当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors.

Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors.

Abstract：

BACKGROUND:Trichoadenoma is a rare benign follicular tumor first described by Nikolowski 50 years ago. Both trichoadenoma and desmoplastic trichoepithelioma are composed of cords of epithelial cells and cornifying cysts embedded in sclerotic stroma. In trichoadenoma the cystic component predominates, while desmoplastic trichoepithelioma is a mostly solid neoplasm. Therefore trichoadenoma was suggested to represent a cystic variant of desmoplastic trichoepithelioma. OBJECTIVE:The aim of this study was to investigate whether the morphologic overlap between trichoadenoma and desmoplastic trichoepithelioma translates into a similar immunohistochemical profile. METHODS:We studied 19 trichoadenomas and 21 desmoplastic trichoepitheliomas for cytokeratin 20, Ber-EP4, and androgen receptor expression. RESULTS:Eighteen of 19 trichoadenomas and all desmoplastic trichoepitheliomas demonstrated the presence of Merkel cells as detected by a monoclonal antibody against cytokeratin 20. In contrast, while all desmoplastic trichepitheliomas were positive for Ber-EP4, only 4 of 19 trichoadenomas showed any kind of reactivity for this marker. None of the trichoadenomas or desmoplastic trichoepitheliomas expressed androgen receptor. LIMITATIONS:This study is limited by the moderate number of these rare tumors available for immunohistochemical analysis. CONCLUSION:Our data demonstrate that trichoadenoma typically retains cytokeratin 20-positive Merkel cells but lacks Ber-EP4 and androgen receptor expression. Trichoadenoma is a distinct follicular tumor related but not identical to desmoplastic trichoepithelioma.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Shimanovich I,Krahl D,Rose C

doi

10.1016/j.jaad.2009.06.086

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

277-83

issue

2

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(09)00964-5

journal_volume

62

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY文献大全
  • Guidelines of care for acne vulgaris management.

    abstract：DISCLAIMER:Adherence to these guidelines will not ensure successful treatment in every situation. Furthermore, these guidelines should not be deemed inclusive of all proper methods of care or exclusive of other methods of care reasonably directed to obtaining the same results. The ultimate judgment regarding the propri...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2006.08.048

    authors： Strauss JS,Krowchuk DP,Leyden JJ,Lucky AW,Shalita AR,Siegfried EC,Thiboutot DM,Van Voorhees AS,Beutner KA,Sieck CK,Bhushan R,American Academy of Dermatology\/American Academy of Dermatology Association.

    更新日期：2007-04-01 00:00:00

  • Sunny days, healthy ways: evaluation of a skin cancer prevention curriculum for elementary school-aged children.

    abstract：BACKGROUND:Primary prevention of skin cancer must start early in life to reduce total life-time sun exposure and severe overexposure in childhood. Childhood is an excellent time to form life-long prevention habits. A school-based curriculum can be an effective prevention strategy. OBJECTIVE:Our purpose was to determin...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(96)90115-2

    authors： Buller DB,Buller MK,Beach B,Ertl G

    更新日期：1996-12-01 00:00:00

  • Propranolol treatment of infantile hemangioma (IH) is not associated with developmental risk or growth impairment at age 4 years.

    abstract：BACKGROUND:Long-term adverse effects of propranolol treatment for infantile hemangioma (IH) in young children have been suggested. OBJECTIVE:To compare growth and development in children treated with propranolol for IH with nontreated healthy controls. METHODS:Eighty two (73%) children with IH aged 43 to 51 months tr...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2016.02.1218

    authors： Moyakine AV,Kerstjens JM,Spillekom-van Koulil S,van der Vleuten CJ

    更新日期：2016-07-01 00:00:00

  • Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation.

    abstract：BACKGROUND:Although there is increased understanding of the alopecia areata (AA) pathogenesis based on studies in scalp tissues, little is known about its systemic profile. OBJECTIVE:To evaluate the blood proteomic signature of AA and determine biomarkers associated with increased disease severity. METHODS:In a cross...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2020.04.138

    authors： Glickman JW,Dubin C,Renert-Yuval Y,Dahabreh D,Kimmel GW,Auyeung K,Estrada YD,Singer G,Krueger JG,Pavel AB,Guttman-Yassky E

    更新日期：2021-02-01 00:00:00

  • The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia.

    abstract：BACKGROUND:It is generally believed that dihydrotestosterone is one of the pivotal mediators of hair loss in androgenetic alopecia (AGA). Finasteride, which blocks the conversion of testosterone to dihydrotestosterone, has now become an integral part of the current treatment approaches for male AGA. Several lines of ev...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/s0190-9622(03)00777-1

    authors： Tang L,Bernardo O,Bolduc C,Lui H,Madani S,Shapiro J

    更新日期：2003-08-01 00:00:00

  • Future considerations for clinical dermatology in the setting of 21st century American policy reform: The Medicare Access and Children's Health Insurance Program Reauthorization Act and Alternative Payment Models in dermatology.

    abstract：:With the introduction of the Medicare Access and Children's Health Insurance Program Reauthorization Act, clinicians who are not eligible for an exemption must choose to participate in 1 of 2 new reimbursement models: the Merit-based Incentive Payment System or Alternative Payment Models (APMs). Although most dermatol...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2017.01.031

    authors： Barbieri JS,Miller JJ,Nguyen HP,Forman HP,Bolognia JL,VanBeek MJ,Group for Research of Policy Dynamics in Dermatology.

    更新日期：2017-06-01 00:00:00

  • Pityriasis rubra pilaris and HIV infection.

    abstract：:Many cutaneous diseases have been reported in patients with human immunodeficiency virus infection. We report two patients with pityriasis rubra pilaris and human immunodeficiency virus infection. In one patient, the onset of pityriasis rubra pilaris preceded the discovery of human immunodeficiency virus infection. In...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(91)70106-c

    authors： Blauvelt A,Nahass GT,Pardo RJ,Kerdel FA

    更新日期：1991-05-01 00:00:00

  • Subcutaneous fat necrosis of the newborn with hypercalcemia.

    abstract：:A newborn infant with subcutaneous fat necrosis and hypercalcemia is presented. Literature on the association between subcutaneous fat necrosis of the newborn and hypercalcemia is reviewed. Affected infants generally experience severe perinatal difficulties. Both vaginal deliveries and cesarean sections can be associa...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(87)70056-5

    authors： Norwood-Galloway A,Lebwohl M,Phelps RG,Raucher H

    更新日期：1987-02-01 00:00:00

  • Clinical effect of imiquimod 5% cream in the treatment of actinic keratosis.

    abstract：BACKGROUND:Actinic keratosis (AK) is the earliest clinical manifestation of squamous cell carcinoma. Metastatic SCC causes the majority of the 1300 to 2300 deaths attributed to nonmelanoma skin cancer in the United States each year. Recent studies have shown that intralesional administration of interferon can be used s...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 临床试验,杂志文章

    doi：10.1067/mjd.2002.123492

    authors： Persaud AN,Shamuelova E,Sherer D,Lou W,Singer G,Cervera C,Lamba S,Lebwohl MG

    更新日期：2002-10-01 00:00:00

  • Eyelid dermatitis: experience in 203 cases.

    abstract：:Allergic contact dermatitis has been considered the most common of the many dermatologic conditions found with eyelid dermatitis. This is a retrospective study of 203 patients who presented with persistent or recurrent eyelid dermatitis with or without dermatitis elsewhere. Almost all underwent patch testing and, when...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2002.122736

    authors： Guin JD

    更新日期：2002-11-01 00:00:00

  • Definitions and outcome measures for bullous pemphigoid: recommendations by an international panel of experts.

    abstract：:Our scientific knowledge of bullous pemphigoid (BP) has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in BP. A major obstacle in sha...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 共识发展会议,杂志文章

    doi：10.1016/j.jaad.2011.06.032

    authors： Murrell DF,Daniel BS,Joly P,Borradori L,Amagai M,Hashimoto T,Caux F,Marinovic B,Sinha AA,Hertl M,Bernard P,Sirois D,Cianchini G,Fairley JA,Jonkman MF,Pandya AG,Rubenstein D,Zillikens D,Payne AS,Woodley D,Zambruno

    更新日期：2012-03-01 00:00:00

  • The spectrum of cutaneous disease in multiple myeloma.

    abstract：BACKGROUND:Multiple myeloma (MM) is a plasma cell dyscrasia characterized by a clonal proliferation of plasma cells that produces a monoclonal protein. There are dermatologic disorders that have been associated with MM, such as amyloidosis, cryoglobulinemia, POEMS syndrome, normolipemic plane xanthoma, and plasmacytoma...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2003.180

    authors： Bayer-Garner IB,Smoller BR

    更新日期：2003-04-01 00:00:00

  • Indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas.

    abstract：BACKGROUND:The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan, and this degradation is an immunosuppressive mechanism that is mainly used by antigen-presenting cells. IDO-expressing dendritic cells and macrophages have previously been identified as components of lymph node granulo...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2010.07.050

    authors： von Bubnoff D,Scheler M,Wilms H,Wenzel J,von Bubnoff N,Häcker G,Schultze J,Popov A,Racz P,Bieber T,Wickenhauser C

    更新日期：2011-10-01 00:00:00

  • Pathogenesis of papular urticaria.

    abstract：:The presence of immunoglobulin and complement deposits in the skin of three patients with papular urticaria suggests that these lesions may be due to a cutaneous vasculitis. These deposits were most frequently found in biopsy specimens taken from lesions within 24 hours of their development. The presence of granular d...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(84)80330-8

    authors： Heng MC,Kloss SG,Haberfelde GC

    更新日期：1984-06-01 00:00:00

  • Histologic and clinical cross-sectional study of chronic hair loss in patients with cutaneous chronic graft-versus-host disease.

    abstract：BACKGROUND:While scalp alopecia represents a distinctive feature of chronic graft-versus-host disease (cGVHD), little is known about the clinical and histologic presentation of hair loss. OBJECTIVES:We sought to classify the clinical presentations and histologic findings of chronic hair loss in patients with cutaneous...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2019.03.031

    authors： Marks DH,Naftulin JS,Penzi LR,Manatis-Lornell A,Yasuda MR,Chapman CM,Rao SR,Saavedra A,Senna MM

    更新日期：2019-11-01 00:00:00

  • WITHDRAWN: Hepatitis B Reactivation in Patients On Biologics: A perfect storm.

    abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, https://doi.org/10.1016/j.jaad.2020.09.006. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2020.09.014

    authors： Elston DM

    更新日期：2020-09-14 00:00:00

  • Aphthous ulcers associated with imiquimod and the treatment of actinic cheilitis.

    abstract：:Our case series report is the first documented depiction of the appearance of aphthous ulcers secondary to imiquimod application. This case series presentation discusses the underlying pathophysiology of aphthous ulcer development and imiquimod therapy in terms of the stimulation of proinflammatory cytokines, such as ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2004.06.045

    authors： Chakrabarty AK,Mraz S,Geisse JK,Anderson NJ

    更新日期：2005-02-01 00:00:00

  • Treatment of blue nevi with the Q-switched ruby laser.

    abstract：:The common blue nevus is a benign, localized collection of dermal melanocytes. To date, removal required excisional surgery to eliminate pigment that usually extends into the reticular dermis. We report the successful long-term elimination of common blue nevi on the nasal skin of two patients whose lesions were treate...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(95)90392-5

    authors： Milgraum SS,Cohen ME,Auletta MJ

    更新日期：1995-02-01 00:00:00

  • Mohs micrographic surgery for eyelid sebaceous carcinoma: A multicenter cohort of 360 patients.

    abstract：BACKGROUND:The decision to perform Mohs micrographic surgery (MMS) or wide local excision (WLE) for eyelid sebaceous carcinoma (SC) is controversial. OBJECTIVE:To compare local recurrence, metastasis, and tumor-related mortality of patients with eyelid SC who were initially treated with MMS versus with WLE. METHODS:A...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jaad.2018.12.053

    authors： Zhou C,Wu F,Chai P,Shi Y,Ye J,Shi X,Tan J,Ding Y,Luo Y,Esmaeli B,Jia R,Fan X

    更新日期：2019-06-01 00:00:00

  • The occurrence of atopic dermatitis in north Europe: an international questionnaire study.

    abstract：BACKGROUND:Atopic dermatitis is a common multifactorial disease that seems to be increasing in frequency. OBJECTIVE:Our purpose was to determine the increased prevalence of atopic dermatitis in North Europe. METHODS:Approximately 3000 7-year-old children in Denmark, Germany, and Sweden were enrolled in a cross-sectio...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(96)90009-2

    authors： Schultz Larsen F,Diepgen T,Svensson A

    更新日期：1996-05-01 00:00:00

  • Unplanned incomplete Mohs micrographic surgery.

    abstract：BACKGROUND:Incomplete Mohs micrographic surgery (MMS) is the cessation of MMS while the tumor margins are known to be still positive. OBJECTIVE:Our purpose was to examine the factors behind unplanned incomplete MMS and to identify means of avoiding and managing this situation when it arises. METHODS:We performed a re...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2000.104889

    authors： Madani S,Huilgol SC,Carruthers A

    更新日期：2000-05-01 00:00:00

  • Severe and refractory solar urticaria treated with intravenous immunoglobulins: a phase II multicenter study.

    abstract：BACKGROUND:Retrospective data have suggested the effectiveness of intravenous immunoglobulins (IVIG) for solar urticaria (SU). OBJECTIVE:We sought to prospectively assess the efficacy of IVIG for SU. METHODS:We conducted a multicentric phase II study to test the efficacy of a single course of IVIG (2 g/kg) in patient...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jaad.2014.07.023

    authors： Aubin F,Porcher R,Jeanmougin M,Léonard F,Bedane C,Moreau A,Schmutz JL,Marguery MC,Adamski H,Viguier M,Société Française de Photodermatologie.

    更新日期：2014-11-01 00:00:00

  • Assessing students' ability to detect melanomas using standardized patients and moulage.

    abstract：BACKGROUND:Detection of melanoma by physicians via opportunistic surveillance during focused physical examinations may reduce mortality. Medical students may not encounter a clinical case of melanoma during a dermatology clerkship. OBJECTIVE:This study examined the proficiency of fourth-year University of Illinois at ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2011.10.032

    authors： Hernandez C,Mermelstein R,Robinson JK,Yudkowsky R

    更新日期：2013-03-01 00:00:00

  • Intravenous cidofovir-induced resolution of disfiguring cutaneous human papillomavirus infection.

    abstract：:Human papillomavirus infection is one of the most common and most distressing cutaneous diseases in patients with HIV infection. It is also a common, and often therapeutically challenging, infection in individuals who are immunologically competent. A wide range of therapeutic options exists for treating cutaneous huma...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2006.01.007

    authors： Kottke MD,Parker SR

    更新日期：2006-09-01 00:00:00

  • Granuloma annulare arising in herpes zoster scars. Report of two cases and review of the literature.

    abstract：:We present two patients who developed granuloma annulare in the scars from previous herpes zoster. The development of granuloma annulare in herpes zoster scars may represent an atypical delayed hypersensitivity immune reaction to herpes zoster/varicella virus antigen(s) or a tissue antigen altered by the virus. ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(86)70091-1

    authors： Friedman SJ,Fox BJ,Albert HL

    更新日期：1986-05-01 00:00:00

  • Pruritus as a presenting sign of acquired immunodeficiency syndrome.

    abstract：:A 65-year-old man with insulin-dependent diabetes developed intractable pruritus preceding weight loss and increasing fatiguability. Esophagogastroduodenoscopy revealed infection with Candida, cytomegalovirus, and Cryptosporidium. His T cell helper/suppressor ratio was inverted, and the serum human immunodeficiency vi...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(87)70145-5

    authors： Shapiro RS,Samorodin C,Hood AF

    更新日期：1987-05-01 00:00:00

  • An analysis of reports of depression and suicide in patients treated with isotretinoin.

    abstract：BACKGROUND:The Food and Drug Administration (FDA) has received reports of depression and suicide in patients treated with isotretinoin. OBJECTIVE:Our purpose was to provide the number and describe the cases of depression and suicide reported to the FDA in US patients treated with isotretinoin and to consider the natur...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2001.117730

    authors： Wysowski DK,Pitts M,Beitz J

    更新日期：2001-10-01 00:00:00

  • Neonatal bullous eruption as a result of transient porphyrinemia in a premature infant with hemolytic disease of the newborn.

    abstract：:We describe the clinical and biochemical features of an infant with marked transient porphyrinemia in whom blistering developed while the infant was undergoing phototherapy for severe Rh isoimmunization. The cause of the transient porphyrinemia was likely to be multifactorial--abnormal porphyrin metabolism or accumula...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(95)91428-5

    authors： Mallon E,Wojnarowska F,Hope P,Elder G

    更新日期：1995-08-01 00:00:00

  • Skin DNA photodamage and its biological consequences.

    abstract：:It is well established that ultraviolet (UV) radiation from sunlight damages skin cells' DNA. Wavelengths in the UVB range are absorbed by DNA and can induce mutagenic lesions such as pyrimidine dimers. On the other hand, genotoxic effects of solar UVA are mainly mediated by the activation of endogenous photosensitize...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2007.12.007

    authors： Marrot L,Meunier JR

    更新日期：2008-05-01 00:00:00

  • The role of wide local excision for the treatment of severe hidradenitis suppurativa (Hurley grade III): Retrospective analysis of 74 patients.

    abstract：BACKGROUND:Effective medical treatment for patients with severe hidradenitis suppurativa (HS) is limited. OBJECTIVES:We sought to measure the impact of wide local excision on quality of life in HS Hurley grade III patients and to examine the rate of postoperative complications, disease recurrences, and satisfaction wi...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2017.01.055

    authors： Posch C,Monshi B,Quint T,Vujic I,Lilgenau N,Rappersberger K

    更新日期：2017-07-01 00:00:00