Abstract:
:We examined the mechanism(s) of hypotensive action of platelet-activating factor (PAF) in anesthetized dogs. PAF (0.5 micrograms/kg i.v.) caused a biphasic hypotension; the first phase was transient and was accompanied by a decrease in systemic vascular resistance and an increase in cardiac output. Aspirin-DL-lysine, a cyclooxygenase inhibitor, had no effect on this phase. The second phase was characterized by a sustained hypotension caused by a reduction in cardiac output and was accompanied by an increase in systemic and pulmonary vascular resistance. The plasma concentrations of 6-ketoprostaglandin F1 alpha and thromboxane B2 also increased. These changes were markedly attenuated by aspirin. Both atrial pressures decreased during the second phase, thereby indicating that the PAF-induced reduction in cardiac output was related to a hindrance in venous return. The hematocrit increased, and aspirin did not affect this change. The extravasation of plasma probably plays a minor role, whereas venodilation would be the primary mechanism of the second-phase hypotension. S-1452, a prostaglandin H2/thromboxane A2 antagonist, abolished the PAF-induced pulmonary vasoconstriction but did not block the hypotensive action of PAF. OKY-046, a thromboxane A2 synthetase inhibitor, almost completely abolished the PAF-induced pulmonary vasoconstriction and the increase in plasma thromboxane B2 level, whereas it potentiated the hypotension and the increase in the plasma concentrations of prostaglandins; aspirin abolished this potentiation. These results suggest that PAF causes hypotension by two different mechanisms: 1) dilatation of resistance vessels independent of prostaglandins and 2) reduction of venous return due to venodilation, as mediated by prostaglandin(s).
journal_name
Circ Resjournal_title
Circulation researchauthors
Yamanaka S,Miura K,Yukimura T,Okumura M,Yamamoto Kdoi
10.1161/01.res.70.5.893subject
Has Abstractpub_date
1992-05-01 00:00:00pages
893-901issue
5eissn
0009-7330issn
1524-4571journal_volume
70pub_type
杂志文章abstract::We determined the extent of convergence of preganglionic fibers from the right and left vagus nerves on postganglionic neurons that supply the sinoatrial node in chloralose-anesthetized dogs. We administered hemicholinium-3 and stimulated the right vagus nerve at a high frequency to deplete acetylcholine from the post...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.67.3.556
更新日期:1990-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2003-06-13 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-08-17 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.115.306996
更新日期:2015-12-04 00:00:00
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doi:10.1161/01.res.52.5.557
更新日期:1983-05-01 00:00:00
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doi:10.1161/CIRCRESAHA.111.243790
更新日期:2011-08-19 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.82.7.803
更新日期:1998-04-20 00:00:00
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更新日期:2013-09-13 00:00:00
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pub_type: 杂志文章
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更新日期:1989-07-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.113.301324
更新日期:2013-06-21 00:00:00
abstract::The role of Ca(2+)-dependent potassium channels in mediating vascular responses to activation of adenylate cyclase in vivo is not known. The goal of this study was to examine the hypothesis that dilatation of cerebral arterioles in response to activation of adenylate cyclase is mediated by activation of Ca(2+)-depende...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.76.6.1057
更新日期:1995-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2000-07-21 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000022854.95998.5c
更新日期:2002-06-14 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.118.313094
更新日期:2018-12-07 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.68.3.847
更新日期:1991-03-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000124394.01180.BE
更新日期:2004-04-16 00:00:00
abstract::The purpose of this study was to explore the changes in fetal blood volume that occur after fetal hemorrhage. Fifteen unanesthetized, chronically catheterized fetal sheep averaging 130 +/- 3 (SD) days gestation were studied 4 to 6 (average 5) days after catheter implantation. The fetuses were hemorrhaged by continuous...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.52.6.730
更新日期:1983-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2001-05-25 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.78.5.893
更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.0000018002.43041.08
更新日期:2002-05-17 00:00:00
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更新日期:1985-12-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.77.6.1087
更新日期:1995-12-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.72.5.1082
更新日期:1993-05-01 00:00:00
abstract::Transgenic mice overexpressing the calcium binding protein, S100A4/Mts1, occasionally develop severe pulmonary vascular obstructive disease. To understand what underlies this propensity, we compared the pulmonary vascular hemodynamic and structural features of S100A4/Mts1 with control C57Bl/6 mice at baseline, followi...
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pub_type: 杂志文章
doi:10.1161/01.RES.0000182425.49768.8a
更新日期:2005-09-16 00:00:00
abstract::Abstract: Macrophages, a key component of the innate defense against pathogens, participate in the initiation and resolution of inflammation, and in the maintenance of tissues. These diverse and at times antithetical functions of macrophages are executed via distinct activation states, ranging from classical to altern...
journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/CIRCRESAHA.110.216523
更新日期:2010-05-28 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.46.1.11
更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-04-29 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000086942.13523.88
更新日期:2003-08-08 00:00:00
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pub_type: 杂志文章
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更新日期:2006-04-28 00:00:00