Anchoring proteins as regulators of signaling pathways.

Abstract:

:Spatial and temporal organization of signal transduction is coordinated through the segregation of signaling enzymes in selected cellular compartments. This highly evolved regulatory mechanism ensures the activation of selected enzymes only in the vicinity of their target proteins. In this context, cAMP-responsive triggering of protein kinase A is modulated by a family of scaffold proteins referred to as A-kinase anchoring proteins. A-kinase anchoring proteins form the core of multiprotein complexes and enable simultaneous but segregated cAMP signaling events to occur in defined cellular compartments. In this review we will focus on the description of A-kinase anchoring protein function in the regulation of cardiac physiopathology.

journal_name

Circ Res

journal_title

Circulation research

authors

Perino A,Ghigo A,Scott JD,Hirsch E

doi

10.1161/CIRCRESAHA.111.262899

subject

Has Abstract

pub_date

2012-08-03 00:00:00

pages

482-92

issue

4

eissn

0009-7330

issn

1524-4571

pii

111/4/482

journal_volume

111

pub_type

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