Abstract:
:The whole-genome sequences of 24 isolates of Neisseria gonorrhoeae with elevated minimum inhibitory concentrations (MICs) to azithromycin (≥2.0 µg/mL) were analyzed against a modified sequence derived from the whole-genome sequence of N. gonorrhoeae FA1090 to determine, by signal ratio, the number of mutant copies of the 23S rRNA gene and the copy number effect on 50S ribosome-mediated azithromycin resistance. Isolates that were predicted to contain four mutated copies were accurately identified compared with the results of direct sequencing. Fewer than four mutated copies gave less accurate results but were consistent with elevated MICs.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Johnson SR,Grad Y,Abrams AJ,Pettus K,Trees DLdoi
10.1016/j.ijantimicag.2016.10.023subject
Has Abstractpub_date
2017-02-01 00:00:00pages
252-254issue
2eissn
0924-8579issn
1872-7913pii
S0924-8579(16)30397-1journal_volume
49pub_type
杂志文章abstract::In recent years, the emergence of methicillin-resistant Staphylococcus aureus (MRSA) strains has been observed in ocular infections. Resistance of MRSA to second- and third-generation fluoroquinolones has increased interest in the fourth-generation fluoroquinolones. In this study, the antibacterial activity of gemiflo...
journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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更新日期:2019-03-01 00:00:00
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journal_title:International journal of antimicrobial agents
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