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Do antibacterial and antifungal combinations have better activity against clinically relevant fusarium species? in vitro synergism.

Abstract：

:The aim of this study was to evaluate the susceptibility of 20 clinical isolates of Fusarium spp. to classic antifungals [amphotericin B (AmB), itraconazole (ITR), voriconazole (VRC) and caspofungin (CAS)] and to non-antifungal agents [amiodarone (AMD), doxycycline (DOX) and moxifloxacin (MFX)] by the broth microdilution method. Combinations between these antifungal and non-antifungal agents were also evaluated to determine the fractional inhibitory concentration indices using the chequerboard technique. Synergistic interactions were observed for the following combinations (% synergism): AMD + VRC, 80%; MFX + AmB, 75%; AMD + AmB, 65%; DOX + VRC, 60%; MFX + VRC, 55%; DOX + AmB, 50%; and AMD + CAS, 30%. Synergism was not observed for associations with ITR. Antagonism was not seen in any combination. These findings suggest that the combinations of AMD, DOX or MFX with AmB or VRC to have potential for future in vivo investigations.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Venturini TP,Al-Hatmi AMS,Rossato L,Azevedo MI,Keller JT,Weiblen C,Santurio JM,Alves SH

doi

10.1016/j.ijantimicag.2017.10.017

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

784-788

issue

5

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(17)30390-4

journal_volume

51

pub_type

杂志文章

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