Membrane structure in ultrarapidly frozen, unpretreated, freeze-fractured myocardium.

abstract：RATIONALE:The mutation A341V in the S6 transmembrane segment of KCNQ1, the α-subunit of the slowly activating delayed-rectifier K(+) (I(Ks)) channel, predisposes to a severe long-QT1 syndrome with sympathetic-triggered ventricular tachyarrhythmias and sudden cardiac death. OBJECTIVE:Several genetic risk modifiers have...

journal_title：Circulation research

authors： Heijman J,Spätjens RL,Seyen SR,Lentink V,Kuijpers HJ,Boulet IR,de Windt LJ,David M,Volders PG

更新日期：2012-01-20 00:00:00

abstract：:Experimental and clinical studies have suggested an increased production of reactive oxygen species (ROS) in the failing myocardium. The present study aimed to obtain direct evidence for increased ROS and to determine the contribution of superoxide anion (*O(2)(-)), H(2)O(2), and hydroxy radical (*OH) in failing myoca...

journal_title：Circulation research

authors： Ide T,Tsutsui H,Kinugawa S,Suematsu N,Hayashidani S,Ichikawa K,Utsumi H,Machida Y,Egashira K,Takeshita A

更新日期：2000-02-04 00:00:00

abstract：:The relationship between cell swelling and plasma membrane disruption has been evaluated in thin myocardial slices incubated in oxygenated or anoxic Krebs-Ringer phosphate media. Electron microscopy and measurements of inulin-diffusible space were used to monitor plasma membrane integrity. Inulin is excluded from the ...

journal_title：Circulation research

authors： Steenbergen C,Hill ML,Jennings RB

更新日期：1985-12-01 00:00:00

abstract：RATIONALE:Higher social integration is associated with lower cardiovascular mortality; however, whether it is associated with incident coronary heart disease (CHD), especially in women, and whether associations differ by case fatality are unclear. OBJECTIVES:This study sought to examine the associations between social...

journal_title：Circulation research

authors： Chang SC,Glymour M,Cornelis M,Walter S,Rimm EB,Tchetgen Tchetgen E,Kawachi I,Kubzansky LD

更新日期：2017-06-09 00:00:00

abstract：RATIONALE:Macrophages are essential regulators of atherosclerosis. They secrete cytokines, process lipoproteins and cholesterol, and take up apoptotic cells. Multiple subsets of plaque macrophages exist and their differential roles are emerging. OBJECTIVE:Here, we explore macrophage heterogeneity in atherosclerosis pl...

journal_title：Circulation research

authors： McArdle S,Buscher K,Ghosheh Y,Pramod AB,Miller J,Winkels H,Wolf D,Ley K

更新日期：2019-12-06 00:00:00

abstract：RATIONALE:Although the fibroblast growth factor (FGF) signaling axis plays important roles in heart development, the molecular mechanism by which the FGF regulates cardiogenesis is not fully understood. OBJECTIVE:To investigate the mechanism by which FGF signaling regulates cardiac progenitor cell differentiation. ME...

journal_title：Circulation research

authors： Zhang J,Liu J,Huang Y,Chang JY,Liu L,McKeehan WL,Martin JF,Wang F

更新日期：2012-02-17 00:00:00

abstract：RATIONALE:Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the pathophysiology of atherosclerotic disease, we need to understand the characteristics of lipid-laden foamy macrophages in the subintimal space during a...

journal_title：Circulation research

authors： Kim K,Shim D,Lee JS,Zaitsev K,Williams JW,Kim KW,Jang MY,Seok Jang H,Yun TJ,Lee SH,Yoon WK,Prat A,Seidah NG,Choi J,Lee SP,Yoon SH,Nam JW,Seong JK,Oh GT,Randolph GJ,Artyomov MN,Cheong C,Choi JH

更新日期：2018-10-26 00:00:00

abstract：:We determined the extent of convergence of preganglionic fibers from the right and left vagus nerves on postganglionic neurons that supply the sinoatrial node in chloralose-anesthetized dogs. We administered hemicholinium-3 and stimulated the right vagus nerve at a high frequency to deplete acetylcholine from the post...

journal_title：Circulation research

authors： Lang SA,Zieske H,Levy MN

更新日期：1990-09-01 00:00:00

abstract：:The cellular basis of reactive oxygen intermediate-induced arrhythmias was investigated in isolated rabbit ventricular cells using the whole-cell voltage- and current-clamp techniques. Singlet oxygen and superoxide were generated by the photoactivation of rose bengal. Single ventricular cells exposed to rose bengal (1...

journal_title：Circulation research

authors： Matsuura H,Shattock MJ

更新日期：1991-02-01 00:00:00

abstract：RATIONALE:A better understanding of the mechanism underlying skeletal muscle repair is required to develop therapies that promote tissue regeneration in adults. Hedgehog signaling has been shown previously to be involved in myogenesis and angiogenesis: 2 crucial processes for muscle development and regeneration. OBJEC...

journal_title：Circulation research

authors： Renault MA,Vandierdonck S,Chapouly C,Yu Y,Qin G,Metras A,Couffinhal T,Losordo DW,Yao Q,Reynaud A,Jaspard-Vinassa B,Belloc I,Desgranges C,Gadeau AP

更新日期：2013-10-25 00:00:00

abstract：:Although peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have an antihypertensive effect in vivo, the precise mechanism has not been fully elucidated. We examined their effects on Rho/Rho kinase pathway, a key regulator of vascular tone. In cultured rat aortic smooth muscle cells (RASMC), Rho kina...

journal_title：Circulation research

authors： Wakino S,Hayashi K,Kanda T,Tatematsu S,Homma K,Yoshioka K,Takamatsu I,Saruta T

更新日期：2004-09-03 00:00:00

abstract：:Atherosclerotic lesion development seems to be inflammatory in nature and involves the recruitment of monocytes to the vessel wall. In this study, we investigated the role of vascular cell adhesion molecule-1 (VCAM-1) and fibronectin (FN) connecting segment-1 containing the amino acid sequence ILDV as functional ligan...

journal_title：Circulation research

authors： Huo Y,Hafezi-Moghadam A,Ley K

更新日期：2000-07-21 00:00:00

abstract：:The purpose of this study was to explore the changes in fetal blood volume that occur after fetal hemorrhage. Fifteen unanesthetized, chronically catheterized fetal sheep averaging 130 +/- 3 (SD) days gestation were studied 4 to 6 (average 5) days after catheter implantation. The fetuses were hemorrhaged by continuous...

journal_title：Circulation research

authors： Brace RA

更新日期：1983-06-01 00:00:00

abstract：:The enzyme heme oxygenase, which exists in inducible (HO-1) and constitutive (HO-2) isoforms, catalyzes the degradation of heme to biliverdin and CO in mammalian tissues. CO has been implicated in the control of vascular tone in a manner similar to that for NO. In the present study, we investigated the contribution of...

journal_title：Circulation research

authors： Motterlini R,Gonzales A,Foresti R,Clark JE,Green CJ,Winslow RM

更新日期：1998-09-07 00:00:00

abstract：:Angiotensin (Ang) II is present inside vascular smooth muscle cells (VSMCs); however, its intracellular functions, if any, are unknown. We tested the hypothesis that intracellular Ang II exerts effects on cytosolic Ca2+ ([Ca2+]i) in VSMCs. Ang II was administered via microinjection. Intracellular Ang II localization w...

journal_title：Circulation research

authors： Haller H,Lindschau C,Erdmann B,Quass P,Luft FC

更新日期：1996-10-01 00:00:00

abstract：RATIONALE:Immune cells play an important role during the generation and resolution of thrombosis. T cells are powerful regulators of immune and nonimmune cell function, however, their role in sterile inflammation in venous thrombosis has not been systematically examined. OBJECTIVE:This study investigated the recruitme...

journal_title：Circulation research

authors： Luther N,Shahneh F,Brähler M,Krebs F,Jäckel S,Subramaniam S,Stanger C,Schönfelder T,Kleis-Fischer B,Reinhardt C,Probst HC,Wenzel P,Schäfer K,Becker C

更新日期：2016-12-09 00:00:00

abstract：:The activity of the adrenergic system plays an important role in the genesis of malignant arrhythmias and the spreading of the infarcted zone in acute myocardial ischemia. Acute myocardial ischemia induces an increased activity of adenylyl cyclase. This sensitization at the enzyme level as shown in the isolated perfus...

journal_title：Circulation research

authors： Strasser RH,Braun-Dullaeus R,Walendzik H,Marquetant R

更新日期：1992-06-01 00:00:00

abstract：:When exposed to an increasing transmural pressure, middle cerebral arteries of the cat exhibit reduction of internal diameter which is mediated by vascular muscle cell depolarization. This laboratory has recently demonstrated that this "pressure-induced" activation is dependent upon the presence of an intact endotheli...

journal_title：Circulation research

authors： Harder DR,Sanchez-Ferrer C,Kauser K,Stekiel WJ,Rubanyi GM

更新日期：1989-07-01 00:00:00

abstract：:Cardiovascular disease is a major killer in postmenopausal women in the industrialized societies. To investigate the effect of progestogen and 17 beta-estradiol replacement therapy on atherogenesis, we studied 60 cholesterol-fed ovariectomized rabbits for 13 weeks. They were randomly assigned to four groups of 15 rabb...

journal_title：Circulation research

authors： Haarbo J,Svendsen OL,Christiansen C

更新日期：1992-06-01 00:00:00

abstract：:After myocardial infarction (MI), the noninfarcted myocardium undergoes significant hypertrophy as part of the post-MI structural remodeling. Electrophysiological changes associated with the hypertrophied remodeled myocardium may play a key role in arrhythmia generation in the post-MI heart. We investigated the cellul...

journal_title：Circulation research

authors： Qin D,Zhang ZH,Caref EB,Boutjdir M,Jain P,el-Sherif N

更新日期：1996-09-01 00:00:00

abstract：:Sinus node recovery time was compared to the recovery time of a slow atrioventricular junctional rhythm in each of the same seven pentobarbital anesthetized dogs. Recovery time and the first five cardiac cycles were examined after pacing atria and ventricles for 20, 40, and 60 seconds at four or more pacing cycle leng...

journal_title：Circulation research

authors： Neely BH,Urthaler F,Hageman GR

更新日期：1985-07-01 00:00:00

abstract：RATIONALE:Activin receptor-like kinase-1 (ALK1) is an endothelial transforming growth factor β receptor involved in angiogenesis. ALK1 expression is high in the embryo vasculature, becoming less detectable in the quiescent endothelium of adult stages. However, ALK1 expression becomes rapidly increased after angiogenic ...

journal_title：Circulation research

authors： Garrido-Martín EM,Blanco FJ,Roquè M,Novensà L,Tarocchi M,Lang UE,Suzuki T,Friedman SL,Botella LM,Bernabéu C

更新日期：2013-01-04 00:00:00

abstract：RATIONALE:Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene locus are frequently found in patients with alveolar capillary dysplasia with misalignment of pulmonary veins, a lethal congenital disorder, which is characterized by severe abnormalities in the respiratory, cardiovascular, and ga...

journal_title：Circulation research

authors： Ren X,Ustiyan V,Pradhan A,Cai Y,Havrilak JA,Bolte CS,Shannon JM,Kalin TV,Kalinichenko VV

更新日期：2014-09-26 00:00:00

abstract：:Experiments were performed to investigate whether balloon injury induces nitric oxide synthase activity in the blood vessel wall. Contractions to phenylephrine were compared in left carotid arteries of the rat, previously injured by balloon catheterization and excised either immediately (t = 0), 6, or 24 hours after t...

journal_title：Circulation research

authors： Joly GA,Schini VB,Vanhoutte PM

更新日期：1992-08-01 00:00:00

abstract：RATIONALE:Depletion of medial smooth muscle cell (SMC) is a major pathological characteristic of abdominal aortic aneurysm (AAA), although the mechanism by which these cells are eliminated remains incompletely understood. We reasoned that necroptosis, a recently described form of necrosis mediated by receptor-interacti...

journal_title：Circulation research

authors： Wang Q,Liu Z,Ren J,Morgan S,Assa C,Liu B

更新日期：2015-02-13 00:00:00

abstract：RATIONALE:We have recently shown that the bone morphogenetic protein (BMP) antagonist Gremlin 2 (Grem2) is required for early cardiac development and cardiomyocyte differentiation. Our initial studies discovered that Grem2 is strongly induced in the adult heart after experimental myocardial infarction (MI). However, th...

journal_title：Circulation research

authors： Sanders LN,Schoenhard JA,Saleh MA,Mukherjee A,Ryzhov S,McMaster WG Jr,Nolan K,Gumina RJ,Thompson TB,Magnuson MA,Harrison DG,Hatzopoulos AK

更新日期：2016-07-22 00:00:00

abstract：:The aims of the current study were to examine the efficacy of acetylcholine (ACh) to mimic ischemic preconditioning in dogs and to determine the role of nitric oxide (NO), muscarinic receptors, and ATP-sensitive K+ (KATP) channels in mediating its effects. Barbital-anesthetized open-chest dogs were subjected to 60 min...

journal_title：Circulation research

authors： Yao Z,Gross GJ

更新日期：1993-12-01 00:00:00

abstract：RATIONALE:The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a significant proportion of patients who receive a proteasome inhibitor-containing regime show cardiotoxicity. Mo...

journal_title：Circulation research

authors： Pan B,Li J,Parajuli N,Tian Z,Wu P,Lewno MT,Zou J,Wang W,Bedford L,Mayer RJ,Fang J,Liu J,Cui T,Su H,Wang X

更新日期：2020-07-31 00:00:00

abstract：:Anisotropic impulse conduction was studied in neonatal rat heart cell monolayers produced by culturing cells on a growth-directing substrate of collagen. Monolayers consisting of parallel-oriented cells without visible intercellular clefts were selected for experiments; cell lengths and widths were 65.8 +/- 12.5 and 1...

journal_title：Circulation research

authors： Fast VG,Kléber AG

更新日期：1994-09-01 00:00:00

abstract：:Twenty-one dogs were studied under conditions of normal oxygenation and hypoxia with the microsphere distribution method to determine the effect of arterial oxygen saturation on the regional distribution of cardiac output. The dogs were anesthetized and artifically ventilated. Cannulas were placed in the left ventricl...

journal_title：Circulation research

authors： Adachi H,Strauss W,Ochi H,Wagner HN Jr

更新日期：1976-09-01 00:00:00