Abstract:
:Myocardial responses to acute ischemia/reperfusion and to chronic ischemic conditions have been studied extensively at all levels of organization. These include subcellular (eg, mitochondria in vitro); intact, large animal models (eg, swine with chronic coronary stenosis); as well as human subjects. Investigations in humans have used positron emission tomographic metabolic and myocardial blood flow measurements, assessment of gene expression and anatomic description of myocardium obtained at the time of coronary artery revascularization, ventricular assist device placement, or heart transplantation. A multitude of genetic, molecular, and metabolic pathways have been identified, which may promote either myocyte survival or death or, most interestingly, both. Many of these potential mediators in both acute ischemia/reperfusion and adaptations to chronic ischemic conditions involve the mitochondria, which play a central role in cellular energy production and homeostasis. The present review is focused on operative survival mechanisms and potential myocardial viability molecular imaging targets in acute and chronic ischemia, especially those which impact mitochondrial function.
journal_name
Circ Resjournal_title
Circulation researchauthors
Gewirtz H,Dilsizian Vdoi
10.1161/CIRCRESAHA.116.307898subject
Has Abstractpub_date
2017-03-31 00:00:00pages
1197-1212issue
7eissn
0009-7330issn
1524-4571pii
CIRCRESAHA.116.307898journal_volume
120pub_type
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