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Crossover assessment of serum bactericidal activity of grepafloxacin, ofloxacin and clarithromycin against respiratory pathogens after oral administration to healthy volunteers.

Abstract：

:Serum bactericidal activity was studied in a crossover manner in 10 volunteers, after 2-day administration of grepafloxacin 600 mg qd, ofloxacin 400 mg bid and clarithromycin 500 mg bid. Bactericidal activity against clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Klebsiella pneumoniae, was estimated using a standardized microdilution method. Grepafloxacin was highly active against Gram-negative organisms and adequate against pneumococci (mean, 1:13.3). Clarithromycin was very active against both penicillin-susceptible and penicillin-partially-resistant S. pneumoniae (1:102.5) but had poor activity against H. influenzae (1:3.1). Minor adverse effects were commonly associated with grepafloxacin.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Dan M,Poch F,Asherov J

doi

10.1016/s0924-8579(01)00333-8

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

491-5

issue

6

eissn

0924-8579

issn

1872-7913

pii

S0924857901003338

journal_volume

17

pub_type

临床试验,杂志文章,随机对照试验

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