Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair.

abstract：:Sixteen years ago, mutations in cardiac troponin (Tn)T and α-tropomyosin were linked to familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β-myosin heavy chain to a disease of the cardiac sarcomere. From the outset, studies suggested that mutations in the regulatory thin filamen...

journal_title：Circulation research

authors： Tardiff JC

更新日期：2011-03-18 00:00:00

abstract：:We developed a mouse myocardial preparation to study cellular dysfunction in acute coxsackievirus myocarditis. Thin right ventricular papillary muscles from normal mice (n = 8) were compared with muscles from mice 7 days after coxsackievirus infection (n = 7). Sarcomere shortening was studied with laser diffraction (H...

journal_title：Circulation research

authors： Hamrell BB,Huber SA,Leslie KO

更新日期：1994-09-01 00:00:00

abstract：:Inhibition of vascular smooth muscle (VSM) delayed rectifier K+ channels (K(DR)) by 4-aminopyridine (4-AP; 200 micromol/L) or correolide (1 micromol/L), a selective inhibitor of Kv1 channels, enhanced myogenic contraction of rat mesenteric arteries (RMAs) in response to increases in intraluminal pressure. The molecula...

journal_title：Circulation research

authors： Plane F,Johnson R,Kerr P,Wiehler W,Thorneloe K,Ishii K,Chen T,Cole W

更新日期：2005-02-04 00:00:00

abstract：:Angiotensin (Ang) II is present inside vascular smooth muscle cells (VSMCs); however, its intracellular functions, if any, are unknown. We tested the hypothesis that intracellular Ang II exerts effects on cytosolic Ca2+ ([Ca2+]i) in VSMCs. Ang II was administered via microinjection. Intracellular Ang II localization w...

journal_title：Circulation research

authors： Haller H,Lindschau C,Erdmann B,Quass P,Luft FC

更新日期：1996-10-01 00:00:00

abstract：:True propagation coefficients of pulse wave harmonics in an artery can be determined in vivo by measuring pulsatile blood pressure and flow at each of two points along the length of the vessel. These coefficients, which are complex numbers that describe the attenuation and the phase shift imposed on a traveling wave, ...

journal_title：Circulation research

authors： Milnor WR,Nichols WW

更新日期：1975-05-01 00:00:00

abstract：:Atherosclerosis is considered to be an inflammatory disease. Tissue factor (TF), a prothrombotic molecule expressed by various cell types within atherosclerotic plaques, is thought to play an essential role in thrombus formation after atherosclerotic plaque rupture. Recent studies suggest that the antiinflammatory cyt...

journal_title：Circulation research

authors： Kamimura M,Viedt C,Dalpke A,Rosenfeld ME,Mackman N,Cohen DM,Blessing E,Preusch M,Weber CM,Kreuzer J,Katus HA,Bea F

更新日期：2005-08-19 00:00:00

abstract：:Triadin 1 (TRD) is an integral membrane protein that associates with the ryanodine receptor (RyR2), calsequestrin (CASQ2) and junctin to form a macromolecular Ca signaling complex in the cardiac junctional sarcoplasmic reticulum (SR). To define the functional role of TRD, we examined the effects of adenoviral-mediated...

journal_title：Circulation research

authors： Terentyev D,Cala SE,Houle TD,Viatchenko-Karpinski S,Gyorke I,Terentyeva R,Williams SC,Gyorke S

更新日期：2005-04-01 00:00:00

abstract：:In the early (3-day) stage of development, long-lasting openings of the L-type Ca2+ channels (mode 2) occur in embryonic chick heart cells. Since mode-2 behavior is infrequently observed in adult heart cells of other species, in the present study, developmental change in behavior of the Ca2+ channel was examined in yo...

journal_title：Circulation research

authors： Tohse N,Mészáros J,Sperelakis N

更新日期：1992-08-01 00:00:00

abstract：:We studied the individual and combined effects of extracellular acidosis and increases in extracellular potassium on action potential characteristics and conduction in order to gain a better understanding of the effects of acute ischemia. At each level of potassium between 2.7 and 17 mm, acidosis induced by increasing...

journal_title：Circulation research

authors： Kagiyama Y,Hill JL,Gettes LS

更新日期：1982-11-01 00:00:00

abstract：:This study was performed to examine, first, the protective effects and responses of collateral vessels of the hind limb in normal and atherosclerotic monkeys and, second, the effects of chronic arterial occlusion on the development of atherosclerosis. The iliac artery was ligated on one side in cynomolgus monkeys. Six...

journal_title：Circulation research

authors： Lopez JA,Armstrong ML,Harrison DG,Piegors DJ,Heistad DD

更新日期：1988-12-01 00:00:00

abstract：:The purpose of this study was to develop an isolated tissue model in which arrhythmic activity could be generated in response to conditions encountered in ischemia followed by reperfusion, and in which intracellular recordings could be used to identify and study arrhythmogenic mechanisms. Isolated canine Purkinje fibe...

journal_title：Circulation research

authors： Ferrier GR,Moffat MP,Lukas A

更新日期：1985-02-01 00:00:00

abstract：RATIONALE:GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, an inflammatory disease associated with increased cardiovascular risk, provides a model to study inflammatory biomarkers in cardiovascular disease (CVD). Whether GlycA associates with psoriasis a...

journal_title：Circulation research

authors： Joshi AA,Lerman JB,Aberra TM,Afshar M,Teague HL,Rodante JA,Krishnamoorthy P,Ng Q,Aridi TZ,Salahuddin T,Natarajan B,Lockshin BN,Ahlman MA,Chen MY,Rader DJ,Reilly MP,Remaley AT,Bluemke DA,Playford MP,Gelfand JM,Meht

更新日期：2016-11-11 00:00:00

abstract：:Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies. Cardiac malformations have been produced in multiple experimental animal models, by perturbing selected molecules that function in the developmental pathways involved in myocyte specification, differentiation, or cardiac morphogene...

journal_title：Circulation research

authors： Fahed AC,Gelb BD,Seidman JG,Seidman CE

更新日期：2013-02-15 00:00:00

abstract：:Body surface electrocardiograms and electrograms recorded from the surfaces of the heart are the basis for diagnosis and treatment of cardiac electrophysiological disorders and arrhythmias. Given recent advances in understanding the molecular mechanisms of arrhythmia, it is important to relate these electrocardiograph...

journal_title：Circulation research

authors： Gima K,Rudy Y

更新日期：2002-05-03 00:00:00

abstract：:Available data demonstrate that oxygen free radicals and derived reactive species of oxygen are produced during myocardial ischemia as well as upon reperfusion of the ischemic tissue. The present study was designed to determine if polyethylene glycol-conjugated superoxide dismutase (PEG-SOD), with its extended plasma ...

journal_title：Circulation research

authors： Chi LG,Tamura Y,Hoff PT,Macha M,Gallagher KP,Schork MA,Lucchesi BR

更新日期：1989-04-01 00:00:00

abstract：:A central role for leukocytes in neointimal hyperplasia after arterial injury is suspected. However, the relative importance of neutrophils and monocytes in balloon or stent-induced injury are not well understood, and mechanistic targeting of leukocyte recruitment or function is crude. We determined the temporal and s...

journal_title：Circulation research

authors： Horvath C,Welt FG,Nedelman M,Rao P,Rogers C

更新日期：2002-03-08 00:00:00

abstract：:Blood pressure (BP) control in patients with hypertension is variable worldwide, and in general, it results largely unsatisfactory. Factors responsible for this phenomenon include insufficient national cardiovascular healthcare policies for prevention, poor patient compliance with prescribed treatment schedules, and t...

journal_title：Circulation research

authors： Mancia G,Rea F,Corrao G,Grassi G

更新日期：2019-03-29 00:00:00

abstract：:In 26 Wistar rats with surface glomeruli, the determinants of glomerular ultrafiltration and peritubular capillary uptake of proximal reabsorbate were studied before and during intravenous infusions of norepinephrine or angiotensin II. Regardless of whether renal perfusion pressure (AP) was permitted to increase, both...

journal_title：Circulation research

authors： Myers BD,Deen WM,Brenner BM

更新日期：1975-07-01 00:00:00

abstract：:The phorbol ester 12-O-tetradecanoyl phorbol-13-acetate was used to probe the role of protein kinase-C in the modulation of alpha-adrenergic receptor-coupled calcium efflux in cultured vascular smooth muscle cells derived from rabbit aorta. Exposure of cells to 12-O-tetradecanoyl phorbol-13-acetate for 6 minutes cause...

journal_title：Circulation research

authors： Colucci WS,Gimbrone MA Jr,Alexander RW

更新日期：1986-03-01 00:00:00

abstract：:The recent discovery of neutral active choline and ethanolamine glycerophospholipid specific phospholipase C in myocardium (Wolf RA, Gross RW. J Biol Chem 1985;260:7295) has demonstrated a novel catabolic pathway that potentially contributes to the accumulation of amphiphilic metabolites during myocardial ischemia. To...

journal_title：Circulation research

authors： Ford DA,Gross RW

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Circumstantial evidence links the development of heart failure to posttranslational modifications of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that Kac compromises mitochondrial performance remains sparse. OBJECTIVE:This study sought to explore the premise that ...

journal_title：Circulation research

authors： Davidson MT,Grimsrud PA,Lai L,Draper JA,Fisher-Wellman KH,Narowski TM,Abraham DM,Koves TR,Kelly DP,Muoio DM

更新日期：2020-09-25 00:00:00

abstract：RATIONALE:Higher social integration is associated with lower cardiovascular mortality; however, whether it is associated with incident coronary heart disease (CHD), especially in women, and whether associations differ by case fatality are unclear. OBJECTIVES:This study sought to examine the associations between social...

journal_title：Circulation research

authors： Chang SC,Glymour M,Cornelis M,Walter S,Rimm EB,Tchetgen Tchetgen E,Kawachi I,Kubzansky LD

更新日期：2017-06-09 00:00:00

abstract：:Inherited restrictive cardiomyopathy (RCM) is a debilitating disease characterized by a stiff heart with impaired ventricular relaxation. Mutations in cardiac troponin I (cTnI) were identified as causal for RCM. Acute genetic engineering of adult cardiac myocytes was used to identify primary structure/function effects...

journal_title：Circulation research

authors： Davis J,Wen H,Edwards T,Metzger JM

更新日期：2007-05-25 00:00:00

abstract：:Morphometric data from stable (nonedematous) isolated dog lungs, perfused with nearly cell-free perfusates, were compared to similar stereological evaluations of isolated dog lungs after induction of severe acute hydrostatic edema. In the edematous lungs, capillary surface and volume densities were substantially incre...

journal_title：Circulation research

authors： DeFouw DO,Berendsen PB

更新日期：1978-07-01 00:00:00

abstract：RATIONALE:Yes-associated protein (YAP), the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEA (transcriptional enhancer activator)-domain sequence-specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyo...

journal_title：Circulation research

authors： Lin Z,Zhou P,von Gise A,Gu F,Ma Q,Chen J,Guo H,van Gorp PR,Wang DZ,Pu WT

更新日期：2015-01-02 00:00:00

abstract：:Neuropeptide Y (NPY) is stored with norepinephrine in sympathetic nerves throughout the cardiovascular system and is released during activation of the sympathetic nervous system in humans and other animals. After stimulation of the cardiac sympathetic nerves in anesthetized dogs, the action of the vagus nerve on heart...

journal_title：Circulation research

authors： Hall GT,Gardner TD,Potter EK

更新日期：1990-07-01 00:00:00

abstract：:Glycerophosphate and carnitine as competing acyl acceptors and the oxidation of different long chain acylcarnitines in isolated mitochondria have been investigated. In the presence of low concentrations of palmitate, glycerophosphate is the preferred acyl acceptor in isolated liver mitochondria, indicating that the gl...

journal_title：Circulation research

authors： Borrebaek B,Christiansen R,Christophersen BO,Bremer J

更新日期：1976-05-01 00:00:00

abstract：RATIONALE:It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function. OBJECTIVE:The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. METHODS AND RESULTS:In 110 patients with systolic heart failu...

journal_title：Circulation research

authors： Parisi V,Rengo G,Perrone-Filardi P,Pagano G,Femminella GD,Paolillo S,Petraglia L,Gambino G,Caruso A,Grimaldi MG,Baldascino F,Nolano M,Elia A,Cannavo A,De Bellis A,Coscioni E,Pellegrino T,Cuocolo A,Ferrara N,Leosco D

更新日期：2016-04-15 00:00:00

abstract：:The prevalence of obesity has increased worldwide over the past few decades. In 2013, the prevalence of obesity exceeded the 50% of the adult population in some countries from Oceania, North Africa, and Middle East. Lower but still alarmingly high prevalence was observed in North America (≈30%) and in Western Europe (...

journal_title：Circulation research

authors： Ortega FB,Lavie CJ,Blair SN

更新日期：2016-05-27 00:00:00

abstract：:An extensive investigation of the cardiac actions of phorbol esters and the potential role of the Na(+)-H+ exchanger in those actions was carried out using isolated rat hearts. Sixty minutes of perfusion with 10(-9) M phorbol 12-myristate 13-acetate (PMA) or 10(-8) M phorbol 12,13-dibutyrate (PDBu) produced marked car...

journal_title：Circulation research

authors： Watson JE,Karmazyn M

更新日期：1991-10-01 00:00:00