Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome.

abstract：RATIONALE:Accurate knowledge of the cellular composition of the heart is essential to fully understand the changes that occur during pathogenesis and to devise strategies for tissue engineering and regeneration. OBJECTIVE:To examine the relative frequency of cardiac endothelial cells, hematopoietic-derived cells, and ...

journal_title：Circulation research

authors： Pinto AR,Ilinykh A,Ivey MJ,Kuwabara JT,D'Antoni ML,Debuque R,Chandran A,Wang L,Arora K,Rosenthal NA,Tallquist MD

更新日期：2016-02-05 00:00:00

abstract：RATIONALE:Deep vein thrombosis (DVT) and its complication pulmonary embolism have high morbidity reducing quality of life and leading to death. Cellular mechanisms of DVT initiation remain poorly understood. OBJECTIVE:We sought to determine the role of mast cells (MCs) in DVT initiation and validate MCs as a potential...

journal_title：Circulation research

authors： Ponomaryov T,Payne H,Fabritz L,Wagner DD,Brill A

更新日期：2017-09-29 00:00:00

abstract：:Targeted expression of genetic material within the vascular endothelium is potentially a powerful tool for the investigation of endothelial cell (EC) biology. We developed, optimized, and characterized an efficient somatic transgenic model of EC-specific gene transfer. Rat carotid arteries were infused with adenovirus...

journal_title：Circulation research

authors： Schulick AH,Dong G,Newman KD,Virmani R,Dichek DA

更新日期：1995-09-01 00:00:00

abstract：:We have previously demonstrated that urokinase-type plasminogen activator (uPA) is highly expressed in the aneurysmal segment of the abdominal aorta (AAA) in apolipoprotein E-deficient (apoE-/-) mice treated with angiotensin II (Ang II). In the present study, we tested the hypothesis that uPA is essential for AAA form...

journal_title：Circulation research

authors： Deng GG,Martin-McNulty B,Sukovich DA,Freay A,Halks-Miller M,Thinnes T,Loskutoff DJ,Carmeliet P,Dole WP,Wang YX

更新日期：2003-03-21 00:00:00

abstract：:To determine the relative importance of protein degradation in the development of starvation-induced cardiac atrophy, in vivo fractional synthetic rates of total cardiac protein, myosin heavy chain, actin, light chain 1, and light chain 2 were measured in fed and fasted rabbits by continuous infusion of [3H] leucine. ...

journal_title：Circulation research

authors： Samarel AM,Parmacek MS,Magid NM,Decker RS,Lesch M

更新日期：1987-06-01 00:00:00

abstract：RATIONALE:Although the health effects of beta carotene have been studied extensively, a systematic examination of serum concentrations and long-term mortality, including cardiovascular disease mortality, has not been reported. OBJECTIVE:Explore whether serum beta carotene is associated with overall and cause-specific ...

journal_title：Circulation research

authors： Huang J,Weinstein SJ,Yu K,Männistö S,Albanes D

更新日期：2018-12-07 00:00:00

abstract：RATIONALE:Myogenic tone, an important regulator of vascular resistance, is dependent on vascular smooth muscle (VSM) depolarization, can be modulated by endothelial factors, and is increased in several models of hypertension. Intermittent hypoxia (IH) elevates blood pressure and causes endothelial dysfunction. Hydrogen...

journal_title：Circulation research

authors： Jackson-Weaver O,Paredes DA,Gonzalez Bosc LV,Walker BR,Kanagy NL

更新日期：2011-06-10 00:00:00

abstract：RATIONALE:G protein-coupled receptor kinase 2 (GRK2) is abundantly expressed in the heart, and its expression and activity are increased in injured or stressed myocardium. This upregulation has been shown to be pathological. GRK2 can promote cell death in ischemic myocytes, and its inhibition by a peptide comprising th...

journal_title：Circulation research

authors： Chen M,Sato PY,Chuprun JK,Peroutka RJ,Otis NJ,Ibetti J,Pan S,Sheu SS,Gao E,Koch WJ

更新日期：2013-04-12 00:00:00

abstract：:Our goal in this review is to discuss the pathophysiology, diagnosis, and treatment of stroke caused by atherosclerosis of the major intracranial arteries. References for the review were identified by searching PubMed for related studies published from 1955 to June 2016 using search terms intracranial stenosis and int...

journal_title：Circulation research

authors： Banerjee C,Chimowitz MI

更新日期：2017-02-03 00:00:00

abstract：:Calcium uptake was measured in homogenates and microsomal preparations enriched in sarcoplasmic reticulum vesicles isolated from hearts of hypertrophic (BIO 14.6) and dilated (BIO 53.58) cardiomyopathic as well as control (F1B) Syrian hamsters at 3, 7, 9, and 11 months of age. Calcium uptake studies were done using th...

journal_title：Circulation research

authors： Whitmer JT,Kumar P,Solaro RJ

更新日期：1988-01-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitor was used in dogs with uranyl nitrate-induced acute renal failure to evaluate (1) a possible protective effect of angiotensin blockade and (2)the role of angiotensin II in the generation of renal failure in this model. Angiotensin-converting enzyme inhibitor treatment attenuated ...

journal_title：Circulation research

authors： Lindner A,Cutler RE,Bell AJ

更新日期：1982-08-01 00:00:00

abstract：:Peripheral blood (PB)-derived CD14+ monocytes were shown to transdifferentiate into endothelial cell (EC) lineage cells and contribute to neovascularization. We investigated whether bone marrow (BM)- or PB-derived CD34-/CD14+ cells are involved in reendothelialization after carotid balloon injury. Although neither hem...

journal_title：Circulation research

authors： Fujiyama S,Amano K,Uehira K,Yoshida M,Nishiwaki Y,Nozawa Y,Jin D,Takai S,Miyazaki M,Egashira K,Imada T,Iwasaka T,Matsubara H

更新日期：2003-11-14 00:00:00

abstract：:We studied the effects of rapid atrial pacing during the final 10 minutes of a 70-minute, 31% reduction in coronary blood flow in anesthetized swine to understand the significance of apparent metabolic improvements during the initial 60 minutes of segmental ischemia. Within 5-10 minutes of ischemia, subendocardial pho...

journal_title：Circulation research

authors： Arai AE,Pantely GA,Anselone CG,Bristow J,Bristow JD

更新日期：1991-12-01 00:00:00

abstract：:We studied the pulmonary vascular effects of prostacylin, PGI2, in the cat with intact chest under conditions of controlled blood flow. Intralobar injections of PGI2, 0.03--1 microgram, decreased arterial pressure in the perfused lobe in a dose-dependent manner. Inasmuch as lobar blood flow was held constant and left ...

journal_title：Circulation research

authors： Hyman AL,Kadowitz PJ

更新日期：1979-09-01 00:00:00

abstract：:To investigate the kinetic parameters of the crossbridge cycle that regulate force and shortening in cardiac muscle, we compared the mechanical properties of cardiac trabeculae with either ATP or 2-deoxy-ATP (dATP) as the substrate for contraction. Comparisons were made in trabeculae from untreated rats (predominantly...

journal_title：Circulation research

authors： Regnier M,Rivera AJ,Chen Y,Chase PB

更新日期：2000-06-23 00:00:00

abstract：:On the basis of animal models of arterial injury, smooth muscle cell proliferation has been posited as a dominant event in restenosis. Unfortunately, little is known about this proliferation in the human restenotic lesion. The purpose of this study was to determine the extent and time course of proliferation in primar...

journal_title：Circulation research

authors： O'Brien ER,Alpers CE,Stewart DK,Ferguson M,Tran N,Gordon D,Benditt EP,Hinohara T,Simpson JB,Schwartz SM

更新日期：1993-08-01 00:00:00

abstract：:Smaller Ca2+ transients and systolic dysfunction in heart failure (HF) can be largely explained by reduced total sarcoplasmic reticulum (SR) Ca2+ content ([Ca]SRT). However, it is unknown whether low [Ca]SRT is manifest as reduced: (1) intra-SR free [Ca2+] ([Ca2+]SR), (2) intra-SR Ca2+ buffering, or (3) SR volume (as ...

journal_title：Circulation research

authors： Guo T,Ai X,Shannon TR,Pogwizd SM,Bers DM

更新日期：2007-10-12 00:00:00

abstract：:A central role for leukocytes in neointimal hyperplasia after arterial injury is suspected. However, the relative importance of neutrophils and monocytes in balloon or stent-induced injury are not well understood, and mechanistic targeting of leukocyte recruitment or function is crude. We determined the temporal and s...

journal_title：Circulation research

authors： Horvath C,Welt FG,Nedelman M,Rao P,Rogers C

更新日期：2002-03-08 00:00:00

abstract：:On endothelial cells, thrombin binds to thrombomodulin (TM), an integral membrane-bound glycoprotein, and to protease-activated receptors (PARs). Thrombin binding to TM modulates endothelial cell and smooth muscle cell proliferation mediated through PAR1. We studied the phosphorylation and nuclear translocation of ext...

journal_title：Circulation research

authors： Olivot JM,Estebanell E,Lafay M,Brohard B,Aiach M,Rendu F

更新日期：2001-04-13 00:00:00

abstract：:Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and posttranslational modifications are known to dir...

journal_title：Circulation research

authors： Metzger JM,Westfall MV

更新日期：2004-02-06 00:00:00

abstract：:Chronic hypoxic pulmonary hypertension is associated with profound vascular remodeling and alterations in Ca(2+) homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Recent studies show that transient receptor potential (TRPC) genes, which encode store-operated and receptor-operated cation channels, play im...

journal_title：Circulation research

authors： Lin MJ,Leung GP,Zhang WM,Yang XR,Yip KP,Tse CM,Sham JS

更新日期：2004-09-03 00:00:00

abstract：RATIONALE:Necrosis is one of the main forms of cardiomyocyte death in heart disease. Recent studies have demonstrated that certain types of necrosis are regulated and programmed dependent on the activation of receptor-interacting serine/threonine-protein kinase (RIPK) 1 and 3 which may be negatively regulated by Fas-as...

journal_title：Circulation research

authors： Wang JX,Zhang XJ,Li Q,Wang K,Wang Y,Jiao JQ,Feng C,Teng S,Zhou LY,Gong Y,Zhou ZX,Liu J,Wang JL,Li PF

更新日期：2015-07-31 00:00:00

abstract：:Nuclear factor kappa B (NF-kappaB) participates in hypertension-induced vascular and target-organ damage. We tested whether or not endothelial cell-specific NF-kappaB suppression would be ameliorative. We generated Cre/lox transgenic mice with endothelial cell-restricted NF-kappaB super-repressor IkappaBalphaDeltaN (T...

journal_title：Circulation research

authors： Henke N,Schmidt-Ullrich R,Dechend R,Park JK,Qadri F,Wellner M,Obst M,Gross V,Dietz R,Luft FC,Scheidereit C,Muller DN

更新日期：2007-08-03 00:00:00

abstract：:The mechanisms underlying the blunted contractile response to beta-adrenergic receptor (beta-AR) stimulation in heart failure (HF) are incompletely understood, especially with regard to beta-AR subtype-specific regulation of L-type Ca2+ channels. We evaluated the impact of HF induced by pacing tachycardia on beta-AR r...

journal_title：Circulation research

authors： He JQ,Balijepalli RC,Haworth RA,Kamp TJ

更新日期：2005-09-16 00:00:00

abstract：:Dimethylarginie dimethylaminohydrolase (DDAH) degrades asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, and comprises 2 isoforms, DDAH1 and DDAH2. To investigate the in vivo role of DDAH2, we generated transgenic mice overexpressing DDAH2. The transgenic mice manifested reduction...

journal_title：Circulation research

authors： Hasegawa K,Wakino S,Tatematsu S,Yoshioka K,Homma K,Sugano N,Kimoto M,Hayashi K,Itoh H

更新日期：2007-07-20 00:00:00

abstract：:The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV nodal myocardium-specific reporter mouse to gain insight into the gene programs determining the formation an...

journal_title：Circulation research

authors： Horsthuis T,Buermans HP,Brons JF,Verkerk AO,Bakker ML,Wakker V,Clout DE,Moorman AF,'t Hoen PA,Christoffels VM

更新日期：2009-07-02 00:00:00

abstract：:Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP. In the case of PDE2, this regulation primarily involves the allosteric st...

journal_title：Circulation research

authors： Zaccolo M,Movsesian MA

更新日期：2007-06-08 00:00:00

abstract：:We investigated the effects of streptozotocin-induced diabetes on atrial natriuretic peptide (ANP) synthesis, hemodynamic parameters, blood volume, and histopathology, as well as the reversibility of such effects with insulin therapy in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). The biatrial A...

journal_title：Circulation research

authors： Matsubara H,Mori Y,Yamamoto J,Inada M

更新日期：1990-10-01 00:00:00

abstract：:The aim was to identify energy-consuming processes, other than contraction, downregulated during moderate hypoxia ( approximately 5 micromol/L, 0.5% O(2)) and severe hypoxia (<0.5 micromol/L, <0.05% O(2)) in isolated neonatal cardiomyocytes. The metabolic response of cardiomyocytes to moderate and severe hypoxia was a...

journal_title：Circulation research

authors： Casey TM,Pakay JL,Guppy M,Arthur PG

更新日期：2002-04-19 00:00:00

abstract：:The purpose of this study was to develop an isolated tissue model in which arrhythmic activity could be generated in response to conditions encountered in ischemia followed by reperfusion, and in which intracellular recordings could be used to identify and study arrhythmogenic mechanisms. Isolated canine Purkinje fibe...

journal_title：Circulation research

authors： Ferrier GR,Moffat MP,Lukas A

更新日期：1985-02-01 00:00:00