Abstract:
:We studied the effects of slow continuous hemorrhage (0.5 ml/kg per min) on measurements of arterial and left atrial pressures, and renal nerve activity in conscious dogs with all reflexes intact, or after sinoaortic baroreceptor denervation, cardiac denervation, or sinoaortic baroreceptor denervation plus vagal denervation. In intact dogs, mean arterial pressure remained relatively constant at 101 +/- 4 mm Hg until 20 +/- 4 ml/kg of hemorrhage, when renal nerve activity increased by 211 +/- 53%. At 39 +/- 2 ml/kg hemorrhage, mean arterial pressure fell by 48 +/- 3 mm Hg, and renal nerve activity returned to the prehemorrhage control level. Cardiac denervation did not affect the response of mean arterial pressure to hemorrhage, whereas, after sinoaortic baroreceptor denervation and sinoaortic baroreceptor plus vagal denervation, mean arterial pressure remained at its control level only through 8 +/- 1 and 4 +/- 1 ml/kg hemorrhage, respectively. The increases in renal nerve activity during nonhypotensive hemorrhage were significantly attenuated by either sinoaortic baroreceptor or cardiac denervation, and were completely blocked by sinoaortic baroreceptor plus vagal denervation. However, the decline in renal nerve activity with hypotensive hemorrhage was not blocked by either cardiac or sinoaortic baroreceptor denervation, and was enhanced after sinoaortic baroreceptor plus vagal denervation. Our data indicate that nonhypotensive hemorrhage in the conscious dog elicits a striking increase in renal nerve activity, which then returns to control levels during hypotensive hemorrhage. Both sinoaortic and cardiopulmonary baroreceptors are involved in mediating the increase in renal nerve activity, whereas the decline in renal nerve activity is not due to either of these baroreflexes.
journal_name
Circ Resjournal_title
Circulation researchauthors
Morita H,Vatner SFdoi
10.1161/01.res.57.5.788subject
Has Abstractpub_date
1985-11-01 00:00:00pages
788-93issue
5eissn
0009-7330issn
1524-4571journal_volume
57pub_type
杂志文章abstract::Connexins have been hypothesized to play an important role in intercellular communication within the vascular wall and may provide a mechanistic explanation for conduction of vasomotor responses. To test this hypothesis, we studied the transmission of vasomotor responses in the intact skeletal muscle microcirculation ...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.86.6.649
更新日期:2000-03-31 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-03-02 00:00:00
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doi:10.1161/01.res.81.1.76
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doi:10.1161/01.res.83.2.204
更新日期:1998-07-27 00:00:00
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更新日期:2012-07-20 00:00:00
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更新日期:1993-05-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000134631.75684.4A
更新日期:2004-07-09 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-03-18 00:00:00
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doi:10.1161/01.res.0000014226.74709.90
更新日期:2002-04-05 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.109.213165
更新日期:2010-04-16 00:00:00
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doi:10.1161/CIRCRESAHA.108.178335
更新日期:2009-02-13 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.255950
更新日期:2012-02-17 00:00:00
abstract::Two NO synthase (NOS) isoforms have been described in vessels, an endothelial constitutive NOS (eNOS) and an inducible NOS (iNOS). The purpose of the present study was to examine the endothelium-dependent and endothelium-independent hypotensive response in aging rats, analyzing the ability of their vessels to produce ...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.83.3.279
更新日期:1998-08-10 00:00:00
abstract::The purpose of this study was to determine whether a quantitative relationship existed between a reduction in regional myocardial blood flow, measured by radiolabeled microspheres, and the degree and type of changes in myocardial activation recorded in bipolar left ventricular subepicardial and subendocardial electrog...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.45.6.764
更新日期:1979-12-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.71.4.906
更新日期:1992-10-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000189259.69645.25
更新日期:2005-11-11 00:00:00
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更新日期:1995-10-01 00:00:00
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更新日期:2007-05-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2019-09-13 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.75.1.33
更新日期:1994-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.43.2.293
更新日期:1978-08-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000237661.18885.f6
更新日期:2006-08-18 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.65.5.1161
更新日期:1989-11-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000029970.97247.57
更新日期:2002-08-09 00:00:00