research

authors： Duan C,Bauchat JR,Hsieh T

更新日期：2000-01-07 00:00:00

abstract：:Arterial segments (less than 250 micron o.d.) excised from canine ileum were mounted in a chamber that permitted arterial transmural pressure (TMP) to be altered and measured. Subsequently, the periarterial nerves were field stimulated with single pulses (0.1 msec, 70 V), and the resting membrane potential (Em) as wel...

journal_title：Circulation research

authors： Smeda JS,Daniel EE

更新日期：1988-06-01 00:00:00

abstract：RATIONALE:Shear stress (SS) has an established role in atherosclerotic plaque localization, but how it exerts its protective effect is not fully understood. OBJECTIVE:To test the hypothesis that SS may downregulate angiotensin type 1 receptors (AT(1)Rs). Angiotensin II has been shown to be proinflammatory and to promo...

journal_title：Circulation research

authors： Ramkhelawon B,Vilar J,Rivas D,Mees B,de Crom R,Tedgui A,Lehoux S

更新日期：2009-10-23 00:00:00

abstract：:Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by life threatening arrhythmias and mutations in the gene encoding the ryanodine receptor (RyR2). Disagreement exists on whether (1) RyR2 mutations induce abnormal calcium transients in the absence of adrenergic stimulat...

journal_title：Circulation research

authors： Liu N,Colombi B,Memmi M,Zissimopoulos S,Rizzi N,Negri S,Imbriani M,Napolitano C,Lai FA,Priori SG

更新日期：2006-08-04 00:00:00

abstract：:Glibenclamide, one of the antidiabetic sulfonylureas, is known to block ATP-dependent K+ channels. We used this drug to determine to what extent K+ loss from acutely ischemic myocardium is mediated via these channels. We also investigated whether glibenclamide would influence ischemic arrhythmias. Isolated rat hearts ...

journal_title：Circulation research

authors： Kantor PF,Coetzee WA,Carmeliet EE,Dennis SC,Opie LH

更新日期：1990-02-01 00:00:00

abstract：RATIONALE:The recent discovery of meningeal lymphatics in mammals is reshaping our understanding of fluid homeostasis and cellular waste management in the brain, but visualization and experimental analysis of these vessels is challenging in mammals. Although the optical clarity and experimental advantages of zebrafish ...

journal_title：Circulation research

authors： Castranova D,Samasa B,Venero Galanternik M,Jung HM,Pham VN,Weinstein BM

更新日期：2021-01-08 00:00:00

abstract：RATIONALE:Hypoxia followed by reoxygenation promotes inflammation by activating nuclear factor κB transcription factors in endothelial cells (ECs). This process involves modification of the signaling intermediary tumor necrosis factor receptor-associated factor 6 with polyubiquitin chains. Thus, cellular mechanisms tha...

journal_title：Circulation research

authors： Luong le A,Fragiadaki M,Smith J,Boyle J,Lutz J,Dean JL,Harten S,Ashcroft M,Walmsley SR,Haskard DO,Maxwell PH,Walczak H,Pusey C,Evans PC

更新日期：2013-06-07 00:00:00

abstract：RATIONALE:Hydrogen peroxide (H(2)O(2)) serves as a key endothelium-derived hyperpolarizing factor mediating flow-induced dilation in human coronary arterioles (HCAs). The precise mechanisms by which H(2)O(2) elicits smooth muscle hyperpolarization are not well understood. An important mode of action of H(2)O(2) involve...

journal_title：Circulation research

authors： Zhang DX,Borbouse L,Gebremedhin D,Mendoza SA,Zinkevich NS,Li R,Gutterman DD

更新日期：2012-02-03 00:00:00

abstract：:Pinocytotic vesicles are one of several anatomic factors relevant to the permeability for macromolecules of capillary endothelia. We quantitified the number and distribution of pinocytotic vesicles present in the endothelium of pulmonary capillaries. Several similar studies have been reported in the past for endotheli...

journal_title：Circulation research

authors： Gil J,Silage DA

更新日期：1980-09-01 00:00:00

abstract：RATIONALE:Smooth muscle precursor cells have previously been reported to reside in bone marrow and in the circulation, but little is currently known regarding the proximate stimuli for smooth muscle cell differentiation of these putative progenitors. OBJECTIVE:Because local thrombin generation occurs as an initial res...

journal_title：Circulation research

authors： Martin K,Weiss S,Metharom P,Schmeckpeper J,Hynes B,O'Sullivan J,Caplice N

更新日期：2009-07-31 00:00:00

abstract：RATIONALE:Lymphatic vasculature constitutes a second vascular system essential for immune surveillance and tissue fluid homeostasis. Maturation of the hierarchical vascular structure, with a highly branched network of capillaries and ducts, is crucial for its function. Environmental cues mediate the remodeling process,...

journal_title：Circulation research

authors： Morooka N,Futaki S,Sato-Nishiuchi R,Nishino M,Totani Y,Shimono C,Nakano I,Nakajima H,Mochizuki N,Sekiguchi K

更新日期：2017-04-14 00:00:00

abstract：:Atrial fibrillation (AF) may result from stationary reentry in the left atrium (LA), with fibrillatory conduction toward the right atrium (RA). We hypothesize that periodic input to the RA at an exceedingly high frequency results in disorganized wave propagation, compatible with fibrillatory conduction. Simultaneous e...

journal_title：Circulation research

authors： Berenfeld O,Zaitsev AV,Mironov SF,Pertsov AM,Jalife J

更新日期：2002-06-14 00:00:00