Abstract:
:Spatial and temporal organization of signal transduction is coordinated through the segregation of signaling enzymes in selected cellular compartments. This highly evolved regulatory mechanism ensures the activation of selected enzymes only in the vicinity of their target proteins. In this context, cAMP-responsive triggering of protein kinase A is modulated by a family of scaffold proteins referred to as A-kinase anchoring proteins. A-kinase anchoring proteins form the core of multiprotein complexes and enable simultaneous but segregated cAMP signaling events to occur in defined cellular compartments. In this review we will focus on the description of A-kinase anchoring protein function in the regulation of cardiac physiopathology.
journal_name
Circ Resjournal_title
Circulation researchauthors
Perino A,Ghigo A,Scott JD,Hirsch Edoi
10.1161/CIRCRESAHA.111.262899subject
Has Abstractpub_date
2012-08-03 00:00:00pages
482-92issue
4eissn
0009-7330issn
1524-4571pii
111/4/482journal_volume
111pub_type
杂志文章,评审abstract::Hypoxia is a potent coronary-vasodilating signal; its mechanisms are still controversial. We have assessed the possible role of nitric oxide (NO) in hypoxic coronary vasodilatation (HCVD) in isolated guinea pig hearts perfused at constant pressure. HCVD was elicited by a 1-minute 100% N2 exposure; coronary flow double...
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abstract::The alpha-adrenergic blocking drugs, phentolamine and Hydergine, both act centrally at different sites to depress and enhance the pressor and sympathetic nerve response to decreased baroreceptor afferent input in anesthetized cats. Depression of the rise in blood pressure and sympathetic nerve discharge during bilater...
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doi:10.1161/01.res.39.5.724
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pub_type: 杂志文章
doi:10.1161/01.res.72.3.671
更新日期:1993-03-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2018-08-03 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.75.6.1006
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pub_type: 杂志文章
doi:10.1161/01.res.0000016960.61087.86
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.119.316075
更新日期:2020-03-27 00:00:00
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pub_type: 杂志文章
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更新日期:1979-12-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.86.11.1173
更新日期:2000-06-09 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2011-06-10 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2001-12-07 00:00:00
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pub_type: 杂志文章
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更新日期:1985-03-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.300119
更新日期:2013-06-07 00:00:00
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pub_type: 杂志文章
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更新日期:1987-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.120.316526
更新日期:2020-10-23 00:00:00
abstract:RATIONALE:Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by telomere shortening or oxidative stress may contribute to pulmonary hypertension associated with chronic lung diseases. OBJECTIVE:To investigate whether cell senescence contributes to pulmonary vessel remodeling and pulmonary hypertension...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.241299
更新日期:2011-08-19 00:00:00
abstract::The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form 2 multiprotein complexes, called mTORC1 (mTOR co...
journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/CIRCRESAHA.117.311147
更新日期:2018-02-02 00:00:00
abstract:RATIONALE:Complementation of pluripotency genes may improve adult stem cell functions. OBJECTIVES:Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or ...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.109.206045
更新日期:2010-04-16 00:00:00
abstract::Caspase-1 processes the interleukin (IL)-1beta and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 ta...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000232324.87983.4b
更新日期:2006-07-07 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-01-03 00:00:00
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更新日期:1976-07-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2009-03-27 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000251231.16993.88
更新日期:2006-11-24 00:00:00
abstract::Transgenic mice overexpressing the calcium binding protein, S100A4/Mts1, occasionally develop severe pulmonary vascular obstructive disease. To understand what underlies this propensity, we compared the pulmonary vascular hemodynamic and structural features of S100A4/Mts1 with control C57Bl/6 mice at baseline, followi...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000182425.49768.8a
更新日期:2005-09-16 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.64.2.287
更新日期:1989-02-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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abstract::Fibroblast growth factor-1 (FGF-1), a prototype member of the heparin-binding growth factor family, is a potent mitogen for vascular endothelial cells and a variety of other cell types. FGF-1 can induce the expression of the platelet-derived growth factor-A chain (PDGF-A) gene in endothelial cells; however, the underl...
journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1997-08-01 00:00:00
abstract:RATIONALE:Increased sympathetic nerve activity has been linked to the pathogenesis of hypertension in humans and animal models. Enhanced peripheral chemoreceptor sensitivity which increases sympathetic nerve activity has been observed in established hypertension but has not been identified as a possible mechanism for i...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.109.206946
更新日期:2010-02-19 00:00:00