Emerging carbapenemases: a global perspective.


:The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants. In particular, the media attention given to the NDM-1 metallo-β-lactamase has highlighted the global consequences of human behaviour on spreading antibiotic resistance.


Walsh TR




Has Abstract


2010-11-01 00:00:00










36 Suppl 3


  • Community-acquired pneumonia: new management strategies for evolving pathogens and antimicrobial susceptibilities.

    abstract::Community-acquired pneumonia (CAP) is still one of the leading causes of mortality and morbidity. The most common bacterial cause of CAP is Streptococcus pneumoniae. The increase in antimicrobial resistance has raised concerns about the efficacy of available therapies, and a call for the reassessment of both existing ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Klugman KP,Low DE,Metlay J,Pechere JC,Weiss K

    更新日期:2004-11-01 00:00:00

  • Non-fermentative Gram-negative bacteria.

    abstract::Over the past decade, non-fermenting Gram-negative bacteria have emerged as important opportunistic pathogens in the increasing population of patients who are immunocompromised by their disease or medical treatment. These bacteria are assisted by their ubiquitous distribution in the environment and have a propensity f...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Enoch DA,Birkett CI,Ludlam HA

    更新日期:2007-05-01 00:00:00

  • Identification and mapping of new chromosomal sites affecting response to beta-lactams in Staphylococcus aureus.

    abstract::Seven new sites leading to increased beta-lactam susceptibility were identified and mapped in Staphylococcus aureus by Tn551 or Tn917 mediated insertional inactivation. Their effect was more pronounced in methicillin resistant than in susceptible strains. Except for inserts each in SmaI-K and SmaI-B, all were located ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Vasilieva E,Labischinski H,Berger-Bächi B

    更新日期:1997-02-01 00:00:00

  • Susceptibility of Streptococcus pneumoniae to penicillin, azithromycin and telithromycin (PROTEKT 1999-2003).

    abstract::Isolates of Streptococcus pneumoniae collected over the first 4 years of the PROTEKT study were tested for susceptibility to penicillin, azithromycin and telithromycin. A total of 20,750 isolates were collected from 39 countries. Penicillin non-susceptibility rates were stable over the study period; overall, 21.8% of ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,多中心研究


    authors: Schito GC,Felmingham D

    更新日期:2005-12-01 00:00:00

  • Developments in PK/PD: optimising efficacy and prevention of resistance. A critical review of PK/PD in in vitro models.

    abstract::In vitro pharmacokinetic models are excellent tools with which to study an antibacterial's pharmacodynamics (pD), being flexible, adaptable, low cost, and correlating well with animal and human systems. They can be used to perform simple descriptive studies on antibacterial effect, determine the dominant pD factor and...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: MacGowan A,Bowker K

    更新日期:2002-04-01 00:00:00

  • Clinical isolates of macrolide-resistant Streptococcus pyogenes in Central Greece.

    abstract::A total of 300 Streptococcus pyogenes isolates, collected during 2001 from five hospitals in the Thessalia district (Central Greece), were examined for their resistance to macrolides. Resistance to erythromycin was detected in 58 isolates (19.3%). Of these, 68.9% were susceptible to clindamycin (M-phenotype) and carri...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Petinaki E,Kontos F,Pratti A,Skulakis C,Maniatis AN

    更新日期:2003-01-01 00:00:00

  • Tuberculosis in patients with systemic rheumatic or pulmonary diseases treated with glucocorticosteroids and the preventive role of isoniazid: a review of the available evidence.

    abstract::Development of tuberculosis (TB) is a concern in patients who receive glucocorticosteroids for the treatment of chronic rheumatic or pulmonary diseases. However, the incidence of development of TB in such patients and the prophylactic role of isoniazid (INH) are unclear. We evaluated the available evidence from 20 rel...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Falagas ME,Voidonikola PT,Angelousi AG

    更新日期:2007-12-01 00:00:00

  • Effects of low, subinhibitory concentrations of antibiotics on expression of a virulence gene cluster of pathogenic Escherichia coli by using a wild-type gene fusion.

    abstract::S fimbrial adhesins (Sfa) represent virulence factors of E. coli wild-type strains causing urinary tract infections and meningitis of the new born. In order to determine the influence of subinhibitory concentration of antibiotics on the expression of the sfa gene cluster, a wild-type strain carrying the lacZ gene, cod...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Hacker J,Ott M,Hof H

    更新日期:1993-01-01 00:00:00

  • Multidrug-resistant high-risk Enterococcus faecium clones: can we really define them?

    abstract::Enterococcus faecium is a significant opportunistic human pathogen with a broad host range, including humans, farm animals, pets and wildlife. Specialised subpopulations have globally evolved towards a powerful and convergent adaption to the healthcare environment by acquiring a cocktail of key antimicrobial resistanc...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Freitas AR,Pereira AP,Novais C,Peixe L

    更新日期:2021-01-01 00:00:00

  • Norfloxacin, the first of a new class of fluoroquinolone antimicrobials, revisited.

    abstract::Norfloxacin is the first in a series of new 4-quinolones that have been introduced into medical practice for the treatment of bacterial infections. This totally synthetic compound is a broad spectrum, bactericidal agent that is much more potent than the earlier analogs, i.e. nalixidic acid, pipemidic acid, cinoxacin, ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Gadebusch HH,Shungu DL

    更新日期:1991-01-01 00:00:00

  • Biochemical and genetic characterization of the beta-lactamases of Y. aldovae, Y. bercovieri, Y. frederiksenii and "Y. ruckeri" strains.

    abstract::The beta-lactamases of five strains each of Y. aldovae and "Y. ruckeri", and 10 strains each of Y. bercovieri and Y. frederiksenii were examined phenotypically and genetically. Beta-lactamase activity and induction assays and SDS-PAGE were applied for phenotypic characterization of these enzymes. Genotypically, PCR ex...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Schiefer AM,Wiegand I,Sherwood KJ,Wiedemann B,Stock I

    更新日期:2005-06-01 00:00:00

  • Co-existence of two novel phosphoethanolamine transferase gene variants in Aeromonas jandaei from retail fish.

    abstract::Two novel phosphoethanolamine transferase genes, eptAv7 and eptAv3, were identified in the chromosome of an Aeromonas jandaei isolate from retail fish. The variants showed 79.9% and 80.0% amino acid identity to MCR-7.1 and MCR-3.1, respectively, and increased colistin resistance 128- to 256-fold in Aeromonas salmonici...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Liu D,Song H,Ke Y,Xia J,Shen Y,Ou Y,Hao Y,He J,Li X,Zhou Y,Fu J,Wang Y,Lv Z,Wu C

    更新日期:2020-01-01 00:00:00

  • Acquired sulphonamide resistance genes in faecal Escherichia coli from healthy children in Bolivia and Peru.

    abstract::Antimicrobial resistance and sulphonamide resistance determinants were studied in 20 co-trimoxazole resistant Escherichia coli in faecal samples from healthy children in Bolivia and Peru. Methods used were disc diffusion susceptibility tests, PCR, sequence analysis and plasmid conjugation assays. All isolates but one ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Infante B,Grape M,Larsson M,Kristiansson C,Pallecchi L,Rossolini GM,Kronvall G

    更新日期:2005-04-01 00:00:00

  • Beta-lactamase production in Prevotella and in vitro susceptibilities to selected beta-lactam antibiotics [corrected].

    abstract::This study looked for beta-lactamase production in 100 Prevotella isolates. MICs were determined for amoxycillin, ticarcillin, amoxycillin+clavulanate, cephalothin, cefuroxime, cefixime, cefpodoxime and cefotaxime using the reference agar dilution method (standard M11 A4, NCCLS). Beta-lactamase activity was detected i...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Dubreuil L,Behra-Miellet J,Vouillot C,Bland S,Sedallian A,Mory F

    更新日期:2003-03-01 00:00:00

  • Lipid-based amphotericin B: a review of the last 10 years of use.

    abstract::The last decade has been remarkable for the dramatic increase in the prevalence of serious fungal infections in patients with haematological disorders and neutropenic cancer patients. The mortality rate of deep-seated infection has been in excess of 90% and there is no doubt that this is one of the greatest challenges...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Hann IM,Prentice HG

    更新日期:2001-03-01 00:00:00

  • Non-polymyxin-based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections.

    abstract::Due to limited therapeutic options, combination therapy has been used empirically to treat carbapenem-resistant Acinetobacter baumannii (CRAB). Polymyxin-based combinations have been widely studied and used in the clinical setting. However, the use of polymyxins is often limited due to nephrotoxicity and neurotoxicity...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Mohd Sazlly Lim S,Naicker S,Ayfan AK,Zowawi H,Roberts JA,Sime FB

    更新日期:2020-10-01 00:00:00

  • Current and future approaches to antimycotic treatment in the era of resistant fungi and immunocompromised hosts.

    abstract::Due to the ever-increasing number of immunocompromised patients, both localised and life-threatening systemic fungal infections are on the increase. Conventional treatment is of limited help, not in the least due to a less optimum benefit-to-risk ratio. Moreover, emerging pathogens with reduced antimicrobial susceptib...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Bastert J,Schaller M,Korting HC,Evans EG

    更新日期:2001-02-01 00:00:00

  • In vitro activities of beta-lactam antibiotics alone and in combination with sulbactam against Gram-negative bacteria.

    abstract::The resistance rates of ampicillin/sulbactam 2:1 against imipenem-susceptible and -resistant Acinetobacter baumannii were 23.5 and 30%, respectively. Ceftazidime/sulbactam combination showed significant reduction of resistant rates against Enterobacter cloacae, A. baumannii, ESBL Klebsiella pneumoniae. MIC90 of cefope...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Wang FD,Lin ML,Lee WS,Liu CY

    更新日期:2004-06-01 00:00:00

  • Rational diagnostic steps in acute pyelonephritis with special reference to ultrasonography and computed tomography scan.

    abstract::Depending on the severity of the clinical syndrome, acute pyelonephritis may require more extensive imaging diagnostics. In the uncomplicated form of the disease, ultrasonography does not appear to be absolutely necessary. In clinically severe cases, however, which fail to respond to antibiotic therapy, ultrasound is ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Weidner W,Ludwig M,Weimar B,Rau W

    更新日期:1999-05-01 00:00:00

  • Interaction of local anaesthetics with other antifungal agents against pathogenic Aspergillus.

    abstract::Aspergillus spp. are responsible for an increasing number of fungal infections in immunocompromised and transplant patients. Local anaesthetics (LAs) are growth inhibitors of bacteria and yeasts. Subinhibitory concentrations of the LAs lidocaine and bupivacaine blocked the germination of Aspergillus fumigatus, Aspergi...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Rodrigues AG,Araujo R,Pina-Vaz C

    更新日期:2006-04-01 00:00:00

  • In vitro activity of clarithromycin in combination with other antimicrobial agents against Mycobacterium abscessus and Mycobacterium massiliense.

    abstract::Macrolides, especially clarithromycin (CLA), remain the cornerstone of therapy for Mycobacterium abscessus complex infections. The purpose of this study was to gather results from in vitro drug susceptibility testing of M. abscessus and Mycobacterium massiliense for the combination of CLA with various other agents, in...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Zhang Z,Lu J,Liu M,Wang Y,Zhao Y,Pang Y

    更新日期:2017-03-01 00:00:00

  • Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.

    abstract::In this study, 619 individual Escherichia coli isolates from food-producing and companion animals were analysed to determine the prevalence of the cephalosporinase gene blaCMY-2. In total, 18 CMY-2-producers (2.9%) were detected and exhibited multidrug-resistant phenotypes. One of the CMY-2-producers was found to poss...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Fang LX,Sun J,Li L,Deng H,Huang T,Yang QE,Li X,Chen MY,Liao XP,Liu YH

    更新日期:2015-08-01 00:00:00

  • SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis (XDR-TB).

    abstract::Multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) are problematic to manage, especially in patients with acquired immune deficiency syndrome (AIDS). There is therefore a dire need for effective anti-MDR/XDR-TB agents. We have previously shown that agents that inhibit the efflux pumps of MDR ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Martins M,Viveiros M,Ramos J,Couto I,Molnar J,Boeree M,Amaral L

    更新日期:2009-05-01 00:00:00

  • Malaria: still a threat to travellers.

    abstract::Each year, some 25-30 million international travellers from non-tropical regions visit malaria endemic countries. Up to 10,000 cases of malaria are imported into industrialised countries with an average case fatality rate of around 1%. Malaria still poses a real threat to travellers, particularly in areas with high tr...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Loutan L

    更新日期:2003-02-01 00:00:00

  • Chemosensitisation of drug-resistant and drug-sensitive yeast cells to antifungals.

    abstract::Multidrug resistance in yeast results from overexpression of genes encoding drug efflux transporters owing to gain-of-function mutations in transcription factors regulating their expression. We have screened a library of synthetic compounds for modulators of drug resistance using the multidrug-resistant Saccharomyces ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Cernicka J,Kozovska Z,Hnatova M,Valachovic M,Hapala I,Riedl Z,Hajós G,Subik J

    更新日期:2007-02-01 00:00:00

  • Antibacterial activity of high concentrations of carvedilol against Gram-positive and Gram-negative bacteria.

    abstract::Many drugs used to treat non-infectious diseases have also shown excellent antibacterial activity or the ability to enhance the action of antibiotics. The aim of this study was to investigate the antibacterial activity of a popular β-blocker, carvedilol, and its mechanism of antibacterial action. The antibacterial act...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Zawadzka K,Bernat P,Felczak A,Różalska S,Lisowska K

    更新日期:2018-03-01 00:00:00

  • In vitro pharmacodynamic evaluation of garenoxacin against quinolone-resistant Streptococcus pneumoniae.

    abstract::The bactericidal activity and resistance selectivity of garenoxacin against Streptococcus pneumoniae with mutations in ParC (S79F) or both GyrA (S81F) and ParC (D83Y and K137N) were investigated using in vitro pharmacokinetic models simulating plasma concentrations for a standard clinical regimen [400mg once daily (q....

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Fukuda Y,Takahata M,Sugiura Y,Shinmura Y,Nomura N

    更新日期:2012-02-01 00:00:00

  • Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii.

    abstract::Treatment options for multidrug-resistant (MDR) strains of Acinetobacter baumannii that acquire resistance to colistin are limited. Acinetobacter baumannii can become highly resistant to colistin through complete loss of lipopolysaccharide (LPS) owing to mutations in the genes encoding the first three enzymes involved...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: García-Quintanilla M,Carretero-Ledesma M,Moreno-Martínez P,Martín-Peña R,Pachón J,McConnell MJ

    更新日期:2015-12-01 00:00:00

  • Mutations in transcription factor Mrr2p contribute to fluconazole resistance in clinical isolates of Candida albicans.

    abstract::The Candida albicans zinc cluster proteins are a family of transcription factors (TFs) that play essential roles in the development of antifungal drug resistance. Gain-of-function mutations in several TFs, such as Tac1p, Mrr1p and Upc2p, have been previously well documented in azole-resistant clinical C. albicans isol...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Wang Y,Liu JY,Shi C,Li WJ,Zhao Y,Yan L,Xiang MJ

    更新日期:2015-11-01 00:00:00

  • Dissemination of carbapenem-resistant Pseudomonas aeruginosa isolates and their susceptibilities to ceftolozane-tazobactam in Germany.

    abstract::Pseudomonas aeruginosa (PA) is a major cause of healthcare-associated infections. Antipseudomonal carbapenems are among the antimicrobial agents used to treat PA infections, but several mechanisms of resistance, including the production of a carbapenemase (CP), may compromise their clinical efficacy. The objectives of...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Kresken M,Körber-Irrgang B,Korte-Berwanger M,Pfennigwerth N,Gatermann SG,Seifert H,German Carbapenem Resistance Study Group.

    更新日期:2020-06-01 00:00:00