Emerging carbapenemases: a global perspective.


:The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants. In particular, the media attention given to the NDM-1 metallo-β-lactamase has highlighted the global consequences of human behaviour on spreading antibiotic resistance.


Walsh TR




Has Abstract


2010-11-01 00:00:00










36 Suppl 3


  • Malaria: still a threat to travellers.

    abstract::Each year, some 25-30 million international travellers from non-tropical regions visit malaria endemic countries. Up to 10,000 cases of malaria are imported into industrialised countries with an average case fatality rate of around 1%. Malaria still poses a real threat to travellers, particularly in areas with high tr...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Loutan L

    更新日期:2003-02-01 00:00:00

  • Surveillance of antimicrobial resistance in Escherichia coli strains isolated from pigs at Spanish slaughterhouses.

    abstract::Antimicrobial resistance can make the efficient treatment of bacterial infections in humans and animals more difficult. Antimicrobial use in food animals may be one of the factors contributing to resistance. The Spanish surveillance network VAV has established a baseline of antimicrobial resistance in Escherichia coli...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Teshager T,Herrero IA,Porrero MC,Garde J,Moreno MA,Domínguez L

    更新日期:2000-07-01 00:00:00

  • In vitro activity of the novel fluorocycline TP-6076 against carbapenem-resistant Acinetobacter baumannii.

    abstract::The activity of the novel, fully synthetic fluorocycline antibiotic TP-6076 against carbapenem-resistant Acinetobacter baumannii (CRAB) isolates with defined carbapenem resistance mechanisms was compared against reference antimicrobials with known activity against Acinetobacter spp. The susceptibility of 323 non-dupli...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Seifert H,Stefanik D,Olesky M,Higgins PG

    更新日期:2020-01-01 00:00:00

  • In vitro and in vivo evaluation of fluoroquinolone resistance associated with DNA gyrase mutations in Francisella tularensis, including in tularaemia patients with treatment failure.

    abstract::Fluoroquinolones (FQs) are highly effective for treating tularaemia, a zoonosis caused by Francisella tularensis, but failures and relapses remain common in patients with treatment delay or immunocompromised status. FQ-resistant strains of F. tularensis harboring mutations in the quinolone-resistance determining regio...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Sutera V,Hoarau G,Renesto P,Caspar Y,Maurin M

    更新日期:2017-09-01 00:00:00

  • MALDI-TOF-MS for rapid detection of staphylococcal Panton-Valentine leukocidin.

    abstract::Toxin-producing gram-positive bacteria are responsible for emerging and life-threatening infections in humans worldwide. Both rapid toxin detection and adapted therapy are essential to limit the morbidity due to such toxins, especially staphylococcal Panton-Valentine leukocidin (PVL). Here we describe the use of a mas...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Bittar F,Ouchenane Z,Smati F,Raoult D,Rolain JM

    更新日期:2009-11-01 00:00:00

  • Leishmaniasis vaccines: past, present and future.

    abstract::No vaccine exists against any form of leishmaniasis. Because recovery from infection is usually accompanied by a strong immunity and because it is possible to protect experimental animals against live challenge, hope for the development of a vaccine for humans has been high. However, leishmaniasis is a disease of the ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Modabber F

    更新日期:2010-11-01 00:00:00

  • Geographic distribution of fluoroquinolone-resistant Escherichia coli strains in Asia.

    abstract::Fluoroquinolone (FQ) resistance is usually caused by point mutations within the quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and/or parE. However, little is known about the worldwide increase in FQ-resistant Escherichia coli or, more specifically, about the geographical distribution of QRDR mut...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Uchida Y,Mochimaru T,Morokuma Y,Kiyosuke M,Fujise M,Eto F,Harada Y,Kadowaki M,Shimono N,Kang D

    更新日期:2010-04-01 00:00:00

  • Susceptibility and resistance genes to fluoroquinolones in methicillin-resistant Staphylococcus aureus isolated in 2002.

    abstract::The activity of six fluoroquinolones (FQs) was determined against 100 methicillin-resistant Staphylococcus aureus (MRSA) isolated in 2002 along with mutations in the grlA and gyrA genes and in the norA promoter of these isolates. Of the isolates tested, 97% had mutations in grlA and gyrA. A single mutation in grlA and...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Noguchi N,Okihara T,Namiki Y,Kumaki Y,Yamanaka Y,Koyama M,Wakasugi K,Sasatsu M

    更新日期:2005-05-01 00:00:00

  • Clinical predictors and outcome impact of community-onset polymicrobial bloodstream infection.

    abstract:OBJECTIVES:Very few studies have characterised community-onset polymicrobial bloodstream infections (BSIs). This study determined the incidence, risk factors, and outcomes of polymicrobial BSI as compared with monomicrobial BSI in a cohort of patients with community-onset BSIs. METHODS:This prospective cohort study en...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Yo CH,Hsein YC,Wu YL,Hsu WT,Ma MH,Tsai CH,Chen SC,Lee CC

    更新日期:2019-12-01 00:00:00

  • Forecasting carbapenem resistance from antimicrobial consumption surveillance: Lessons learnt from an OXA-48-producing Klebsiella pneumoniae outbreak in a West London renal unit.

    abstract::This study aimed to forecast the incidence rate of carbapenem resistance and to assess the impact of an antimicrobial stewardship intervention using routine antimicrobial consumption surveillance data. Following an outbreak of OXA-48-producing Klebsiella pneumoniae (January 2008-April 2010) in a renal cohort in London...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Gharbi M,Moore LS,Gilchrist M,Thomas CP,Bamford K,Brannigan ET,Holmes AH

    更新日期:2015-08-01 00:00:00

  • Trends in antimicrobial susceptibility of bacterial pathogens isolated from patients with bloodstream infections in the USA, Canada and Latin America. SENTRY Participants Group.

    abstract::From January through June of 1998, 4579 bloodstream infections (BSI) due to bacterial pathogens were reported from SENTRY hospitals in Canada, the USA and Latin America. Staphylococcus aureus, Escherichia coli, and coagulase-negative staphylococcus (CoNS) were the most common pathogens, together accounting for 55.2% o...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Diekema DJ,Pfaller MA,Jones RN,Doern GV,Kugler KC,Beach ML,Sader HS

    更新日期:2000-02-01 00:00:00

  • Recombinant human erythropoietin for treatment of anemia in persons with AIDS not receiving zidovudine.

    abstract::Because few data exist on the effect of recombinant human erythropoietin (EPO) for anemia not induced by zidovudine (ZDV) in persons with AIDS, we analyzed a subset of 523 subjects not taking ZDV ('non-ZDV') who participated in an open-label EPO treatment program involving 1943 subjects. Non-ZDV subjects had a mean he...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Balfour HH Jr

    更新日期:1997-01-01 00:00:00

  • Asymptomatic bacteriuria. Clinical significance and management.

    abstract::The clinical significance and management of asymptomatic bacteriuria (ASB) differs according to different groups of patients. ASB requires antibiotic treatment in pregnant women, children aged 5-6 years and prior to invasive genitourinary procedures. However, there is a consensus that ASB in the elderly, healthy schoo...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Raz R

    更新日期:2003-10-01 00:00:00

  • In vitro susceptibility of Achromobacter spp. isolates: comparison of disk diffusion, Etest and agar dilution methods.

    abstract::In this study, we analysed the antimicrobial susceptibility of 92 strains of Achromobacter spp. isolated from clinical samples to 18 antimicrobial agents. The disk diffusion method and Etest were compared with the agar dilution method, and the breakpoints of susceptibility and resistance for the disk diffusion method ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Almuzara M,Limansky A,Ballerini V,Galanternik L,Famiglietti A,Vay C

    更新日期:2010-01-01 00:00:00

  • Ciprofloxacin versus chloramphenicol in the treatment of salmonella infection.

    abstract::Strains of Salmonella typhi resistant to chloramphenicol and ampicillin have been isolated in several countries. This study compares treatment of Salmonella infection using ciprofloxacin (500 mg twice daily) for 10 days with chloramphenicol (50 mg/kg per day divided into four doses) for 14 days. The pathogen eradicati...

    journal_title:International journal of antimicrobial agents

    pub_type: 临床试验,杂志文章


    authors: Liberti A,Loiacono L

    更新日期:2000-11-01 00:00:00

  • Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.

    abstract::In this study, 619 individual Escherichia coli isolates from food-producing and companion animals were analysed to determine the prevalence of the cephalosporinase gene blaCMY-2. In total, 18 CMY-2-producers (2.9%) were detected and exhibited multidrug-resistant phenotypes. One of the CMY-2-producers was found to poss...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Fang LX,Sun J,Li L,Deng H,Huang T,Yang QE,Li X,Chen MY,Liao XP,Liu YH

    更新日期:2015-08-01 00:00:00

  • Incidence of nosocomial urinary tract infections on a surgical intensive care unit and implications for management.

    abstract::The incidence of nosocomial infections (NIs) in our surgical intensive care unit was evaluated with special consideration of nosocomial urinary tract infections (NUTIs). The trial was a prospective, single-centre, 6-month cohort study. Infections according to CDC criteria, pathogens, devices, APACHE II scores, infecti...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Wagenlehner FM,Loibl E,Vogel H,Naber KG

    更新日期:2006-08-01 00:00:00

  • Variability of piperacillin concentrations in relation to tazobactam concentrations in critically ill patients.

    abstract::Therapeutic drug monitoring for critically ill patients receiving piperacillin/tazobactam is described as a useful tool. However, the minimum inhibitory concentration of piperacillin depends on a sufficiently high concentration of tazobactam in case of β-lactamase-producing strains. Therefore, the relationship between...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Zander J,Döbbeler G,Nagel D,Scharf C,Huseyn-Zada M,Jung J,Frey L,Vogeser M,Zoller M

    更新日期:2016-10-01 00:00:00

  • What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review.

    abstract::As treatment options for critically ill patients with multidrug-resistant bacteria diminish, older antibiotics such as fosfomycin are being investigated for use as last-resort drugs. Fosfomycin is a broad-spectrum antibiotic with activity both against Gram-positive and Gram-negative bacteria. The aim of this review wa...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Parker S,Lipman J,Koulenti D,Dimopoulos G,Roberts JA

    更新日期:2013-10-01 00:00:00

  • Chemosensitisation of drug-resistant and drug-sensitive yeast cells to antifungals.

    abstract::Multidrug resistance in yeast results from overexpression of genes encoding drug efflux transporters owing to gain-of-function mutations in transcription factors regulating their expression. We have screened a library of synthetic compounds for modulators of drug resistance using the multidrug-resistant Saccharomyces ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Cernicka J,Kozovska Z,Hnatova M,Valachovic M,Hapala I,Riedl Z,Hajós G,Subik J

    更新日期:2007-02-01 00:00:00

  • Telaprevir is a substrate and moderate inhibitor of P-glycoprotein, a strong inductor of ABCG2, but not an activator of PXR in vitro.

    abstract::Triple therapy combining the protease inhibitor telaprevir with interferon-α and ribavirin is a promising new option for long-term treatment of hepatitis C. The interaction potential of telaprevir has not yet been fully elucidated. The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast c...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Weiss J,Becker JP,Haefeli WE

    更新日期:2014-02-01 00:00:00

  • Urinary tract infections in adults with diabetes.

    abstract::Urinary tract (UTI) is a major disease burden for many patients with diabetes. Asymptomatic bacteriuria is several-fold more common among women and acute plyelonephritis is five to ten times more common in both sexes. The complications of pyelonephritis are also more common in patients with diabetes. These complicatio...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Ronald A,Ludwig E

    更新日期:2001-04-01 00:00:00

  • Sepsis redefined: the search for surrogate markers.

    abstract::Sepsis is a common and severe medical condition with substantial associated morbidity, mortality and cost. Furthermore, the incidence of sepsis has been rising annually over the past three decades, and morbidity and mortality remain high. The management of sepsis is further complicated by its very heterogeneous nature...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Tsalik EL,Woods CW

    更新日期:2009-01-01 00:00:00

  • Bacterial strain-independent AUC/MIC and strain-specific dose-response relationships reflecting comparative fluoroquinolone anti-pseudomonal pharmacodynamics in an in vitro dynamic model.

    abstract::To compare the antimicrobial effects (AMEs) of two quinolones in terms of the AUC/MIC- and dose (D)-response relationships, five differentially susceptible clinical isolates of Pseudomonas aeruginosa were exposed to decreasing concentrations of ciprofloxacin (two 12-h doses with T(1/2) = 4 h) and trovafloxacin (a sing...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Lubenko IY,Vostrov SN,Portnoy YA,Zinner SH,Firsov AA

    更新日期:2002-07-01 00:00:00

  • Geographically-based evaluation of multidrug resistance trends among Streptococcus pneumoniae in the USA: findings of the FAST surveillance initiative (2003-2004).

    abstract::Surveillance initiatives to track Streptococcus pneumoniae resistance trends are important for understanding the current in vitro effectiveness of available antimicrobial agents. The antimicrobial susceptibility profiles of S. pneumoniae (n=1479 isolates) collected from 17 geographical areas across the USA (2003-2004)...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Draghi DC,Jones ME,Sahm DF,Tillotson GS

    更新日期:2006-12-01 00:00:00

  • Vancomycin versus teicoplanin in the therapy of experimental methicillin-resistant Staphylococcus aureus (MRSA) meningitis.

    abstract::The aim of this study was to compare the antibacterial activity of teicoplanin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis using a rabbit meningitis model. The MRSA strain ATCC 43300 was used to infect the rabbits. The vancomycin group received 20 mg/kg vancomycin e...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Sipahi OR,Arda B,Yurtseven T,Sipahi H,Ozgiray E,Suntur BM,Ulusoy S

    更新日期:2005-11-01 00:00:00

  • Does consistent piperacillin dosing result in consistent therapeutic concentrations in critically ill patients? A longitudinal study over an entire antibiotic course.

    abstract::Piperacillin plasma concentrations are known to vary between critically ill patients. However, there are no comprehensive data on the variability of antibiotic concentrations within the same patient. The purpose of this study was to investigate the adequacy of dosing during an entire 7-day antibiotic course and to inv...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Carlier M,Carrette S,Stove V,Verstraete AG,De Waele JJ

    更新日期:2014-05-01 00:00:00

  • Community-acquired pneumonia: new management strategies for evolving pathogens and antimicrobial susceptibilities.

    abstract::Community-acquired pneumonia (CAP) is still one of the leading causes of mortality and morbidity. The most common bacterial cause of CAP is Streptococcus pneumoniae. The increase in antimicrobial resistance has raised concerns about the efficacy of available therapies, and a call for the reassessment of both existing ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审


    authors: Klugman KP,Low DE,Metlay J,Pechere JC,Weiss K

    更新日期:2004-11-01 00:00:00

  • In vitro activity of clarithromycin in combination with other antimicrobial agents against Mycobacterium abscessus and Mycobacterium massiliense.

    abstract::Macrolides, especially clarithromycin (CLA), remain the cornerstone of therapy for Mycobacterium abscessus complex infections. The purpose of this study was to gather results from in vitro drug susceptibility testing of M. abscessus and Mycobacterium massiliense for the combination of CLA with various other agents, in...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Zhang Z,Lu J,Liu M,Wang Y,Zhao Y,Pang Y

    更新日期:2017-03-01 00:00:00

  • Managing skin and soft-tissue infection and nosocomial pneumonia caused by MRSA: a 2014 follow-up survey.

    abstract::As a follow-up to our 2009 survey, in order to explore opinion and practice on the epidemiology and management of meticillin-resistant Staphylococcus aureus (MRSA) in Europe, we conducted a second survey to elicit current opinions on this topic, particularly around antibiotic choice, dose, duration and route of admini...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章


    authors: Dryden M,Andrasevic AT,Bassetti M,Bouza E,Chastre J,Baguneid M,Esposito S,Giamarellou H,Gyssens I,Nathwani D,Unal S,Voss A,Wilcox M

    更新日期:2015-04-24 00:00:00