当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Chemosensitisation of drug-resistant and drug-sensitive yeast cells to antifungals.

Chemosensitisation of drug-resistant and drug-sensitive yeast cells to antifungals.

Abstract：

:Multidrug resistance in yeast results from overexpression of genes encoding drug efflux transporters owing to gain-of-function mutations in transcription factors regulating their expression. We have screened a library of synthetic compounds for modulators of drug resistance using the multidrug-resistant Saccharomyces cerevisiae pdr3-9 mutant strain. One of the compounds, 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine (CTBT), displayed weak antifungal activity and strongly inhibited the growth of yeast cells in combination with subinhibitory concentrations of other antifungals with a different mode of action. Biological activity of CTBT was demonstrated in Saccharomyces, Kluyveromyces and Candida yeast species grown on solid and in liquid media. The chemosensitising effect of CTBT, manifested as increased antifungal activity of fluconazole, was demonstrated in yeast mutant strains with deleted genes encoding the major multidrug resistance transcription factors Yap1p, Pdr1p and Pdr3p as well as the drug efflux pumps Pdr5p and Snq2p in S. cerevisiae or their counterparts in Candida albicans and Candida glabrata, named Cdr1p and Mdr1p, respectively. Importantly, CTBT also increased the sensitivity to fluconazole in multidrug-resistant cells overexpressing the efflux pumps. Yeast cells grown in the presence of subinhibitory concentrations of CTBT exhibited an altered sterol composition and a slightly enhanced accumulation of Rhodamine 6G, which suggests that the plasma membrane plays a role in sensitisation. This novel chemosensitisation by CTBT that can overcome multidrug resistance in yeast may prove useful in combined treatment of infections caused by drug-resistant fungal pathogens.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Cernicka J,Kozovska Z,Hnatova M,Valachovic M,Hapala I,Riedl Z,Hajós G,Subik J

doi

10.1016/j.ijantimicag.2006.08.037

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

170-8

issue

2

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(06)00397-9

journal_volume

29

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Clinical aspects and cost of invasive Streptococcus pneumoniae infections in children: resistant vs. susceptible strains.

    abstract：:Invasive Streptococcus pneumoniae infections in children are associated with serious consequences in terms of morbidity and mortality. The main objective of the study was to determine if invasive infections caused by penicillin-resistant Streptococcus pneumoniae (PRSP) differed in clinical presentation, outcome, risk ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00127-9

    authors： Quach C,Weiss K,Moore D,Rubin E,McGeer A,Low DE

    更新日期：2002-08-01 00:00:00

  • Evaluation of the activity of fusidic acid tested against contemporary Gram-positive clinical isolates from the USA and Canada.

    abstract：:We evaluated the antimicrobial activity of fusidic acid (CEM-102) against 1140 clinical strains of Gram-positive bacteria obtained from patients with bacteraemia or skin and skin-structure infections collected in more than 30 medical centres in the USA and Canada over a 10-year period (1997-2006). Fusidic acid was ver...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2009.10.023

    authors： Pfaller MA,Castanheira M,Sader HS,Jones RN

    更新日期：2010-03-01 00:00:00

  • suPAR: The unspecific marker for disease presence, severity and prognosis.

    abstract：:Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most promising biomarker is solub...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2015.10.011

    authors： Eugen-Olsen J,Giamarellos-Bourboulis EJ

    更新日期：2015-12-01 00:00:00

  • Antibiotic susceptibilities of livestock isolates of leptospira.

    abstract：:Leptospirosis is the most common zoonotic disease and is endemic worldwide. The antibiotic susceptibilities of Leptospira strains isolated from both humans and animals are poorly documented. This issue is particularly important for isolates from food-producing animals which are regularly exposed to antibiotic treatmen...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.12.024

    authors： Liegeon G,Delory T,Picardeau M

    更新日期：2018-05-01 00:00:00

  • In vitro pharmacodynamic evaluation of garenoxacin against quinolone-resistant Streptococcus pneumoniae.

    abstract：:The bactericidal activity and resistance selectivity of garenoxacin against Streptococcus pneumoniae with mutations in ParC (S79F) or both GyrA (S81F) and ParC (D83Y and K137N) were investigated using in vitro pharmacokinetic models simulating plasma concentrations for a standard clinical regimen [400mg once daily (q....

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2011.09.021

    authors： Fukuda Y,Takahata M,Sugiura Y,Shinmura Y,Nomura N

    更新日期：2012-02-01 00:00:00

  • Target site bacterial killing of cefpirome and fosfomycin in critically ill patients.

    abstract：:We employed an in-vivo pharmacokinetic/in-vitro pharmacodynamic method to simulate bacterial killing in plasma and the interstitium of skeletal muscle tissue after intravenous administration of 2 g of cefpirome and 8 g of fosfomycin alone and in combination to patients with sepsis. Interstitial antimicrobial concentra...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(03)00047-5

    authors： Zeitlinger MA,Marsik C,Georgopoulos A,Müller M,Heinz G,Joukhadar C

    更新日期：2003-06-01 00:00:00

  • Increasing burden of urinary tract infections due to intrinsic colistin-resistant bacteria in hospitals in Marseille, France.

    abstract：:The emergence of multidrug-resistant (MDR) Gram-negative bacteria has become a major public health problem, eliciting renewed interest in colistin, an old antibiotic that is now routinely used to treat MDR bacterial infections. Here we investigated whether colistin use has affected the prevalence of infections due to ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2014.10.010

    authors： Abat C,Desboves G,Olaitan AO,Chaudet H,Roattino N,Fournier PE,Colson P,Raoult D,Rolain JM

    更新日期：2015-02-01 00:00:00

  • Differences in the evolution of imipenem susceptibility among Klebsiella pneumoniae and Escherichia coli isolates during a 6-year period in a tertiary care hospital.

    abstract：:The evolution of imipenem disk-diffusion susceptibility results of 2652 strains of Klebsiella pneumoniae and 7596 Escherichia coli isolated during the period 2000-2005 were analysed. Screening for production of metallo-beta-lactamases was performed using the EDTA-synergy method. The percentage rate of K. pneumoniae is...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.09.010

    authors： Papaparaskevas J,Pantazatou A,Stefanou I,Mela V,Galatidis N,Avlamis A

    更新日期：2007-02-01 00:00:00

  • Susceptibility of lactic acid bacteria, bifidobacteria and other bacteria of intestinal origin to chemotherapeutic agents.

    abstract：:Chemotherapy is a cornerstone of cancer treatment but it can have serious side effects, such as intestinal mucositis. This work reports the susceptibility/resistance profiles of 34 species of lactic acid bacteria (LAB), bifidobacteria and other intestinal bacteria from different collections to various chemotherapeutic...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.07.011

    authors： Flórez AB,Sierra M,Ruas-Madiedo P,Mayo B

    更新日期：2016-11-01 00:00:00

  • Old agent, new experience: colistin use in the paediatric Intensive Care Unit--a multicentre study.

    abstract：:Nosocomial infections caused by multidrug-resistant (MDR) microorganisms are a common problem around the world, especially in Intensive Care Units. The aim of this study was to investigate the efficacy and safety of colistin therapy in paediatric patients with severe nosocomial infections caused by MDR Gram-negative b...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijantimicag.2012.04.010

    authors： Paksu MS,Paksu S,Karadag A,Sensoy G,Asilioglu N,Yildizdas D,Akyildiz BN,Kendirli T,Demirkol D,Akgun M,Alp E,Ciftci E,Guney AK,Murat N

    更新日期：2012-08-01 00:00:00

  • Eradication of meticillin-resistant Staphylococcus aureus from human skin by the novel LL-37-derived peptide P10 in four pharmaceutical ointments.

    abstract：:Skin bacterial colonization/infection is a frequent cause of morbidity in patients with chronic wounds and allergic/inflammatory skin diseases. This study aimed to develop a novel approach to eradicate meticillin-resistant Staphylococcus aureus (MRSA) from human skin. To achieve this, the stability and antibacterial a...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.07.014

    authors： Nibbering PH,Göblyös A,Adriaans AE,Cordfunke RA,Ravensbergen B,Rietveld MH,Zwart S,Commandeur S,van Leeuwen R,Haisma EM,Schimmel KJM,den Hartigh J,Drijfhout JW,Ghalbzouri AE

    更新日期：2019-11-01 00:00:00

  • Daptomycin activity tested against 164457 bacterial isolates from hospitalised patients: summary of 8 years of a Worldwide Surveillance Programme (2005-2012).

    abstract：:We report the results of 8 years (2005-2012) of the Daptomycin Surveillance Programme Worldwide. Consecutive non-duplicate bacterial isolates (prevalence design) were collected from patients with documented infections in 410 medical centres and were susceptibility tested by reference broth microdilution methods. A tot...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2014.01.018

    authors： Sader HS,Farrell DJ,Flamm RK,Jones RN

    更新日期：2014-05-01 00:00:00

  • Epidemiological shifts in opportunistic and nosocomial Candida infections: mycological aspects.

    abstract：:Increases in the prevalence of yeast species other than C. albicans as agents of disseminated mycoses in immunosuppressed patients and of fluconazole-resistant C. albicans isolates from patients infected with HIV indicate changes in the epidemiology of Candida infections. The precise reasons for alterations in prevale...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(95)00049-6

    authors： Odds FC

    更新日期：1996-02-01 00:00:00

  • Insights and clinical perspectives of daptomycin resistance in Staphylococcus aureus: A review of the available evidence.

    abstract：:The emergence of glycopeptide reduced susceptibility and resistance in Staphylococcus aureus strains is a growing clinical problem that poses significant clinical challenges in treatment. Its development is a complex and novel process involving many subtle physiological changes in the micro-organism. Daptomycin is the...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2015.05.008

    authors： Stefani S,Campanile F,Santagati M,Mezzatesta ML,Cafiso V,Pacini G

    更新日期：2015-09-01 00:00:00

  • In vitro activities of various piperacillin and sulbactam combinations against bacterial pathogens isolated from Intensive Care Units in Taiwan: SMART 2004 programme data.

    abstract：:We investigated the in vitro activity of various piperacillin and sulbactam combinations against Gram-negative bacterial isolates from Intensive Care Units (ICUs) in Taiwan. Antimicrobial susceptibility testing of 1030 bacterial isolates recovered from ICUs of nine major teaching hospitals was performed using the agar...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.02.017

    authors： Hung MN,Hsueh PR,Chang HT,Lee WS,Chou MY,Chen IS,Wang JH,Lin CF,Shyr JM,Ko WC,Wu JJ,Liu YC,Huang WK,Teng LJ,Liu CY,Luh KT

    更新日期：2007-02-01 00:00:00

  • Comparative in vitro activities of four new fluoroquinolones against Streptococcus pneumoniae determined by Etest.

    abstract：:Clinafloxacin, levofloxacin, sparfloxacin and trovafloxacin were tested by Etest against 188 Streptococcus pneumoniae isolates. Clinafloxacin and trovafloxacin were 2-4-fold more potent than sparfloxacin and 8-fold more than levofloxacin. Two isolates, both serotype 6, with high-level quinolone resistance (> or = 8 mi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(97)00053-8

    authors： Waites K,Brookings E,Nix S,Robinson A,Gray B,Swiatlo E

    更新日期：1998-02-01 00:00:00

  • Use of imipenem as empirical treatment of febrile neutropenia.

    abstract：:Based on past information from the literature and our own review, it appears that imipenem can be used effectively as an initial empirical therapy of febrile neutropenia, as a monotherapy, even in patients with haematological malignancies. The response rate is outstanding in microbiologically documented infections, na...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(03)00002-5

    authors： Klastersky JA

    更新日期：2003-05-01 00:00:00

  • Genetic diversity of Streptococcus pneumoniae in Tunisia.

    abstract：OBJECTIVES:This study aimed to explore the genetic diversity of Streptococcus pneumoniae isolates in a Tunisian pneumology hospital. METHODS:A total of 141 S. pneumoniae strains isolated between 2009-2016 in the microbiology laboratory at A. Mami Hospital of Pneumology were investigated. Antimicrobial susceptibility t...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.09.023

    authors： Midouni B,Mehiri E,Ghariani A,Draoui H,Essalah L,Bouzouita I,Raoult D,Slim-Saidi L,Fournier PE

    更新日期：2019-01-01 00:00:00

  • Drug combinations with amoxycillin reduce selection of clarithromycin resistance during Helicobacter pylori eradication therapy.

    abstract：:This study investigated the relationship between the drug combinations of the eradication regimens and the prevalence of acquired resistance to clarithromycin. Of 540 patients treated with anti-Helicobacter pylori regimens containing clarithromycin, 55 patients (31 males, mean age, 45.6 years) with failed eradication ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00456-3

    authors： Murakami K,Fujioka T,Okimoto T,Sato R,Kodama M,Nasu M

    更新日期：2002-01-01 00:00:00

  • Forecasting carbapenem resistance from antimicrobial consumption surveillance: Lessons learnt from an OXA-48-producing Klebsiella pneumoniae outbreak in a West London renal unit.

    abstract：:This study aimed to forecast the incidence rate of carbapenem resistance and to assess the impact of an antimicrobial stewardship intervention using routine antimicrobial consumption surveillance data. Following an outbreak of OXA-48-producing Klebsiella pneumoniae (January 2008-April 2010) in a renal cohort in London...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.03.005

    authors： Gharbi M,Moore LS,Gilchrist M,Thomas CP,Bamford K,Brannigan ET,Holmes AH

    更新日期：2015-08-01 00:00:00

  • In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis.

    abstract：:The recent re-emergence of tuberculosis, especially the multidrug-resistant cases, has highlighted the importance of screening effective novel drugs against Mycobacterium tuberculosis. In this study, the in vitro activities of small peptides isolated from snake venom were investigated against multidrug-resistant M. tu...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(03)00110-9

    authors： Xie JP,Yue J,Xiong YL,Wang WY,Yu SQ,Wang HH

    更新日期：2003-08-01 00:00:00

  • An intervention programme for the management of multidrug-resistant tuberculosis in France.

    abstract：:As shown in a previous study, the outcome of multidrug-resistant tuberculosis (MDR-TB) in France is not satisfactory (41% success rate). To improve the management and outcome of patients with MDR-TB, a prospective intervention study was carried out in 1998-1999 by National Reference Centre (NRC) staff. NRC staff conta...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.11.023

    authors： Uffredi ML,Truffot-Pernot C,Dautzenberg B,Renard M,Jarlier V,Robert J

    更新日期：2007-04-01 00:00:00

  • Pan-European resistance monitoring programmes encompassing food-borne bacteria and target pathogens of food-producing and companion animals.

    abstract：:Antimicrobial resistance is a concern both for animal and human health. Veterinary programmes monitoring resistance of animal and zoonotic pathogens are therefore essential. Various European countries have implemented national surveillance programmes, particularly for zoonotic and commensal bacteria, and the European ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2012.11.004

    authors： de Jong A,Thomas V,Klein U,Marion H,Moyaert H,Simjee S,Vallé M

    更新日期：2013-05-01 00:00:00

  • A multidisciplinary approach to antimicrobial stewardship: evolution into the 21st century.

    abstract：:In the 21st century, we face the problems of escalating antibiotic resistance, difficult-to-treat infections and slowed new drug development. Healthcare practitioners are increasingly recognising the importance of good antimicrobial stewardship. Various strategies such as formulary management, prior approval, clinical...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2004.09.001

    authors： Paskovaty A,Pflomm JM,Myke N,Seo SK

    更新日期：2005-01-01 00:00:00

  • Transcriptional profiling of the two-component regulatory system VraSR in Staphylococcus aureus with low-level vancomycin resistance.

    abstract：:The objective of this study was to comprehensively identify the target genes regulated by the two-component regulatory system VraSR in Staphylococcus aureus and to clarify the role of VraSR in low-level vancomycin resistance. Expression of vraS was determined by real-time quantitative reverse transcriptase PCR (qRT-PC...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.02.003

    authors： Chen H,Xiong Z,Liu K,Li S,Wang R,Wang X,Zhang Y,Wang H

    更新日期：2016-05-01 00:00:00

  • Variability of piperacillin concentrations in relation to tazobactam concentrations in critically ill patients.

    abstract：:Therapeutic drug monitoring for critically ill patients receiving piperacillin/tazobactam is described as a useful tool. However, the minimum inhibitory concentration of piperacillin depends on a sufficiently high concentration of tazobactam in case of β-lactamase-producing strains. Therefore, the relationship between...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.06.013

    authors： Zander J,Döbbeler G,Nagel D,Scharf C,Huseyn-Zada M,Jung J,Frey L,Vogeser M,Zoller M

    更新日期：2016-10-01 00:00:00

  • Linezolid pharmacodynamics with Staphylococcus aureus in an in vitro dynamic model.

    abstract：:To describe the relationship between the ratio of the 24-h area under the concentration-time curve (AUC(24)) to minimum inhibitory concentration (MIC) as well as the effect of linezolid on Staphylococcus aureus, the killing kinetics of three S. aureus strains was studied by in vitro simulation of 5-day antibiotic dosi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.09.006

    authors： Strukova EN,Smirnova MV,Vostrov SN,Lubenko IY,Firsov AA,Zinner SH,Portnoy YA

    更新日期：2009-03-01 00:00:00

  • Therapeutic potential of dalbavancin in a rat model of methicillin-resistant Staphylococcus aureus (MRSA)-osteomyelitis.

    abstract：:Bacterial osteomyelitis is a major clinical challenge in human and veterinary patients. This infection is an infrequent but feared complication of orthopedic surgery and is mainly caused by methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to evaluate the efficacy of dalbavancin (dosed for ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.106021

    authors： Silva V,Miranda C,Antão HS,Guimarães J,Prada J,Pires I,Maltez L,Pereira JE,Capelo JL,Igrejas G,Poeta P

    更新日期：2020-07-01 00:00:00

  • Daptomycin-containing regimens for treatment of Gram-positive endocarditis.

    abstract：PURPOSE:Infective endocarditis (IE) is a severe infection, and a leading cause of mortality and morbidity. Due to its favourable microbiological and pharmacological characteristics, daptomycin is routinely used in clinical practice for treating IE. METHODS:A prospective study was conducted at a large tertiary-care hos...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.08.011

    authors： Russo A,Peghin M,Givone F,Ingani M,Graziano E,Bassetti M

    更新日期：2019-10-01 00:00:00

  • Strategies for the control of catheter encrustation.

    abstract：:Two general strategies have been adopted to develop catheter materials that resist encrustaion by bacterial biofilms: (a) the incorporation of antimicrobial agents into the polymers and (b) the production of materials with surface properties which prevent the adherence of bacterial cells. Our experience to develop non...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00091-2

    authors： Stickler DJ,Evans A,Morris N,Hughes G

    更新日期：2002-06-01 00:00:00