Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A.

abstract：:Astrocyte signals can modulate arteriolar tone, contributing to regulation of cerebral blood flow, but specific intercellular communication mechanisms are unclear. Here we used isolated cerebral arteriole myocytes, astrocytes, and brain slices to investigate whether carbon monoxide (CO) generated by the enzyme heme ox...

journal_title：Circulation research

authors： Li A,Xi Q,Umstot ES,Bellner L,Schwartzman ML,Jaggar JH,Leffler CW

更新日期：2008-02-01 00:00:00

abstract：:Whereas numerous studies have investigated the role of prostacyclin and thromboxane A2 in the maintenance of coronary blood flow, most of these have focused on normal vessels. In the present investigation, we examined the prostaglandin- and thromboxane-synthesizing capacity of isolated coronary artery segments obtaine...

journal_title：Circulation research

authors： Schmitz JM,Apprill PG,Buja LM,Willerson JT,Campbell WB

更新日期：1985-08-01 00:00:00

abstract：:The spatial and dynamic properties of ventricular fibrillation (VF) may be random or related to cellular electrical properties of the normal heart. Local activation intervals (AIs) in VF may depend on the local refractory period (RP), and sustained VF may require a steep action potential (AP) restitution curve. In gui...

journal_title：Circulation research

authors： Choi BR,Liu T,Salama G

更新日期：2001-03-16 00:00:00

abstract：RATIONALE:Complementation of pluripotency genes may improve adult stem cell functions. OBJECTIVES:Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or ...

journal_title：Circulation research

authors： Koyanagi M,Iwasaki M,Rupp S,Tedesco FS,Yoon CH,Boeckel JN,Trauth J,Schütz C,Ohtani K,Goetz R,Iekushi K,Bushoven P,Momma S,Mummery C,Passier R,Henschler R,Akintuerk H,Schranz D,Urbich C,Galvez BG,Cossu G,Zeiher A

更新日期：2010-04-16 00:00:00

abstract：:Elevated plasma levels of plasminogen activator inhibitor type I (PAI-1), a significant risk factor of ischemic heart disease, are associated with insulin resistance in which insulin and transforming growth factor (TGF)-beta play a pivotal role in regulating PAI-1 production. Forkhead transcription factor FOXC2 is an ...

journal_title：Circulation research

authors： Fujita H,Kang M,Eren M,Gleaves LA,Vaughan DE,Kume T

更新日期：2006-03-17 00:00:00

abstract：RATIONALE:7-Ketocholesterol (7-KC), a form of cholesterol oxidation product, plays an essential role in the atherogenesis in animal models. OBJECTIVE:We sought to determine the association of circulating 7-KC with clinical cardiovascular outcomes and total mortality in patients with stable coronary artery disease. ME...

journal_title：Circulation research

authors： Song J,Wang D,Chen H,Huang X,Zhong Y,Jiang N,Chen C,Xia M

更新日期：2017-05-12 00:00:00

abstract：RATIONALE:Our insights into physiological and pathophysiological cardiac excitation-contraction coupling has greatly benefited from significant advancement in optical technologies such as high-speed confocal microscopy. This has pushed pixel dwell times into the time domain of nanoseconds, resulting in low signal-to-no...

journal_title：Circulation research

authors： Tian Q,Kaestner L,Lipp P

更新日期：2012-06-22 00:00:00

abstract：:The direct oral anticoagulants (DOACs) represent a major advance in oral anticoagulant therapy and have replaced the vitamin K antagonists as the preferred treatment for many indications. By simplifying long-term anticoagulant therapy and improving its safety, the DOACs have the potential to reduce the global burden o...

journal_title：Circulation research

authors： Chan NC,Eikelboom JW,Weitz JI

更新日期：2016-04-29 00:00:00

abstract：:Smooth muscle cell migration in response to platelet-derived growth factor (PDGF) is a key event in several vascular pathologies, including atherosclerosis and restenosis. PDGF increases intracellular levels of reactive oxygen species (ROS) in vascular smooth muscle cells (VSMCs), but the ROS sensitivity of migration ...

journal_title：Circulation research

authors： Weber DS,Taniyama Y,Rocic P,Seshiah PN,Dechert MA,Gerthoffer WT,Griendling KK

更新日期：2004-05-14 00:00:00

abstract：:Heparin has growth inhibitory effects on pulmonary artery smooth muscle cell (PASMC) in vitro and in vivo. However, the mechanism has not been fully defined. In this study, we investigated the role of cyclin-dependent kinase inhibitors, p21(WAF1/cip1) (p21) and p27Kip1 (p27), in the inhibitory effect of heparin on PAS...

journal_title：Circulation research

authors： Yu L,Quinn DA,Garg HG,Hales CA

更新日期：2005-10-28 00:00:00

abstract：:The adenosine analogue phenylisopropyladenosine decreased the basal and isoproterenol-stimulated contractile state of isolated rat left atria. The ED50 levels for both responses were similar, suggesting that direct and antiadrenergic effects may be mediated by the same receptor. Phenylisopropyladenosine decreased the ...

journal_title：Circulation research

authors： Linden J,Hollen CE,Patel A

更新日期：1985-05-01 00:00:00

abstract：:We determined age-related differences in automaticity and responsiveness of cardiac Purkinje fibers from adult and neonatal dogs to graded concentrations of epinephrine, isoproterenol, and phenylephrine. Purkinje fibers were studied with standard microelectrode techniques during superfusion with Tyrode's solution at 3...

journal_title：Circulation research

authors： Rosen MR,Hordof AJ,Ilvento JP,Danilo P Jr

更新日期：1977-04-01 00:00:00

abstract：RATIONALE:Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels, which poorly reflects direct glucose variation. People with prediabetes and diabetes mellitus spend >50% of their time outside the optimal glucose range. These glucose variations, termed tra...

journal_title：Circulation research

authors： Flynn MC,Kraakman MJ,Tikellis C,Lee MKS,Hanssen NMJ,Kammoun HL,Pickering RJ,Dragoljevic D,Al-Sharea A,Barrett TJ,Hortle F,Byrne FL,Olzomer E,McCarthy DA,Schalkwijk CG,Forbes JM,Hoehn K,Makowski L,Lancaster GI,El-Ost

更新日期：2020-09-11 00:00:00

abstract：RATIONALE:It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function. OBJECTIVE:The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. METHODS AND RESULTS:In 110 patients with systolic heart failu...

journal_title：Circulation research

authors： Parisi V,Rengo G,Perrone-Filardi P,Pagano G,Femminella GD,Paolillo S,Petraglia L,Gambino G,Caruso A,Grimaldi MG,Baldascino F,Nolano M,Elia A,Cannavo A,De Bellis A,Coscioni E,Pellegrino T,Cuocolo A,Ferrara N,Leosco D

更新日期：2016-04-15 00:00:00

abstract：:Volume densities of mitochondria, myofibrils, and unspecified cytoplasm were measured by ultrastructural morphometry in myocardium from dogs, rats, hamsters, mice, and in biopsied tissue from human hearts. Human myocardium was composed of 23% mitochondria, 59% myofibrils, and 18% cytoplasm. Volume densities for mitoch...

journal_title：Circulation research

authors： Schaper J,Meiser E,Stämmler G

更新日期：1985-03-01 00:00:00

abstract：:The fat-derived hormone adiponectin has been shown to have a protective role in macrovascular disorders. However, nothing is known about the function of adiponectin in retinal microvessel disease. Here, we investigated the causal role of adiponectin in retinal vessel formation and inflammation under conditions of hypo...

journal_title：Circulation research

authors： Higuchi A,Ohashi K,Kihara S,Walsh K,Ouchi N

更新日期：2009-05-08 00:00:00

abstract：:Cultured quail myocytes were much more resistant to H2O2 toxicity than cultured mouse myocytes. The intracellular concentration of glutathione ([GSH]i) and the activity of gamma-glutamylcysteine synthetase (gamma-GCS) in quail heart cells were about five and three times higher, respectively, than in mouse heart cells,...

journal_title：Circulation research

authors： Nakamura TY,Yamamoto I,Kanno Y,Shiba Y,Goshima K

更新日期：1994-05-01 00:00:00

abstract：:Electrotonic coupling of cardiac myocytes at gap junctions may influence patterns of conduction in myocardium. To delineate the three-dimensional structure and distribution of intercellular junctions, we analyzed serial ultrathin sections of canine myocardium with transmission electron microscopy and disaggregated myo...

journal_title：Circulation research

authors： Hoyt RH,Cohen ML,Saffitz JE

更新日期：1989-03-01 00:00:00

abstract：:Blockade of angiotensin type 1 (AT1) receptors induces smooth muscle cell (SMC) death and regression of aortic hypertrophy in spontaneously hypertensive rats (SHR). We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk), a tripeptide inhibitor of cas...

journal_title：Circulation research

authors： Marchand EL,Der Sarkissian S,Hamet P,deBlois D

更新日期：2003-04-18 00:00:00

abstract：:Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear str...

journal_title：Circulation research

authors： Lin T,Zeng L,Liu Y,DeFea K,Schwartz MA,Chien S,Shyy JY

更新日期：2003-06-27 00:00:00

abstract：:Dimethylarginie dimethylaminohydrolase (DDAH) degrades asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, and comprises 2 isoforms, DDAH1 and DDAH2. To investigate the in vivo role of DDAH2, we generated transgenic mice overexpressing DDAH2. The transgenic mice manifested reduction...

journal_title：Circulation research

authors： Hasegawa K,Wakino S,Tatematsu S,Yoshioka K,Homma K,Sugano N,Kimoto M,Hayashi K,Itoh H

更新日期：2007-07-20 00:00:00

abstract：:The epicardium, the tissue layer covering the cardiac muscle (myocardium), develops from the proepicardium, a mass of coelomic progenitors located at the venous pole of the embryonic heart. Proepicardium cells attach to and spread over the myocardium to form the primitive epicardial epithelium. The epicardium subseque...

journal_title：Circulation research

authors： Pérez-Pomares JM,de la Pompa JL

更新日期：2011-12-09 00:00:00

abstract：:Previously, we have reported on the selective accumulation of an atrial-like myosin light chain-1 (ALC1) in different forms of human ventricular hypertrophy. The present study involves the determination of ALC1 content in a control group and in patients with aortic stenosis or insufficiency before and 56 +/- 23 months...

journal_title：Circulation research

authors： Sütsch G,Brunner UT,von Schulthess C,Hirzel HO,Hess OM,Turina M,Krayenbuehl HP,Schaub MC

更新日期：1992-05-01 00:00:00

abstract：:Direct binding of apolipoprotein (apo)B-containing lipoproteins to proteoglycans is the initiating event in atherosclerosis, but the processes involved at later stages of development are unclear. Here, we investigated the importance of the apoB-proteoglycan interaction in the development of atherosclerosis over time a...

journal_title：Circulation research

authors： Gustafsson M,Levin M,Skålén K,Perman J,Fridén V,Jirholt P,Olofsson SO,Fazio S,Linton MF,Semenkovich CF,Olivecrona G,Borén J

更新日期：2007-10-12 00:00:00

abstract：:The present series of experiments used gas chromatography to identify vapor-phase photoproducts liberated during excimer laser irradiation of cardiovascular tissues in air and blood. In air, laser beams produced from ArF (193 nm) and XeF (351 nm) excimer laser gas mixtures were delivered to samples of myocardium and a...

journal_title：Circulation research

authors： Clarke RH,Isner JM,Donaldson RF,Jones G 2nd

更新日期：1987-03-01 00:00:00

abstract：:Recent evidence suggests that functional diversity of vascular smooth muscle is produced in part by a differential expression of ion channels. The aim of the present study was to examine the role of Ca(2+)-activated K(+) channels (K(Ca) channels) in the expression of smooth muscle cell functional phenotype. We found t...

journal_title：Circulation research

authors： Neylon CB,Lang RJ,Fu Y,Bobik A,Reinhart PH

更新日期：1999-10-29 00:00:00

abstract：:We have recently characterized the promoter region of the rabbit embryonic smooth muscle myosin heavy chain (SMemb/NMHC-B) gene and identified the 15-bp sequence, designated SE1, located at -105 from the transcriptional start site as an important regulatory element for its transcriptional activity in a smooth muscle c...

journal_title：Circulation research

authors： Watanabe N,Kurabayashi M,Shimomura Y,Kawai-Kowase K,Hoshino Y,Manabe I,Watanabe M,Aikawa M,Kuro-o M,Suzuki T,Yazaki Y,Nagai R

更新日期：1999-07-23 00:00:00

abstract：RATIONALE:Cardiac myosin-binding protein-C (cMyBP-C) phosphorylation at Ser-273, Ser-282, and Ser-302 regulates myocardial contractility. In vitro and in vivo experiments suggest the nonequivalence of these sites and the potential importance of Ser-282 phosphorylation in modulating the protein's overall phosphorylation...

journal_title：Circulation research

authors： Sadayappan S,Gulick J,Osinska H,Barefield D,Cuello F,Avkiran M,Lasko VM,Lorenz JN,Maillet M,Martin JL,Brown JH,Bers DM,Molkentin JD,James J,Robbins J

更新日期：2011-07-08 00:00:00

abstract：:Although estradiol (E(2)) has been recognized to exert several vasculoprotective effects in several species, its effects in mouse vasomotion are unknown, and consequently, so is the estrogen receptor subtype mediating these effects. We investigated the effect of E(2) (80 microg/kg/day for 15 days) on NO production in ...

journal_title：Circulation research

authors： Darblade B,Pendaries C,Krust A,Dupont S,Fouque MJ,Rami J,Chambon P,Bayard F,Arnal JF

更新日期：2002-03-08 00:00:00

abstract：RATIONALE:Myosin light chain (MLC) phosphorylation determines vascular contractile status. In addition to the classic Ca²⁺-dependent MLC kinase (MLCK), another unidentified kinase(s) also contributes to MLC phosphorylation in living cells. Inhibitor κB kinase 2 (IKK2)-deficient mouse embryonic fibroblasts demonstrate a...

journal_title：Circulation research

authors： Ying Z,do Carmo JM,Xiang L,da Silva AA,Chen M,Ryan MJ,Ostrowski M,Rajagopalan S,Hall JE

更新日期：2013-08-16 00:00:00