Abstract:
:Growth of Staphylococcus aureus in the presence of salicylate leads to reduced ciprofloxacin and ethidium accumulation and increased resistance to ethidium. Salicylate induced reduction in ciprofloxacin accumulation is energy-independent while salicylate induced alterations in ethidium accumulation and efflux is proton motive force-dependent. NorA is an intrinsic multidrug efflux pump that contributes to intrinsic levels of fluoroquinolone and ethidium resistance in S. aureus. The NorA inhibitor reserpine did not dramatically affect the ability of salicylate to induce increased ciprofloxacin and ethidium resistance. Inactivation of norA did not alter the ability of salicylate to induce increased ciprofloxacin and ethidium resistance levels and a reduction in ciprofloxacin accumulation. These data demonstrate that NorA is not absolutely required for the salicylate-inducible multidrug resistance mechanism of S. aureus.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Price CT,Kaatz GW,Gustafson JEdoi
10.1016/s0924-8579(02)00162-0subject
Has Abstractpub_date
2002-09-01 00:00:00pages
206-13issue
3eissn
0924-8579issn
1872-7913pii
S0924857902001620journal_volume
20pub_type
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journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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pub_type: 杂志文章
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journal_title:International journal of antimicrobial agents
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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