Attenuation of long-lasting effects of sympathetic stimulation after repeated stimulation.

abstract：:To test the hypothesis that the capacity to develop left ventricular (LV) hypertrophy might diminish with advancing age, we examined the hypertrophic response to ascending aortic constriction in 3 groups of adult Fischer 344 rats (9 months, 18 months, and 22 months of age). Aortic constriction was created so that aort...

journal_title：Circulation research

authors： Isoyama S,Wei JY,Izumo S,Fort P,Schoen FJ,Grossman W

更新日期：1987-09-01 00:00:00

abstract：:Calcineurin, a calcium/calmodulin-regulated protein phosphatase, modulates gene expression in cardiac and skeletal muscles during development and in remodeling responses such as cardiac hypertrophy that are evoked by environmental stresses or disease. Recently, we identified two genes encoding proteins (MCIP1 and MCIP...

journal_title：Circulation research

authors： Yang J,Rothermel B,Vega RB,Frey N,McKinsey TA,Olson EN,Bassel-Duby R,Williams RS

更新日期：2000-12-08 00:00:00

abstract：:The extracellular and intracellular potassium (K+) activities of isolated superfused rabbit atrial muscle were measured using K+-sensitive liquid ion exchanger microelectrodes. When the pH of the bathing medium was decreased from 7.5 to 6.8, intracellular K+ activity fell and extracellular K+ activity rose from a mean...

journal_title：Circulation research

authors： Skinner RB Jr,Kunze DL

更新日期：1976-11-01 00:00:00

abstract：:To study the effects of stretch on the function of rat left atrium, we recorded contraction force, calcium transients, and intracellular action potentials (APs) during stretch manipulations. The stretch of the atrium was controlled by intra-atrial pressure. The Frank-Starling behavior of the atrium was manifested as a...

journal_title：Circulation research

authors： Tavi P,Han C,Weckström M

更新日期：1998-11-30 00:00:00

abstract：:The role of the central nervous system in the mechanism(s) involved in acute carotid baroreflex resetting was studied in six conscious, chronically instrumented, aortic-denervated dogs. Dogs were prepared for reversible vascular isolation of the carotid sinuses. Acute baroreflex resetting was induced by holding the le...

journal_title：Circulation research

authors： Tan W,Panzenbeck MJ,Hajdu MA,Zucker IH

更新日期：1989-07-01 00:00:00

abstract：RATIONALE:Lipid-free apolipoprotein (apo) A-I and discoidal reconstituted high-density lipoproteins (rHDL) containing apoA-I, (A-I)rHDL, inhibit vascular inflammation by increasing 3β-hydroxysteroid-Δ24 reductase (DHCR24) expression. OBJECTIVE:To determine whether the lipid-free apoA-I-mediated and (A-I)rHDL-mediated ...

journal_title：Circulation research

authors： Wu BJ,Chen K,Shrestha S,Ong KL,Barter PJ,Rye KA

更新日期：2013-01-18 00:00:00

abstract：:Diadenosine triphosphate is present in platelet-dense granules and released quantitatively on platelet aggregation. We have found that intact porcine aortic endothelial cells can efficiently hydrolyze extracellular diadenosine triphosphate. The products of diadenosine triphosphate hydrolysis are adenosine monophosphat...

journal_title：Circulation research

authors： Goldman SJ,Gordon EL,Slakey LL

更新日期：1986-09-01 00:00:00

abstract：RATIONALE:Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. However, the long-term (>5 weeks) effects, potential tumorigenicity, and fate of transplanted CPCs are unknown. OBJECTIVE:To assess the outcome of CPC therapy at 1 year. METHODS AND...

journal_title：Circulation research

authors： Tang XL,Li Q,Rokosh G,Sanganalmath SK,Chen N,Ou Q,Stowers H,Hunt G,Bolli R

更新日期：2016-04-01 00:00:00

abstract：:Hemodynamic shear stress elicits a rise in endothelial [Ca2+]i, which may serve as a key second messenger to regulate many flow-associated physiological and biochemical processes. In the present study, we used Mn2+ quenching of fluorescent dye Fluo3 as an assay to investigate the Ca2+ influx of rat aortic endothelial ...

journal_title：Circulation research

authors： Kwan HY,Leung PC,Huang Y,Yao X

更新日期：2003-02-21 00:00:00

abstract：:Stem cells can differentiate into a variety of cells to replace dead cells or to repair damaged tissues. Recent evidence indicates that stem cells are involved in the pathogenesis of transplant arteriosclerosis, an alloimmune initiated vascular stenosis that often results in transplant organ failure. Although the path...

journal_title：Circulation research

authors： Xu Q

更新日期：2008-05-09 00:00:00

abstract：:Cyclic GMP modulates gene expression in vascular smooth muscle cells (SMCs) in part by stimulating cGMP-dependent protein kinase I (PKGI) and the phosphorylation of transcription factors. In some cells, cGMP increases nuclear translocation of PKGI and PKGI-dependent phosphorylation of transcription regulators; however...

journal_title：Circulation research

authors： Sugiura T,Nakanishi H,Roberts JD Jr

更新日期：2008-07-03 00:00:00

abstract：:The small (21 kDa) guanine nucleotide-binding protein (small G protein) superfamily comprises 5 subfamilies (Ras, Rho, ADP ribosylation factors [ARFs], Rab, and Ran) that act as molecular switches to regulate numerous cellular responses. Cardiac myocyte hypertrophy is associated with cell growth and changes in the cyt...

journal_title：Circulation research

authors： Clerk A,Sugden PH

更新日期：2000-05-26 00:00:00

abstract：:The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression, and heterozygous mutations of transcription factors have frequently been implicated in human cardiovascular malformations. A novel mechanism involving posttranscriptional regulation by small, noncod...

journal_title：Circulation research

authors： Cordes KR,Srivastava D

更新日期：2009-03-27 00:00:00

abstract：RATIONALE:Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family of secreted factors. A recent study showed that reduced GDF11 blood levels with aging was associated with pathological cardiac hypertrophy (PCH) and restoring GDF11 to normal levels in old mice rescued PCH. ...

journal_title：Circulation research

authors： Smith SC,Zhang X,Zhang X,Gross P,Starosta T,Mohsin S,Franti M,Gupta P,Hayes D,Myzithras M,Kahn J,Tanner J,Weldon SM,Khalil A,Guo X,Sabri A,Chen X,MacDonnell S,Houser SR

更新日期：2015-11-06 00:00:00

abstract：RATIONALE:A hallmark of chronic inflammatory disorders is persistence of proinflammatory macrophages in diseased tissues. In atherosclerosis, this is associated with dyslipidemia and oxidative stress, but mechanisms linking these phenomena to macrophage activation remain incompletely understood. OBJECTIVE:To investiga...

journal_title：Circulation research

authors： Chen Y,Yang M,Huang W,Chen W,Zhao Y,Schulte ML,Volberding P,Gerbec Z,Zimmermann MT,Zeighami A,Demos W,Zhang J,Knaack DA,Smith BC,Cui W,Malarkannan S,Sodhi K,Shapiro JI,Xie Z,Sahoo D,Silverstein RL

更新日期：2019-12-06 00:00:00

abstract：:The type 1B angiotensin II (AT1B) receptor cloned from rat kidney was stably expressed in Chinese hamster ovary cells. The stably expressed receptor was characterized by radioligand binding studies and functional coupling to inositol 1,4,5-triphosphate (IP3) formation. Exposure of cells expressing the AT1B receptor to...

journal_title：Circulation research

authors： Tang H,Shirai H,Inagami T

更新日期：1995-08-01 00:00:00

abstract：:Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-...

journal_title：Circulation research

authors： Shorofsky SR,January CT

更新日期：1992-03-01 00:00:00

abstract：:Ca2+ influx through the L-type calcium channel (LTCC) induces Ca2+ release from the sarcoplasmic reticulum (SR) and maintains SR Ca2+ loading. Alterations in LTCC properties, their contribution to the blunted adrenergic responsiveness in failing hearts and their recovery after support with LV assist devices (LVAD) wer...

journal_title：Circulation research

authors： Chen X,Piacentino V 3rd,Furukawa S,Goldman B,Margulies KB,Houser SR

更新日期：2002-09-20 00:00:00

abstract：:It has been reported that immunization against tonin normalizes blood pressure, and that sialoadenectomy, during which the tonin-rich salivary glands are removed, decreases blood pressure in one-kidney, one-clip hypertension. To investigate the role of tonin on this form of hypertension further, we actively immunized ...

journal_title：Circulation research

authors： Seto S,Rabito SF,Scicli AG,Carretero OA

更新日期：1984-11-01 00:00:00

abstract：RATIONALE:Hypoxia promotes renal damage and progression of chronic kidney disease (CKD). The erythrocyte is the only cell type for oxygen (O2) delivery. Sphingosine 1-phosphate (S1P)-a highly enriched biolipid in erythrocytes-is recently reported to be induced under high altitude in normal humans to enhance O2 delivery...

journal_title：Circulation research

authors： Xie T,Chen C,Peng Z,Brown BC,Reisz JA,Xu P,Zhou Z,Song A,Zhang Y,Bogdanov MV,Kellems RE,D'Alessandro A,Zhang W,Xia Y

更新日期：2020-07-17 00:00:00

abstract：:Nitric oxide (NO) functions principally as a diffusible paracrine effector. The exception is in cardiomyocytes where both NO synthases (NOS) and target proteins coexist, allowing NO to work in an autocrine/intracrine fashion. However, the most abundant myocyte isoform (NOS3) is far more expressed in vascular endotheli...

journal_title：Circulation research

authors： Champion HC,Georgakopoulos D,Takimoto E,Isoda T,Wang Y,Kass DA

更新日期：2004-03-19 00:00:00

abstract：:In urethane-anesthetized rats, electrophysiological recordings of spontaneously active neurons in the vasopressor area of the rostral ventrolateral medulla were analyzed for participation in cardiovascular regulation. A total of 138 units were found which were inhibited by transient increases in mean arterial pressure...

journal_title：Circulation research

authors： Brown DL,Guyenet PG

更新日期：1985-03-01 00:00:00

abstract：:It has been proposed that lipopolysaccharide (LPS) bound to the 60-kD LPS binding protein (LBP) forms an LPS/LBP complex that, in turn, binds to the CD14 receptor on monocytes/macrophages and stimulates the release of cytokines. We examined the role of LBP and CD14 in tumor necrosis factor-alpha (TNF-alpha) production...

journal_title：Circulation research

authors： Ishii Y,Wang Y,Haziot A,del Vecchio PJ,Goyert SM,Malik AB

更新日期：1993-07-01 00:00:00

abstract：:Although coronary artery spasm has been implicated as an important cause of myocardial ischemia in humans, an animal model of reversible segmental coronary constriction has not been described. To provoke coronary spasm in open-chest dogs, selected vasoconstricting agents adsorbed to viscous ion exchange gels were appl...

journal_title：Circulation research

authors： Pérez JE,Saffitz JE,Gutiérrez FA,Henry PD

更新日期：1983-04-01 00:00:00

abstract：:Recent advances in cardiac physiology identify the integrin-linked kinase (ILK) as an essential molecule regulating cardiac growth, contractility, and repair. A key transducer of biochemical signals initiated at the plasma membrane by cell-matrix interactions, ILK now emerges as a crucial player in mechanotransduction...

journal_title：Circulation research

authors： Hannigan GE,Coles JG,Dedhar S

更新日期：2007-05-25 00:00:00

abstract：:The solid angle theory has long been applied to the interpretation of the ECG; however, quantitative evaluation of its applicability has been minimal. We applied solid angle analysis to the interpretation of the TQ-ST deflection during acute ischemia. Five anesthetized pigs were studied 1--3 hours after coronary occlu...

journal_title：Circulation research

authors： Richeson JF,Akiyama T,Schenk E

更新日期：1978-12-01 00:00:00

abstract：:Endothelins exert potent excitatory cardiac effects by acting on specific receptors on myocytes. In this study, we have examined the signal transduction mechanism for the chronotropic effect of endothelins in guinea pig atria. A competition binding of [125I]endothelin 1 ([125I]ET-1) using the recently developed ETA re...

journal_title：Circulation research

authors： Ono K,Eto K,Sakamoto A,Masaki T,Shibata K,Sada T,Hashimoto K,Tsujimoto G

更新日期：1995-02-01 00:00:00

abstract：:Heart failure is associated with death of cardiomyocytes leading to loss of contractility. Previous studies using membrane-targeted Akt (myristolated-Akt), an enzyme involved in antiapoptotic signaling, showed inhibition of cell death and prevention of pathogenesis induced by cardiomyopathic stimuli. However, recent s...

journal_title：Circulation research

authors： Shiraishi I,Melendez J,Ahn Y,Skavdahl M,Murphy E,Welch S,Schaefer E,Walsh K,Rosenzweig A,Torella D,Nurzynska D,Kajstura J,Leri A,Anversa P,Sussman MA

更新日期：2004-04-16 00:00:00

abstract：:The migration of medial smooth muscle cells (SMCs) into the intima is proposed to be an important process of intimal thickening in atherosclerotic lesions. The present study examined the possible effect of a novel endothelium-derived relaxing peptide, C-type natriuretic peptide (CNP), on oxidized low-density lipoprote...

journal_title：Circulation research

authors： Kohno M,Yokokawa K,Yasunari K,Kano H,Minami M,Ueda M,Yoshikawa J

更新日期：1997-10-01 00:00:00

abstract：:The 2-amino-3-benzoylthiophene derivative PD 81,723 is an allosteric enhancer of agonist binding to brain A1 adenosine receptors. One aim of this study was to characterize and contrast the effects of PD 81,723 on the A1 receptor-mediated negative dromotropic and A2a receptor-mediated vasodilatory actions of adenosine ...

journal_title：Circulation research

authors： Kollias-Baker C,Ruble J,Dennis D,Bruns RF,Linden J,Belardinelli L

更新日期：1994-12-01 00:00:00