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The burden of invasive pneumococcal disease and the potential for reduction by immunisation.

Abstract：

:Streptococcus pneumoniae causes invasive disease world-wide and in all age groups. The reported incidence varies geographically and is increased in certain population groups. The incidence is highest in children less than 2 years and is also increased in the elderly. Mortality remains substantial even in the developed world despite appropriate antimicrobial therapy. The emergence of penicillin-resistant pneumococci highlights the importance of immunisation as a means to prevent disease. This review discusses the burden of invasive pneumococcal disease, identifies high-risk patients and analyses evidence for vaccine efficacy and cost-effectiveness.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Parsons HK,Dockrell DH

doi

10.1016/s0924-8579(01)00491-5

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

85-93

issue

2

eissn

0924-8579

issn

1872-7913

pii

S0924857901004915

journal_volume

19

pub_type

杂志文章,评审

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