Abstract:
:To investigate the spread of contraction in the rabbit ear artery, changes in segment diameter were measured after local stimulation. No spread of contraction was produced by direct current or local application of norepinephrine (NE). Repetitive electrical stimulation caused contraction which spread far from the point of excitation. Since 2 x 10(-7) g/ml tetrodotoxin (TTX) or 10(-5) M phentolamine prevented this spread of contraction, we concluded that it depends on normal function of periarterial nerves and of the alpha-adrenergic receptors at the site of the smooth muscle cells. To check this conclusion and exclude the possibility of myogenic propagation, which normally is due to the conduction of action potentials, the relation between membrane potential of smooth muscle cells and the rapid phase of the contractile response after rapid addition of NE was investigated. In both polarized and depolarized tissues NE induces a biphasic contractile response with no difference in latency. Membrane potential does not change during mechanical latency after the rapid addition of 5 x 10(-9) - 5 x 10(-6) g/ml NE. There are only slight differences in contraction amplitude and maximum rate of tension development when strips from polarized and depolarized tissues incubated in Ca2+-free solution are stimulated by NE. These findings support the conclusion that spread of contraction is not due to myogenic propagation.
journal_name
Circ Resjournal_title
Circulation researchauthors
Vonderlage Mdoi
10.1161/01.res.49.3.600subject
Has Abstractpub_date
1981-09-01 00:00:00pages
600-8issue
3eissn
0009-7330issn
1524-4571journal_volume
49pub_type
杂志文章abstract::Calcific aortic valve sclerosis involves inflammatory processes and occurs preferentially on the aortic side of endothelialized valve leaflets. Although the endothelium is recognized to play critical roles in focal vascular sclerosis, the contributions of valvular endothelial phenotypes to aortic valve sclerosis and s...
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更新日期:1984-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:1982-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-10-04 00:00:00
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更新日期:1988-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-10-15 00:00:00
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pub_type: 杂志文章,收录出版
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更新日期:1981-10-01 00:00:00
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更新日期:1988-01-01 00:00:00
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更新日期:2015-11-06 00:00:00
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更新日期:1998-03-09 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.68.6.1713
更新日期:1991-06-01 00:00:00