Abstract:
:Volume densities of mitochondria, myofibrils, and unspecified cytoplasm were measured by ultrastructural morphometry in myocardium from dogs, rats, hamsters, mice, and in biopsied tissue from human hearts. Human myocardium was composed of 23% mitochondria, 59% myofibrils, and 18% cytoplasm. Volume densities for mitochondria were 22% for dogs, 28% for rats and hamsters, and 32% for mice. Myofibrillar volume densities were highest in dogs with 63%, 57% for rats and hamsters, and 49% for mice. Differences were significant between all except man and dog, and rat and hamster. In an extensive analysis of canine myocardium, it could be shown that the quantitative composition of tissue from the left ventricular free wall (anterior, lateral, posterior) and the papillary muscles was identical. There were also no differences between subepi- and subendocardium as well as the midmyocardium. Volume densities from longitudinal sections were identical to those from transversal sections. Fixation with glutaraldehyde by perfusion or immersion provided identical results. There were no differences between volume densities in samples from the left ventricular free wall (anterior, lateral, and posterior) in rats, hamsters, and mice. It is concluded that each mammalian species is characterized by a very typical quantitative composition of the myocardium. The increase in mitochondrial volume correlated well with the increase in heart rate and oxygen consumption in smaller animals. These quantitative data are regarded as the morphological correlate of the differing functional capacity of hearts from different species.
journal_name
Circ Resjournal_title
Circulation researchauthors
Schaper J,Meiser E,Stämmler Gdoi
10.1161/01.res.56.3.377subject
Has Abstractpub_date
1985-03-01 00:00:00pages
377-91issue
3eissn
0009-7330issn
1524-4571journal_volume
56pub_type
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更新日期:1990-12-01 00:00:00
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更新日期:2000-01-07 00:00:00
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更新日期:1998-06-29 00:00:00
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更新日期:1984-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-08 00:00:00
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pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-07-07 00:00:00
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pub_type: 杂志文章
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更新日期:1992-02-01 00:00:00
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doi:10.1161/CIRCRESAHA.116.309004
更新日期:2016-10-28 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.64.5.882
更新日期:1989-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.73.1.193
更新日期:1993-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.RES.0000138449.85324.c5
更新日期:2004-08-20 00:00:00
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更新日期:2005-02-04 00:00:00
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更新日期:1992-06-01 00:00:00
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更新日期:2009-02-13 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-04-13 00:00:00
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更新日期:2003-11-14 00:00:00
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更新日期:1986-09-01 00:00:00
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更新日期:2009-09-11 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.72.1.176
更新日期:1993-01-01 00:00:00
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更新日期:2013-07-19 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.82.2.195
更新日期:1998-02-09 00:00:00