当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > In vitro activities of beta-lactam antibiotics alone and in combination with sulbactam against Gram-negative bacteria.

In vitro activities of beta-lactam antibiotics alone and in combination with sulbactam against Gram-negative bacteria.

Abstract：

:The resistance rates of ampicillin/sulbactam 2:1 against imipenem-susceptible and -resistant Acinetobacter baumannii were 23.5 and 30%, respectively. Ceftazidime/sulbactam combination showed significant reduction of resistant rates against Enterobacter cloacae, A. baumannii, ESBL Klebsiella pneumoniae. MIC90 of cefoperazone against E. cloacae, Serratia marcescens, A. baumannii and ESBL K. pneumoniae were > 128 mg/l. Addition of sulbactam enhanced the antimicrobial activities significantly. When imipenem was combined with sulbactam, the resistant rates against imipenem-resistant A. baumanni were significantly reduced. Cefepime/sulbactam combination was active against imipenem-resistant A. baumanni. The resistance rates of aztreonam/sulbactam combination against E. cloacae, imipenem-sensitive and resistant A. baumannii, ESBL K. pneumoniae were lowered significantly. The cefotaxime/sulbactam combination showed a significant improvement of activities against E. cloacae, S. marcescens, A. baumannii and ESBL K. pneumoniae.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Wang FD,Lin ML,Lee WS,Liu CY

doi

10.1016/j.ijantimicag.2003.10.008

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

590-5

issue

6

eissn

0924-8579

issn

1872-7913

pii

S0924857904000688

journal_volume

23

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Comparison of minocycline and azithromycin for the treatment of mild scrub typhus in northern China.

    abstract：:Scrub typhus, caused by Orientia tsutsugamushi, has recently emerged in northern China where the disease had not been known to exist. Although doxycycline and azithromycin are the recommended agents for the treatment of scrub typhus, clinical responses depend both on the susceptibilities of various O. tsutsugamushi st...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.05.019

    authors： Zhao M,Wang T,Yuan X,Du W,Lin M,Shen Y

    更新日期：2016-09-01 00:00:00

  • Outpatient parenteral antibiotic therapy (OPAT) in different countries: a comparison.

    abstract：:In order to assess how outpatient parenteral antibiotic therapy (OPAT) is managed in different countries, we analyzed the data collected in the USA, UK and Italy by the International OPAT Registry using an ad hoc Access/Excel Microsoft program. The analysis of data concerned 9826 patients in the USA, 981 in the UK and...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.06.004

    authors： Esposito S,Noviello S,Leone S,Tice A,Seibold G,Nathwani D,Scaglione F,International OPAT Registry.

    更新日期：2004-11-01 00:00:00

  • Colistin use and colistin resistance in bacteria from animals.

    abstract：:Colistin has been used in veterinary medicine for decades, mainly for the prevention and treatment of Enterobacteriaceae infections. However, data regarding colistin resistance in bacteria from animals and food of animal origin are relatively scarce, partly because there are methodological difficulties hampering the a...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2016.09.016

    authors： Kempf I,Jouy E,Chauvin C

    更新日期：2016-12-01 00:00:00

  • Relationship between susceptibility to antimicrobials and virulence factors in paediatric Escherichia coli isolates.

    abstract：:The in vitro susceptibilities to several antibiotics of 136 Escherichia coli strains containing virulence factors isolated from children with urinary tract infection were analysed. Escherichia coli strains were analysed by multiplex polymerase chain reaction for genes encoding the following virulence factors: pyelonep...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2007.07.030

    authors： Arisoy M,Rad AY,Akin A,Akar N

    更新日期：2008-02-01 00:00:00

  • Characterisation of extended-spectrum β-lactamase/plasmid AmpC-β-lactamase-producing Escherichia coli isolates from long-term recurrent bloodstream infections.

    abstract：:The aim of this study was to investigate recurrent infections in individual patients caused by extended-spectrum β-lactamase and plasmid AmpC β-lactamase-producing Escherichia coli (ESBL/pAmpC-Ec) isolates with >12-month interval. The Danish national collection of ESBL/pAmpC-Ec isolates collected from January 2014 thr...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.106041

    authors： Roer L,Hansen F,Hasman H,Hammerum AM,Cavaco LM

    更新日期：2020-07-01 00:00:00

  • Prophylaxis, pre-emptive or empirical antifungal therapy: which is best in non-lung transplant recipients?

    abstract：:Renal, liver, heart and lung transplantation are now considered to be the standard therapeutic interventions in patients with end-stage organ failure. Infectious complications following solid organ transplantation (SOT) are relatively common owing to the transplant recipient's overall immunosuppressed status. The inci...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(08)70017-7

    authors： Salavert M

    更新日期：2008-11-01 00:00:00

  • Evaluation of the activity of fusidic acid tested against contemporary Gram-positive clinical isolates from the USA and Canada.

    abstract：:We evaluated the antimicrobial activity of fusidic acid (CEM-102) against 1140 clinical strains of Gram-positive bacteria obtained from patients with bacteraemia or skin and skin-structure infections collected in more than 30 medical centres in the USA and Canada over a 10-year period (1997-2006). Fusidic acid was ver...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2009.10.023

    authors： Pfaller MA,Castanheira M,Sader HS,Jones RN

    更新日期：2010-03-01 00:00:00

  • Chemosensitisation of drug-resistant and drug-sensitive yeast cells to antifungals.

    abstract：:Multidrug resistance in yeast results from overexpression of genes encoding drug efflux transporters owing to gain-of-function mutations in transcription factors regulating their expression. We have screened a library of synthetic compounds for modulators of drug resistance using the multidrug-resistant Saccharomyces ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.08.037

    authors： Cernicka J,Kozovska Z,Hnatova M,Valachovic M,Hapala I,Riedl Z,Hajós G,Subik J

    更新日期：2007-02-01 00:00:00

  • Role of piperacillin/tazobactam as a carbapenem-sparing antibiotic for treatment of acute pyelonephritis due to extended-spectrum β-lactamase-producing Escherichia coli.

    abstract：:Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a frequent cause of acute pyelonephritis (APN), requiring carbapenem therapy. However, alternatives to carbapenems are needed due to the emergence of carbapenemase-producing micro-organisms. The purpose of this study was to compare the clinical effi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.12.017

    authors： Yoon YK,Kim JH,Sohn JW,Yang KS,Kim MJ

    更新日期：2017-04-01 00:00:00

  • Use of whole-genome sequencing data to analyze 23S rRNA-mediated azithromycin resistance.

    abstract：:The whole-genome sequences of 24 isolates of Neisseria gonorrhoeae with elevated minimum inhibitory concentrations (MICs) to azithromycin (≥2.0 µg/mL) were analyzed against a modified sequence derived from the whole-genome sequence of N. gonorrhoeae FA1090 to determine, by signal ratio, the number of mutant copies of ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.10.023

    authors： Johnson SR,Grad Y,Abrams AJ,Pettus K,Trees DL

    更新日期：2017-02-01 00:00:00

  • Mutations in transcription factor Mrr2p contribute to fluconazole resistance in clinical isolates of Candida albicans.

    abstract：:The Candida albicans zinc cluster proteins are a family of transcription factors (TFs) that play essential roles in the development of antifungal drug resistance. Gain-of-function mutations in several TFs, such as Tac1p, Mrr1p and Upc2p, have been previously well documented in azole-resistant clinical C. albicans isol...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.08.001

    authors： Wang Y,Liu JY,Shi C,Li WJ,Zhao Y,Yan L,Xiang MJ

    更新日期：2015-11-01 00:00:00

  • Non-fermentative Gram-negative bacteria.

    abstract：:Over the past decade, non-fermenting Gram-negative bacteria have emerged as important opportunistic pathogens in the increasing population of patients who are immunocompromised by their disease or medical treatment. These bacteria are assisted by their ubiquitous distribution in the environment and have a propensity f...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(07)72176-3

    authors： Enoch DA,Birkett CI,Ludlam HA

    更新日期：2007-05-01 00:00:00

  • Transcriptional profiling of the two-component regulatory system VraSR in Staphylococcus aureus with low-level vancomycin resistance.

    abstract：:The objective of this study was to comprehensively identify the target genes regulated by the two-component regulatory system VraSR in Staphylococcus aureus and to clarify the role of VraSR in low-level vancomycin resistance. Expression of vraS was determined by real-time quantitative reverse transcriptase PCR (qRT-PC...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.02.003

    authors： Chen H,Xiong Z,Liu K,Li S,Wang R,Wang X,Zhang Y,Wang H

    更新日期：2016-05-01 00:00:00

  • Genetic characterisation of drug resistance and clonal dynamics of Acinetobacter baumannii in a hospital setting in Mexico.

    abstract：:The aim of this study was to determine the clinical characteristics, molecular epidemiology and biofilm production of Acinetobacter baumannii clinical isolates obtained from a tertiary-care hospital in Mexico. Clinical isolates of A. baumannii (n=152) isolated from 2007 to 2012 were included. Clonal diversity was anal...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2014.10.022

    authors： Bocanegra-Ibarias P,Peña-López C,Camacho-Ortiz A,Llaca-Díaz J,Silva-Sánchez J,Barrios H,Garza-Ramos U,Rodríguez-Flores AM,Garza-González E

    更新日期：2015-03-01 00:00:00

  • Bacterial agents of lower respiratory tract infections (LRTIs), beta-lactamase production, and resistance to antibiotics in elderly people. DEDALO Study Group.

    abstract：:This study determined the etiology of lower respiratory tract infections in the elderly and assessed whether the growth of beta-lactamase producing bacteria is particularly favoured in these patients. Between December 1998 and May 1999, 187 patients with community-acquired pneumonia (CAP), and 887 patients with acute ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00277-6

    authors： Sanguinetti CM,De Benedetto F,Miragliotta G

    更新日期：2000-12-01 00:00:00

  • Sepsis redefined: the search for surrogate markers.

    abstract：:Sepsis is a common and severe medical condition with substantial associated morbidity, mortality and cost. Furthermore, the incidence of sepsis has been rising annually over the past three decades, and morbidity and mortality remain high. The management of sepsis is further complicated by its very heterogeneous nature...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/S0924-8579(09)70560-6

    authors： Tsalik EL,Woods CW

    更新日期：2009-01-01 00:00:00

  • Formula to help select rational antimicrobial therapy (FRAT): its application to community- and hospital-acquired urinary tract infections.

    abstract：:The selection of antimicrobial agents is guided by the use of formularies which often constrain prescribing options. There are several factors which influence the inclusion of specific agents. Two of the most important factors are microbial etiology of a disease and the incidence of antibiotic resistance. Various surv...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(98)00107-1

    authors： Blondeau JM,Tillotson GS

    更新日期：1999-07-01 00:00:00

  • Steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in hospitalised patients.

    abstract：:The objective of this study was to evaluate the steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in hospitalised patients requiring antimicrobial therapy. Nine patients received 1g every 8h (q8h), infused over 4h, and steady-state pharmacokinetic parameters were determi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2010.08.016

    authors： Cheatham SC,Shea KM,Healy DP,Humphrey ML,Fleming MR,Wack MF,Smith DW,Sowinski KM,Kays MB

    更新日期：2011-01-01 00:00:00

  • Sequences of a co-existing SXT element, a chromosomal integron (CI) and an IncA/C plasmid and their roles in multidrug resistance in a Vibrio cholerae O1 El Tor strain.

    abstract：:The ongoing seventh cholera pandemic is attributed to Vibrio cholerae O1 El Tor biotype strains. Although antibiotic therapy ameliorates symptoms in patients and reduces pathogen transfer to the environment, multidrug resistance remains a major clinical threat. An O1 El Tor strain isolated from a patient in 1998 was i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.05.020

    authors： Wang R,Li J,Kan B

    更新日期：2016-09-01 00:00:00

  • Nosocomial pneumonia: importance of recognition of aetiological agents to define an appropriate initial empirical therapy.

    abstract：:Of the 16,024 patients hospitalized from January 1995 to October 1997, 397 (2.4%) acquired nosocomial pneumonia and the aetiological agent was defined in 101 (25%). About 82% developed late onset pneumonia (>7 days of hospitalization). The site of isolation of microorganisms was bronchoalveolar lavage (BAL) (49%), blo...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00316-2

    authors： Costa SF,Newbaer M,Santos CR,Basso M,Soares I,Levin AS

    更新日期：2001-02-01 00:00:00

  • The safety of azithromycin in the treatment of adults with community-acquired respiratory tract infections.

    abstract：:The comparative safety of azithromycin was assessed in adult patients (> or =12 years) with community-acquired respiratory tract infections. Of 3229 patients evaluated, 1616 received azithromycin 500 mg once daily for 3 days and 1613 received standard regimens of amoxycillin, amoxycillin/clavulanic acid, cefaclor, cla...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00490-3

    authors： Treadway G,Pontani D,Reisman A

    更新日期：2002-03-01 00:00:00

  • Use of Etests with carbapenems for Gram-negative rods producing beta-lactamases.

    abstract：:The in vitro activity of imipenem and meropenem on strains of Gram-negative rods producing extended-spectrum beta-lactamase (ESBL) and inducible beta-lactamase (IBL) was studied using the Etest. In all, 185 strains from the surgical intensive care units of four different hospitals were looked at over 2 years. Of these...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00487-3

    authors： Kocazeybek BS,Arabaci U

    更新日期：2002-02-01 00:00:00

  • Hot topics in the diagnosis and management of skin and soft-tissue infections.

    abstract：:Eighteen hot topics regarding the diagnosis and management of skin and soft-tissue infections (SSTIs) were selected and reviewed by members of the SSTI Working Group of the International Society of Chemotherapy (ISC). Despite the large amount of literature available on the issue selected, there are still many unknowns...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2016.04.011

    authors： Esposito S,Bassetti M,Bonnet E,Bouza E,Chan M,De Simone G,Dryden M,Gould I,Lye DC,Saeed K,Segreti J,Unal S,Yalcin AN,International Society of Chemotherapy (ISC).

    更新日期：2016-07-01 00:00:00

  • In vitro activity of older and newer fluoroquinolones against efflux-mediated high-level ciprofloxacin-resistant Streptococcus pneumoniae.

    abstract：:The effect of high-level efflux activity on the MICs of fluoroquinolones against Streptococcus pneumoniae in the absence of topoisomerase mutations leading to fluoroquinolones resistance was investigated. A S. pneumoniae ATCC 46619-derived strain with high-level efflux activity was obtained (SP-25A). Both the parent a...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.01.012

    authors： Daporta MT,Muñoz Bellido JL,Guirao GY,Hernández MS,García-Rodríguez JA

    更新日期：2004-08-01 00:00:00

  • Antimicrobial activities of LCB10-0200, a novel siderophore cephalosporin, against the clinical isolates of Pseudomonas aeruginosa and other pathogens.

    abstract：:Infections caused by multidrug-resistant bacteria, including Pseudomonas aeruginosa, are threatening public health worldwide. Therefore, a novel antibacterial agent is needed to treat these infections. Here, we investigated the in vitro and in vivo activities of a novel siderophore-conjugated cephalosporin, LCB10-0200...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.06.001

    authors： Oh SH,Park HS,Kim HS,Yun JY,Oh K,Cho YL,Kwak JH

    更新日期：2017-12-01 00:00:00

  • Potentially multidrug-resistant non-fermentative Gram-negative pathogens causing nosocomial pneumonia.

    abstract：:Owing to its high morbidity and mortality, nosocomial pneumonia represents a particularly serious illness and one of the most frequent complications in ventilated patients admitted to the Intensive Care Unit. Gram-negative microorganisms, such as Pseudomonas aeruginosa, Acinetobacter baumannii and Stenotrophomonas mal...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2005.11.005

    authors： Ferrara AM

    更新日期：2006-03-01 00:00:00

  • Time-kill curves as a tool for targeting ceftazidime serum concentration during continuous infusion for treatment of septicaemic melioidosis.

    abstract：:Melioidosis is a fatal community-acquired infection endemic in tropical areas. Ten isolates of the causative microorganism were subjected to time-kill study using a range of ceftazidime concentrations. This study demonstrated that a ceftazidime concentration of eight times the minimum inhibitory concentration yielded ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2005.07.016

    authors： Soontornpas C,Saraya S,Chulasiri M,Chindavijak B,Mootsikapun P

    更新日期：2005-11-01 00:00:00

  • The burden of invasive pneumococcal disease and the potential for reduction by immunisation.

    abstract：:Streptococcus pneumoniae causes invasive disease world-wide and in all age groups. The reported incidence varies geographically and is increased in certain population groups. The incidence is highest in children less than 2 years and is also increased in the elderly. Mortality remains substantial even in the developed...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(01)00491-5

    authors： Parsons HK,Dockrell DH

    更新日期：2002-02-01 00:00:00

  • Sulbactam in combination with mezlocillin, piperacillin or cefotaxime: clinical and bacteriological findings in the treatment of serious bacterial infections.

    abstract：:An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections. A total of 155 patients were recruited into the study, of whom 48 were suffe...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：

    authors： Manncke K,Springsklee M,Heizmann WR,Sonntag HG

    更新日期：1996-04-01 00:00:00

  • Activity of the ketolide telithromycin (HMR-3647) against erythromycin-susceptible and -resistant pneumococci isolated in the UK.

    abstract：:The novel ketolide telithromycin (formerly HMR-3647) was tested against a collection of pneumococci of varying sensitivity to erythromycin and clindamycin, isolated in geographically diverse UK hospitals. Telithromycin was highly active against erythromycin-susceptible pneumococci, the MIC(90) being 0.015 mg/l. Erythr...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00346-6

    authors： Johnson AP,Henwood CJ,Tysall L,Warner M

    更新日期：2001-07-01 00:00:00