Comparison of detection of varicella-zoster virus by the Tzanck smear, direct immunofluorescence with a monoclonal antibody, and virus isolation.

Abstract:

:A study comparing direct immunofluorescence assay using a new monoclonal antibody specific for a varicella-zoster virus glycoprotein complex, the Tzanck smear, and virus isolation for detection of varicella-zoster virus in 56 patients with clinically apparent herpes zoster is presented. Of 47 patients with clinical herpes zoster and with cultures negative for herpes simplex virus, 30 (64%) had positive Tzanck smears, direct immunofluorescence assay results were positive in 26 (55%), and cultures were positive in only 12 (26%). Both direct immunofluorescence assay and the Tzanck smear were found to be superior to culture technics; however, direct immunofluorescence assay was found to have greater specificity.

journal_name

J Am Acad Dermatol

authors

Sadick NS,Swenson PD,Kaufman RL,Kaplan MH

doi

10.1016/s0190-9622(87)70172-8

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

64-9

issue

1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(87)70172-8

journal_volume

17

pub_type

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