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Susceptibility and resistance genes to fluoroquinolones in methicillin-resistant Staphylococcus aureus isolated in 2002.

Abstract：

:The activity of six fluoroquinolones (FQs) was determined against 100 methicillin-resistant Staphylococcus aureus (MRSA) isolated in 2002 along with mutations in the grlA and gyrA genes and in the norA promoter of these isolates. Of the isolates tested, 97% had mutations in grlA and gyrA. A single mutation in grlA and gyrA resulted in a decrease of susceptibility to old generation FQs (norfloxacin, enoxacin, ciprofloxacin, fleroxacin, sparfloxacin and levofloxacin) but not to new generation FQs (gatifloxacin and moxifloxacin). Double mutations of both grlA and gyrA resulted in high-level resistance to all FQs tested. All norA mutants (15%) contained double mutations in grlA and gyrA and showed no decrease of MIC in the presence of reserpine, which is known to inhibit the drug-efflux pump. Our results showed that double mutations in grlA and gyrA were necessary for the expression of high-level resistance to new generation FQs. As different FQ-resistant mutants occur in the same PFGE type, FQ-resistant MRSA may well develop individually.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Noguchi N,Okihara T,Namiki Y,Kumaki Y,Yamanaka Y,Koyama M,Wakasugi K,Sasatsu M

doi

10.1016/j.ijantimicag.2004.11.016

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

374-9

issue

5

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(05)00032-4

journal_volume

25

pub_type

杂志文章

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