当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species.

Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species.

Abstract：

:Pneumococcal infections elicited by Streptococcus pneumoniae (pneumococcus) (pneumonia, otitis media, sinusitis, meningitis) are frequently occurring diseases that are associated with considerable morbidity and mortality even in developed countries. Pneumococci colonise the nasopharynx of up to 50% of children, and up to 5% of adults are pneumococcal carriers. Two pneumococcal vaccines are currently in clinical use. One of them contains 23 capsular polysaccharides of the as yet known 91 different pneumococcal serotypes. Because polysaccharide vaccines primarily induce a B-cell-dependent immune response, this type of vaccine prevents bacteraemia but does not efficiently protect the host against pneumococcal infection. In 2000, a vaccination programme was launched in the USA making use of a novel pneumococcal conjugate vaccine containing capsular polysaccharides derived from the seven most frequent pneumococcal serotypes causing pneumococcal disease in children <2 years of age. Conjugation of capsular polysaccharides with a highly immunogenic protein, i.e. a non-toxic diphtheria toxoid, induces a B- and T-cell response resulting in mucosal immunity and thus effectively protects against vaccine serotypes that induce invasive pneumococcal disease, thereby at the same time reducing vaccine serotype carrier rates. Pronounced herd immunity resulted in a decrease in invasive pneumococcal diseases in vaccinees and non-vaccinees as well as reduced antibiotic resistance rates. However, recent studies report that serotypes eradicated by the vaccine are being replaced by non-vaccine pneumococcal serotypes. This so-called 'replacement' might soon threaten the success of vaccine use.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Pletz MW,Maus U,Krug N,Welte T,Lode H

doi

10.1016/j.ijantimicag.2008.01.021

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

199-206

issue

3

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(08)00053-8

journal_volume

32

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Legal framework of antimicrobial stewardship in hospitals (LEASH): a European Society of Clinical Microbiology and Infectious Diseases (ESCMID) cross-sectional international survey.

    abstract：:Antimicrobial stewardship (AMS) is the cornerstone activity in the combat against antimicrobial resistance. In order to ensure sustainable deployment and development of AMS, a strategic and regulatory framework needs to be provided by national healthcare authorities. Experts from 32 European countries, Israel and Turk...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.07.019

    authors： Beović B,Pulcini C,Dumartin C,Béraud G,Nerat B,Maurel C,Doušak M,Čižman M,LEASH Study Group on behalf of ESCMID Study Group for Antimicrobial StewardshiP (ESGAP).

    更新日期：2018-11-01 00:00:00

  • A need to revisit clinical breakpoints of tigecycline: effect of atypical non-linear plasma protein binding.

    abstract：:Tigecycline is highly active against various drug-resistant bacteria. The US Food and Drug Administration (FDA) recently issued a black box warning for tigecycline owing to an associated increase in all-cause mortality. Clinical breakpoints of antibiotics are vital in susceptibility testing of pathogens for the select...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.12.008

    authors： Singh RSP,Mukker JK,Drescher SK,Deitchman AN,Derendorf H

    更新日期：2017-04-01 00:00:00

  • Evaluation of peptoid mimics of short, lipophilic peptide antimicrobials.

    abstract：INTRODUCTION:Antimicrobial peptides are proving to be promising lead compounds for therapeutics. The major disadvantage of antimicrobial peptides is their proteolytic instability in the body, with half-lives averaging less than an hour. Peptoids, or N-substituted glycines, have emerged as a promising field of peptidomi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.106048

    authors： Green RM,Bicker KL

    更新日期：2020-08-01 00:00:00

  • Ridinilazole: a novel therapy for Clostridium difficile infection.

    abstract：:Clostridium difficile infection (CDI) is the leading cause of infectious healthcare-associated diarrhoea. Recurrent CDI increases disease morbidity and mortality, posing a high burden to patients and a growing economic burden to the healthcare system. Thus, there exists a significant unmet and increasing medical need ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2016.04.026

    authors： Vickers RJ,Tillotson G,Goldstein EJ,Citron DM,Garey KW,Wilcox MH

    更新日期：2016-08-01 00:00:00

  • Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 β-lactamase.

    abstract：:Fifteen carbapenem-non-susceptible Escherichia coli isolates obtained during the period May 2010 to April 2011 in a hospital and a long-term care facility (LTCF) in Larissa (Central Greece) were investigated. Minimum inhibitory concentrations (MICs) to various antimicrobial agents were determined by Etest. Carriage of...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2011.11.003

    authors： Mavroidi A,Miriagou V,Malli E,Stefos A,Dalekos GN,Tzouvelekis LS,Petinaki E

    更新日期：2012-03-01 00:00:00

  • Retrospective survey of mcr-1 and mcr-2 in German pig-fattening farms, 2011-2012.

    abstract：:In November 2015, the first plasmid-encoded colistin resistance gene, mcr-1, was described in animals and in humans in China. Subsequently, a multitude of further studies was performed and quite recently the global spread of mcr-1 as well as the occurrence of a new gene variant, mcr-2, was reported. To obtain an overv...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.03.007

    authors： Roschanski N,Falgenhauer L,Grobbel M,Guenther S,Kreienbrock L,Imirzalioglu C,Roesler U

    更新日期：2017-08-01 00:00:00

  • Antibacterial effects of theaflavin and synergy with epicatechin against clinical isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia.

    abstract：:Stenotrophomonas maltophilia and Acinetobacter baumannii are recognised as important nosocomial pathogens; however, due to their intrinsic resistance to multiple antibiotics, treatment options are limited. Polyphenols from black tea have been shown to possess antibacterial action. In this study, the antibacterial effe...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2011.07.006

    authors： Betts JW,Kelly SM,Haswell SJ

    更新日期：2011-11-01 00:00:00

  • High rates of off-label use in antibiotic prescriptions in a context of dramatic resistance increase: a prospective study in a tertiary hospital.

    abstract：:The use of antibiotics, as any other drug, is regulated by the terms of its marketing authorisation, notified in the Summary of Product Characteristics (SPC). If a prescription is not in accordance with the SPC, the physician prescribes off-label. There is very little literature regarding off-label use of antibiotics ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.04.010

    authors： Davido B,Bouchand F,Calin R,Makhloufi S,Lagrange A,Senard O,Perronne C,Villart M,Salomon J,Dinh A

    更新日期：2016-06-01 00:00:00

  • Outcomes of adjunctive therapy with intrathecal or intraventricular administration of colistin for post-neurosurgical meningitis and ventriculitis due to carbapenem-resistant acinetobacter baumannii.

    abstract：:The efficacy and safety of intrathecal (ITH) or intraventricular (IVT) colistin in addition to intravenous (IV) colistin for meningitis and ventriculitis due to carbapenem-resistant Acinetobacter baumannii (CRAB) is unclear. In this retrospective observational study of 40 patients with post-neurosurgical meningitis an...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.12.002

    authors： Chusri S,Sakarunchai I,Kositpantawong N,Panthuwong S,Santimaleeworagun W,Pattharachayakul S,Singkhamanan K,Doi Y

    更新日期：2018-04-01 00:00:00

  • Antimicrobial susceptibility of uropathogens causing acute uncomplicated cystitis in female outpatients in South Korea: a multicentre study in 2002.

    abstract：:The objective of this study was to obtain data on the susceptibility of pathogens responsible for acute uncomplicated cystitis in South Korea to currently used antimicrobial agents. A total of 239 isolates were obtained from female outpatients with acute uncomplicated cystitis. The most prevalent causative organism wa...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijantimicag.2004.02.012

    authors： Lee SJ,Lee SD,Cho IR,Sim BS,Lee JG,Kim CS,Kim ME,Cho YH,Woo YN

    更新日期：2004-09-01 00:00:00

  • In vivo development of tigecycline resistance in Klebsiella pneumoniae owing to deletion of the ramR ribosomal binding site.

    abstract：:Tigecycline resistance is emerging among Klebsiella pneumoniae, but knowledge regarding in vivo development of tigecycline resistance is limited. Here we report a new mechanism of tigecycline resistance in K. pneumoniae that evolved during tigecycline therapy. Klebsiella pneumoniae isolates were consecutively obtained...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.04.024

    authors： Ye M,Ding B,Qian H,Xu Q,Jiang J,Huang J,Ou H,Hu F,Wang M

    更新日期：2017-10-01 00:00:00

  • In vitro activity of KRM-1648, either singly or in combination with ofloxacin, against Mycobacterium ulcerans.

    abstract：:The antimicrobial effect of a benzoxazinorifamycin, KRM-1648, either alone or in combination with ofloxacin, was evaluated in vitro against two type strains and six clinical isolates of Mycobacterium ulcerans. Growth of M. ulcerans was measured by plate counts and the BACTEC radiometric method. The minimal inhibitory ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00306-x

    authors： Dhople AM

    更新日期：2001-01-01 00:00:00

  • Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.

    abstract：:In this study, 619 individual Escherichia coli isolates from food-producing and companion animals were analysed to determine the prevalence of the cephalosporinase gene blaCMY-2. In total, 18 CMY-2-producers (2.9%) were detected and exhibited multidrug-resistant phenotypes. One of the CMY-2-producers was found to poss...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.04.003

    authors： Fang LX,Sun J,Li L,Deng H,Huang T,Yang QE,Li X,Chen MY,Liao XP,Liu YH

    更新日期：2015-08-01 00:00:00

  • Current challenges in the diagnosis and management of invasive fungal infections: report from the 15th International Symposium on Infections in the Immunocompromised Host: Thessaloniki, Greece, 22-25 June 2008.

    abstract：:New, aggressive forms of immunosuppression and an increasing population of patients at risk provide fertile ground for opportunistic invasive fungal infections (IFIs). Particularly challenging is the changing epidemiology of IFIs: rare pathogens are now more common and resistant strains are emerging among species that...

    journal_title：International journal of antimicrobial agents

    pub_type：

    doi：10.1016/j.ijantimicag.2008.08.014

    authors： Groll AH,McNeil Grist L

    更新日期：2009-02-01 00:00:00

  • Evaluation of the activity of fusidic acid tested against contemporary Gram-positive clinical isolates from the USA and Canada.

    abstract：:We evaluated the antimicrobial activity of fusidic acid (CEM-102) against 1140 clinical strains of Gram-positive bacteria obtained from patients with bacteraemia or skin and skin-structure infections collected in more than 30 medical centres in the USA and Canada over a 10-year period (1997-2006). Fusidic acid was ver...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2009.10.023

    authors： Pfaller MA,Castanheira M,Sader HS,Jones RN

    更新日期：2010-03-01 00:00:00

  • Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health.

    abstract：:Since its introduction in the 1950s, colistin has been used mainly as a topical treatment in human medicine owing to its toxicity when given systemically. Sixty years later, colistin is being used as a last-resort drug to treat infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter bauman...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2015.06.005

    authors： Catry B,Cavaleri M,Baptiste K,Grave K,Grein K,Holm A,Jukes H,Liebana E,Lopez Navas A,Mackay D,Magiorakos AP,Moreno Romo MA,Moulin G,Muñoz Madero C,Matias Ferreira Pomba MC,Powell M,Pyörälä S,Rantala M,Ružauskas M,Sa

    更新日期：2015-09-01 00:00:00

  • In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds.

    abstract：:Salicylidene acylhydrazide compounds have been shown to inhibit bacterial pathogens, including Chlamydia and Neisseria gonorrhoeae. If such compounds could also target HIV-1, their potential use as topical microbicides to prevent sexually transmitted infections would be considerable. In this study, the in vitro anti-H...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2012.05.023

    authors： Forthal DN,Phan TB,Slepenkin AV,Landucci G,Chu H,Elofsson M,Peterson E

    更新日期：2012-10-01 00:00:00

  • Steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in hospitalised patients.

    abstract：:The objective of this study was to evaluate the steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in hospitalised patients requiring antimicrobial therapy. Nine patients received 1g every 8h (q8h), infused over 4h, and steady-state pharmacokinetic parameters were determi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2010.08.016

    authors： Cheatham SC,Shea KM,Healy DP,Humphrey ML,Fleming MR,Wack MF,Smith DW,Sowinski KM,Kays MB

    更新日期：2011-01-01 00:00:00

  • Increasing burden of urinary tract infections due to intrinsic colistin-resistant bacteria in hospitals in Marseille, France.

    abstract：:The emergence of multidrug-resistant (MDR) Gram-negative bacteria has become a major public health problem, eliciting renewed interest in colistin, an old antibiotic that is now routinely used to treat MDR bacterial infections. Here we investigated whether colistin use has affected the prevalence of infections due to ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2014.10.010

    authors： Abat C,Desboves G,Olaitan AO,Chaudet H,Roattino N,Fournier PE,Colson P,Raoult D,Rolain JM

    更新日期：2015-02-01 00:00:00

  • Antifungal resistance in Candida spp. isolated in Italy between 2002 and 2005 from children and adults.

    abstract：:The activity of amphotericin B, fluconazole, flucytosine, itraconazole and voriconazole was tested in vitro against 618 clinical Candida spp. isolates, using the broth microdilution or the disk diffusion method (voriconazole). Amphotericin B and voriconazole were the most potent antifungal agents assayed (100% of susc...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.08.047

    authors： Gualco L,Debbia EA,Bandettini R,Pescetto L,Cavallero A,Ossi MC,Schito AM,Marchese A

    更新日期：2007-02-01 00:00:00

  • Therapeutic potential of dalbavancin in a rat model of methicillin-resistant Staphylococcus aureus (MRSA)-osteomyelitis.

    abstract：:Bacterial osteomyelitis is a major clinical challenge in human and veterinary patients. This infection is an infrequent but feared complication of orthopedic surgery and is mainly caused by methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to evaluate the efficacy of dalbavancin (dosed for ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.106021

    authors： Silva V,Miranda C,Antão HS,Guimarães J,Prada J,Pires I,Maltez L,Pereira JE,Capelo JL,Igrejas G,Poeta P

    更新日期：2020-07-01 00:00:00

  • Multidrug-resistant high-risk Enterococcus faecium clones: can we really define them?

    abstract：:Enterococcus faecium is a significant opportunistic human pathogen with a broad host range, including humans, farm animals, pets and wildlife. Specialised subpopulations have globally evolved towards a powerful and convergent adaption to the healthcare environment by acquiring a cocktail of key antimicrobial resistanc...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2020.106227

    authors： Freitas AR,Pereira AP,Novais C,Peixe L

    更新日期：2021-01-01 00:00:00

  • Potentially multidrug-resistant non-fermentative Gram-negative pathogens causing nosocomial pneumonia.

    abstract：:Owing to its high morbidity and mortality, nosocomial pneumonia represents a particularly serious illness and one of the most frequent complications in ventilated patients admitted to the Intensive Care Unit. Gram-negative microorganisms, such as Pseudomonas aeruginosa, Acinetobacter baumannii and Stenotrophomonas mal...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2005.11.005

    authors： Ferrara AM

    更新日期：2006-03-01 00:00:00

  • Prophylaxis, pre-emptive or empirical antifungal therapy: which is best in non-lung transplant recipients?

    abstract：:Renal, liver, heart and lung transplantation are now considered to be the standard therapeutic interventions in patients with end-stage organ failure. Infectious complications following solid organ transplantation (SOT) are relatively common owing to the transplant recipient's overall immunosuppressed status. The inci...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(08)70017-7

    authors： Salavert M

    更新日期：2008-11-01 00:00:00

  • Co-existence of two novel phosphoethanolamine transferase gene variants in Aeromonas jandaei from retail fish.

    abstract：:Two novel phosphoethanolamine transferase genes, eptAv7 and eptAv3, were identified in the chromosome of an Aeromonas jandaei isolate from retail fish. The variants showed 79.9% and 80.0% amino acid identity to MCR-7.1 and MCR-3.1, respectively, and increased colistin resistance 128- to 256-fold in Aeromonas salmonici...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.11.013

    authors： Liu D,Song H,Ke Y,Xia J,Shen Y,Ou Y,Hao Y,He J,Li X,Zhou Y,Fu J,Wang Y,Lv Z,Wu C

    更新日期：2020-01-01 00:00:00

  • Clinical outcomes and therapeutic options of bloodstream infections caused by extended-spectrum beta-lactamase-producing Escherichia coli.

    abstract：:This study was conducted to assess the clinical outcomes of bloodstream infections caused by extended-spectrum beta-lactamase-producing Escherichia coli. A total of 53 patients were included in the study. Forty-five patients (84.9%) received appropriate antibiotic therapy. Initial empirical treatment was appropriate i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2005.06.012

    authors： Metan G,Zarakolu P,Cakir B,Hascelik G,Uzun O

    更新日期：2005-09-01 00:00:00

  • Mupirocin resistance among Malaysian isolates of methicillin-resistant Staphylococcus aureus.

    abstract：:Four hundred methicillin-resistant Staphylococcus aureus strains (MRSA) from different geographical areas in Malaysia were tested for mupirocin susceptibility using minimum inhibitory concentration (MIC) determination. The majority of these strains (98.75%) were susceptible to mupirocin with MICs of < or = 4 mg/l. Fif...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00314-4

    authors： Norazah A,Koh YT,Ghani Kamel A,Alias R,Lim VK

    更新日期：2001-05-01 00:00:00

  • Antibacterial activity of moxifloxacin against periodontal anaerobic pathogens involved in systemic infections.

    abstract：:The in vitro activity of moxifloxacin was compared with that of penicillin G, amoxycillin/clavulanate, cefoxitin, erythromycin, clindamycin and metronidazole against 158 isolates associated with periodontal infections. MIC(50)/MIC(90) values of moxifloxacin were respectively 0.06/0.5 mg/l for Porphyromonas gingivalis ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00190-5

    authors： Milazzo I,Blandino G,Musumeci R,Nicoletti G,Lo Bue AM,Speciale A

    更新日期：2002-12-01 00:00:00

  • Antimicrobial susceptibilities of Campylobacter isolated from food-producing animals on farms (1999-2001): results from the Japanese Veterinary Antimicrobial Resistance Monitoring Program.

    abstract：:Nationwide monitoring of antimicrobial resistance in Campylobacter isolated from food-producing animals on farms was performed in Japan. A total of 468 Campylobacter isolates were obtained during the period from June 1999 to March 2001. Campylobacter species showed high frequencies of resistance to oxytetracycline and...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.03.017

    authors： Ishihara K,Kira T,Ogikubo K,Morioka A,Kojima A,Kijima-Tanaka M,Takahashi T,Tamura Y

    更新日期：2004-09-01 00:00:00

  • Prevalence of meticillin-resistant and -susceptible coagulase-negative staphylococci with the first detection of the mecC gene among cows, humans and manure in Tunisia.

    abstract：:In Europe, a novel mecA homologue - mecC (formerly mecALGA251) - has emerged recently in staphylococci from animals, humans and the environment. This paper reports the first occurrence of the mecC gene in Staphylococcus sciuri from cows and manure in Tunisia and Africa. Forty-nine coagulase-negative staphylococci (CNS...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.10.007

    authors： Dhaouadi S,Soufi L,Campanile F,Dhaouadi F,Sociale M,Lazzaro L,Cherif A,Stefani S,Elandoulsi RB

    更新日期：2020-01-01 00:00:00