Morphological changes in isolated perfused dog lungs after acute hydrostatic edema.

abstract：RATIONALE:We have recently shown that the bone morphogenetic protein (BMP) antagonist Gremlin 2 (Grem2) is required for early cardiac development and cardiomyocyte differentiation. Our initial studies discovered that Grem2 is strongly induced in the adult heart after experimental myocardial infarction (MI). However, th...

journal_title：Circulation research

authors： Sanders LN,Schoenhard JA,Saleh MA,Mukherjee A,Ryzhov S,McMaster WG Jr,Nolan K,Gumina RJ,Thompson TB,Magnuson MA,Harrison DG,Hatzopoulos AK

更新日期：2016-07-22 00:00:00

abstract：:Angiotensin II (Ang II) has powerful modulatory actions on cardiovascular function that are mediated by specific receptors located on neurons within the hypothalamus and brain stem. Incubation of neuronal cocultures of rat hypothalamus and brain stem with Ang II elicits an Ang II type 1 (AT1) receptor-mediated inhibit...

journal_title：Circulation research

authors： Gelband CH,Warth JD,Mason HS,Zhu M,Moore JM,Kenyon JL,Horowitz B,Sumners C

更新日期：1999-02-19 00:00:00

abstract：:The bioactivity of nitric oxide (.NO) depends, in part, on its interaction with superoxide. Usually, superoxide dismutase (SOD) preserves .NO bioactivity by limiting the availability of superoxide. Ascorbic acid also effectively scavenges superoxide, but the extent to which this interaction is necessary for intact .NO...

journal_title：Circulation research

authors： Jackson TS,Xu A,Vita JA,Keaney JF Jr

更新日期：1998-11-02 00:00:00

abstract：:Our previous studies suggested that enhanced fibronectin mRNA translation in ductus arteriosus compared with aortic smooth muscle cells is related to increased expression of light chain 3 (LC3) of microtubule-associated protein 1, which binds an AU-rich element in the 3' untranslated region of fibronectin mRNA. We the...

journal_title：Circulation research

authors： Zhou B,Rabinovitch M

更新日期：1998-09-07 00:00:00

abstract：:First-generation, E1-deleted adenoviral vectors (E1-AV) can transduce the vascular endothelium with high efficiency, but their use is limited by the resulting acute endothelial injury and the long-term development of intimal hyperplasia. To reduce the impact of viral proteins on the gene-modified cells, a second-gener...

journal_title：Circulation research

authors： Qian HS,Channon K,Neplioueva V,Wang Q,Finer M,Tsui L,George SE,McArthur J

更新日期：2001-05-11 00:00:00

abstract：:Atherosclerosis causes clinical disease through luminal narrowing or by precipitating thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic stroke), or lower extremities (peripheral vascular disease). The most common of these manifestations is coronary heart disease, including stable ...

journal_title：Circulation research

authors： Bentzon JF,Otsuka F,Virmani R,Falk E

更新日期：2014-06-06 00:00:00

abstract：:One of the major manifestations of obesity is increased production of the adipocyte-derived 16-kDa peptide leptin, which is also elevated in heart disease, including congestive heart failure. However, whether leptin can directly alter the cardiac phenotype is not known. We therefore studied the effect of leptin as a p...

journal_title：Circulation research

authors： Rajapurohitam V,Gan XT,Kirshenbaum LA,Karmazyn M

更新日期：2003-08-22 00:00:00

abstract：RATIONALE:Protein kinase (PK)C-induced phosphorylation of cardiac troponin (cTn)I has been shown to regulate cardiac contraction. OBJECTIVE:Characterize functional effects of increased PKC-induced cTnI phosphorylation and identify underlying mechanisms using a transgenic mouse model (cTnI(PKC-P)) expressing mutant cTn...

journal_title：Circulation research

authors： Kirk JA,MacGowan GA,Evans C,Smith SH,Warren CM,Mamidi R,Chandra M,Stewart AF,Solaro RJ,Shroff SG

更新日期：2009-12-04 00:00:00

abstract：:Controversy exists regarding the mechanism by which catecholamines stimulate renin secretion in vivo. A sensitive rat kidney slice system was utilized to study the direct effects of adrenergic agonists and antagonists on renin release in vitro. Catecholamines were protected from degradation by the addition of ascorbic...

journal_title：Circulation research

authors： Weinberger MH,Aoi W,Henry DP

更新日期：1975-09-01 00:00:00

abstract：:The role of the Na+-Ca2+ exchanger as a major determinant of cell Ca2+ is well defined in cardiac tissue, and there has been much effort to develop specific inhibitors of the exchanger. We use a novel system to test the specificity of two putative specific inhibitors, KB-R7943 and SEA0400. The drugs are applied to ele...

journal_title：Circulation research

authors： Reuter H,Henderson SA,Han T,Matsuda T,Baba A,Ross RS,Goldhaber JI,Philipson KD

更新日期：2002-07-26 00:00:00

abstract：:We have used tryptic digestion to determine whether Ca(2+) can regulate cardiac ryanodine receptor (RyR) channel gating from within the lumen of the sarcoplasmic reticulum (SR) or whether Ca(2+) must first flow through the channel and act via cytosolically located binding sites. Cardiac RyRs were incorporated into bil...

journal_title：Circulation research

authors： Ching LL,Williams AJ,Sitsapesan R

更新日期：2000-08-04 00:00:00

abstract：:Apoptosis of smooth muscle cells (SMC) and degradation of the extracellular matrix (ECM) have both been implicated in atherosclerotic plaque rupture. We have previously reported that degraded type I collagen fragments induce a rapid but transient apoptotic burst initiated by calpains in SMC. The aim of the current stu...

journal_title：Circulation research

authors： von Wnuck Lipinski K,Keul P,Ferri N,Lucke S,Heusch G,Fischer JW,Levkau B

更新日期：2006-06-23 00:00:00

abstract：:The effects of endothelin on systemic and renal hemodynamics in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats were examined. Endothelin (500 ng i.v. +1,000 ng/hr per 300-g rat) elevated mean blood pressure by 13% (p less than 0.02) and decreased renal blood flow by 71% and glomerular filtrat...

journal_title：Circulation research

authors： Hirata Y,Matsuoka H,Kimura K,Fukui K,Hayakawa H,Suzuki E,Sugimoto T,Sugimoto T,Yanagisawa M,Masaki T

更新日期：1989-11-01 00:00:00

abstract：RATIONALE:One of the physiological mechanisms by which the heart adapts to a rise in blood pressure is by augmenting myocyte stretch-mediated intracellular calcium, with a subsequent increase in contractility. This slow force response was first described over a century ago and has long been considered compensatory, but...

journal_title：Circulation research

authors： Cingolani OH,Kirk JA,Seo K,Koitabashi N,Lee DI,Ramirez-Correa G,Bedja D,Barth AS,Moens AL,Kass DA

更新日期：2011-12-09 00:00:00

abstract：:Myocardial responses to acute ischemia/reperfusion and to chronic ischemic conditions have been studied extensively at all levels of organization. These include subcellular (eg, mitochondria in vitro); intact, large animal models (eg, swine with chronic coronary stenosis); as well as human subjects. Investigations in ...

journal_title：Circulation research

authors： Gewirtz H,Dilsizian V

更新日期：2017-03-31 00:00:00

abstract：:This study was performed to examine, first, the protective effects and responses of collateral vessels of the hind limb in normal and atherosclerotic monkeys and, second, the effects of chronic arterial occlusion on the development of atherosclerosis. The iliac artery was ligated on one side in cynomolgus monkeys. Six...

journal_title：Circulation research

authors： Lopez JA,Armstrong ML,Harrison DG,Piegors DJ,Heistad DD

更新日期：1988-12-01 00:00:00

abstract：:Sarcolemmal and microsomal membranes prepared from adult canine cardiac myocytes (sarcolemmal Na+, K+-ATPase = 71.8 mumol/mg per hr and microsomal rotenone-insensitive NADH cytochrome c reductase = 114 mumol/mg per hr) were each preincubated at 37 degrees C in the presence of a free radical generating system consistin...

journal_title：Circulation research

authors： Kramer JH,Mak IT,Weglicki WB

更新日期：1984-07-01 00:00:00

abstract：:The study was performed to determine whether there is a structural vascular abnormality in normotensive subjects with hypertensive relatives. We examined maximal vasodilator capacity of forearm resistance vessels in 23 normotensive young men (mean blood pressure 94 +/- 0.4 mm Hg, mean +/- SE) with hypertensive relativ...

journal_title：Circulation research

authors： Takeshita A,Imaizumi T,Ashihara T,Yamamoto K,Hoka S,Nakamura M

更新日期：1982-05-01 00:00:00

abstract：:The programmed onset of myocardial dysfunction and its progression to congestive heart failure in the cardiomyopathic Syrian hamster is hallmarked by alterations in myocellular calcium regulation. To determine whether calcium channel blockade is effective in halting the progressive depression of myocardial contractile...

journal_title：Circulation research

authors： Capasso JM,Sonnenblick EH,Anversa P

更新日期：1990-12-01 00:00:00

abstract：:The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to regenerate upon injury. In the adult heart, however, the actual rate of cardiomyocyte renewal is too low to efficiently counteract substantial ...

journal_title：Circulation research

authors： Derks W,Bergmann O

更新日期：2020-02-14 00:00:00

abstract：RATIONALE:Complementation of pluripotency genes may improve adult stem cell functions. OBJECTIVES:Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or ...

journal_title：Circulation research

authors： Koyanagi M,Iwasaki M,Rupp S,Tedesco FS,Yoon CH,Boeckel JN,Trauth J,Schütz C,Ohtani K,Goetz R,Iekushi K,Bushoven P,Momma S,Mummery C,Passier R,Henschler R,Akintuerk H,Schranz D,Urbich C,Galvez BG,Cossu G,Zeiher A

更新日期：2010-04-16 00:00:00

abstract：:Therapeutic angiogenesis using vascular endothelial growth factor (VEGF) is considered a promising new therapy for patients with arterial obstructive disease. Clinical improvements observed consist of improved muscle function and regression of rest pain or angina. However, direct evidence for improved vascularization,...

journal_title：Circulation research

authors： van Weel V,Deckers MM,Grimbergen JM,van Leuven KJ,Lardenoye JH,Schlingemann RO,van Nieuw Amerongen GP,van Bockel JH,van Hinsbergh VW,Quax PH

更新日期：2004-07-09 00:00:00

abstract：:To evaluate the degree and lateral extent of dysfunction in nonischemic myocardium adjacent to ischemic muscle, we measured systolic wall thickening with sonomicrometers during circumflex coronary occlusion in 12 anesthetized, open-chest dogs. The locations of the wall thickness measurements relative to the perfusion ...

journal_title：Circulation research

authors： Gallagher KP,Gerren RA,Stirling MC,Choy M,Dysko RC,McManimon SP,Dunham WR

更新日期：1986-04-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play important roles in cardiovascular development. However, how BMP-signaling pathways regulate cardiac gene expression is less clear. We have previously identified myocardin as a cardiac and smooth muscle-specific transcriptional cofactor for serum response factor (SRF). Myocardin ...

journal_title：Circulation research

authors： Callis TE,Cao D,Wang DZ

更新日期：2005-11-11 00:00:00

abstract：:The purpose of this study was to evaluate the limitations of the double sucrose gap voltage clamp technique in the determination of tension-voltage relationships for frog atrial muscle. Tension-voltage relationships were determined under two conditions. In one case we determined both the tension response and slow inwa...

journal_title：Circulation research

authors： Tarr M,Trank JW

更新日期：1976-07-01 00:00:00

abstract：:Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are inherited diseases with a high incidence of death due to electric abnormalities or outflow tract obstruction. In many of the families afflicted with either disease, causative mutations have been identified in various sarcomeric proteins. In this review, we focu...

journal_title：Circulation research

authors： Moore JR,Leinwand L,Warshaw DM

更新日期：2012-07-20 00:00:00

abstract：:Although isoform-selective translocation of protein kinase C (PKC) epsilon appears to play an important role in the late phase of ischemic preconditioning (PC), the mechanism(s) responsible for such translocation remains unclear. Furthermore, the signaling pathway that leads to the development of late PC after exogeno...

journal_title：Circulation research

authors： Ping P,Takano H,Zhang J,Tang XL,Qiu Y,Li RC,Banerjee S,Dawn B,Balafonova Z,Bolli R

更新日期：1999-03-19 00:00:00

abstract：:The pulmonary vein is sleeved by myocardium, which is a major source of atrial fibrillation and is involved in congenital sinus venosus defects. Little is known about the cellular origin and mechanism of formation of the pulmonary myocardium. We observed a biphasic process of pulmonary myocardium formation in mice. Fi...

journal_title：Circulation research

authors： Mommersteeg MT,Brown NA,Prall OW,de Gier-de Vries C,Harvey RP,Moorman AF,Christoffels VM

更新日期：2007-10-26 00:00:00

abstract：:The effects of exercise training on the coronary vasodilation following activation of the Bezold-Jarisch reflex were examined in conscious dogs. Mongrel dogs were chronically instrumented using sterile techniques for measurements of systemic hemodynamics and left circumflex coronary blood flow (CBF). With the heart ra...

journal_title：Circulation research

authors： Zhao G,Zhang X,Xu X,Ochoa M,Hintze TH

更新日期：1997-06-01 00:00:00

abstract：:Chronic hypoxic pulmonary hypertension is associated with profound vascular remodeling and alterations in Ca(2+) homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Recent studies show that transient receptor potential (TRPC) genes, which encode store-operated and receptor-operated cation channels, play im...

journal_title：Circulation research

authors： Lin MJ,Leung GP,Zhang WM,Yang XR,Yip KP,Tse CM,Sham JS

更新日期：2004-09-03 00:00:00