Role of glycogen synthase kinase-3beta in cardioprotection.

abstract：:We studied postclamp renal artery pressure and renin release in eight conscious dogs with one-kidney Goldblatt hypertension. On normal sodium intake, intrarenal blockade of angiotensin II with Sar1-Ala8-angiotension II (P-113, saralasin acetate) markedly decreased postclamp renal artery pressure and increased renin re...

journal_title：Circulation research

authors： Ayers CR,Katholi RE,Vaughan ED Jr,Carey RM,Kimbrough HM Jr,Yancey MR,Morton CL

更新日期：1977-03-01 00:00:00

abstract：:The kinetics of contractions and Ca(2+) transients are slowed in myocytes from failing hearts. The mechanisms accounting for these abnormalities remain unclear. Myocardial infarction (MI) was produced by ligation of the circumflex artery in rabbits. We used confocal microscopy to record spatially resolved Ca(2+) trans...

journal_title：Circulation research

authors： Litwin SE,Zhang D,Bridge JH

更新日期：2000-11-24 00:00:00

abstract：:Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules and engages diverse ligands relevant to distinct pathological processes. One class of RAGE ligands includes glycoxidation products, termed advanced glycation end products, which occur in diabetes...

journal_title：Circulation research

authors： Schmidt AM,Yan SD,Wautier JL,Stern D

更新日期：1999-03-19 00:00:00

abstract：RATIONALE:Lipoprotein(a) [Lp(a)] is a highly atherogenic low-density lipoprotein-like particle characterized by the presence of apoprotein(a) [apo(a)] bound to apolipoprotein B. Proprotein convertase subtilisin/kexin type 9 (PCSK9) selectively binds low-density lipoprotein; we hypothesized that it can also be associate...

journal_title：Circulation research

authors： Tavori H,Christian D,Minnier J,Plubell D,Shapiro MD,Yeang C,Giunzioni I,Croyal M,Duell PB,Lambert G,Tsimikas S,Fazio S

更新日期：2016-06-24 00:00:00

abstract：:Studies were performed to determine whether an alteration in coronary vascular resistance and a reduction in the reflow phenomenon occurred in the blood-perfused, heparinized canine heart after various periods of myocaridal ischemia. Regional myocardial blood flow was measured with radioactive microspheres. Proximal l...

journal_title：Circulation research

authors： Willerson JT,Watson JT,Hutton I,Templeton GH,Fixler DE

更新日期：1975-06-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is a critical event in the development and progression of vascular diseases, including atherosclerosis. We investigated whether the activation of adenosine monophosphate-activated protein kinase (AMPK) could suppress VSMC proliferation and inhibit cell cycle progression...

journal_title：Circulation research

authors： Igata M,Motoshima H,Tsuruzoe K,Kojima K,Matsumura T,Kondo T,Taguchi T,Nakamaru K,Yano M,Kukidome D,Matsumoto K,Toyonaga T,Asano T,Nishikawa T,Araki E

更新日期：2005-10-14 00:00:00

abstract：:We stimulated the aortic chemoreceptors in dogs that were anesthetized with chloralose and artificially ventilated by perfusing the isolated aortic arch with venous blood. Inotropic responses were determined by measuring the maximum rate of change of left ventricular pressure (dP/dt max) with aortic pressure and heart...

journal_title：Circulation research

authors： Karim F,Hainsworth R,Sofola OA,Wood LM

更新日期：1980-01-01 00:00:00

abstract：:Heptanol blocks sodium current (INa) in nerve, but its effects on cardiac INa have not been well characterized. Block of INa by heptanol was studied in 16 internally perfused voltage-clamped cardiac Purkinje cells at reduced Na+ (45 mM outside, 0 mM inside). Heptanol block of peak sodium conductance was well described...

journal_title：Circulation research

authors： Nelson WL,Makielski JC

更新日期：1991-04-01 00:00:00

abstract：:Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are inherited diseases with a high incidence of death due to electric abnormalities or outflow tract obstruction. In many of the families afflicted with either disease, causative mutations have been identified in various sarcomeric proteins. In this review, we focu...

journal_title：Circulation research

authors： Moore JR,Leinwand L,Warshaw DM

更新日期：2012-07-20 00:00:00

abstract：:Recent studies have shown that the primary heart tube continues to grow by addition of cells from the coelomic wall. This growth occurs concomitantly with embryonic folding and formation of the coelomic cavity, making early heart formation morphologically complex. A scarcity of data on localized growth parameters furt...

journal_title：Circulation research

authors： van den Berg G,Abu-Issa R,de Boer BA,Hutson MR,de Boer PA,Soufan AT,Ruijter JM,Kirby ML,van den Hoff MJ,Moorman AF

更新日期：2009-01-30 00:00:00

abstract：:Gene transfer to blood vessels is a promising new approach to the treatment of the vascular diseases, but the feasibility of gene transfer to adult human vessels has not been explored. We introduced an adenovirus vector encoding a marker gene human placental alkaline phosphatase into normal and atherosclerotic human v...

journal_title：Circulation research

authors： Rekhter MD,Simari RD,Work CW,Nabel GJ,Nabel EG,Gordon D

更新日期：1998-06-29 00:00:00

abstract：RATIONALE:Lipid-free apolipoprotein (apo) A-I and discoidal reconstituted high-density lipoproteins (rHDL) containing apoA-I, (A-I)rHDL, inhibit vascular inflammation by increasing 3β-hydroxysteroid-Δ24 reductase (DHCR24) expression. OBJECTIVE:To determine whether the lipid-free apoA-I-mediated and (A-I)rHDL-mediated ...

journal_title：Circulation research

authors： Wu BJ,Chen K,Shrestha S,Ong KL,Barter PJ,Rye KA

更新日期：2013-01-18 00:00:00

abstract：:The synthesis of an angiotensin II (A II) antagonist, sarcosyl1-cysteinyl(S-methyl)8-angiotensin II [Sar1-Cys(Me)8-A II], showing partial organ selectivity and properties of a noncompetitive antagonist, is described. The compound was found to be an extremely potent antagonist on vascular smooth muscle both in vitro (p...

journal_title：Circulation research

authors： Freer RJ,Sutherland JC Jr,Day AR

更新日期：1980-05-01 00:00:00

abstract：:We investigated whether the heart, like other mammalian organs, possesses internal clocks, and, if so, whether pressure overload-induced hypertrophy alters the clock mechanism. Clock genes are intrinsically maintained, as shown by rhythmic changes even in single cells. Clocks are believed to confer a selective advanta...

journal_title：Circulation research

authors： Young ME,Razeghi P,Taegtmeyer H

更新日期：2001-06-08 00:00:00

abstract：:The global prevalence of overweight and obesity has risen substantially over the past 4 decades and is accompanied by an increasing burden of cardiovascular risk factors such as hypertension. Metabolic surgery is the most effective method to treat obesity and may further improve associated conditions. Although most re...

journal_title：Circulation research

authors： Pareek M,Bhatt DL,Schiavon CA,Schauer PR

更新日期：2019-03-29 00:00:00

abstract：RATIONALE:Mitochondrial dysfunction plays an important role in heart failure (HF). However, the molecular mechanisms regulating mitochondrial functions via selective mitochondrial autophagy (mitophagy) are poorly understood. OBJECTIVE:We sought to determine the role of AMPK (AMP-activated protein kinase) in selective ...

journal_title：Circulation research

authors： Wang B,Nie J,Wu L,Hu Y,Wen Z,Dong L,Zou MH,Chen C,Wang DW

更新日期：2018-03-02 00:00:00

abstract：:Hearts from rabbits with 8-16 weeks of alloxan-diabetes were compared with hearts from normal rabbits to determine whether diabetic myocardium is more sensitive to ischemic injury. In isolated buffer-perfused hearts, left ventricular developed pressure, diastolic pressure, time to peak pressure (TTPP), time to half-ma...

journal_title：Circulation research

authors： Vogel WM,Apstein CS

更新日期：1988-05-01 00:00:00

abstract：:Activation of protein kinase C has been implicated in the regulation of a variety of cellular reactions. Although we, and others, have found protein kinase C and its substrate proteins to be present in both membrane and cytosolic fractions in the heart, the physiologic role of this kinase in the regulation of cardiac ...

journal_title：Circulation research

authors： Yuan SH,Sunahara FA,Sen AK

更新日期：1987-09-01 00:00:00

abstract：:Vagal afferents from the cardiopulmonary region exert a tonic inhibition on the vasomotor center. This is demonstrated by constriction of systemic resistance and splanchnic capacitance vessels and by increased output of renin when the vagi are cut or blocked. In dogs, removal or selective denervation of organs showed ...

journal_title：Circulation research

authors： Thorén PN,Donald DE,Shepherd JT

更新日期：1976-06-01 00:00:00

abstract：:The bioactivity of nitric oxide (.NO) depends, in part, on its interaction with superoxide. Usually, superoxide dismutase (SOD) preserves .NO bioactivity by limiting the availability of superoxide. Ascorbic acid also effectively scavenges superoxide, but the extent to which this interaction is necessary for intact .NO...

journal_title：Circulation research

authors： Jackson TS,Xu A,Vita JA,Keaney JF Jr

更新日期：1998-11-02 00:00:00

abstract：:Existing evidence led us to hypothesize that increases in p85alpha, a regulatory subunit of PI3-kinase, in presympathetic brain areas contribute to hypertension. PI3-kinase p85alpha, p110alpha, and p110delta mRNA was 1.5- to 2-fold higher in the paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHR) co...

journal_title：Circulation research

authors： Veerasingham SJ,Yamazato M,Berecek KH,Wyss JM,Raizada MK

更新日期：2005-02-18 00:00:00

abstract：RATIONALE:Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, cardiac regeneration has been demonstrated in fish and newborn mice after apex resection or cardiac infarctions. Two key issues remain to translat...

journal_title：Circulation research

authors： Haubner BJ,Schneider J,Schweigmann U,Schuetz T,Dichtl W,Velik-Salchner C,Stein JI,Penninger JM

更新日期：2016-01-22 00:00:00

abstract：:Mechanical forces participate in morphogenesis from the level of individual cells to whole organism patterning. This article reviews recent research that has identified specific roles for mechanical forces in important developmental events. One well defined example is that dynein-driven cilia create fluid flow that de...

journal_title：Circulation research

authors： Patwari P,Lee RT

更新日期：2008-08-01 00:00:00

abstract：:Postnatal development of the mammalian heart is associated with changes in the population of isoforms of the thin filament proteins. We correlated the change in thin filament proteins, which occur in rabbit hearts between 5 days and 22 days of age, with changes in Ca2+ dependence of myofibrillar ATPase activity, force...

journal_title：Circulation research

authors： McAuliffe JJ,Gao LZ,Solaro RJ

更新日期：1990-05-01 00:00:00

abstract：RATIONALE:Depletion of medial smooth muscle cell (SMC) is a major pathological characteristic of abdominal aortic aneurysm (AAA), although the mechanism by which these cells are eliminated remains incompletely understood. We reasoned that necroptosis, a recently described form of necrosis mediated by receptor-interacti...

journal_title：Circulation research

authors： Wang Q,Liu Z,Ren J,Morgan S,Assa C,Liu B

更新日期：2015-02-13 00:00:00

abstract：:Freshly dispersed rabbit ear artery cells were studied using patch-clamp techniques to measure membrane currents in whole cells and single-channel currents in membrane patches. Whole-cell calcium currents recorded at physiologic extracellular calcium concentrations were small (approximately 10 pA). Recordings with 110...

journal_title：Circulation research

authors： Benham CD,Hess P,Tsien RW

更新日期：1987-10-01 00:00:00

abstract：:Power ratios were derived from the principle of ultrasonic Doppler velocimetry to determine a ratio of the volume of vortices to the total vessel volume under the ultrasonic beam. This ratio also equals the ratio of the cross-sectional area of vortices to the vessel lumen. In vitro pulsatile flow experiments were perf...

journal_title：Circulation research

authors： Tamura T,Fronek A

更新日期：1990-07-01 00:00:00

abstract：:Blockade of angiotensin type 1 (AT1) receptors induces smooth muscle cell (SMC) death and regression of aortic hypertrophy in spontaneously hypertensive rats (SHR). We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk), a tripeptide inhibitor of cas...

journal_title：Circulation research

authors： Marchand EL,Der Sarkissian S,Hamet P,deBlois D

更新日期：2003-04-18 00:00:00

abstract：:Long QT syndrome (LQTS) type 3 (LQT3), typified by the DeltaKPQ mutation (LQT3 mutation in which amino acid residues 1505 to 1507 [KPQ] are deleted), is caused by increased sodium entry during the action potential plateau resulting from mutation-altered inactivation of the Na(v)1.5 channel. Although rare, LQT3 is the ...

journal_title：Circulation research

authors： Fredj S,Lindegger N,Sampson KJ,Carmeliet P,Kass RS

更新日期：2006-11-24 00:00:00

abstract：RATIONALE:Thousands of mutations across >50 genes have been implicated in inherited cardiomyopathies. However, options for sequencing this rapidly evolving gene set are limited because many sequencing services and off-the-shelf kits suffer from slow turnaround, inefficient capture of genomic DNA, and high cost. Further...

journal_title：Circulation research

authors： Wilson KD,Shen P,Fung E,Karakikes I,Zhang A,InanlooRahatloo K,Odegaard J,Sallam K,Davis RW,Lui GK,Ashley EA,Scharfe C,Wu JC

更新日期：2015-09-11 00:00:00