Intravascular lymphomatosis of the skin as a manifestation of recurrent B-cell lymphoma.

Abstract:

:Intravascular lymphomatosis (IVL) is a rare type of lymphoma with a poor prognosis. Its distinctive clinical and histopathologic features are generated by the proliferation of neoplastic mononuclear cells within blood vessels. We describe a patient with IVL of the skin as a manifestation of a recurrent diffuse large B-cell lymphoma of ureteral origin. Lymphoma cells were located both within the vessels and the parenchyma in an early cutaneous lesion. After recurrence in the skin, lymphoma cells gradually located only in the vascular lumina. This transition suggests that cells localized within the vessels were selected as a consequence of chemotherapy. Immunohistochemical examination revealed that the expression of surface adhesion molecules of lymphoma cells did not significantly change. The results of polymerase chain reaction revealed that the ureteral and cutaneous tumors were identical in clonality. Our findings suggest that conventional diffuse large B-cell lymphoma can change into IVL.

journal_name

J Am Acad Dermatol

authors

Asagoe K,Fujimoto W,Yoshino T,Mannami T,Liu Y,Kanzaki H,Arata J

doi

10.1067/mjd.2003.112

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

S1-4

issue

2 Suppl

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(02)61516-6

journal_volume

48

pub_type

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