Creatine phosphate consumption and the actomyosin crossbridge cycle in cardiac muscles.

abstract：:The direct oral anticoagulants (DOACs) represent a major advance in oral anticoagulant therapy and have replaced the vitamin K antagonists as the preferred treatment for many indications. By simplifying long-term anticoagulant therapy and improving its safety, the DOACs have the potential to reduce the global burden o...

journal_title：Circulation research

authors： Chan NC,Eikelboom JW,Weitz JI

更新日期：2016-04-29 00:00:00

abstract：:Reductions in fluid shear stress produce endothelium-dependent vasoconstriction and promote neointimal hyperplasia, but the intracellular signaling mechanisms involved in these processes are poorly understood. To examine whether decreases in fluid shear stress affect endothelial cytosolic pH, carboxy-seminaphthorhodaf...

journal_title：Circulation research

authors： Ziegelstein RC,Blank PS,Cheng L,Capogrossi MC

更新日期：1998-04-20 00:00:00

abstract：:In a freshly isolated endothelial cell preparation from rabbit aorta, the regulation of the acetylcholine (ACh)-sensitive intracellular Ca2+ store and the effects of the Ca(2+)-induced Ca2+ release agonists ryanodine and caffeine were studied using fura 2 imaging fluorescence microscopy. ACh (10 mumol/L) caused a tran...

journal_title：Circulation research

authors： Wang X,Lau F,Li L,Yoshikawa A,van Breemen C

更新日期：1995-07-01 00:00:00

abstract：:Net cellular L-lactate efflux associated with accelerated anaerobic glycolysis has been implicated as a potential cause of the marked cellular K+ loss contributing to lethal cardiac arrhythmias in ischemic heart and to impaired function of fatigued skeletal muscle. To examine the mechanisms of transsarcolemmal L-lacta...

journal_title：Circulation research

authors： Shieh RC,Goldhaber JI,Stuart JS,Weiss JN

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:Innate and adaptive immune responses alter numerous homeostatic processes that are controlled by nuclear hormone receptors. NR4A1 is a nuclear receptor that is induced in vascular pathologies, where it mediates protection. OBJECTIVE:The underlying mechanisms that regulate the activity of NR4A1 during vascula...

journal_title：Circulation research

authors： Papac-Milicevic N,Breuss JM,Zaujec J,Ryban L,Plyushch T,Wagner GA,Fenzl S,Dremsek P,Cabaravdic M,Steiner M,Glass CK,Binder CJ,Uhrin P,Binder BR

更新日期：2012-04-13 00:00:00

abstract：:We studied mitochondrial structure and intermediates of fatty acid metabolism in mitochondria isolated from ischemic hearts. By electron microscopy, no structural difference was detected between mitochondria isolated from control hearts and from ischemic hearts receiving glucose as the only substrate. However, major d...

journal_title：Circulation research

authors： Feuvray D,Plouët J

更新日期：1981-05-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play important roles in cardiovascular development. However, how BMP-signaling pathways regulate cardiac gene expression is less clear. We have previously identified myocardin as a cardiac and smooth muscle-specific transcriptional cofactor for serum response factor (SRF). Myocardin ...

journal_title：Circulation research

authors： Callis TE,Cao D,Wang DZ

更新日期：2005-11-11 00:00:00

abstract：RATIONALE:Myosin light chain (MLC) phosphorylation determines vascular contractile status. In addition to the classic Ca²⁺-dependent MLC kinase (MLCK), another unidentified kinase(s) also contributes to MLC phosphorylation in living cells. Inhibitor κB kinase 2 (IKK2)-deficient mouse embryonic fibroblasts demonstrate a...

journal_title：Circulation research

authors： Ying Z,do Carmo JM,Xiang L,da Silva AA,Chen M,Ryan MJ,Ostrowski M,Rajagopalan S,Hall JE

更新日期：2013-08-16 00:00:00

abstract：:We evaluated the contribution of intramural electrical events in initiation and maintenance of ventricular tachycardia in 15 dogs 3-8 days after either permanent (n = 2) or transient (n = 13) coronary artery occlusion. Seven of the dogs (47%) demonstrated eight distinct monomorphic ventricular tachycardia patterns whi...

journal_title：Circulation research

authors： Kramer JB,Saffitz JE,Witkowski FX,Corr PB

更新日期：1985-05-01 00:00:00

abstract：:Fibrinopeptide A (FPA) levels were measured in a group of 130 controls and patients with various types of primary hyperlipidemia to investigate whether an increased steady state level of thrombin activity is present in hyperlipidemic patients. In a subset of 56 subjects, levels of clotting factors II, VII, and X were ...

journal_title：Circulation research

authors： Nossel HL,Smith FR,Seplowitz AH,Dell RB,Sciacca RR,Merskey C,Goodman DS

更新日期：1979-09-01 00:00:00

abstract：:Abstract: Macrophages, a key component of the innate defense against pathogens, participate in the initiation and resolution of inflammation, and in the maintenance of tissues. These diverse and at times antithetical functions of macrophages are executed via distinct activation states, ranging from classical to altern...

journal_title：Circulation research

authors： Chawla A

更新日期：2010-05-28 00:00:00

abstract：:The mechanisms underlying the blunted contractile response to beta-adrenergic receptor (beta-AR) stimulation in heart failure (HF) are incompletely understood, especially with regard to beta-AR subtype-specific regulation of L-type Ca2+ channels. We evaluated the impact of HF induced by pacing tachycardia on beta-AR r...

journal_title：Circulation research

authors： He JQ,Balijepalli RC,Haworth RA,Kamp TJ

更新日期：2005-09-16 00:00:00

abstract：:This study addresses the structural requirements for the intracellular processing and receptor binding properties of endothelin-1 (ET-1). Point mutants of preproendothelin-1 cDNA, with replacement of the codons for Lys9 of ET-1 by ones for Ala and Glu and of Ile20 and Trp21 by ones encoding Ala, were expressed in COS-...

journal_title：Circulation research

authors： Ergul A,Tackett RL,Puett D

更新日期：1995-12-01 00:00:00

abstract：:Synthetic atrial natriuretic factor (ANF) was either added to suffusate solutions (30 nM) or infused into the jugular vein (0.1 nanomol/min/100 g) of anesthetized rats. Steady-state blood flow was calculated from arteriolar diameter and red blood cell velocity measurements using video microscopy in the intestinal or s...

journal_title：Circulation research

authors： Proctor KG,Bealer SL

更新日期：1987-07-01 00:00:00

abstract：:We designed this study to test the hypothesis that in acute mitral regurgitation the mitral regurgitant area (MRA) is a dynamic quantity which varies with the time variation of ventricular volume. Mitral insufficiency was created in five open-chest dogs in which a portion of the anterior leaflet was excised. Phasic ao...

journal_title：Circulation research

authors： Yellin EL,Yoran C,Sonnenblick EH,Gabbay S,Frater RW

更新日期：1979-11-01 00:00:00

abstract：RATIONALE:Human heregulins, neuregulin-1 type I polypeptides that activate proliferation, differentiation, and survival of glial cells, neurons, and myocytes, are expressed in macrophage foam cells within human coronary atherosclerotic lesions. Macrophage foam cell formation, characterized by cholesterol ester accumula...

journal_title：Circulation research

authors： Xu G,Watanabe T,Iso Y,Koba S,Sakai T,Nagashima M,Arita S,Hongo S,Ota H,Kobayashi Y,Miyazaki A,Hirano T

更新日期：2009-08-28 00:00:00

abstract：RATIONALE:During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca(2+) channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule-sarcoplasmic reticulum anchoring...

journal_title：Circulation research

authors： Li RC,Tao J,Guo YB,Wu HD,Liu RF,Bai Y,Lv ZZ,Luo GZ,Li LL,Wang M,Yang HQ,Gao W,Han QD,Zhang YY,Wang XJ,Xu M,Wang SQ

更新日期：2013-02-15 00:00:00

abstract：:When exposed to an increasing transmural pressure, middle cerebral arteries of the cat exhibit reduction of internal diameter which is mediated by vascular muscle cell depolarization. This laboratory has recently demonstrated that this "pressure-induced" activation is dependent upon the presence of an intact endotheli...

journal_title：Circulation research

authors： Harder DR,Sanchez-Ferrer C,Kauser K,Stekiel WJ,Rubanyi GM

更新日期：1989-07-01 00:00:00

abstract：RATIONALE:Individuals with naturally occurring loss-of-function proprotein convertase subtilisin/kexin type 9 (PCSK9) mutations experience reduced low-density lipoprotein cholesterol levels and protection against cardiovascular disease. OBJECTIVE:The goal of this study was to assess whether genome editing using a clus...

journal_title：Circulation research

authors： Ding Q,Strong A,Patel KM,Ng SL,Gosis BS,Regan SN,Cowan CA,Rader DJ,Musunuru K

更新日期：2014-08-15 00:00:00

abstract：RATIONALE:Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. OBJECTIVE:To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. METHODS AND RESULTS:We measure...

journal_title：Circulation research

authors： Augustine D,Ayers LV,Lima E,Newton L,Lewandowski AJ,Davis EF,Ferry B,Leeson P

更新日期：2014-01-03 00:00:00

abstract：:Endothelin-1 (ET-1) and endothelin-3 (ET-3) produced positive inotropic effects on electrically stimulated left atria and increased the frequency of spontaneously beating right atria of adult rats. The potency of the inotropic effect of ET-1 was greater than that of ET-3, but the potencies of the chronotropic effects ...

journal_title：Circulation research

authors： Ishikawa T,Li LM,Shinmi O,Kimura S,Yanagisawa M,Goto K,Masaki T

更新日期：1991-10-01 00:00:00

abstract：:Ventricular arrhythmias that accompany myocardial infarction in dogs may be secondary to the altered electrophysiological properties of the subendocardial Purkinje fibers that survive 24 hours after the coronary occlusion. To better understand the ionic mechanisms that underlie the altered electrical activity of these...

journal_title：Circulation research

authors： Boyden PA,Albala A,Dresdner KP Jr

更新日期：1989-10-01 00:00:00

abstract：:Inhibition of vascular smooth muscle (VSM) delayed rectifier K+ channels (K(DR)) by 4-aminopyridine (4-AP; 200 micromol/L) or correolide (1 micromol/L), a selective inhibitor of Kv1 channels, enhanced myogenic contraction of rat mesenteric arteries (RMAs) in response to increases in intraluminal pressure. The molecula...

journal_title：Circulation research

authors： Plane F,Johnson R,Kerr P,Wiehler W,Thorneloe K,Ishii K,Chen T,Cole W

更新日期：2005-02-04 00:00:00

abstract：:Different myosin isoenzymes of pig and human atrium and ventricle and rat ventricle were characterized by two approaches: pyrophosphate polyacrylamide gel electrophoresis (PP-PAGE) and analysis of the myosin P light chains by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). We further investigated the rel...

journal_title：Circulation research

authors： Morano I,Arndt H,Gärtner C,Rüegg JC

更新日期：1988-03-01 00:00:00

abstract：:This study aimed at identifying the type and functional significance of potassium channels and voltage-dependent calcium channels (Ca(v)) in single rat JG cells using whole-cell patch clamp. Single JG cells displayed outward rectification at positive membrane potentials and limited net currents between -60 and -10 mV....

journal_title：Circulation research

authors： Friis UG,Jørgensen F,Andreasen D,Jensen BL,Skøtt O

更新日期：2003-08-08 00:00:00

abstract：:Vascular calcification is a common finding in atherosclerosis and a serious problem in diabetic and uremic patients. Because of the correlation of hyperphosphatemia and vascular calcification, the ability of extracellular inorganic phosphate levels to regulate human aortic smooth muscle cell (HSMC) culture mineralizat...

journal_title：Circulation research

authors： Jono S,McKee MD,Murry CE,Shioi A,Nishizawa Y,Mori K,Morii H,Giachelli CM

更新日期：2000-09-29 00:00:00

abstract：:The effects of acute renovascular hypertension on the sympathetic nervous system, regional blood flow and cardiac function were studied in conscious dogs submitted to renal artery occlusion by inflation of a cuff implanted previously around one renal artery. We then compared the alterations in plasma renin and catecho...

journal_title：Circulation research

authors： Gavras H,Liang C

更新日期：1980-09-01 00:00:00

abstract：:We studied a Syrian family with 3 children who had low-density lipoprotein cholesterol (LDL) concentrations of 13.3, 12.2, and 8.6 mmol/L, respectively. Three other siblings and the parents all had LDL values <4.52 mmol/L, suggesting an autosomal-recessive mode of inheritance. The extended pedigree had 66 additional p...

journal_title：Circulation research

authors： Al-Kateb H,Bähring S,Hoffmann K,Strauch K,Busjahn A,Nürnberg G,Jouma M,Bautz EK,Dresel HA,Luft FC

更新日期：2002-05-17 00:00:00

abstract：RATIONALE:Myocardial infarction (MI) results in loss of cardiac myocytes in the ischemic zone of the heart, followed by fibrosis and scar formation, which diminish cardiac contractility and impede angiogenesis and repair. Myofibroblasts, a specialized cell type that switches from a fibroblast-like state to a contractil...

journal_title：Circulation research

authors： Small EM,Thatcher JE,Sutherland LB,Kinoshita H,Gerard RD,Richardson JA,Dimaio JM,Sadek H,Kuwahara K,Olson EN

更新日期：2010-07-23 00:00:00

abstract：:Over the last 4 decades, heart transplantation (HTx) has evolved as a mainstream therapy for heart failure. Approximately half of patients needing HTx have organ failure consequent to atherosclerosis. Despite advances in immunosuppressive drugs, long-term success of HTx is limited by the development of a particular ty...

journal_title：Circulation research

authors： Rahmani M,Cruz RP,Granville DJ,McManus BM

更新日期：2006-10-13 00:00:00