Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle Cell KCa channels.

abstract：RATIONALE:Molecular imaging is useful for longitudinal assessment of engraftment. However, it is not known which factors, other than cell number, can influence the molecular imaging signal obtained from reporter genes. OBJECTIVE:The effects of cell dissociation/suspension on cellular bioenergetics and the signal obtai...

journal_title：Circulation research

authors： Chang C,Chan A,Lin X,Higuchi T,Terrovitis J,Afzal JM,Rittenbach A,Sun D,Vakrou S,Woldemichael K,O'Rourke B,Wahl R,Pomper M,Tsui B,Abraham MR

更新日期：2013-02-01 00:00:00

abstract：:The arterial pressure of rabbits with chronic one-kidney hypertension can be lowered to normotensive levels by direct immunization with preparations made from the cortex of hog kidneys. Hypertensive rabbits that are immunized with large amounts of renin may develop high plasma antirenin titers without affecting their ...

journal_title：Circulation research

authors： Skeggs LT,Kahn JR,Levine M,Dorer FE,Lentz KE

更新日期：1976-09-01 00:00:00

abstract：:In 57 normal subjects (age 20-60 years), we analyzed the spontaneous beat-to-beat oscillation in R-R interval during control recumbent position, 90 degrees upright tilt, controlled respiration (n = 16) and acute (n = 10) and chronic (n = 12) beta-adrenergic receptor blockade. Automatic computer analysis provided the a...

journal_title：Circulation research

authors： Pagani M,Lombardi F,Guzzetti S,Rimoldi O,Furlan R,Pizzinelli P,Sandrone G,Malfatto G,Dell'Orto S,Piccaluga E

更新日期：1986-08-01 00:00:00

abstract：:[3H](+/-)Carazolol, a newly available beta-adrenergic receptor antagonist, can be used to characterize beta-adrenergic receptor subtypes present in membrane vesicles derived from canine ventricular myocardium and canine lung. [3H](+/-)Carazolol binding is saturable, of high affinity, and is displaceable by beta-adrene...

journal_title：Circulation research

authors： Manalan AS,Besch HR Jr,Watanabe AM

更新日期：1981-08-01 00:00:00

abstract：:The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore seems an att...

journal_title：Circulation research

authors： Duisters RF,Tijsen AJ,Schroen B,Leenders JJ,Lentink V,van der Made I,Herias V,van Leeuwen RE,Schellings MW,Barenbrug P,Maessen JG,Heymans S,Pinto YM,Creemers EE

更新日期：2009-01-30 00:00:00

abstract：:Focal ectopic activity in cardiac tissue is a key factor in the initiation and perpetuation of tachyarrhythmias. Because myofibroblasts as present in fibrotic remodeled myocardia and infarct scars depolarize cardiomyocytes by heterocellular electrotonic interactions via gap junctions in vitro, we investigated using st...

journal_title：Circulation research

authors： Miragoli M,Salvarani N,Rohr S

更新日期：2007-10-12 00:00:00

abstract：:The lung parenchyma as a tissue has a rather unusual stress-strain relationship. A theoretical derivation of this relationship is presented which connects the surface tension and the tissue elastic stress in the alveolar septa with the alveolar geometry. The mathematical expression contains a few meaningful physical c...

journal_title：Circulation research

authors： Fung YC

更新日期：1975-10-01 00:00:00

abstract：:The effects of two types of repeated transient coronary artery occlusions on collateral development were examined in chronically instrumented, conscious dogs. A 2-minute coronary occlusion at 32-minute intervals (group 1, n = 11) or a 15-second occlusion at 4-minute intervals (group 2, n = 7) were repeated day and nig...

journal_title：Circulation research

authors： Mohri M,Tomoike H,Noma M,Inoue T,Hisano K,Nakamura M

更新日期：1989-02-01 00:00:00

abstract：RATIONALE:In the myocardium, redox/cysteine modification of proteins regulating Ca(2+) cycling can affect contraction and may have therapeutic value. Nitroxyl (HNO), the one-electron-reduced form of nitric oxide, enhances cardiac function in a manner that suggests reversible cysteine modifications of the contractile ma...

journal_title：Circulation research

authors： Gao WD,Murray CI,Tian Y,Zhong X,DuMond JF,Shen X,Stanley BA,Foster DB,Wink DA,King SB,Van Eyk JE,Paolocci N

更新日期：2012-09-28 00:00:00

abstract：RATIONALE:Kawasaki disease (KD), an acute febrile vasculitis, is the most common cause of acquired heart disease in childhood; however, diagnosing KD can be difficult. OBJECTIVE:To identify unique proteomic biomarkers that can be used to facilitate earlier diagnosis of KD. METHODS AND RESULTS:We enrolled 214 children...

journal_title：Circulation research

authors： Ko TM,Kuo HC,Chang JS,Chen SP,Liu YM,Chen HW,Tsai FJ,Lee YC,Chen CH,Wu JY,Chen YT

更新日期：2015-02-27 00:00:00

abstract：:Fibrinopeptide A (FPA) levels were measured in a group of 130 controls and patients with various types of primary hyperlipidemia to investigate whether an increased steady state level of thrombin activity is present in hyperlipidemic patients. In a subset of 56 subjects, levels of clotting factors II, VII, and X were ...

journal_title：Circulation research

authors： Nossel HL,Smith FR,Seplowitz AH,Dell RB,Sciacca RR,Merskey C,Goodman DS

更新日期：1979-09-01 00:00:00

abstract：:Angiotensin II (Ang II) plays an important role in post-myocardial infarction (MI) remodeling. Most Ang II effects related to remodeling involve activation of the type 1 receptor (AT(1)). Although the AT(1) receptor is upregulated on cardiac fibroblasts post-MI, little is known about the mechanisms involved in the pro...

journal_title：Circulation research

authors： Gurantz D,Cowling RT,Villarreal FJ,Greenberg BH

更新日期：1999-08-06 00:00:00

abstract：:The study was performed to determine whether there is a structural vascular abnormality in normotensive subjects with hypertensive relatives. We examined maximal vasodilator capacity of forearm resistance vessels in 23 normotensive young men (mean blood pressure 94 +/- 0.4 mm Hg, mean +/- SE) with hypertensive relativ...

journal_title：Circulation research

authors： Takeshita A,Imaizumi T,Ashihara T,Yamamoto K,Hoka S,Nakamura M

更新日期：1982-05-01 00:00:00

abstract：:Because phospholemman (PLM) regulates the Na(+)/K(+) pump (NKA) and is a major cardiac phosphorylation target for both protein kinase A (at Ser68) and protein kinase C (PKC) (at both Ser63 and Ser68), we evaluated whether PLM mediates the PKC-dependent regulation of NKA function and protein kinase A/PKC crosstalk in v...

journal_title：Circulation research

authors： Han F,Bossuyt J,Despa S,Tucker AL,Bers DM

更新日期：2006-12-08 00:00:00

abstract：:Postnatal development of the mammalian heart is associated with changes in the population of isoforms of the thin filament proteins. We correlated the change in thin filament proteins, which occur in rabbit hearts between 5 days and 22 days of age, with changes in Ca2+ dependence of myofibrillar ATPase activity, force...

journal_title：Circulation research

authors： McAuliffe JJ,Gao LZ,Solaro RJ

更新日期：1990-05-01 00:00:00

abstract：:Glycerophosphate and carnitine as competing acyl acceptors and the oxidation of different long chain acylcarnitines in isolated mitochondria have been investigated. In the presence of low concentrations of palmitate, glycerophosphate is the preferred acyl acceptor in isolated liver mitochondria, indicating that the gl...

journal_title：Circulation research

authors： Borrebaek B,Christiansen R,Christophersen BO,Bremer J

更新日期：1976-05-01 00:00:00

abstract：:Increasing attention is currently devoted to the multiple roles that pericytes (also defined as mural, Rouget, or perivascular cells) may play during angiogenesis, vascular homeostasis, and pathology. Many recent excellent reviews thoroughly address these topics (see below); hence, we will not discuss them in detail h...

journal_title：Circulation research

authors： Cappellari O,Cossu G

更新日期：2013-07-19 00:00:00

abstract：:We examined whether albumin-derived advanced glycosylation end products (AGEs) downregulate the expression of endothelial nitric oxide synthase (NOS). Significant reductions in NOS activity and cGMP levels in bovine aortic endothelial cells were observed when exposed to different concentrations of albumin-derived AGEs...

journal_title：Circulation research

authors： Rojas A,Romay S,González D,Herrera B,Delgado R,Otero K

更新日期：2000-02-18 00:00:00

abstract：:The ionic currents that cross the myocardial membrane during cardiac activation have a corresponding return path in the extracellular space. The transmembrane current (Im) during activation of cardiac cells in situ has previously been envisioned only in mathematical models. We have developed a remarkably simple in viv...

journal_title：Circulation research

authors： Witkowski FX,Kavanagh KM,Penkoske PA,Plonsey R

更新日期：1993-02-01 00:00:00

abstract：:On endothelial cells, thrombin binds to thrombomodulin (TM), an integral membrane-bound glycoprotein, and to protease-activated receptors (PARs). Thrombin binding to TM modulates endothelial cell and smooth muscle cell proliferation mediated through PAR1. We studied the phosphorylation and nuclear translocation of ext...

journal_title：Circulation research

authors： Olivot JM,Estebanell E,Lafay M,Brohard B,Aiach M,Rendu F

更新日期：2001-04-13 00:00:00

abstract：:Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP. In the case of PDE2, this regulation primarily involves the allosteric st...

journal_title：Circulation research

authors： Zaccolo M,Movsesian MA

更新日期：2007-06-08 00:00:00

abstract：:Tyrosine kinase cascades may play a role in the hypoxic regulation of hypoxia-inducible factor (HIF)-1. We investigated the role of tyrosine kinase phosphorylation and of the Shc/Ras cascade on hypoxic HIF-1 stabilization. Exposure of human umbilical vein endothelial cells to hypoxia results in HIF protein stabilizati...

journal_title：Circulation research

authors： Jung F,Haendeler J,Hoffmann J,Reissner A,Dernbach E,Zeiher AM,Dimmeler S

更新日期：2002-07-12 00:00:00

abstract：:Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The mechanism of FTI increase was investigated using sinusoidal length perturbation analysis to compare crossbridge function in skinned left ventricular (LV) epicar...

journal_title：Circulation research

authors： Mulieri LA,Barnes W,Leavitt BJ,Ittleman FP,LeWinter MM,Alpert NR,Maughan DW

更新日期：2002-01-11 00:00:00

abstract：:In vivo studies of the rheological behavior of blood in the microcirculation were conducted by direct in situ measurements in cat mesentery. Upstream to downstream pressure drops were measured in unbranched arterioles, capillaries, and venules, with diameters from 7 to 58 micrometer. Simultaneous measurements of red c...

journal_title：Circulation research

authors： Lipowsky HH,Kovalcheck S,Zweifach BW

更新日期：1978-11-01 00:00:00

abstract：RATIONALE:Hydrogen peroxide (H(2)O(2)) serves as a key endothelium-derived hyperpolarizing factor mediating flow-induced dilation in human coronary arterioles (HCAs). The precise mechanisms by which H(2)O(2) elicits smooth muscle hyperpolarization are not well understood. An important mode of action of H(2)O(2) involve...

journal_title：Circulation research

authors： Zhang DX,Borbouse L,Gebremedhin D,Mendoza SA,Zinkevich NS,Li R,Gutterman DD

更新日期：2012-02-03 00:00:00

abstract：:The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by treatment with NO donors. In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six 4-minute coronary occlusion/4-minute reperfusion...

journal_title：Circulation research

authors： Takano H,Tang XL,Qiu Y,Guo Y,French BA,Bolli R

更新日期：1998-07-13 00:00:00

abstract：:Cardiac and arterial tissues of six male and six female adult baboons were examined for nuclear uptake of tritiated 5-alpha-dihydrotestosterone (3H-DHT) or tritiated estradiol-17 beta (3H-E2) by autoradiography. 3H-DHT uptake occurred in nuclei of most atrial and ventricular myocardial fibers, no cardiac interstitial ...

journal_title：Circulation research

authors： McGill HC Jr,Sheridan PJ

更新日期：1981-02-01 00:00:00

abstract：:E1A can evoke G1 exit in cardiac myocytes and other cell types by displacing E2F transcription factors from tumor suppressor "pocket" proteins and by a less well-characterized p300-dependent pathway. Bypassing pocket proteins (through overexpression of E2F-1) reproduces the effect of inactivating pocket proteins (thro...

journal_title：Circulation research

authors： Akli S,Zhan S,Abdellatif M,Schneider MD

更新日期：1999-08-20 00:00:00

abstract：:Inflammation is an important driver of atherosclerosis, the underlying pathology of cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is suggested to improve cardiovascular outcomes in patients with cardiovascular diseases. This concept was recently proven by CANTOS (Canakinumab Anti-I...

journal_title：Circulation research

authors： Grebe A,Hoss F,Latz E

更新日期：2018-06-08 00:00:00

abstract：:After cervical aortic nerve section, mean arterial pressure in the unanesthetized dog increased by an average of 7.4 mm Hg. Following a more extensive denervation of aortic arch receptors by section of intrathoracic vagal branches, arterial pressure increased by 16.7 mm Hg. The above changes were seen in the stable st...

journal_title：Circulation research

authors： Ito CS,Scher AM

更新日期：1979-07-01 00:00:00